JP2014532671A5 - - Google Patents
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- Publication number
- JP2014532671A5 JP2014532671A5 JP2014539246A JP2014539246A JP2014532671A5 JP 2014532671 A5 JP2014532671 A5 JP 2014532671A5 JP 2014539246 A JP2014539246 A JP 2014539246A JP 2014539246 A JP2014539246 A JP 2014539246A JP 2014532671 A5 JP2014532671 A5 JP 2014532671A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- carbonate
- particles
- aqueous solution
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 description 23
- 239000007900 aqueous suspension Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 19
- 239000007864 aqueous solution Substances 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 14
- 102000010445 Lactoferrin Human genes 0.000 description 10
- 108010063045 Lactoferrin Proteins 0.000 description 10
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 10
- 229940078795 lactoferrin Drugs 0.000 description 10
- 235000021242 lactoferrin Nutrition 0.000 description 10
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 239000002324 mouth wash Substances 0.000 description 9
- 229940051866 mouthwash Drugs 0.000 description 9
- 229910052712 strontium Inorganic materials 0.000 description 9
- 150000003437 strontium Chemical class 0.000 description 9
- 239000011575 calcium Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- IATRAKWUXMZMIY-UHFFFAOYSA-N strontium oxide Chemical compound [O-2].[Sr+2] IATRAKWUXMZMIY-UHFFFAOYSA-N 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000018 strontium carbonate Inorganic materials 0.000 description 1
- UUCCCPNEFXQJEL-UHFFFAOYSA-L strontium dihydroxide Chemical compound [OH-].[OH-].[Sr+2] UUCCCPNEFXQJEL-UHFFFAOYSA-L 0.000 description 1
- 229910001866 strontium hydroxide Inorganic materials 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2011/005601 WO2013068020A1 (en) | 2011-11-08 | 2011-11-08 | Dental care products containing biomimetic hydroxyapatite particles having a lactoferrin-functionalized surface |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532671A JP2014532671A (ja) | 2014-12-08 |
| JP2014532671A5 true JP2014532671A5 (enExample) | 2015-01-22 |
| JP5973585B2 JP5973585B2 (ja) | 2016-08-23 |
Family
ID=44999728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539246A Active JP5973585B2 (ja) | 2011-11-08 | 2011-11-08 | ラクトフェリン機能化表面を有する生体模倣ヒドロキシアパタイト粒子を含有するデンタルケア製品 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP5973585B2 (enExample) |
| WO (1) | WO2013068020A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6649251B2 (ja) | 2013-09-25 | 2020-02-19 | クレデンティス・アクチェンゲゼルシャフトＣｒｅｄｅｎｔｉｓ ＡＧ | 歯を白くするためのデンタルケア製品 |
| EP2853256A1 (en) | 2013-09-25 | 2015-04-01 | Credentis AG | Dental care product for tooth whitening |
| ITUB20156918A1 (it) * | 2015-12-10 | 2017-06-10 | Curasept A D S S R L | Apatiti multi sostituite e loro uso nella rimineralizzazione e riduzione della sensibilita? dentale |
| JP6435061B1 (ja) * | 2017-04-27 | 2018-12-05 | ブレイニー株式会社 | ハイドロキシアパタイト、化粧品及び食品、並びにその製造方法 |
| CN108888770A (zh) * | 2018-07-30 | 2018-11-27 | 郑州兰茜生物工程有限公司 | 一种健齿固齿抗菌消炎的口腔保健剂及其制备方法 |
| US11154470B1 (en) | 2020-07-31 | 2021-10-26 | vVardis AG | Anti-inflammatory and senolytic dental care product with tooth whitening characteristics |
| EP3984517A1 (en) | 2020-10-19 | 2022-04-20 | Credentis AG | Accelerating tooth remineralisation and bone regeneration with self-assembling peptides and amorphous calcium phosphate |
| IT202100011492A1 (it) * | 2021-05-05 | 2022-11-05 | Kalichem Srl | Idrossiapatite biomimetica funzionalizzata |
| WO2025252565A1 (en) * | 2024-06-03 | 2025-12-11 | TDC Technology Dedicated to Care srl | Oral care foam based on lactoferrin and hydroxyapatite |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534244A (en) * | 1989-05-24 | 1996-07-09 | Tung; Ming S. | Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds |
| JP2673320B2 (ja) * | 1990-01-25 | 1997-11-05 | 雪印乳業株式会社 | う蝕原菌付着阻止剤 |
| IT1299563B1 (it) | 1998-07-17 | 2000-03-16 | Giovanni Dolci | Uso odontostomatologico di materiali a base apatitica nanostrutturati |
| SI2029480T1 (sl) | 2006-05-30 | 2017-08-31 | Coswell S.P.A. | Biološko aktivni nanodelci karbonatno substituiranega hidroksiapatita, postopek za njihovo pripravo in sestavki, ki jih vključujejo |
| JP2007332072A (ja) | 2006-06-15 | 2007-12-27 | Snow Brand Milk Prod Co Ltd | 歯質硬度維持剤 |
| CN110075069A (zh) * | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| DE102010063720B4 (de) | 2010-12-21 | 2020-06-18 | Lr Health & Beauty Systems Gmbh | Silberhaltige Zahnpflegezusammensetzung |
-
2011
- 2011-11-08 WO PCT/EP2011/005601 patent/WO2013068020A1/en not_active Ceased
- 2011-11-08 JP JP2014539246A patent/JP5973585B2/ja active Active
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