JP2014533275A5 - - Google Patents
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- Publication number
- JP2014533275A5 JP2014533275A5 JP2014541293A JP2014541293A JP2014533275A5 JP 2014533275 A5 JP2014533275 A5 JP 2014533275A5 JP 2014541293 A JP2014541293 A JP 2014541293A JP 2014541293 A JP2014541293 A JP 2014541293A JP 2014533275 A5 JP2014533275 A5 JP 2014533275A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- group
- glycoloyl
- tetradecahydro
- phenanthren
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 15
- 210000001508 eye Anatomy 0.000 claims description 11
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims description 8
- 206010061218 Inflammation Diseases 0.000 claims description 7
- 230000004054 inflammatory process Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 5
- 206010013774 Dry eye Diseases 0.000 claims description 5
- 208000010217 blepharitis Diseases 0.000 claims description 5
- 210000005252 bulbus oculi Anatomy 0.000 claims description 5
- 210000000795 conjunctiva Anatomy 0.000 claims description 5
- 201000004700 rosacea Diseases 0.000 claims description 5
- 206010010741 Conjunctivitis Diseases 0.000 claims description 4
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims description 4
- 208000028006 Corneal injury Diseases 0.000 claims description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 208000010412 Glaucoma Diseases 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- 208000001344 Macular Edema Diseases 0.000 claims description 4
- 206010025415 Macular oedema Diseases 0.000 claims description 4
- 206010037508 Punctate keratitis Diseases 0.000 claims description 4
- 206010038848 Retinal detachment Diseases 0.000 claims description 4
- 206010046851 Uveitis Diseases 0.000 claims description 4
- 208000002205 allergic conjunctivitis Diseases 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 208000024998 atopic conjunctivitis Diseases 0.000 claims description 4
- 210000004087 cornea Anatomy 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 230000002458 infectious effect Effects 0.000 claims description 4
- 230000009545 invasion Effects 0.000 claims description 4
- 208000002780 macular degeneration Diseases 0.000 claims description 4
- 201000010230 macular retinal edema Diseases 0.000 claims description 4
- 230000002980 postoperative effect Effects 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 230000004264 retinal detachment Effects 0.000 claims description 4
- 208000004644 retinal vein occlusion Diseases 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 206010072139 Ocular rosacea Diseases 0.000 claims description 3
- 206010030865 Ophthalmic herpes zoster Diseases 0.000 claims description 3
- 210000000744 eyelid Anatomy 0.000 claims description 3
- 239000003862 glucocorticoid Substances 0.000 claims description 3
- 230000002757 inflammatory effect Effects 0.000 claims description 3
- 230000004410 intraocular pressure Effects 0.000 claims description 3
- 201000004614 iritis Diseases 0.000 claims description 3
- 230000007170 pathology Effects 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 241001303601 Rosacea Species 0.000 claims description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 10
- 239000000872 buffer Substances 0.000 claims 10
- 239000008213 purified water Substances 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 239000008363 phosphate buffer Substances 0.000 claims 5
- 239000001103 potassium chloride Substances 0.000 claims 5
- 235000011164 potassium chloride Nutrition 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- 229920001983 poloxamer Polymers 0.000 claims 4
