|
WO2010045659A1
(en)
|
2008-10-17 |
2010-04-22 |
American Gene Technologies International Inc. |
Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
KR20140041505A
(ko)
|
2011-04-29 |
2014-04-04 |
셀렉타 바이오사이언시즈, 인크. |
조절 b 세포 유도를 위한 관용원성 합성 나노운반체
|
|
US12024568B2
(en)
|
2012-09-13 |
2024-07-02 |
Cornell University |
Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
DK2931897T3
(en)
|
2012-12-12 |
2018-02-05 |
Broad Inst Inc |
CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS
|
|
HUE052599T2
(hu)
|
2013-05-03 |
2021-05-28 |
Selecta Biosciences Inc |
CD4+ szabályozó T-sejtek fokozására szolgáló eljárások és készítmények
|
|
KR20160019553A
(ko)
*
|
2013-06-17 |
2016-02-19 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유사분열 후 세포의 질병 및 장애를 표적화하고 모델링하기 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
HK1222673A1
(zh)
*
|
2013-07-12 |
2017-07-07 |
The Children's Hospital Of Philadelphia |
Aav载体和用於抗aav(腺相关病毒)中和抗体的检测
|
|
KR20240090694A
(ko)
*
|
2013-07-22 |
2024-06-21 |
더 칠드런스 호스피탈 오브 필라델피아 |
변종 ａａｖ 및 조성물, 세포, 기관 및 조직으로의 유전자 전이를 위한 방법 및 용도
|
|
WO2015035190A1
(en)
*
|
2013-09-05 |
2015-03-12 |
Cornell University |
Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
|
|
MX2016007325A
(es)
|
2013-12-12 |
2017-07-19 |
Broad Inst Inc |
Composiciones y metodos de uso de sistemas crispr-cas en desordenes debidos a repeticion de nucleotidos.
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
BR112016013207A2
(pt)
|
2013-12-12 |
2017-09-26 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para o hbv e distúrbios e doenças virais
|
|
AU2014361781B2
(en)
|
2013-12-12 |
2021-04-01 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015191508A1
(en)
|
2014-06-09 |
2015-12-17 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
US10781459B2
(en)
|
2014-06-20 |
2020-09-22 |
University Of Florida Research Foundation, Incorporated |
Methods of packaging multiple adeno-associated virus vectors
|
|
AU2015311704B2
(en)
|
2014-09-07 |
2021-12-09 |
Selecta Biosciences, Inc. |
Methods and compositions for attenuating gene editing anti-viral transfer vector immune responses
|
|
WO2016054554A1
(en)
*
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Heterologous targeting peptide grafted aavs
|
|
CN107002096A
(zh)
*
|
2014-10-06 |
2017-08-01 |
阿罗根有限公司 |
基于aav的基因疗法
|
|
AU2015335923B2
(en)
*
|
2014-10-21 |
2021-04-29 |
University Of Massachusetts |
Recombinant AAV variants and uses thereof
|
|
SG11201703148TA
(en)
|
2014-11-05 |
2017-05-30 |
Voyager Therapeutics Inc |
Aadc polynucleotides for the treatment of parkinson's disease
|
|
GB201420139D0
(en)
|
2014-11-12 |
2014-12-24 |
Ucl Business Plc |
Factor IX gene therapy
|
|
CN119876138A
(zh)
|
2014-11-14 |
2025-04-25 |
沃雅戈治疗公司 |
调节性多核苷酸
|
|
CA3193811A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
HK1245326A1
(zh)
|
2014-12-12 |
2018-08-24 |
Voyager Therapeutics, Inc. |
用於生产scaav的组合物和方法
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
WO2016164920A1
(en)
*
|
2015-04-09 |
2016-10-13 |
Cornell University |
Gene therapy to prevent reactions to allergens
|
|
JP6573991B2
(ja)
*
|
2015-05-28 |
2019-09-11 |
コーネル ユニヴァーシティー |
血管性浮腫の治療としてのｃ１ｅｉのアデノ随伴ウイルス介在性送達
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
TWI813532B
(zh)
|
2015-06-18 |
2023-09-01 |
美商博得學院股份有限公司 |
降低脱靶效應的ｃｒｉｓｐｒ酶突變
|
|
WO2016210170A1
(en)
|
2015-06-23 |
2016-12-29 |
The Children's Hospital Of Philadelphia |
Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
JP6890831B2
(ja)
|
2015-07-08 |
2021-06-18 |
アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド |
Ｈｉｖ予備免疫化および免疫療法
|
|
WO2017096162A1
(en)
|
2015-12-02 |
2017-06-08 |
Voyager Therapeutics, Inc. |
Assays for the detection of aav neutralizing antibodies
|
|
US10137144B2
(en)
|
2016-01-15 |
2018-11-27 |
American Gene Technologies International Inc. |
Methods and compositions for the activation of gamma-delta T-cells
|
|
DK3402483T3
(da)
|
2016-01-15 |
2024-01-02 |
