JP2014526503A5 - - Google Patents

Download PDF

Info

Publication number
JP2014526503A5
JP2014526503A5 JP2014530636A JP2014530636A JP2014526503A5 JP 2014526503 A5 JP2014526503 A5 JP 2014526503A5 JP 2014530636 A JP2014530636 A JP 2014530636A JP 2014530636 A JP2014530636 A JP 2014530636A JP 2014526503 A5 JP2014526503 A5 JP 2014526503A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
compound
bendamustine
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014530636A
Other languages
English (en)
Japanese (ja)
Other versions
JP6330118B2 (ja
JP2014526503A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/051470 external-priority patent/WO2013039488A1/en
Publication of JP2014526503A publication Critical patent/JP2014526503A/ja
Publication of JP2014526503A5 publication Critical patent/JP2014526503A5/ja
Application granted granted Critical
Publication of JP6330118B2 publication Critical patent/JP6330118B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014530636A 2011-09-13 2011-09-13 ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用 Expired - Fee Related JP6330118B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/051470 WO2013039488A1 (en) 2011-09-13 2011-09-13 Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

Publications (3)

Publication Number Publication Date
JP2014526503A JP2014526503A (ja) 2014-10-06
JP2014526503A5 true JP2014526503A5 (cg-RX-API-DMAC10.html) 2014-11-20
JP6330118B2 JP6330118B2 (ja) 2018-05-30

Family

ID=47883567

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014530636A Expired - Fee Related JP6330118B2 (ja) 2011-09-13 2011-09-13 ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用

Country Status (14)

Country Link
US (1) US9492423B2 (cg-RX-API-DMAC10.html)
EP (1) EP2755648B1 (cg-RX-API-DMAC10.html)
JP (1) JP6330118B2 (cg-RX-API-DMAC10.html)
KR (1) KR101892788B1 (cg-RX-API-DMAC10.html)
CN (1) CN103917231B (cg-RX-API-DMAC10.html)
AU (1) AU2011376953B2 (cg-RX-API-DMAC10.html)
CA (1) CA2845806C (cg-RX-API-DMAC10.html)
ES (1) ES2627820T3 (cg-RX-API-DMAC10.html)
MX (1) MX365393B (cg-RX-API-DMAC10.html)
NZ (1) NZ621221A (cg-RX-API-DMAC10.html)
RU (1) RU2609833C2 (cg-RX-API-DMAC10.html)
SG (1) SG2014014419A (cg-RX-API-DMAC10.html)
UA (1) UA110853C2 (cg-RX-API-DMAC10.html)
WO (1) WO2013039488A1 (cg-RX-API-DMAC10.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120090100A (ko) 2006-12-26 2012-08-16 파마시클릭스, 인코포레이티드 병용 치료에 있어서 히스톤 디아세틸라제 억제제 이용 및 생체표지 감시 방법
CN103917231B (zh) 2011-09-13 2016-09-28 药品循环有限责任公司 组蛋白脱乙酰酶抑制剂与苯达莫司汀的联合制剂及其用途
TWI573792B (zh) 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
EP3226903A1 (en) * 2014-12-05 2017-10-11 University of Modena and Reggio Emila Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma
US20180185345A1 (en) * 2015-06-19 2018-07-05 Trustees Of Boston University Methods and compositions for treating herpesvirus induced conditions
CN114209667A (zh) 2016-04-08 2022-03-22 赛伦诺科技有限公司 包含丙戊酸的延迟释放药物制剂和其用途
WO2017175010A1 (en) * 2016-04-08 2017-10-12 Cereno Scientific Ab Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation
CN109069439A (zh) * 2016-04-21 2018-12-21 瓦尔库里亚公司 用于预处理癌症的组合物和方法
WO2018013962A1 (en) 2016-07-15 2018-01-18 Viracta Therapeutics, Inc. Histone deacetylase inhibitors for use in immunotherapy
US11266631B2 (en) 2016-10-11 2022-03-08 Purdue Pharmaceutical Products L.P. Hodgkin lymphoma therapy
SG10201609137PA (en) * 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Gamma-polyglutamic acid and zinc compositions
SG10201609131YA (en) 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Zinc-pga compositions and methods for treating cancer
GB201706544D0 (en) * 2017-04-25 2017-06-07 Plasticell Ltd Method
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
GB201709403D0 (en) * 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
TR201900059A2 (tr) * 2018-01-05 2019-07-22 Gnt Biotech & Medicals Corp Bi̇r farmasöti̇k kombi̇nasyon ve tümör mi̇kroortaminin ve i̇mmünoterapi̇ni̇n regülasyonu i̇çi̇n yöntem
CA3124005A1 (en) 2018-12-18 2020-06-25 Mundipharma International Corporation Limited Compounds for treating multiple myeloma
EP3976198A4 (en) 2019-05-31 2023-07-19 Viracta Subsidiary, Inc. METHODS OF TREATMENT OF VIRAL ASSOCIATED CANCER WITH HISTONE DEACETYLASE INHIBITORS
WO2022159852A1 (en) * 2021-01-25 2022-07-28 Icahn School Of Medicine At Mount Sinai Methods and compositions for treating adenoid cystic carcinoma
WO2024086688A1 (en) * 2022-10-21 2024-04-25 Viracta Subsidiary, Inc. Dosing methods for hdac inhibitor compounds