- 229960000502 poloxamer Drugs 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 229940069328 povidone Drugs 0.000 claims 4
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 239000008351 acetate buffer Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000007981 phosphate-citrate buffer Substances 0.000 claims 3
- JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 2
- 229960004926 chlorobutanol Drugs 0.000 claims 2
- 239000007979 citrate buffer Substances 0.000 claims 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
- 239000007951 isotonicity adjuster Substances 0.000 claims 2
- 229940096826 phenylmercuric acetate Drugs 0.000 claims 2
- PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 claims 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 2
- 229940033663 thimerosal Drugs 0.000 claims 2
- 239000012929 tonicity agent Substances 0.000 claims 2
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 1
- 102100021316 Mineralocorticoid receptor Human genes 0.000 claims 1
- 210000004240 ciliary body Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 230000001886 ciliary effect Effects 0.000 description 2
- 206010023332 keratitis Diseases 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000004406 elevated intraocular pressure Effects 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558775P | 2011-11-11 | 2011-11-11 | |
| US61/558,775 | 2011-11-11 | ||
| PCT/US2012/064296 WO2013071010A1 (en) | 2011-11-11 | 2012-11-09 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11ß-17-21-TRIOL-3,20-DIONE DERIVATIVES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533275A JP2014533275A (ja) | 2014-12-11 |
| JP2014533275A5 true JP2014533275A5 (enExample) | 2016-07-28 |
| JP6158201B2 JP6158201B2 (ja) | 2017-07-05 |
Family
ID=47179019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541293A Expired - Fee Related JP6158201B2 (ja) | 2011-11-11 | 2012-11-09 | ４−プレゲネン−１１β−１７−２１−トリオール−３，２０−ジオン誘導体の医薬組成物および使用方法 |
| JP2014541292A Expired - Fee Related JP6216719B2 (ja) | 2011-11-11 | 2012-11-09 | 眼病態の治療のための４−プレゲネン−１１ｓｓ−１７−２１−トリオール−３，２０−ジオン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541292A Expired - Fee Related JP6216719B2 (ja) | 2011-11-11 | 2012-11-09 | 眼病態の治療のための４−プレゲネン−１１ｓｓ−１７−２１−トリオール−３，２０−ジオン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US8865691B2 (enExample) |
| EP (2) | EP2776040B1 (enExample) |
| JP (2) | JP6158201B2 (enExample) |
| KR (2) | KR102049615B1 (enExample) |
| CN (2) | CN104185472B (enExample) |
| AR (1) | AR088846A1 (enExample) |
| AU (3) | AU2012335589B2 (enExample) |
| BR (2) | BR112014011333B1 (enExample) |
| CA (3) | CA2991883C (enExample) |
| CL (2) | CL2014001243A1 (enExample) |
| CO (2) | CO6970598A2 (enExample) |
| ES (1) | ES2806603T3 (enExample) |
| HK (1) | HK1200366A1 (enExample) |
| IL (2) | IL232535B (enExample) |
| IN (2) | IN2014CN03919A (enExample) |
| MX (3) | MX365859B (enExample) |
| MY (2) | MY182222A (enExample) |
| PH (2) | PH12014501078B1 (enExample) |
| RU (2) | RU2683775C2 (enExample) |
| SG (3) | SG10201603766PA (enExample) |
| TW (1) | TWI584809B (enExample) |
| UA (2) | UA116622C2 (enExample) |
| WO (2) | WO2013071009A1 (enExample) |
| ZA (2) | ZA201403431B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| UA116622C2 (uk) * | 2011-11-11 | 2018-04-25 | Аллерган, Інк. | Похідні 4-прегенен-11ss-17-21-тріол-3,20-діону для лікування хвороб очей |
| EA201500651A1 (ru) | 2012-12-18 | 2015-11-30 | Альмираль, С.А. | НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛ- И ХИНУКЛИДИНИЛКАРБАМАТА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| US10065984B2 (en) * | 2013-12-13 | 2018-09-04 | Allergan, Inc. | Polymorphic forms of a steroid-like compound and methods for the preparation and use thereof |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| AU2016226224B2 (en) * | 2015-03-05 | 2021-07-08 | Allergan, Inc. | Self-emulsifying drug delivery system (SEDDS) for ophthalmic drug delivery |
