JP2013507415A5 - - Google Patents
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- JP2013507415A5 JP2013507415A5 JP2012533589A JP2012533589A JP2013507415A5 JP 2013507415 A5 JP2013507415 A5 JP 2013507415A5 JP 2012533589 A JP2012533589 A JP 2012533589A JP 2012533589 A JP2012533589 A JP 2012533589A JP 2013507415 A5 JP2013507415 A5 JP 2013507415A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25085209P | 2009-10-12 | 2009-10-12 | |
| US61/250,852 | 2009-10-12 | ||
| PCT/EP2010/065149 WO2011054620A1 (en) | 2009-10-12 | 2010-10-11 | Combinations of a pi3k inhibitor and a mek inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014202819A Division JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507415A JP2013507415A (ja) | 2013-03-04 |
| JP2013507415A5 true JP2013507415A5 (cg-RX-API-DMAC10.html) | 2014-04-24 |
Family
ID=43072663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533589A Ceased JP2013507415A (ja) | 2009-10-12 | 2010-10-11 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
| JP2014202819A Expired - Fee Related JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014202819A Expired - Fee Related JP5745678B2 (ja) | 2009-10-12 | 2014-10-01 | Ｐｉ３ｋ阻害剤とｍｅｋ阻害剤の併用 |
Country Status (24)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110028651A (ko) | 2008-07-11 | 2011-03-21 | 노파르티스 아게 | (ａ) 포스포이노시타이드 3-키나제 억제제 및 (ｂ) ｒａｓ/ｒａｆ/ｍｅｋ 경로의 조절제의 조합물 |
| HRP20150947T1 (hr) | 2009-01-08 | 2015-10-09 | Curis, Inc. | Inhibitori fosfoinositid 3-kinaze sa skupinom koja veže cink |
| PH12012501361A1 (en) | 2009-12-31 | 2012-10-22 | Centro Nac De Investigaciones Oncologicas Cnio | Tricyclic compounds for use as kinase inhibitors |
| WO2012098387A1 (en) | 2011-01-18 | 2012-07-26 | Centro Nacional De Investigaciones Oncológicas (Cnio) | 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors |
| LT3111938T (lt) | 2011-04-01 | 2019-06-25 | Curis, Inc. | Fosfoinozitido 3-kinazės inhibitorius su cinko rišamąja dalimi |
| BR112014002353B1 (pt) | 2011-08-01 | 2022-09-27 | Genentech, Inc | Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit |
| RU2607944C2 (ru) * | 2011-08-31 | 2017-01-11 | Новартис Аг | Синергические композиции ингибиторов pi3k и мек |
| CA2849331A1 (en) | 2011-10-13 | 2013-04-18 | Genentech, Inc. | Treatment of pharmacological-induced hypochlorhydria |
| EP2776051A4 (en) * | 2011-10-28 | 2015-06-17 | Hoffmann La Roche | THERAPEUTIC COMBINATIONS AND METHOD FOR THE TREATMENT OF MELANOMA |
| WO2013082511A1 (en) | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Methods for overcoming tumor resistance to vegf antagonists |
| WO2013152165A1 (en) * | 2012-04-06 | 2013-10-10 | Sanofi | Methods for treating cancer using pi3k inhibitor and mek inhibitor |
| US9566307B2 (en) | 2012-04-19 | 2017-02-14 | Kyushu University, National University Corporation | Pharmaceutical composition |
| MX2014014831A (es) | 2012-06-08 | 2015-02-12 | Hoffmann La Roche | Selectividad de mutante y combinaciones de un compuesto inhibidor de fosfoinositida 3 cinasa y agentes quimioterapeuticos para el tratamiento de cancer. |
| MX2015001399A (es) | 2012-08-02 | 2015-09-07 | Genentech Inc | Anticuerpos anti-etbr e inmunoconjugados. |
| MX2015001407A (es) | 2012-08-02 | 2015-05-08 | Genentech Inc | Inmunoconjugados y anticuerpos anti-etbr. |
| KR20150038068A (ko) * | 2012-08-17 | 2015-04-08 | 에프. 호프만-라 로슈 아게 | 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법 |
| CN105246508A (zh) * | 2013-03-14 | 2016-01-13 | 基因泰克公司 | Mek抑制剂化合物与her3/egfr抑制剂化合物的组合及使用方法 |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| DK3698790T3 (da) * | 2014-02-07 | 2023-06-19 | Verastem Inc | Fremgangsmåder til behandling af abnorm cellevækst |
| CN106573060A (zh) | 2014-07-15 | 2017-04-19 | 豪夫迈·罗氏有限公司 | 使用pd‑1轴结合拮抗剂和mek抑制剂治疗癌症的组合物 |
| CN107073066B (zh) * | 2014-09-11 | 2021-09-17 | 加利福尼亚大学董事会 | mTORC1抑制剂 |
| US11234986B2 (en) | 2018-09-11 | 2022-02-01 | Curis, Inc. | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
| CN110420330B (zh) * | 2019-07-19 | 2020-05-29 | 南京医科大学 | 一种pi3k与mth1靶向药组合物的制药用途 |
| JP2022547358A (ja) | 2019-09-13 | 2022-11-14 | ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル | 治療組成物、組み合わせ、及び使用方法 |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470356A1 (de) * | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| BE754606A (fr) * | 1969-08-08 | 1971-02-08 | Thomae Gmbh Dr K | Nouvelles 2-aminoalcoylamino-thieno(3,2-d)pyrimidines et leurs procedesde fabrication |