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
US2789118A (en) 1956-03-30 1957-04-16 American Cyanamid Co 16-alpha oxy-belta1, 4-pregnadienes
US2990401A (en) 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3048581A (en) 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3749712A (en) 1970-09-25 1973-07-31 Sigma Tau Ind Farmaceuti Triamcinolone acetonide esters and process for their preparation
BE794063A (fr) 1972-01-17 1973-07-16 Henkel & Cie Gmbh Anti-inflammatoires pour compositions cosmetiques
SE378110B (cg-RX-API-DMAC10.html) 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378109B (cg-RX-API-DMAC10.html) 1972-05-19 1975-08-18 Bofors Ab
US3775656A (en) 1972-05-22 1973-11-27 Aviat Inc Platform stabilization system
CH581818A5 (cg-RX-API-DMAC10.html) 1973-02-27 1976-11-15 Cierva Juan J De
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
EP0084236A3 (en) 1981-12-22 1983-08-03 Fbc Limited Fungicidal heterocyclic compounds and compositions containing them
US4498038A (en) 1983-02-15 1985-02-05 Malueg Richard M Stabilization system for soft-mounted platform
US4624848A (en) 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
GB8518301D0 (en) 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
DE3684446D1 (de) 1985-12-28 1992-04-23 Sumitomo Pharma Arzneimittel mit verzoegerter stossweiser freisetzung.
US4968509A (en) 1987-07-27 1990-11-06 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
KR970006890B1 (ko) 1987-10-20 1997-04-30 오스카 세이야꾸 가부시끼가이샤 페닐카르복시산 유도체 및 그 염
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5612059A (en) 1988-08-30 1997-03-18 Pfizer Inc. Use of asymmetric membranes in delivery devices
IL92966A (en) 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
JPH03215470A (ja) 1990-01-22 1991-09-20 Suntory Ltd プロピオン酸アミド誘導体,その製造法及びそれを有効成分として含有する除草剤
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
ES2111065T5 (es) 1991-04-16 2005-06-16 Nippon Shinyaku Company, Limited Procedimiento para producir una dispersion solida.
DE4124345A1 (de) 1991-07-23 1993-01-28 Gruenenthal Gmbh Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5229135A (en) 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
WO1993009785A1 (en) 1991-11-22 1993-05-27 Procter & Gamble Pharmaceuticals, Inc. Risedronate delayed-release compositions
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5260068A (en) 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
KR100291362B1 (ko) 1992-10-16 2001-09-17 니뽄 신야쿠 가부시키가이샤 왁스매트릭스의제법
US5260069A (en) 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5686105A (en) 1993-10-19 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
DE4327365A1 (de) 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
US5448938A (en) 1993-10-18 1995-09-12 Guardian Technologies International, Inc. Removable ballistic resistant armor seat cover and floor mat
US5567441A (en) 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
JPH11505258A (ja) 1995-05-17 1999-05-18 セダーシナイ メディカル センター 小腸における消化および吸収を改善させる脂肪酸を含む組成物
US5798119A (en) 1995-06-13 1998-08-25 S. C. Johnson & Son, Inc. Osmotic-delivery devices having vapor-permeable coatings
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5958957A (en) 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
WO2000072726A1 (en) 1999-05-28 2000-12-07 Grober David E Autonomous, self leveling, self correcting stabilized platform
US6718130B2 (en) 1999-05-28 2004-04-06 David E. Grober Stabilized camera and marker buoy for media coverage of aquatic events
EP1204868A1 (en) 1999-08-10 2002-05-15 Pangene Corporation Cancer treatments and diagnostics utilizing rad51 related molecules and methods
WO2001014331A2 (en) 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
US6660744B1 (en) 1999-09-17 2003-12-09 Abbott Gmbh & Co. Kg Pyrazolopyrimidines as therapeutic agents
KR20070053362A (ko) 1999-11-23 2007-05-23 메틸진, 인크. 히스톤 디아세틸라제의 억제제
JP2004507502A (ja) 2000-08-30 2004-03-11 ファイザー・プロダクツ・インク 成長ホルモン分泌促進物質のための徐放性製剤
GB0023983D0 (en) 2000-09-29 2000-11-15 Prolifix Ltd Therapeutic compounds
CA2423744C (en) 2000-09-29 2012-04-03 Prolifix Limited Hydroxamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
ATE419239T1 (de) 2000-10-20 2009-01-15 Eisai R&D Man Co Ltd Verfahren zur herstellung von 4-phenoxy chinolin derivaten
JP2004527229A (ja) 2000-12-28 2004-09-09 エピダウロス バイオテクノロジー アクツィエンゲゼルシャフト 多型cyp3a5発現の遺伝的決定基の同定
MXPA01013172A (es) 2001-02-14 2002-08-21 Warner Lambert Co Inhibidores sulfonamida de metaloproteinasa de matriz.