| WO2018053321A1 (en) * | 2016-09-16 | 2018-03-22 | Kala Pharmaceuticals, Inc. | Particles, compositions, and methods for ophthalmic and/or other applications |
| WO2019055028A1 (en) * | 2017-09-15 | 2019-03-21 | Kala Pharmaceuticals, Inc. | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC APPLICATIONS AND / OR OTHER APPLICATIONS |
| CN116023425B (zh) * | 2023-03-28 | 2023-06-20 | 南京师范大学 | 曲安西龙衍生物及其医药用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6605514A (enExample) * | 1966-04-25 | 1967-10-26 | ||
| IT1056711B (it) * | 1967-04-01 | 1982-02-20 | Vismara F Spa | Derivati dell idrocortisone |
| US3484436A (en) | 1967-09-07 | 1969-12-16 | Syntex Corp | Bicyclo(2.2.2)octane - 1 - -carboxylate esters of delta**4 - pregnene corticoid steroids |
| GB1227992A (enExample) * | 1968-01-23 | 1971-04-15 | Koninklijke Gist Spiritus | |
| US3693032A (en) | 1971-04-23 | 1972-09-19 | Ibm | Antisaturation technique for ttl circuits |
| US3984544A (en) * | 1975-02-28 | 1976-10-05 | Schering Corporation | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor |
| JPS52136157A (en) * | 1976-04-14 | 1977-11-14 | Taisho Pharmaceut Co Ltd | Preparation of steroid 17-esters |
| JPS60994B2 (ja) * | 1976-07-26 | 1985-01-11 | 大正製薬株式会社 | プレグナン系化合物の１７α―エステル類の製造法 |
| DE2735110A1 (de) * | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
| US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
| US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
| DE4025342A1 (de) | 1990-08-10 | 1992-02-13 | Hoechst Ag | In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US6011023A (en) * | 1997-08-27 | 2000-01-04 | Alcon Laboratories, Inc. | Angiostatic steroids |
| EP1232173B1 (en) * | 1999-10-15 | 2003-05-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Fusidic acid derivatives |
| US6395721B1 (en) | 2000-01-05 | 2002-05-28 | Leonard Bloom | Low potency unpreserved sterile topical corticosteroid compositions for dermatitis |
| EP1539141B1 (en) * | 2002-08-29 | 2010-07-14 | Boehringer Ingelheim Pharmaceuticals Inc. | 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| JP2005008596A (ja) * | 2003-06-20 | 2005-01-13 | Kobayashi Pharmaceut Co Ltd | 眼科用組成物 |
| EP1755616B1 (en) * | 2004-04-08 | 2013-08-14 | Advanced Ocular Systems Limited | Treatment of exudative retinopathy with mineralcorticoids |
| BRPI0513243B8 (pt) * | 2004-07-12 | 2021-05-25 | Allergan Inc | composições oftálmicas e respectivos usos |
| US7687484B2 (en) * | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| SI1864668T1 (sl) * | 2006-06-01 | 2013-04-30 | Novagali Pharma S.A. | Uporaba predzdravil za okularno intravitrealno dajanje |
| ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
| JP2009053880A (ja) | 2007-08-27 | 2009-03-12 | Sony Broadband Solution Corp | 情報処理装置、ならびにｃｐｕユニット |
| TW200944540A (en) * | 2007-12-21 | 2009-11-01 | Schering Corp | C20-C21 substituted glucocorticoid receptor agonists |
| US20110212157A1 (en) * | 2008-06-26 | 2011-09-01 | Anterios, Inc. | Dermal delivery |
| UA116622C2 (uk) | 2011-11-11 | 2018-04-25 | Аллерган, Інк. | Похідні 4-прегенен-11ss-17-21-тріол-3,20-діону для лікування хвороб очей |
-
2012
- 2012-09-11 UA UAA201406244A patent/UA116622C2/uk unknown
- 2012-09-11 UA UAA201406457A patent/UA111867C2/uk unknown
- 2012-11-09 JP JP2014541293A patent/JP6158201B2/ja not_active Expired - Fee Related
- 2012-11-09 IN IN3919CHN2014 patent/IN2014CN03919A/en unknown
