JP2014532649A5 - - Google Patents
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- JP2014532649A5 JP2014532649A5 JP2014538974A JP2014538974A JP2014532649A5 JP 2014532649 A5 JP2014532649 A5 JP 2014532649A5 JP 2014538974 A JP2014538974 A JP 2014538974A JP 2014538974 A JP2014538974 A JP 2014538974A JP 2014532649 A5 JP2014532649 A5 JP 2014532649A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- monoclonal antibody
- antibody according
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551918P | 2011-10-26 | 2011-10-26 | |
| US61/551,918 | 2011-10-26 | ||
| US201261699300P | 2012-09-11 | 2012-09-11 | |
| US61/699,300 | 2012-09-11 | ||
| PCT/US2012/061782 WO2013063186A2 (en) | 2011-10-26 | 2012-10-25 | Monoclonal antibodies and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532649A JP2014532649A (ja) | 2014-12-08 |
| JP2014532649A5 true JP2014532649A5 (enExample) | 2016-02-12 |
| JP6316195B2 JP6316195B2 (ja) | 2018-04-25 |
Family
ID=48168777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538974A Active JP6316195B2 (ja) | 2011-10-26 | 2012-10-25 | モノクローナル抗体および使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9790280B2 (enExample) |
| EP (3) | EP2771694A4 (enExample) |
| JP (1) | JP6316195B2 (enExample) |
| AU (1) | AU2012328819B2 (enExample) |
| BR (1) | BR112014010008A2 (enExample) |
| CA (1) | CA2853637C (enExample) |
| RU (1) | RU2623122C2 (enExample) |
| WO (1) | WO2013063186A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790280B2 (en) | 2011-10-26 | 2017-10-17 | Elanco Tiergesundheit Ag | Monoclonal canine CD20 antibodies and methods of use |
| RS64268B1 (sr) | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
| AU2014368453B2 (en) | 2013-12-20 | 2020-04-16 | Intervet International B.V. | Caninized murine anti-canine PD-1 antibodies |
| CN106103476B (zh) | 2013-12-24 | 2020-11-27 | 阿尔金克斯有限公司 | FcRn拮抗剂及使用方法 |
| ES2853823T3 (es) | 2014-09-30 | 2021-09-17 | Intervet Int Bv | Anticuerpos de PD-L1 que se unen a PD-L1 canino |
| MX386491B (es) * | 2015-03-09 | 2025-03-18 | argenx BV | Metodos para reducir los niveles de suero de agentes que contienen fc que usan antagonistas de fcrn. |
| ES3014160T3 (en) | 2015-12-18 | 2025-04-21 | Intervet Int Bv | Caninized human antibodies to human and canine il-4r alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| CA3014461C (en) * | 2016-02-18 | 2023-02-28 | Elanco Us Inc. | Chimeric canine anti-cd20 antibody |
| JP7301002B2 (ja) | 2017-05-30 | 2023-06-30 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｌａｇ－３抗体または抗ｌａｇ－３抗体および抗ｐｄ－１もしくは抗ｐｄ－ｌ１抗体を含む組成物 |
| WO2018222718A1 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
| AU2018318440A1 (en) | 2017-08-15 | 2020-02-13 | Kindred Biosciences, Inc. | IgG Fc variants for veterinary use |
| MA51032A (fr) | 2017-12-08 | 2021-03-17 | Argenx Bvba | Utilisation d'antagonistes de fcrn pour le traitement de la myasthénie grave généralisée |
| JP7486437B2 (ja) | 2018-06-08 | 2024-05-17 | アルジェニクス ビーブイ | 免疫性血小板減少症を治療する組成物及び方法 |
| EP3866842A4 (en) * | 2018-10-18 | 2022-07-13 | Kindred Biosciences, Inc. | FC VARIANTS WITH MODIFIED BINDING TO THE NEONATAL FC RECEPTOR (FCRN) FOR VETERINARY USE |
| WO2020139984A1 (en) * | 2018-12-27 | 2020-07-02 | Kindred Biosciences, Inc. | Igg fc variants for veterinary use |
| BR112021024632A2 (pt) | 2019-06-07 | 2022-01-18 | Argenx Bvba | Formulações farmacêuticas de inibidores de fcrn adequados para administração subcutânea |
| JP2021059499A (ja) | 2019-10-03 | 2021-04-15 | 日本全薬工業株式会社 | イヌｃｄ２０に対するモノクローナル抗体又は抗体フラグメント |
| ES2992247T3 (es) | 2020-01-08 | 2024-12-11 | argenx BV | Antagonistas del receptor de Fc neonatal humano (FcRn) para el tratamiento de trastornos del pénfigo |
| CN115135669B (zh) * | 2020-02-19 | 2026-05-19 | 硕腾服务有限责任公司 | 修饰的Fc区 |
| MX2022013840A (es) * | 2020-05-04 | 2023-02-09 | Inhibrx Inc | Polipéptidos de unión a pd-1 canina y usos de los mismos. |
| US20220024904A1 (en) * | 2020-07-06 | 2022-01-27 | Research Foundation Of The City University Of New York | Reagent for bioconjugation via irreversible rebridging of disulfide linkages |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| WO2022263864A1 (en) | 2021-06-17 | 2022-12-22 | Petmedix Ltd | Anti canine cd20 antibodies |
| EP4380974A1 (en) * | 2021-08-06 | 2024-06-12 | Petmedix Ltd. | Antibody fc variants |
| KR20250037789A (ko) | 2022-06-15 | 2025-03-18 | 아르젠엑스 비브이 | Fcrn/항원-결합 분자 및 사용 방법 |
| KR20250137204A (ko) | 2022-12-27 | 2025-09-17 | 인베티엑스 인코포레이티드 | 신생아 fc 수용체(fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법 |
