BR112014011333B1 - composto, composição farmacêutica e uso do composto de fórmula - Google Patents

composto, composição farmacêutica e uso do composto de fórmula Download PDF

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Publication number
BR112014011333B1
BR112014011333B1 BR112014011333A BR112014011333A BR112014011333B1 BR 112014011333 B1 BR112014011333 B1 BR 112014011333B1 BR 112014011333 A BR112014011333 A BR 112014011333A BR 112014011333 A BR112014011333 A BR 112014011333A BR 112014011333 B1 BR112014011333 B1 BR 112014011333B1
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BR
Brazil
Prior art keywords
compound
glucocorticoid
pharmaceutical compositions
pregenen
triol
Prior art date
Application number
BR112014011333A
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English (en)
Other versions
BR112014011333A2 (pt
Inventor
Nehme Alissar
L Edelman Jeffrey
C Malone Thomas
Original Assignee
Allergan Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47179019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014011333(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112014011333A2 publication Critical patent/BR112014011333A2/pt
Publication of BR112014011333B1 publication Critical patent/BR112014011333B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

abstract the present invention relates to novel 4-pregenen-11ß-17-21-triol-3,20-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals, as modulators of glucocorticoid or mineralocorticoid receptors. the invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with glucocorticoid or mineralocorticoid receptor modulation. __________________________ tradução do resumo resumo patente de invenção: "derivados de pregenen-11ss-17-21-triol-3,20-diona para o tratamento de condições oculares". a presente invenção refere-se a novos derivados de 4-pregenen-11-17-21-triol-3,20-diona, processo para sua preparação, composições farmacêuticas contendo-os e seu uso como agentes farmacêuticos, como moduladores de receptores de glucocorticoide ou mineralocorticoide. a invenção refere-se especificamente ao uso desses compostos e suas composições farmacêuticas para tratar distúrbios associados com modulação de receptor de glucocorticoide ou mineralocorticoide.
BR112014011333A 2011-11-11 2012-11-09 composto, composição farmacêutica e uso do composto de fórmula BR112014011333B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161558775P 2011-11-11 2011-11-11
PCT/US2012/064293 WO2013071009A1 (en) 2011-11-11 2012-11-09 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions

Publications (2)

Publication Number Publication Date
BR112014011333A2 BR112014011333A2 (pt) 2017-05-02
BR112014011333B1 true BR112014011333B1 (pt) 2020-04-28

Family

ID=47179019

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112014011341A BR112014011341A2 (pt) 2011-11-11 2012-11-09 composições farmacèuticas e métodos de uso de derivados de 4-pregenen-11beta-17-21-triol-3,20-diona
BR112014011333A BR112014011333B1 (pt) 2011-11-11 2012-11-09 composto, composição farmacêutica e uso do composto de fórmula

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112014011341A BR112014011341A2 (pt) 2011-11-11 2012-11-09 composições farmacèuticas e métodos de uso de derivados de 4-pregenen-11beta-17-21-triol-3,20-diona

Country Status (24)

Country Link
US (7) US8865691B2 (pt)
EP (2) EP2776041A1 (pt)
JP (2) JP6216719B2 (pt)
KR (2) KR102049615B1 (pt)
CN (2) CN104185472B (pt)
AR (1) AR088846A1 (pt)
AU (3) AU2012335589B2 (pt)
BR (2) BR112014011341A2 (pt)
CA (3) CA2991883C (pt)
CL (2) CL2014001243A1 (pt)
CO (2) CO6970598A2 (pt)
ES (1) ES2806603T3 (pt)
HK (2) HK1200367A1 (pt)
IL (2) IL232535B (pt)
IN (2) IN2014CN03919A (pt)
MX (3) MX365859B (pt)
MY (2) MY182222A (pt)
PH (2) PH12014501078A1 (pt)
RU (2) RU2688159C2 (pt)
SG (3) SG11201402247PA (pt)
TW (1) TWI584809B (pt)
UA (2) UA116622C2 (pt)
WO (2) WO2013071009A1 (pt)
ZA (2) ZA201403431B (pt)

