JP2014529629A5 - - Google Patents
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- JP2014529629A5 JP2014529629A5 JP2014528963A JP2014528963A JP2014529629A5 JP 2014529629 A5 JP2014529629 A5 JP 2014529629A5 JP 2014528963 A JP2014528963 A JP 2014528963A JP 2014528963 A JP2014528963 A JP 2014528963A JP 2014529629 A5 JP2014529629 A5 JP 2014529629A5
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- Prior art keywords
- chem
- xaa
- lys
- linker
- derivative according
- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180265.8 | 2011-09-06 | ||
| EP11180265 | 2011-09-06 | ||
| US201161532323P | 2011-09-08 | 2011-09-08 | |
| US61/532,323 | 2011-09-08 | ||
| PCT/EP2012/067364 WO2013037690A1 (en) | 2011-09-06 | 2012-09-06 | Glp-1 derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529629A JP2014529629A (ja) | 2014-11-13 |
| JP2014529629A5 true JP2014529629A5 (https=) | 2015-10-01 |
| JP6126097B2 JP6126097B2 (ja) | 2017-05-10 |
Family
ID=47882647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528963A Active JP6126097B2 (ja) | 2011-09-06 | 2012-09-06 | Ｇｌｐ−１誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9758560B2 (https=) |
| EP (1) | EP2753642B8 (https=) |
| JP (1) | JP6126097B2 (https=) |
| CN (2) | CN104039822A (https=) |
| ES (1) | ES2626013T3 (https=) |
| WO (1) | WO2013037690A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2629735T3 (es) | 2012-05-08 | 2017-08-14 | Novo Nordisk A/S | Derivados de GLP-1 doblemente acilados |
| JP6250034B2 (ja) | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| LT3004155T (lt) * | 2013-05-28 | 2021-12-27 | Takeda Pharmaceutical Company Limited | Peptidų junginys |
| US10689429B2 (en) | 2014-04-07 | 2020-06-23 | Novo Nordisk A/S | Double-acylated GLP-1 compounds |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| JP7221694B2 (ja) * | 2016-04-28 | 2023-02-14 | ノヴォ ノルディスク アー／エス | 心血管状態におけるセマグルチド |
| WO2017204219A1 (ja) | 2016-05-24 | 2017-11-30 | 武田薬品工業株式会社 | ペプチド化合物 |
| CN109248323B (zh) * | 2017-07-14 | 2023-09-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| HRP20240485T1 (hr) | 2017-08-24 | 2024-07-05 | Novo Nordisk A/S | Pripravci glp-1 i njihova upotreba |
| RS63523B1 (sr) | 2018-04-05 | 2022-09-30 | Sun Pharmaceutical Ind Ltd | Novi glp-1 analozi |
| CN110386975B (zh) * | 2018-04-19 | 2021-06-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| CN115260313B (zh) | 2019-12-31 | 2023-07-18 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| CN119841865A (zh) | 2020-02-07 | 2025-04-18 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| PE20230819A1 (es) | 2020-02-18 | 2023-05-19 | Novo Nordisk As | Composiciones y usos de glp-1 |
| FI4143183T3 (fi) | 2020-04-29 | 2026-01-07 | Gasherbrum Bio Inc | Heterosyklisiä glp-1-agonisteja |
| CN113292646B (zh) * | 2020-05-29 | 2022-05-13 | 东莞云璟生物技术有限公司 | Glp-1/胰高血糖素双重激动剂融合蛋白 |
| PE20231181A1 (es) | 2020-08-06 | 2023-08-11 | Gasherbrum Bio Inc | Agonistas del glp-1 heterociclicos |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| CN114874314B (zh) * | 2021-12-28 | 2022-11-11 | 北京惠之衡生物科技有限公司 | 一种高表达glp-1类似物的重组工程菌及其构建方法 |
| CN119137124A (zh) | 2022-03-09 | 2024-12-13 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN114891090B (zh) * | 2022-03-11 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| WO2023179542A1 (en) | 2022-03-21 | 2023-09-28 | Gasherbrum Bio , Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| CN114958883B (zh) * | 2022-04-12 | 2023-01-31 | 北京惠之衡生物科技有限公司 | 一种表达glp-1类似物的重组工程菌及其构建方法 |
| WO2023198140A1 (en) | 2022-04-14 | 2023-10-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| KR20250110330A (ko) * | 2022-11-21 | 2025-07-18 | 일라이 릴리 앤드 캄파니 | Gip/glp1 이중 효능제의 제조 방법 |
| JP2026502644A (ja) * | 2023-01-23 | 2026-01-23 | クロスケム・リミテッド | ケラチン処理用化合物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525491A (en) * | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| ATE241011T1 (de) | 1991-02-27 | 2003-06-15 | Micromet Ag | Serin-reiche peptidlinker |
| US5662907A (en) | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
| US5698522A (en) | 1992-12-04 | 1997-12-16 | Abbott Laboratories | 6-position modified decapeptide LHRH antagonists |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5663907A (en) | 1996-04-25 | 1997-09-02 | Bright Microelectronics, Inc. | Switch driver circuit for providing small sector sizes for negative gate erase flash EEPROMS using a standard twin-well CMOS process |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| JP2002512175A (ja) * | 1998-02-27 | 2002-04-23 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−１類似体の誘導体類 |
| JP4394279B2 (ja) | 1998-03-09 | 2010-01-06 | ジーランド ファーマ アクティーゼルスカブ | 酵素加水分解に対する傾向が減少した薬理学的に活性なペプチド複合体 |
| BR0116024A (pt) | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| JP2007537142A (ja) * | 2003-12-18 | 2007-12-20 | ノボ ノルディスク アクティーゼルスカブ | アルブミン様物質に結合した新規のｇｌｐ−１類似物 |
| JP2008537873A (ja) | 2004-03-31 | 2008-10-02 | セントカー・インコーポレーテツド | ヒトｇｌｐ−１ミメティボディ、組成物、方法および用途 |
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| US20110144010A1 (en) | 2007-06-01 | 2011-06-16 | Novo Nordisk A/S | Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier |
| WO2009030774A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| EP2190872B1 (en) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| EP2512518A1 (en) * | 2009-12-16 | 2012-10-24 | Novo Nordisk A/S | Glp-1 receptor agonist compounds with a modified n-terminus |
| EP2637698B1 (en) | 2010-11-09 | 2022-04-20 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6250034B2 (ja) | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| ES2629735T3 (es) | 2012-05-08 | 2017-08-14 | Novo Nordisk A/S | Derivados de GLP-1 doblemente acilados |
-
2012
- 2012-09-06 EP EP12805429.3A patent/EP2753642B8/en active Active
- 2012-09-06 CN CN201280054416.0A patent/CN104039822A/zh active Pending
- 2012-09-06 JP JP2014528963A patent/JP6126097B2/ja active Active
- 2012-09-06 WO PCT/EP2012/067364 patent/WO2013037690A1/en not_active Ceased
- 2012-09-06 ES ES12805429.3T patent/ES2626013T3/es active Active
- 2012-09-06 CN CN201710403766.8A patent/CN107266558A/zh active Pending
- 2012-09-06 US US14/343,152 patent/US9758560B2/en active Active
-
2017
- 2017-01-12 US US15/404,808 patent/US10308700B2/en active Active
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