| BE759493A (fr) * | 1969-11-26 | 1971-05-25 | Thomae Gmbh Dr K | Nouvelles 2-(5-nitro-2-furyl)-thieno(3,2-d) pyrimidines et procedes pour les fabriquer |
| US3763156A (en) * | 1970-01-28 | 1973-10-02 | Boehringer Sohn Ingelheim | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines |
| CH592668A5 (cg-RX-API-DMAC10.html) * | 1973-10-02 | 1977-10-31 | Delalande Sa | |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| US4510139A (en) * | 1984-01-06 | 1985-04-09 | Sterling Drug Inc. | Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity |
| BR9507203A (pt) * | 1994-04-01 | 1997-09-09 | Shionogi & Co | Derivado de oxima e bactericida que contém o mesmo como ingredientes ativo |
| US6974878B2 (en) * | 2001-03-21 | 2005-12-13 | Symyx Technologies, Inc. | Catalyst ligands, catalytic metal complexes and processes using same |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| CN1219753C (zh) * | 2000-07-19 | 2005-09-21 | 沃尼尔·朗伯公司 | 4－碘苯氨基苯氧肟酸的氧合酯 |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| CA2517517C (en) * | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20050049276A1 (en) * | 2003-07-23 | 2005-03-03 | Warner-Lambert Company, Llc | Imidazopyridines and triazolopyridines |
| US7144907B2 (en) * | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US7538120B2 (en) * | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| US8084645B2 (en) * | 2003-09-19 | 2011-12-27 | Chugai Seiyaku Kabushiki Kaisha | 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors |
| US7517994B2 (en) * | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| NZ567140A (en) * | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| CL2007001165A1 (es) | 2006-04-26 | 2008-01-25 | Hoffmann La Roche | 2-(1h-indazol-4-il)-6-(4-metanosulfonil-piperazin-1-ilmetil)-4-morfolin-4-il-tieno[3,2-d]pirimidina; procedimiento de preparacion; composicion farmaceutica; proceso de preparacion de dicha composicion; kit farmaceutico; y uso para tratar enfermedades tales como cancer, desordenes inmunes y enfermedades cardiovasculares. |
| CA2658725A1 (en) * | 2006-08-16 | 2008-02-21 | Exelixis, Inc. | Using pi3k and mek modulators in treatments of cancer |
| AR064155A1 (es) * | 2006-12-07 | 2009-03-18 | Piramed Ltd | Compuestos de inhibidores de fosfoinositido-3 quinasa y metodos de uso |
| CA2699202C (en) | 2007-09-12 | 2016-09-27 | F. Hoffmann-La Roche Ag | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| CN103841976A (zh) * | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
-
2010
- 2010-10-11 MX MX2012004286A patent/MX345155B/es active IP Right Grant
- 2010-10-11 NZ NZ599939A patent/NZ599939A/en not_active IP Right Cessation
- 2010-10-11 ES ES10768448.2T patent/ES2609767T3/es active Active
- 2010-10-11 BR BR112012008483A patent/BR112012008483A2/pt not_active IP Right Cessation
- 2010-10-11 CN CN2010800563069A patent/CN102740851B/zh not_active Expired - Fee Related
- 2010-10-11 AU AU2010314287A patent/AU2010314287A1/en not_active Abandoned
- 2010-10-11 PE PE2012000470A patent/PE20121816A1/es not_active Application Discontinuation
- 2010-10-11 TW TW099134615A patent/TWI428336B/zh not_active IP Right Cessation
- 2010-10-11 US US12/902,062 patent/US20110086837A1/en not_active Abandoned
- 2010-10-11 JP JP2012533589A patent/JP2013507415A/ja not_active Ceased
- 2010-10-11 EP EP10768448.2A patent/EP2488178B1/en not_active Not-in-force
- 2010-10-11 PH PH1/2012/500709A patent/PH12012500709A1/en unknown
- 2010-10-11 MA MA34821A patent/MA33974B1/fr unknown
- 2010-10-11 CA CA2776944A patent/CA2776944A1/en not_active Abandoned
- 2010-10-11 WO PCT/EP2010/065149 patent/WO2011054620A1/en not_active Ceased
- 2010-10-11 KR KR1020127012069A patent/KR101489045B1/ko not_active Expired - Fee Related
- 2010-10-11 RU RU2012118974/15A patent/RU2563193C2/ru not_active IP Right Cessation
- 2010-10-12 AR ARP100103706A patent/AR078588A1/es not_active Application Discontinuation
-
2012
- 2012-04-05 IL IL219105A patent/IL219105A0/en unknown
- 2012-04-10 CR CR20120173A patent/CR20120173A/es unknown
- 2012-04-11 CL CL2012000913A patent/CL2012000913A1/es unknown
- 2012-04-11 ZA ZA2012/02618A patent/ZA201202618B/en unknown
- 2012-04-20 CO CO12065784A patent/CO6531463A2/es not_active Application Discontinuation
- 2012-05-03 EC ECSP12011865 patent/ECSP12011865A/es unknown
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2014
- 2014-10-01 JP JP2014202819A patent/JP5745678B2/ja not_active Expired - Fee Related