JP2014525461A5 - - Google Patents
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- JP2014525461A5 JP2014525461A5 JP2014528651A JP2014528651A JP2014525461A5 JP 2014525461 A5 JP2014525461 A5 JP 2014525461A5 JP 2014528651 A JP2014528651 A JP 2014528651A JP 2014528651 A JP2014528651 A JP 2014528651A JP 2014525461 A5 JP2014525461 A5 JP 2014525461A5
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- JP
- Japan
- Prior art keywords
- liposome
- motomeko
- rna
- liposome according
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002502 liposome Substances 0.000 claims description 36
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims description 17
- 230000002163 immunogen Effects 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 241000710929 Alphavirus Species 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 108010012057 RNA Replicase Proteins 0.000 claims description 2
- 108060006943 RdRp Proteins 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 125000003827 glycol group Chemical group 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 244000045947 parasites Species 0.000 claims description 2
- 230000001681 protective Effects 0.000 claims description 2
- 230000001580 bacterial Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
- 101710006371 EIF2AK2 Proteins 0.000 description 4
- 102100011490 EIF2AK2 Human genes 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 1
- 108020004461 Double-Stranded RNA Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 210000000987 Immune System Anatomy 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 102000010982 eIF-2 Kinase Human genes 0.000 description 1
Description
ＰＫＲは、二本鎖ＲＮＡ依存性プロテインキナーゼである。これは、先天的免疫系において重要な役割を果たす。「ＥＩＦ２ＡＫ２」（真核生物翻訳開始因子２−αキナーゼ２（ｅｕｋａｒｙｏｔｉｃ ｔｒａｎｓｌａｔｉｏｎ ｉｎｉｔｉａｔｉｏｎ ｆａｃｔｏｒ ２−ａｌｐｈａ ｋｉｎａｓｅ ２）について）は、この酵素をコードする遺伝子の承認されたＨＧＮＣ名であり、その特有のＨＧＮＣ ＩＤは、ＨＧＮＣ：９４３７である。ヒトＰＫＲ遺伝子のＲｅｆＳｅｑ配列は、ＧＩ：２０８４３１８２５である。
例えば、本発明は、以下の項目を提供する：
（項目１）
目的の免疫原をコードするＲＮＡが被包されているリポソームであって、ここで該リポソームは、ポリエチレングリコールが該リポソームの外側に存在するようにポリエチレングリコール部分を含む少なくとも１種の脂質を含み、該ポリエチレングリコールの平均分子量は、３ｋＤａより高いが１１ｋＤａ未満である、リポソーム。
（項目２）
ＰＥＧ−ＤＭＧおよび／もしくは式（Ｘ）の脂質を含む、項目１に記載のリポソーム。
（項目３）
上記リポソームは、８０〜１６０ｎｍの範囲の直径を有する、上述の項目のいずれかに記載のリポソーム。
（項目４）
上記リポソームは、カチオン性ヘッド基を有する脂質を含む、上述の項目のいずれかに記載のリポソーム。
（項目５）
上記リポソームは、両性イオン性ヘッド基を有する脂質を含む、上述の項目のいずれかに記載のリポソーム。
（項目６）
上記ＲＮＡは、自己複製ＲＮＡである、上述の項目のいずれかに記載のリポソーム。
（項目７）
上記自己複製ＲＮＡ分子は、（ｉ）該自己複製ＲＮＡ分子からＲＮＡを転写し得るＲＮＡ依存性ＲＮＡポリメラーゼ、および（ｉｉ）免疫原をコードする、項目６に記載のリポソーム。
（項目８）
上記ＲＮＡ分子は、２つのオープンリーディングフレームを有し、該オープンリーディングフレームのうちの第１のものは、アルファウイルスレプリカーゼをコードし、該オープンリーディングフレームのうちの第２のものは、上記免疫原をコードする、項目７に記載のリポソーム。
（項目９）
上記ＲＮＡ分子は、９０００〜１２０００ヌクレオチド長である、上述の項目のいずれかに記載のリポソーム。
（項目１０）
上記免疫原は、細菌、ウイルス、真菌もしくは寄生生物に対してインビボで免疫応答を誘発し得る、上述の項目のいずれかに記載のリポソーム。
（項目１１）
上述の項目のいずれかに記載のリポソームを含む、薬学的組成物。
（項目１２）
脊椎動物において防御免疫応答を惹起するための方法であって、該方法は、該脊椎動物に、有効量の、項目１〜１０に記載のリポソームまたは項目１１に記載の薬学的組成物を投与する工程を包含する、方法。
例えば、本発明は、以下の項目を提供する：
（項目１）
目的の免疫原をコードするＲＮＡが被包されているリポソームであって、ここで該リポソームは、ポリエチレングリコールが該リポソームの外側に存在するようにポリエチレングリコール部分を含む少なくとも１種の脂質を含み、該ポリエチレングリコールの平均分子量は、３ｋＤａより高いが１１ｋＤａ未満である、リポソーム。