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UA116622C2 (uk) * 2011-11-11 2018-04-25 Аллерган, Інк. Похідні 4-прегенен-11ss-17-21-тріол-3,20-діону для лікування хвороб очей
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TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
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AR088846A1 (es) 2014-07-10
IL232535B (en) 2019-09-26
CN104185472B (zh) 2017-06-13
AU2012335590A1 (en) 2014-05-29
ZA201403431B (en) 2016-05-25
AU2012335589A1 (en) 2014-05-29
JP6158201B2 (ja) 2017-07-05
MX2019006877A (es) 2019-08-22
AU2018200436B2 (en) 2019-10-24
CA2991883C (en) 2020-03-10
AU2012335590B2 (en) 2017-10-19
US20130123223A1 (en) 2013-05-16
MX2014005678A (es) 2014-12-10
CA2855929C (en) 2018-03-27
MX363669B (es) 2019-03-29
AU2012335589B2 (en) 2017-08-31
UA111867C2 (uk) 2016-06-24
WO2013071010A1 (en) 2013-05-16
EP2776040A1 (en) 2014-09-17
CA2991883A1 (en) 2013-05-16
UA116622C2 (uk) 2018-04-25
RU2683775C2 (ru) 2019-04-02
TWI584809B (zh) 2017-06-01
PH12014501079B1 (en) 2014-07-28
BR112014011341A2 (pt) 2017-05-02
US9717743B2 (en) 2017-08-01
KR20140095548A (ko) 2014-08-01
CL2014001244A1 (es) 2014-11-14
SG11201402225RA (en) 2014-06-27
IL232535A0 (en) 2014-06-30
ES2806603T3 (es) 2021-02-18
BR112014011333A2 (pt) 2017-05-02
HK1200366A1 (en) 2015-08-07
US20190365786A1 (en) 2019-12-05
JP6216719B2 (ja) 2017-10-18
TW201325596A (zh) 2013-07-01
CN104203247A (zh) 2014-12-10
RU2014123471A (ru) 2015-12-20
NZ624920A (en) 2017-06-30
CO6970598A2 (es) 2014-06-13
AU2018200436A1 (en) 2018-02-08
US9433631B2 (en) 2016-09-06
CN104185472A (zh) 2014-12-03
PH12014501078B1 (en) 2014-07-28
CA2855929A1 (en) 2013-05-16
CA2855290A1 (en) 2013-05-16
MX365859B (es) 2019-06-18
US10493082B2 (en) 2019-12-03
JP2014533275A (ja) 2014-12-11
RU2014123472A (ru) 2015-12-20
NZ624919A (en) 2016-10-28
RU2688159C2 (ru) 2019-05-20
US20150057258A1 (en) 2015-02-26
PH12014501078A1 (en) 2014-07-28
US10188667B2 (en) 2019-01-29
IN2014CN03919A (pt) 2015-09-04
US20130123226A1 (en) 2013-05-16
IN2014CN03903A (pt) 2015-10-16
EP2776041A1 (en) 2014-09-17
EP2776040B1 (en) 2020-04-22
CO6970609A2 (es) 2014-06-13
MY182222A (en) 2021-01-18
ZA201403430B (en) 2016-05-25
IL232534A0 (en) 2014-06-30
MX2014005679A (es) 2014-12-10
US8906892B2 (en) 2014-12-09
US8865691B2 (en) 2014-10-21
CN104203247B (zh) 2017-06-06
SG11201402247PA (en) 2014-06-27
KR20140095549A (ko) 2014-08-01
WO2013071009A1 (en) 2013-05-16
MY172227A (en) 2019-11-18
US20180147217A1 (en) 2018-05-31
CL2014001243A1 (es) 2014-11-28
US20150005519A1 (en) 2015-01-01
KR102049615B1 (ko) 2019-11-28
SG10201603766PA (en) 2016-07-28
US20170182062A1 (en) 2017-06-29
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