JP2014524411A5 - - Google Patents

Info

Publication number

JP2014524411A5

JP2014524411A5 JP2014523151A JP2014523151A JP2014524411A5 JP 2014524411 A5 JP2014524411 A5 JP 2014524411A5 JP 2014523151 A JP2014523151 A JP 2014523151A JP 2014523151 A JP2014523151 A JP 2014523151A JP 2014524411 A5 JP2014524411 A5 JP 2014524411A5

Authority

JP

Japan

Prior art keywords

alkyl

compound

branched

chain alkyl

cycloalkyl

Prior art date

2012-07-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 125000000217 alkyl group Chemical group 0.000 claims 46
• 150000001875 compounds Chemical class 0.000 claims 27
• 125000000753 cycloalkyl group Chemical group 0.000 claims 15
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000001424 substituent group Chemical group 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 6
• 239000012453 solvate Substances 0.000 claims 6
• 125000003342 alkenyl group Chemical group 0.000 claims 5
• 125000003118 aryl group Chemical group 0.000 claims 5
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
• 229910052731 fluorine Inorganic materials 0.000 claims 4
• 239000011737 fluorine Substances 0.000 claims 4
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 0 C1=CC=I*=C1 Chemical compound C1=CC=I*=C1 0.000 description 3
• -1 4'-carbamoylbiphenyl-4-yl Chemical group 0.000 description 1
• HMUMQJBSKMSHFK-JBSCERNYSA-N CC(C)(/C=C\C=C(/C)\OC)C1=CC=[I]C=C1 Chemical compound CC(C)(/C=C\C=C(/C)\OC)C1=CC=[I]C=C1 HMUMQJBSKMSHFK-JBSCERNYSA-N 0.000 description 1
• YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
• 229940126214 compound 3 Drugs 0.000 description 1