AR088846A1 - COMPOSICIONES FARMACEUTICAS Y METODOS DE USO DE DERIVADOS DE 4-PREGENEN-11b-17-21-TRIOL-3,20-DIONA - Google Patents

COMPOSICIONES FARMACEUTICAS Y METODOS DE USO DE DERIVADOS DE 4-PREGENEN-11b-17-21-TRIOL-3,20-DIONA

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Publication number
AR088846A1
AR088846A1 ARP120104261A ARP120104261A AR088846A1 AR 088846 A1 AR088846 A1 AR 088846A1 AR P120104261 A ARP120104261 A AR P120104261A AR P120104261 A ARP120104261 A AR P120104261A AR 088846 A1 AR088846 A1 AR 088846A1
Authority
AR
Argentina
Prior art keywords
tetradecahydro
glycolyl
phenanthren
cyclopenta
oxo
Prior art date
Application number
ARP120104261A
Other languages
English (en)
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47179019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR088846(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AR088846A1 publication Critical patent/AR088846A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composiciones farmacéuticas que comprenden derivados de 4-pregenen-11b-17-21-triol-3,20-diona, y su uso como productos farmacéuticos como moduladores de los receptores de glucocorticoides (GR) y/o los receptores de mineralocorticoides (MR). Uso de estos compuestos y sus composiciones farmacéuticas para el tratamiento de afecciones oculares asociadas con los receptores de glucocorticoides (GR) y/o los receptores de mineralocorticoides (MR). Reivindicación 1: Un método para tratar una afección ocular vinculada con la modulación del receptor mineralcorticoide y/o glucocorticoide que incluye la administración a un paciente que la necesita, una composición farmacéutica que contiene una cantidad terapéuticamente efectiva de al menos un compuesto seleccionado a partir de: (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il fenilacetato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il butirato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il propionato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il octanoato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il hexanoato; (8R,9R,10S,11R,13R,14R,17S)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il benzoato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il heptanoato; (8S,9S,10R,11S,13S,14S,17R)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il 2-metilpropanoato y (8R,9R,10S,11R,13R,14R,17S)-17-glicoloil-11-hidroxi-10,13-dimetil-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahidro-1H-ciclopenta[a]fenantren-17-il rel-ciclopentanecarboxilato.
ARP120104261A 2011-11-11 2012-11-12 COMPOSICIONES FARMACEUTICAS Y METODOS DE USO DE DERIVADOS DE 4-PREGENEN-11b-17-21-TRIOL-3,20-DIONA AR088846A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161558775P 2011-11-11 2011-11-11

Publications (1)

Publication Number Publication Date
AR088846A1 true AR088846A1 (es) 2014-07-10

Family

ID=47179019

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104261A AR088846A1 (es) 2011-11-11 2012-11-12 COMPOSICIONES FARMACEUTICAS Y METODOS DE USO DE DERIVADOS DE 4-PREGENEN-11b-17-21-TRIOL-3,20-DIONA

Country Status (24)

Country Link
US (7) US8865691B2 (es)
EP (2) EP2776040B1 (es)
JP (2) JP6158201B2 (es)
KR (2) KR102049615B1 (es)
CN (2) CN104203247B (es)
AR (1) AR088846A1 (es)
AU (3) AU2012335590B2 (es)
BR (2) BR112014011333B1 (es)
CA (3) CA2855929C (es)
CL (2) CL2014001244A1 (es)
CO (2) CO6970598A2 (es)
ES (1) ES2806603T3 (es)
HK (2) HK1200367A1 (es)
IL (2) IL232535B (es)
IN (2) IN2014CN03903A (es)
MX (3) MX365859B (es)
MY (2) MY172227A (es)
PH (2) PH12014501078A1 (es)
RU (2) RU2688159C2 (es)
SG (3) SG11201402225RA (es)
TW (1) TWI584809B (es)
UA (2) UA116622C2 (es)
WO (2) WO2013071009A1 (es)
ZA (2) ZA201403430B (es)