US6465014B1 (en) 2001-03-21 2002-10-15 Isp Investments Inc. pH-dependent sustained release, drug-delivery composition
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
RU2286784C2 (ru) 2001-06-28 2006-11-10 ЮСиБи ФАРШИМ С.А. Таблетка, содержащая цетиризин и псевдоэфедрин
US7247426B2 (en) 2001-08-02 2007-07-24 Agilent Technologies, Inc. Classifying cancers
ITMI20011733A1 (it) 2001-08-07 2003-02-07 Italfarmaco Spa Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
RU2298414C2 (ru) 2001-08-21 2007-05-10 Астеллас Фарма Инк. Медицинское применение ингибитора гистоновой дезацетилазы и способ оценки его противоопухолевого действия
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20030166026A1 (en) 2002-01-09 2003-09-04 Lynx Therapeutics, Inc. Identification of specific biomarkers for breast cancer cells
US20060078879A1 (en) 2002-02-04 2006-04-13 Epidauros Biotechnologie Ag Polymorphisms in the human gene for tpmt and their use in diagnostic and therapeutic applications
JPWO2003070691A1 (ja) 2002-02-21 2005-06-09 財団法人大阪産業振興機構 N−ヒドロキシカルボキサミド誘導体
US20040132825A1 (en) 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
MXPA05001334A (es) 2002-08-02 2005-09-08 Argenta Discovery Ltd Acidos tienil-hidroxamicos sustituidos como inhibidores de la desacetilasa de histona.
EP1400806A1 (en) 2002-09-18 2004-03-24 G2M Cancer Drugs AG The use of molecular markers for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity
US6769347B1 (en) 2002-11-26 2004-08-03 Recon/Optical, Inc. Dual elevation weapon station and method of use
MXPA05008904A (es) 2003-02-19 2005-10-05 Astellas Pharma Inc Metodo para estimar el efecto antitumoral del inhibidor de desacetilasa de histona.
GB0303910D0 (en) 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
EP1608628A2 (en) 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
CN1768031A (zh) * 2003-04-07 2006-05-03 Axys药物公司 作为治疗剂的异羟肟酸酯
WO2004092115A2 (en) 2003-04-07 2004-10-28 Axys Pharmaceuticals Inc. Hydroxamates as therapeutic agents
PE20050206A1 (es) 2003-05-26 2005-03-26 Schering Ag Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
PL2263694T3 (pl) 2003-09-25 2013-11-29 Astellas Pharma Inc Środek przeciwnowotworowy zawierający FK228 jako inhibitor deacetylazy histonowej i doksorubicynę jako inhibitor topoizomerazy II
US20070099190A1 (en) 2003-11-04 2007-05-03 Martin Dugas Method for distinguishing leukemia subtypes
EP1694866A4 (en) 2003-12-12 2007-12-26 Bayer Pharmaceuticals Corp GENE EXPRESSION PROFILES AND METHOD OF USE
US8019552B2 (en) 2004-03-05 2011-09-13 The Netherlands Cancer Institute Classification of breast cancer patients using a combination of clinical criteria and informative genesets
US7368476B2 (en) 2004-04-07 2008-05-06 Pharmacyclics, Inc. Hydroxamates as therapeutic agents
SI1591109T1 (sl) 2004-04-30 2008-10-31 Topotarget Germany Ag Formulacija, ki obsega inhibitor histon-deacetilaze in izkazuje dvofazno sproščanje
BRPI0511065A (pt) 2004-06-04 2007-12-26 Pfizer Prod Inc método para tratar crescimento de célula anormal
CA2575557A1 (en) 2004-07-30 2006-02-09 Rosetta Inpharmatics Llc Prognosis of breast cancer patients
WO2006042035A2 (en) 2004-10-07 2006-04-20 Pharmacyclics, Inc. Method of monitoring anti-tumor activity of an hdac inhibitor
AR054094A1 (es) 2004-11-05 2007-06-06 Cephalon Inc Tratamientos de cancer
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
WO2006101454A1 (en) 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
WO2007109178A2 (en) 2006-03-16 2007-09-27 Pharmacyclics, Inc. Indole derivatives as inhibitors of histone deacetylase
HRP20130080T1 (hr) 2006-09-15 2013-02-28 Janssen Pharmaceutica Nv Inhibitori histonske deacetilaze sa spojenom aktivnosti protiv histonskih deacetilaza klase-i i klase-iib u kombinaciji sa inhibitorima proteasoma
KR20120090100A (ko) 2006-12-26 2012-08-16 파마시클릭스, 인코포레이티드 병용 치료에 있어서 히스톤 디아세틸라제 억제제 이용 및 생체표지 감시 방법
EP2993473A1 (en) 2007-01-30 2016-03-09 Pharmacyclics, Inc. Methods for determining cancer resistance to histone deacetylase inhibitors
EP2060565A1 (en) * 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
EP2110377A1 (en) * 2008-04-15 2009-10-21 DAC S.r.l. Spirocyclic derivatives as histone deacetylase inhibitors
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
UY34295A (es) 2011-09-08 2013-04-30 Servier Lab Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida
CN103917231B (zh) 2011-09-13 2016-09-28 药品循环有限责任公司 组蛋白脱乙酰酶抑制剂与苯达莫司汀的联合制剂及其用途
WO2015017812A1 (en) 2013-08-02 2015-02-05 Pharmacyclics, Inc. Methods for the treatment of solid tumors

