JP2014528696A - 前立腺特異幹細胞抗原に対する抗体およびその使用 - Google Patents

前立腺特異幹細胞抗原に対する抗体およびその使用 Download PDF

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JP2014528696A
JP2014528696A JP2014517736A JP2014517736A JP2014528696A JP 2014528696 A JP2014528696 A JP 2014528696A JP 2014517736 A JP2014517736 A JP 2014517736A JP 2014517736 A JP2014517736 A JP 2014517736A JP 2014528696 A JP2014528696 A JP 2014528696A
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antibody
seq
psca
cells
variable region
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JP2014528696A5 (cg-RX-API-DMAC7.html
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バッハマン・ミヒャエル
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Avencell Europe GmbH
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Gemoab GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2014517736A 2011-06-30 2012-06-29 前立腺特異幹細胞抗原に対する抗体およびその使用 Pending JP2014528696A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011118022.6A DE102011118022B4 (de) 2011-06-30 2011-06-30 Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung
DE102011118022.6 2011-06-30
PCT/EP2012/062716 WO2013001065A1 (de) 2011-06-30 2012-06-29 Antikörper gegen das prostata-spezifische stammzellantigen und dessen verwendung

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JP2017002983A Division JP6549622B2 (ja) 2011-06-30 2017-01-12 前立腺特異幹細胞抗原に対する抗体およびその使用

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JP2014528696A true JP2014528696A (ja) 2014-10-30
JP2014528696A5 JP2014528696A5 (cg-RX-API-DMAC7.html) 2015-10-01

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JP2014517736A Pending JP2014528696A (ja) 2011-06-30 2012-06-29 前立腺特異幹細胞抗原に対する抗体およびその使用
JP2017002983A Expired - Fee Related JP6549622B2 (ja) 2011-06-30 2017-01-12 前立腺特異幹細胞抗原に対する抗体およびその使用
JP2019117977A Active JP6886491B2 (ja) 2011-06-30 2019-06-26 前立腺特異幹細胞抗原に対する抗体およびその使用
JP2021081553A Active JP7341185B2 (ja) 2011-06-30 2021-05-13 前立腺特異幹細胞抗原に対する抗体およびその使用

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JP2019117977A Active JP6886491B2 (ja) 2011-06-30 2019-06-26 前立腺特異幹細胞抗原に対する抗体およびその使用
JP2021081553A Active JP7341185B2 (ja) 2011-06-30 2021-05-13 前立腺特異幹細胞抗原に対する抗体およびその使用

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US (1) US9200078B2 (cg-RX-API-DMAC7.html)
EP (2) EP2726507B1 (cg-RX-API-DMAC7.html)
JP (4) JP2014528696A (cg-RX-API-DMAC7.html)
AU (1) AU2012277784B2 (cg-RX-API-DMAC7.html)
CY (1) CY1121249T1 (cg-RX-API-DMAC7.html)
DE (1) DE102011118022B4 (cg-RX-API-DMAC7.html)
DK (1) DK2726507T3 (cg-RX-API-DMAC7.html)
ES (2) ES2711978T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20190289T1 (cg-RX-API-DMAC7.html)
HU (1) HUE042008T2 (cg-RX-API-DMAC7.html)
LT (1) LT2726507T (cg-RX-API-DMAC7.html)
PL (1) PL2726507T3 (cg-RX-API-DMAC7.html)
PT (1) PT2726507T (cg-RX-API-DMAC7.html)
RS (1) RS58448B1 (cg-RX-API-DMAC7.html)
SI (1) SI2726507T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201900085T1 (cg-RX-API-DMAC7.html)
TR (1) TR201901991T4 (cg-RX-API-DMAC7.html)
WO (1) WO2013001065A1 (cg-RX-API-DMAC7.html)

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DE102011118022B4 (de) * 2011-06-30 2018-01-18 Gemoab Monoclonals Gmbh Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung
ES2688035T3 (es) 2014-08-29 2018-10-30 Gemoab Monoclonals Gmbh Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes
CA3221995C (en) 2017-02-08 2024-05-28 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
SG11201907646YA (en) 2017-02-20 2019-09-27 Dragonfly Therapeutics Inc Proteins binding her2, nkg2d and cd16
WO2019066093A1 (ko) * 2017-09-26 2019-04-04 주식회사 와이바이오로직스 Scf 특이적 항체
PT3749346T (pt) 2018-02-08 2024-09-05 Dragonfly Therapeutics Inc Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d
KR20200118824A (ko) 2018-02-08 2020-10-16 드래곤플라이 쎄라퓨틱스, 인크. 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법
CA3091424A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
CA3108646A1 (en) 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and a tumor-associated antigen
AU2019318083A1 (en) 2018-08-08 2021-02-25 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
MX2022013944A (es) 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
CN116406381A (zh) * 2020-05-19 2023-07-07 希望之城 工程化抗前列腺干细胞抗原融合蛋白及其用途
JP2024508894A (ja) 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法
WO2024233662A2 (en) * 2023-05-09 2024-11-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Molecules that bind to psca polypeptides
WO2025179294A2 (en) 2024-02-22 2025-08-28 Capstan Therapeutics, Inc. Immune engineering amplification

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JP2002511740A (ja) * 1997-03-10 2002-04-16 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ｐｓｃａ：前立腺幹細胞抗原
JP2003515330A (ja) * 1999-10-29 2003-05-07 ジェネンテック・インコーポレーテッド 抗前立腺幹細胞抗原（ｐｓｃａ）抗体組成物及び使用方法
JP2007537714A (ja) * 2003-10-16 2007-12-27 マイクロメット アクツィエン ゲゼルシャフト 多重特異的脱免疫ｃｄ３−結合物質
JP2008500833A (ja) * 2004-05-28 2008-01-17 アジェンシス， インコーポレイテッド Ｐｓｃａタンパク質に結合する抗体および関連分子
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EP2726507B1 (de) 2018-11-21
EP3505536B1 (de) 2024-08-07
TR201901991T4 (tr) 2019-03-21
JP2019193652A (ja) 2019-11-07
AU2012277784A1 (en) 2014-02-06
US20140134155A1 (en) 2014-05-15
DK2726507T3 (en) 2019-03-11
JP6549622B2 (ja) 2019-07-24
JP6886491B2 (ja) 2021-06-16
PT2726507T (pt) 2019-02-26
DE102011118022A1 (de) 2013-01-03
JP2021121201A (ja) 2021-08-26
ES2989975T3 (es) 2024-11-28
ES2711978T3 (es) 2019-05-08
US9200078B2 (en) 2015-12-01
JP2017104113A (ja) 2017-06-15
DE102011118022B4 (de) 2018-01-18
HUE042008T2 (hu) 2019-06-28
EP3505536C0 (de) 2024-08-07
HRP20190289T1 (hr) 2019-05-03
RS58448B1 (sr) 2019-04-30
JP7341185B2 (ja) 2023-09-08
SMT201900085T1 (it) 2019-05-10
EP3505536A1 (de) 2019-07-03
CY1121249T1 (el) 2020-05-29
LT2726507T (lt) 2019-04-10
EP2726507A1 (de) 2014-05-07
WO2013001065A1 (de) 2013-01-03
AU2012277784B2 (en) 2015-08-20
PL2726507T3 (pl) 2019-06-28
SI2726507T1 (sl) 2019-05-31

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