| CN121002059A (zh) | 2023-01-20 | 2025-11-21 | 因外泰克斯公司 | 用于伴侣动物的双特异性结合剂 |
| WO2024158001A1 (ja) | 2023-01-25 | 2024-08-02 | 日本全薬工業株式会社 | イヌのｂ細胞リンパ腫の治療方法 |
| WO2025121944A1 (ko) * | 2023-12-08 | 2025-06-12 | 주식회사 박셀바이오 | 개 cd20을 표적으로 하는 항체, 키메라 항원 수용체 및 이의 용도 |
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| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| AU640397B2 (en) | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
| ATE139900T1 (de) | 1992-11-13 | 1996-07-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| WO1997000271A1 (en) * | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| PT1974747E (pt) | 1998-08-11 | 2012-09-05 | Biogen Idec Inc | Terapias de combinação para linfomas de células b compreendendo a administração de anticorpo anti-cd20 |
| US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
| US8383081B2 (en) | 1999-05-10 | 2013-02-26 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods of use |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
| DE60042785D1 (de) | 1999-06-09 | 2009-10-01 | Immunomedics Inc | Immuntherapie von autoimmunerkrankungen durch die verwendung von b-zell spezifischen antikörpern |
| US8501471B2 (en) | 2000-10-18 | 2013-08-06 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US8165535B2 (en) | 2006-06-04 | 2012-04-24 | Samsung Electro-Mechanics | Systems, methods and apparatuses for complementary metal oxide semiconductor (CMOS) antenna switches using switched resonators |
| CA2476166C (en) * | 2002-02-14 | 2011-11-15 | Immunomedics, Inc. | Anti-cd20 antibodies and fusion proteins thereof and methods of use |
| US8287864B2 (en) | 2002-02-14 | 2012-10-16 | Immunomedics, Inc. | Structural variants of antibodies for improved therapeutic characteristics |
| KR101017732B1 (ko) | 2002-03-01 | 2011-02-28 | 이뮤노메딕스, 인코오포레이티드 | 내재화 항-ｃｄ74 항체 및 그 이용방법 |
| WO2003089930A1 (en) * | 2002-04-22 | 2003-10-30 | Georgetown University | Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration |
| KR100944575B1 (ko) | 2002-10-17 | 2010-02-25 | 젠맵 에이/에스 | Ｃｄ20에 대한 인간 모노클로날 항체 |
| US8084582B2 (en) | 2003-03-03 | 2011-12-27 | Xencor, Inc. | Optimized anti-CD20 monoclonal antibodies having Fc variants |
| US7981843B2 (en) | 2004-01-20 | 2011-07-19 | Kalobios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| JPWO2005075640A1 (ja) | 2004-02-10 | 2008-01-10 | 学校法人日本大学 | イヌｃｄ２０遺伝子 |
| EP1751187A2 (en) | 2004-05-28 | 2007-02-14 | Idexx Laboratories, Inc. | Canine cd20 compositions |
| PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
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| GB0708002D0 (en) * | 2007-04-25 | 2007-06-06 | Univ Sheffield | Antibodies |
| US20110045536A1 (en) | 2007-12-21 | 2011-02-24 | Novartis Ag | Mammalian expression vector |
| US9758779B2 (en) | 2008-08-28 | 2017-09-12 | Novartis Ag | Cell surface display of polypeptide isoforms by stop codon readthrough |
| EP2331579B1 (en) * | 2008-09-04 | 2017-07-05 | Vet Therapeutics, Inc. | Monoclonal antibodies |
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| CA2754408A1 (en) * | 2009-03-30 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Fusion proteins comprising canine fc portions |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| EP2496604B1 (en) * | 2009-11-06 | 2017-08-23 | IDEXX Laboratories, Inc. | Canine anti-cd20 antibodies |
| EP2542258A4 (en) | 2010-03-04 | 2013-08-21 | Vet Therapeutics Inc | ON CD52 MONOCLONAL ANTIBODIES |
| BR112012022338A2 (pt) | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais direcionados a cd20 |
| US9790280B2 (en) * | 2011-10-26 | 2017-10-17 | Elanco Tiergesundheit Ag | Monoclonal canine CD20 antibodies and methods of use |
-
2012
- 2012-10-25 US US14/354,280 patent/US9790280B2/en active Active
- 2012-10-25 JP JP2014538974A patent/JP6316195B2/ja active Active
- 2012-10-25 BR BR112014010008-0A patent/BR112014010008A2/en not_active Application Discontinuation
- 2012-10-25 EP EP12842976.8A patent/EP2771694A4/en not_active Ceased
- 2012-10-25 AU AU2012328819A patent/AU2012328819B2/en active Active
- 2012-10-25 EP EP18165199.3A patent/EP3378489A1/en not_active Withdrawn
- 2012-10-25 WO PCT/US2012/061782 patent/WO2013063186A2/en not_active Ceased
- 2012-10-25 CA CA2853637A patent/CA2853637C/en active Active
- 2012-10-25 RU RU2014120804A patent/RU2623122C2/ru active
- 2012-10-25 EP EP24217016.5A patent/EP4530630A3/en active Pending
-
2017
- 2017-08-24 US US15/685,257 patent/US11319377B2/en active Active
-
2022
- 2022-03-24 US US17/703,542 patent/US12600792B2/en active Active
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