Similar Documents

Publication Publication Date Title
JP2014526503A5 (cg-RX-API-DMAC10.html)
RU2014111069A (ru) Лекарственные формы ингибитора гистондиацетилазы в комбинации с бендамутином и их применение
JP2012255026A5 (cg-RX-API-DMAC10.html)
JP2016515628A5 (cg-RX-API-DMAC10.html)
JP2017057230A5 (cg-RX-API-DMAC10.html)
JP2016540738A5 (cg-RX-API-DMAC10.html)
JP2012193216A5 (cg-RX-API-DMAC10.html)
JP2006504795A5 (cg-RX-API-DMAC10.html)
JP2014515373A5 (cg-RX-API-DMAC10.html)
JP2015522630A5 (cg-RX-API-DMAC10.html)
JP2011529968A5 (cg-RX-API-DMAC10.html)
JP2012525393A5 (cg-RX-API-DMAC10.html)
JP2011173928A5 (cg-RX-API-DMAC10.html)
JP2013507415A5 (cg-RX-API-DMAC10.html)
FI3782612T3 (fi) Sytidiinianalogien oraalisia formulaatioita ja menetelmiä niiden käyttämiseksi
JP2015536964A5 (cg-RX-API-DMAC10.html)
FI3936130T3 (fi) Valbenatsiinin annostusohjelma hyperkineettisten liikehäiriöiden hoitoon
JP2015038135A5 (cg-RX-API-DMAC10.html)
JP2012533565A5 (cg-RX-API-DMAC10.html)
JP2017537126A5 (cg-RX-API-DMAC10.html)
JP2013541583A5 (cg-RX-API-DMAC10.html)
JP2013522326A5 (cg-RX-API-DMAC10.html)
PH12014502447A1 (en) Use of high dose laquinimod for treating multiple sclerosis
ME02474B (me) Terapijski režimi
JP2016507500A5 (cg-RX-API-DMAC10.html)