American Gene Tech Int Inc |
Fremgangsmåder og sammensætninger til aktivering af gamma-delta-T-celler
|
|
US10888613B2
(en)
|
2016-02-08 |
2021-01-12 |
American Gene Technologies International Inc. |
Method of producing cells resistant to HIV infection
|
|
DK3426777T3
(da)
|
2016-03-09 |
2022-04-25 |
American Gene Tech Int Inc |
Kombinationsvektorer og fremgangsmåder til behandling af cancer
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
EP3448987A4
(en)
|
2016-04-29 |
2020-05-27 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
WO2017197301A1
(en)
*
|
2016-05-12 |
2017-11-16 |
Hanley Brian P |
Safe delivery of crispr and other gene therapies to large fractions of somatic cells in humans and animals
|
|
CA3024448C
(en)
|
2016-05-18 |
2025-09-09 |
Voyager Therapeutics, Inc. |
MODULATING POLYNUCLEOTIDES
|
|
CA3024449A1
(en)
|
2016-05-18 |
2017-11-23 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating huntington's disease
|
|
US11976292B2
(en)
*
|
2016-06-08 |
2024-05-07 |
American Gene Technologies International Inc. |
Non-integrating viral delivery system and methods related thereto
|
|
IL284348B2
(en)
|
2016-07-08 |
2025-06-01 |
American Gene Tech Int Inc |
Hiv pre-immunization and immunotherapy
|
|
JP7176756B2
(ja)
|
2016-07-21 |
2022-11-22 |
アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド |
パーキンソン病を処置するためのウイルスベクター
|
|
WO2018044933A1
(en)
|
2016-08-30 |
2018-03-08 |
The Regents Of The University Of California |
Methods for biomedical targeting and delivery and devices and systems for practicing the same
|
|
EP3526333A4
(en)
|
2016-10-13 |
2020-07-29 |
University of Massachusetts |
AAV CAPSIDE DESIGNS
|
|
CA3040179A1
(en)
|
2016-10-19 |
2018-04-26 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
|
CN110139933B
(zh)
|
2016-11-09 |
2024-03-08 |
英特瑞克斯顿股份有限公司 |
共济蛋白表达构建体
|
|
BR112019016769A2
(pt)
*
|
2017-02-15 |
2020-05-26 |
The University Of North Carolina At Chapel Hill |
Métodos e composições para transferência genética através da vasculatura
|
|
WO2018169811A1
(en)
|
2017-03-11 |
2018-09-20 |
Selecta Biosciences, Inc. |
Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
|
|
CA3057142A1
(en)
|
2017-04-03 |
2018-10-11 |
American Gene Technologies International Inc. |
Compositions and methods for treating phenylketonuria
|
|
WO2018191450A2
(en)
|
2017-04-14 |
2018-10-18 |
National Taiwan University Hospital |
Gene therapy for aadc deficiency
|
|
EP3618839A4
(en)
|
2017-05-05 |
2021-06-09 |
Voyager Therapeutics, Inc. |
COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
JP2020518259A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
ハンチントン病治療組成物および方法
|
|
CN110945127B
(zh)
|
2017-05-22 |
2024-07-12 |
武田药品工业株式会社 |
用于血友病b的基因疗法的编码具有增加的表达的重组fix的病毒载体
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
CA3064442A1
(en)
|
2017-06-16 |
2018-12-20 |
American Gene Technologies International Inc. |
Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells
|
|
JP7229989B2
(ja)
|
2017-07-17 |
2023-02-28 |
ボイジャー セラピューティクス インコーポレイテッド |
軌道アレイガイドシステム
|
|
US20200263199A1
(en)
|
2017-09-29 |
2020-08-20 |
Voyager Therapeutics, Inc. |
Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery
|
|
WO2019079242A1
(en)
|
2017-10-16 |
2019-04-25 |
Voyager Therapeutics, Inc. |
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
TW202413649A
(zh)
|
2017-10-16 |
2024-04-01 |
美商航海家醫療公司 |
肌萎縮性脊髓側索硬化症(als)之治療
|
|
US20210371877A1
(en)
*
|
2017-12-18 |
2021-12-02 |
Spark Therapeutics, Inc. |
Adeno-associated virus (aav) vector lipid nanoparticle compositions and methods of use
|
|
CN111902164A
(zh)
|
2018-02-01 |
2020-11-06 |
同源药物公司 |
用于恢复pah基因功能的腺相关病毒组合物及其使用方法
|
|
US10610606B2
(en)
|
2018-02-01 |
2020-04-07 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
|
|
CN112041437A
(zh)
|
2018-02-19 |
2020-12-04 |
同源药物公司 |
用于恢复f8基因功能的腺相关病毒组合物和其使用方法
|
|
WO2019178288A2
(en)
*
|
2018-03-13 |
2019-09-19 |
The Regents Of The University Of California |
