JP2014533297A - フェブキソスタットの多形の調製方法 - Google Patents

フェブキソスタットの多形の調製方法 Download PDF

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Publication number
JP2014533297A
JP2014533297A JP2014541812A JP2014541812A JP2014533297A JP 2014533297 A JP2014533297 A JP 2014533297A JP 2014541812 A JP2014541812 A JP 2014541812A JP 2014541812 A JP2014541812 A JP 2014541812A JP 2014533297 A JP2014533297 A JP 2014533297A
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JP
Japan
Prior art keywords
febuxostat
solvent
ester
ethyl acetate
process according
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Pending
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JP2014541812A
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English (en)
Japanese (ja)
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JP2014533297A5 (https=
Inventor
ラマコテスワラ・ラオ・ジェッティ
バラクリシュナ・レディ・ボガラ
サティッシュ・ベラヴェッリ
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Mylan Laboratories Ltd
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Mylan Laboratories Ltd
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Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Publication of JP2014533297A publication Critical patent/JP2014533297A/ja
Publication of JP2014533297A5 publication Critical patent/JP2014533297A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014541812A 2011-11-15 2012-11-14 フェブキソスタットの多形の調製方法 Pending JP2014533297A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3909/CHE/2011 2011-11-15
IN3909CH2011 2011-11-15
PCT/IN2012/000748 WO2013076738A2 (en) 2011-11-15 2012-11-14 Process for the preparation of febuxostat polymorphs

Publications (2)

Publication Number Publication Date
JP2014533297A true JP2014533297A (ja) 2014-12-11
JP2014533297A5 JP2014533297A5 (https=) 2015-12-24

Family

ID=47710247

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014541812A Pending JP2014533297A (ja) 2011-11-15 2012-11-14 フェブキソスタットの多形の調製方法

Country Status (7)

Country Link
US (1) US20140283486A1 (https=)
EP (1) EP2780335B1 (https=)
JP (1) JP2014533297A (https=)
CN (1) CN104114545B (https=)
AU (1) AU2012342011A1 (https=)
CA (1) CA2855923A1 (https=)
WO (1) WO2013076738A2 (https=)

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009279A1 (fr) * 1990-11-30 1992-06-11 Teijin Limited Derive de 2-arylthiazole et composition pharmaceutique contenant ce derive
CN101085761A (zh) * 2007-06-29 2007-12-12 上海华拓医药科技发展股份有限公司 非布他特微晶及其组合物
CN101139325A (zh) * 2006-09-07 2008-03-12 上海医药工业研究院 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法
CN101386605A (zh) * 2008-10-23 2009-03-18 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
CN101412700A (zh) * 2007-10-19 2009-04-22 上海医药工业研究院 非布司他的晶型及其制备方法
CN101671315A (zh) * 2009-08-19 2010-03-17 何广卫 非布索坦的新晶型及其制备方法
CN101759656A (zh) * 2008-12-12 2010-06-30 重庆医药工业研究院有限责任公司 非布司他新晶型及其制备方法
CN101768150A (zh) * 2009-01-05 2010-07-07 北京利乐生制药科技有限公司 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法
CN101817801A (zh) * 2009-08-12 2010-09-01 北京红惠新医药科技有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸新晶型k及其他晶型的制备方法
CN101857578A (zh) * 2009-04-08 2010-10-13 北京海步国际医药科技发展有限公司 非布司他新晶型及制备方法
WO2011107911A1 (en) * 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Polymorph of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid
WO2011139886A2 (en) * 2010-04-29 2011-11-10 Dr. Reddy's Laboratories Ltd. Preparation of febuxostat
WO2012140632A1 (en) * 2011-04-15 2012-10-18 Ranbaxy Laboratories Limited Febuxostat solid dispersion
JP2013531020A (ja) * 2010-07-13 2013-08-01 インテルキム、ソシエダッド アノニマ ２−［３−シアノ−４−（２−ｉ−ブトキシ）フェニル］−４−メチル−５−チアゾール−カルボン酸（フェブキソスタット）の結晶形Ａを調製するための方法
JP2013531021A (ja) * 2010-07-13 2013-08-01 インテルキム、ソシエダッド アノニマ フェブキソスタットの結晶形ｉｉを調製するための方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566652C (en) 1998-06-19 2008-10-21 Teijin Limited Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof
ES2395381T3 (es) 2009-06-10 2013-02-12 Teva Pharmaceutical Industries Ltd. Formas cristalinas de Febuxostat
WO2011080651A2 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Polymorphic forms of febuxostat
EP2536699A2 (en) * 2010-02-19 2012-12-26 Cadila Healthcare Limited Substantially pure salts of febuxostat and processes for preparation thereof

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009279A1 (fr) * 1990-11-30 1992-06-11 Teijin Limited Derive de 2-arylthiazole et composition pharmaceutique contenant ce derive
CN101139325A (zh) * 2006-09-07 2008-03-12 上海医药工业研究院 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法
CN101085761A (zh) * 2007-06-29 2007-12-12 上海华拓医药科技发展股份有限公司 非布他特微晶及其组合物
CN101412700A (zh) * 2007-10-19 2009-04-22 上海医药工业研究院 非布司他的晶型及其制备方法
CN101386605A (zh) * 2008-10-23 2009-03-18 中国科学院上海药物研究所 非布司他新型晶体及其制备方法
CN101759656A (zh) * 2008-12-12 2010-06-30 重庆医药工业研究院有限责任公司 非布司他新晶型及其制备方法
CN101768150A (zh) * 2009-01-05 2010-07-07 北京利乐生制药科技有限公司 2-[3-氰基-4-异丁氧基苯基]-4-甲基噻唑-5-甲酸晶型及其制备方法
CN101857578A (zh) * 2009-04-08 2010-10-13 北京海步国际医药科技发展有限公司 非布司他新晶型及制备方法
CN101817801A (zh) * 2009-08-12 2010-09-01 北京红惠新医药科技有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸新晶型k及其他晶型的制备方法
CN101671315A (zh) * 2009-08-19 2010-03-17 何广卫 非布索坦的新晶型及其制备方法
WO2011107911A1 (en) * 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Polymorph of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid
WO2011139886A2 (en) * 2010-04-29 2011-11-10 Dr. Reddy's Laboratories Ltd. Preparation of febuxostat
JP2013531020A (ja) * 2010-07-13 2013-08-01 インテルキム、ソシエダッド アノニマ ２−［３−シアノ−４−（２−ｉ−ブトキシ）フェニル］−４−メチル−５−チアゾール−カルボン酸（フェブキソスタット）の結晶形Ａを調製するための方法
JP2013531021A (ja) * 2010-07-13 2013-08-01 インテルキム、ソシエダッド アノニマ フェブキソスタットの結晶形ｉｉを調製するための方法
WO2012140632A1 (en) * 2011-04-15 2012-10-18 Ranbaxy Laboratories Limited Febuxostat solid dispersion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
実験化学講座（続）２ 分離と精製, JPN6009058003, 25 January 1967 (1967-01-25), pages 159 - 162, ISSN: 0003555040 *

Also Published As

Publication number Publication date
NZ625043A (en) 2016-06-24
CN104114545B (zh) 2018-06-01
US20140283486A1 (en) 2014-09-25
WO2013076738A3 (en) 2013-10-10
CN104114545A (zh) 2014-10-22
EP2780335B1 (en) 2019-04-10
CA2855923A1 (en) 2013-05-30
WO2013076738A2 (en) 2013-05-30
EP2780335A2 (en) 2014-09-24
AU2012342011A1 (en) 2014-06-05

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