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BR112015013628A2 (pt) 2012-12-18 2017-07-11 Almirall Sa derivados de carbamato de ciclo-hexila e quinuclidinila tendo atividades agonista adrenérgica de beta2 e antagonista muscarínica de m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
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Publication number Publication date
EP2776041A1 (en) 2014-09-17
JP6216719B2 (ja) 2017-10-18
US20150057258A1 (en) 2015-02-26
US10188667B2 (en) 2019-01-29
US9433631B2 (en) 2016-09-06
ES2806603T3 (es) 2021-02-18
NZ624919A (en) 2016-10-28
RU2688159C2 (ru) 2019-05-20
IL232535B (en) 2019-09-26
MX2014005678A (es) 2014-12-10
US8906892B2 (en) 2014-12-09
AU2012335590A1 (en) 2014-05-29
AU2018200436B2 (en) 2019-10-24
HK1200367A1 (en) 2015-08-07
CL2014001243A1 (es) 2014-11-28
US20130123223A1 (en) 2013-05-16
AU2012335589B2 (en) 2017-08-31
JP6158201B2 (ja) 2017-07-05
IL232534A0 (en) 2014-06-30
TW201325596A (zh) 2013-07-01
EP2776040B1 (en) 2020-04-22
US20180147217A1 (en) 2018-05-31
RU2014123472A (ru) 2015-12-20
CO6970598A2 (es) 2014-06-13
CA2991883C (en) 2020-03-10
US10493082B2 (en) 2019-12-03
SG10201603766PA (en) 2016-07-28
PH12014501078B1 (en) 2014-07-28
US8865691B2 (en) 2014-10-21
TWI584809B (zh) 2017-06-01
BR112014011333A2 (pt) 2017-05-02
JP2014533274A (ja) 2014-12-11
WO2013071009A1 (en) 2013-05-16
CA2855290A1 (en) 2013-05-16
IN2014CN03919A (es) 2015-09-04
PH12014501078A1 (en) 2014-07-28
UA116622C2 (uk) 2018-04-25
CA2991883A1 (en) 2013-05-16
ZA201403431B (en) 2016-05-25
JP2014533275A (ja) 2014-12-11
KR20140095549A (ko) 2014-08-01
PH12014501079B1 (en) 2014-07-28
MX2019006877A (es) 2019-08-22
CA2855290C (en) 2017-02-28
MX2014005679A (es) 2014-12-10
ZA201403430B (en) 2016-05-25
CA2855929A1 (en) 2013-05-16
SG11201402225RA (en) 2014-06-27
US20170182062A1 (en) 2017-06-29
IN2014CN03903A (es) 2015-10-16
BR112014011333B1 (pt) 2020-04-28
PH12014501079A1 (en) 2014-07-28
CN104185472A (zh) 2014-12-03
CN104203247A (zh) 2014-12-10
CN104203247B (zh) 2017-06-06
BR112014011341A2 (pt) 2017-05-02
MX365859B (es) 2019-06-18
SG11201402247PA (en) 2014-06-27
IL232535A0 (en) 2014-06-30
CO6970609A2 (es) 2014-06-13
UA111867C2 (uk) 2016-06-24
AU2018200436A1 (en) 2018-02-08
MX363669B (es) 2019-03-29
CA2855929C (en) 2018-03-27
RU2683775C2 (ru) 2019-04-02
KR102049615B1 (ko) 2019-11-28
RU2014123471A (ru) 2015-12-20
KR20140095548A (ko) 2014-08-01
MY172227A (en) 2019-11-18
CN104185472B (zh) 2017-06-13
US20130123226A1 (en) 2013-05-16
CL2014001244A1 (es) 2014-11-14
WO2013071010A1 (en) 2013-05-16
AU2012335590B2 (en) 2017-10-19
NZ624920A (en) 2017-06-30
US20190365786A1 (en) 2019-12-05
US20150005519A1 (en) 2015-01-01
MY182222A (en) 2021-01-18
EP2776040A1 (en) 2014-09-17
HK1200366A1 (en) 2015-08-07
AU2012335589A1 (en) 2014-05-29
US9717743B2 (en) 2017-08-01

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