（項目２）
ＰＥＧ−ＤＭＧおよび／もしくは式（Ｘ）の脂質を含む、項目１に記載のリポソーム。
（項目３）
上記リポソームは、８０〜１６０ｎｍの範囲の直径を有する、上述の項目のいずれかに記載のリポソーム。
（項目４）
上記リポソームは、カチオン性ヘッド基を有する脂質を含む、上述の項目のいずれかに記載のリポソーム。
（項目５）
上記リポソームは、両性イオン性ヘッド基を有する脂質を含む、上述の項目のいずれかに記載のリポソーム。
（項目６）
上記ＲＮＡは、自己複製ＲＮＡである、上述の項目のいずれかに記載のリポソーム。
（項目７）
上記自己複製ＲＮＡ分子は、（ｉ）該自己複製ＲＮＡ分子からＲＮＡを転写し得るＲＮＡ依存性ＲＮＡポリメラーゼ、および（ｉｉ）免疫原をコードする、項目６に記載のリポソーム。
（項目８）
上記ＲＮＡ分子は、２つのオープンリーディングフレームを有し、該オープンリーディングフレームのうちの第１のものは、アルファウイルスレプリカーゼをコードし、該オープンリーディングフレームのうちの第２のものは、上記免疫原をコードする、項目７に記載のリポソーム。
（項目９）
上記ＲＮＡ分子は、９０００〜１２０００ヌクレオチド長である、上述の項目のいずれかに記載のリポソーム。
（項目１０）
上記免疫原は、細菌、ウイルス、真菌もしくは寄生生物に対してインビボで免疫応答を誘発し得る、上述の項目のいずれかに記載のリポソーム。
（項目１１）
上述の項目のいずれかに記載のリポソームを含む、薬学的組成物。
（項目１２）
脊椎動物において防御免疫応答を惹起するための方法であって、該方法は、該脊椎動物に、有効量の、項目１〜１０に記載のリポソームまたは項目１１に記載の薬学的組成物を投与する工程を包含する、方法。
Claims (12)
- 目的の免疫原をコードするＲＮＡが被包されているリポソームであって、ここで該リポソームは、ポリエチレングリコールが該リポソームの外側に存在するようにポリエチレングリコール部分を含む少なくとも１種の脂質を含み、該ポリエチレングリコールの平均分子量は、３ｋＤａより高いが１１ｋＤａ未満である、リポソーム。
- ＰＥＧ−ＤＭＧおよび／もしくは式（Ｘ）の脂質を含む、請求項１に記載のリポソーム。
- 前記リポソームは、８０〜１６０ｎｍの範囲の直径を有する、請求項１〜２のいずれかに記載のリポソーム。
- 前記リポソームは、カチオン性ヘッド基を有する脂質を含む、請求項１〜３のいずれかに記載のリポソーム。
- 前記リポソームは、両性イオン性ヘッド基を有する脂質を含む、請求項１〜４のいずれかに記載のリポソーム。
- 前記ＲＮＡは、自己複製ＲＮＡである、請求項１〜５のいずれかに記載のリポソーム。
- 前記自己複製ＲＮＡ分子は、（ｉ）該自己複製ＲＮＡ分子からＲＮＡを転写し得るＲＮＡ依存性ＲＮＡポリメラーゼ、および（ｉｉ）免疫原をコードする、請求項６に記載のリポソーム。
- 前記ＲＮＡ分子は、２つのオープンリーディングフレームを有し、該オープンリーディングフレームのうちの第１のものは、アルファウイルスレプリカーゼをコードし、該オープンリーディングフレームのうちの第２のものは、前記免疫原をコードする、請求項７に記載のリポソーム。
- 前記ＲＮＡ分子は、９０００〜１２０００ヌクレオチド長である、請求項１〜８のいずれかに記載のリポソーム。
- 前記免疫原は、細菌、ウイルス、真菌もしくは寄生生物に対してインビボで免疫応答を誘発し得る、請求項１〜９のいずれかに記載のリポソーム。
- 請求項１〜１０のいずれかに記載のリポソームを含む、薬学的組成物。
- 脊椎動物において防御免疫応答を惹起するための、有効量の請求項１〜１０に記載のリポソームを含む組成物または請求項１１に記載の薬学的組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529878P | 2011-08-31 | 2011-08-31 | |
| US61/529,878 | 2011-08-31 | ||
| PCT/US2012/053391 WO2013033563A1 (en) | 2011-08-31 | 2012-08-31 | Pegylated liposomes for delivery of immunogen-encoding rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014525461A JP2014525461A (ja) | 2014-09-29 |
| JP2014525461A5 true JP2014525461A5 (ja) | 2015-10-15 |
Family
ID=47003206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528651A Pending JP2014525461A (ja) | 2011-08-31 | 2012-08-31 | 免疫原をコードするｒｎａの送達のためのｐｅｇ化リポソーム |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20140255472A1 (ja) |
| EP (2) | EP3508220A1 (ja) |
| JP (1) | JP2014525461A (ja) |
| CN (1) | CN103974719A (ja) |
| AU (1) | AU2012301715B2 (ja) |
| BR (1) | BR112014004607A2 (ja) |
| CA (1) | CA2846043A1 (ja) |
| CY (1) | CY1121122T1 (ja) |
| DK (1) | DK2750707T3 (ja) |
| ES (1) | ES2705498T3 (ja) |
| HR (1) | HRP20190032T1 (ja) |
| HU (1) | HUE041800T2 (ja) |
| LT (1) | LT2750707T (ja) |
| MX (1) | MX366055B (ja) |
| PL (1) | PL2750707T3 (ja) |
| PT (1) | PT2750707T (ja) |
| RU (1) | RU2628705C2 (ja) |
| SG (2) | SG11201400250UA (ja) |
| SI (1) | SI2750707T1 (ja) |
| TR (1) | TR201900264T4 (ja) |
| WO (1) | WO2013033563A1 (ja) |
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