Virus-like nanocapsid for oral delivery of insulin
|
|
US20210363191A1
(en)
|
2018-04-03 |
2021-11-25 |
Stridebio, Inc. |
Antibody-evading virus vectors
|
|
CN112543766A
(zh)
|
2018-04-03 |
2021-03-23 |
斯特里迪比奥公司 |
抗体逃避性病毒载体
|
|
CA3094465A1
(en)
|
2018-04-03 |
2019-10-10 |
Stridebio, Inc. |
Virus vectors for targeting ophthalmic tissues
|
|
US12054724B2
(en)
|
2018-04-10 |
2024-08-06 |
President And Fellows Of Harvard College |
AAV vectors encoding clarin-1 or GJB2 and uses thereof
|
|
SG11202011296VA
(en)
|
2018-05-15 |
2020-12-30 |
Voyager Therapeutics Inc |
Compositions and methods for the treatment of parkinson's disease
|
|
US11466055B2
(en)
*
|
2018-06-06 |
2022-10-11 |
The Regents Of The University Of California |
Virus-like nanoparticles for oral delivery
|
|
US10842885B2
(en)
|
2018-08-20 |
2020-11-24 |
Ucl Business Ltd |
Factor IX encoding nucleotides
|
|
GB201813528D0
(en)
|
2018-08-20 |
2018-10-03 |
Ucl Business Plc |
Factor IX encoding nucleotides
|
|
US12281321B2
(en)
|
2018-09-28 |
2025-04-22 |
Voyager Therapeutics, Inc. |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
MX2021005727A
(es)
*
|
2018-11-16 |
2021-09-10 |
Spark Therapeutics Inc |
Ensayo in vitro para detectar potenciadores e inhibidores de la transducción de vectores virales adenoasociados (aav) y/o para detectar o cuantificar anticuerpos de unión anti-aav.
|
|
BR112021018776A2
(pt)
|
2019-03-21 |
2021-11-30 |
Stridebio Inc |
Vetores de vírus adenoassociado recombinante
|
|
EP3722434B1
(en)
|
2019-04-12 |
2022-07-27 |
Freeline Therapeutics Limited |
Plasmid system
|
|
AU2020272557A1
(en)
|
2019-04-12 |
2021-12-09 |
Ascend Gene And Cell Therapies Ltd |
Plasmid system
|
|
CN114207440A
(zh)
|
2019-06-04 |
2022-03-18 |
西莱克塔生物科技公司 |
聚乙二醇化尿酸酶的制剂和剂量
|
|
US20200405824A1
(en)
*
|
2019-06-26 |
2020-12-31 |
University Of Washington |
Use of ribonucleotide reductase alone or in combination with micro-dystrophin to treat duchenne muscular dystrophy striated muscle disease
|
|
MX2022001425A
(es)
*
|
2019-08-01 |
2022-05-02 |
Univ North Carolina Chapel Hill |
Composiciones y metodos para la union de anticuerpos y la inhibicion de anticuerpos neutralizantes.
|
|
US11155835B2
(en)
*
|
2019-08-19 |
2021-10-26 |
The Catholic University Of America |
Prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells
|
|
KR20220083714A
(ko)
|
2019-10-17 |
2022-06-20 |
스트라이드바이오 인코포레이티드 |
니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터
|
|
CN114929869A
(zh)
|
2019-11-08 |
2022-08-19 |
科亚韦治疗公司 |
修饰的腺相关病毒载体及将其递送至中枢神经系统
|
|
IL293658A
(en)
*
|
2019-12-10 |
2022-08-01 |
Homology Medicines Inc |
Adeno-associated virus preparations and a method of using them
|
|
TW202140791A
(zh)
|
2020-01-13 |
2021-11-01 |
美商霍蒙拉奇醫藥公司 |
治療苯酮尿症之方法
|
|
CA3179895A1
(en)
*
|
2020-04-24 |
2021-10-28 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods for preventing induction of immune responses to the transduced cells expressing a transgene product after ocular gene therapy
|
|
TW202208632A
(zh)
|
2020-05-27 |
2022-03-01 |
美商同源醫藥公司 |
用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
|
|
EP4200408A1
(en)
|
2020-08-19 |
2023-06-28 |
Sarepta Therapeutics, Inc. |
Adeno-associated virus vectors for treatment of rett syndrome
|
|
US12129287B2
(en)
|
2020-09-14 |
2024-10-29 |
President And Fellows Of Harvard College |
Recombinant adeno associated virus encoding clarin-1 and uses thereof
|
|
GB202016254D0
(en)
|
2020-10-13 |
2020-11-25 |
Freeline Therapeutics Ltd |
Plasmid system
|
|
CN116802279A
(zh)
|
2020-11-06 |
2023-09-22 |
科亚韦治疗公司 |
内酰胺修饰的腺相关病毒载体
|
|
EP4727963A2
(en)
*
|
2023-06-14 |
2026-04-22 |
Fractyl Health, Inc. |
Gene therapies for metabolic disorders
|
|
EP4628576A1
(en)
|
2024-04-07 |
2025-10-08 |
Ascend Advanced Therapies GmbH |
Microrna molecules for use in methods for improving recombinant aav production
|
|
WO2025238067A1
(en)
|
2024-05-15 |
2025-11-20 |
Ascend Advanced Therapies Gmbh |
Novel vector system for aav production
|