- 2012-11-09 MX MX2014005679A patent/MX365859B/es active IP Right Grant
- 2012-11-09 HK HK15101080.2A patent/HK1200366A1/xx unknown
- 2012-11-09 WO PCT/US2012/064293 patent/WO2013071009A1/en not_active Ceased
- 2012-11-09 EP EP12787336.2A patent/EP2776040B1/en active Active
- 2012-11-09 MY MYPI2014001372A patent/MY182222A/en unknown
- 2012-11-09 TW TW101141986A patent/TWI584809B/zh not_active IP Right Cessation
- 2012-11-09 IN IN3903CHN2014 patent/IN2014CN03903A/en unknown
- 2012-11-09 SG SG10201603766PA patent/SG10201603766PA/en unknown
- 2012-11-09 MY MYPI2014001373A patent/MY172227A/en unknown
- 2012-11-09 JP JP2014541292A patent/JP6216719B2/ja not_active Expired - Fee Related
- 2012-11-09 BR BR112014011333A patent/BR112014011333B1/pt not_active IP Right Cessation
- 2012-11-09 KR KR1020147015647A patent/KR102049615B1/ko not_active Expired - Fee Related
- 2012-11-09 WO PCT/US2012/064296 patent/WO2013071010A1/en not_active Ceased
- 2012-11-09 US US13/673,074 patent/US8865691B2/en not_active Expired - Fee Related
- 2012-11-09 CA CA2991883A patent/CA2991883C/en not_active Expired - Fee Related
- 2012-11-09 KR KR1020147015650A patent/KR20140095549A/ko not_active Abandoned
- 2012-11-09 CN CN201280066021.2A patent/CN104185472B/zh not_active Expired - Fee Related
- 2012-11-09 CN CN201280065948.4A patent/CN104203247B/zh not_active Expired - Fee Related
- 2012-11-09 AU AU2012335589A patent/AU2012335589B2/en not_active Ceased
- 2012-11-09 AU AU2012335590A patent/AU2012335590B2/en not_active Ceased
- 2012-11-09 CA CA2855929A patent/CA2855929C/en not_active Expired - Fee Related
- 2012-11-09 CA CA2855290A patent/CA2855290C/en not_active Expired - Fee Related
- 2012-11-09 RU RU2014123471A patent/RU2683775C2/ru not_active IP Right Cessation
- 2012-11-09 EP EP12787337.0A patent/EP2776041A1/en not_active Withdrawn
- 2012-11-09 MX MX2014005678A patent/MX363669B/es unknown
- 2012-11-09 RU RU2014123472A patent/RU2688159C2/ru not_active IP Right Cessation
- 2012-11-09 SG SG11201402225RA patent/SG11201402225RA/en unknown
- 2012-11-09 SG SG11201402247PA patent/SG11201402247PA/en unknown
- 2012-11-09 US US13/673,623 patent/US8906892B2/en not_active Expired - Fee Related
- 2012-11-09 BR BR112014011341A patent/BR112014011341A2/pt not_active Application Discontinuation
- 2012-11-09 ES ES12787336T patent/ES2806603T3/es active Active
- 2012-11-12 AR ARP120104261A patent/AR088846A1/es unknown
-
2014
- 2014-05-09 MX MX2019006877A patent/MX2019006877A/es unknown
- 2014-05-09 PH PH12014501078A patent/PH12014501078B1/en unknown
- 2014-05-09 PH PH12014501079A patent/PH12014501079B1/en unknown
- 2014-05-11 IL IL232535A patent/IL232535B/en active IP Right Grant
- 2014-05-11 IL IL232534A patent/IL232534A0/en active IP Right Grant
- 2014-05-12 CL CL2014001243A patent/CL2014001243A1/es unknown
- 2014-05-12 CL CL2014001244A patent/CL2014001244A1/es unknown
- 2014-05-13 ZA ZA2014/03431A patent/ZA201403431B/en unknown
- 2014-05-13 ZA ZA2014/03430A patent/ZA201403430B/en unknown
- 2014-05-29 CO CO14116546A patent/CO6970598A2/es unknown
- 2014-06-09 CO CO14124183A patent/CO6970609A2/es unknown
- 2014-09-12 US US14/485,335 patent/US9717743B2/en not_active Expired - Fee Related
- 2014-11-05 US US14/533,847 patent/US9433631B2/en not_active Expired - Fee Related
-
2016
- 2016-08-04 US US15/228,674 patent/US10493082B2/en not_active Expired - Fee Related
-
2017
- 2017-06-30 US US15/640,093 patent/US10188667B2/en not_active Expired - Fee Related
-
2018
- 2018-01-19 AU AU2018200436A patent/AU2018200436B2/en not_active Ceased
- 2018-12-24 US US16/231,901 patent/US20190365786A1/en not_active Abandoned
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