JP2014524246A5 - - Google Patents
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- Publication number
- JP2014524246A5 JP2014524246A5 JP2014524458A JP2014524458A JP2014524246A5 JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5 JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5
- Authority
- JP
- Japan
- Prior art keywords
- host
- crocetin
- seq
- set forth
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- PANKHBYNKQNAHN-JTBLXSOISA-N Crocetin Natural products OC(=O)C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)C(O)=O PANKHBYNKQNAHN-JTBLXSOISA-N 0.000 claims 9
- PANKHBYNKQNAHN-JUMCEFIXSA-N carotenoid dicarboxylic acid Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)O)C=CC=C(/C)C(=O)O PANKHBYNKQNAHN-JUMCEFIXSA-N 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- PANKHBYNKQNAHN-MQQNZMFNSA-N crocetin Chemical compound OC(=O)C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C(O)=O PANKHBYNKQNAHN-MQQNZMFNSA-N 0.000 claims 7
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 3
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 3
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 claims 3
- SEBIKDIMAPSUBY-JAUCNNNOSA-N Crocin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C=CC=C(/C)C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O SEBIKDIMAPSUBY-JAUCNNNOSA-N 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 3
- 102000007317 Farnesyltranstransferase Human genes 0.000 claims 3
- 108010007508 Farnesyltranstransferase Proteins 0.000 claims 3
- 108010091656 beta-carotene hydroxylase Proteins 0.000 claims 3
- 102000000340 Glucosyltransferases Human genes 0.000 claims 2
- 108010055629 Glucosyltransferases Proteins 0.000 claims 2
- 101710173432 Phytoene synthase Proteins 0.000 claims 2
- WMHJCSAICLADIN-MVVLZTAMSA-N Picrocrocin Natural products O=CC=1C(C)(C)C[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)CC=1C WMHJCSAICLADIN-MVVLZTAMSA-N 0.000 claims 2
- 241000235342 Saccharomycetes Species 0.000 claims 2
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 2
- 235000013734 beta-carotene Nutrition 0.000 claims 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 2
- 239000011648 beta-carotene Substances 0.000 claims 2
- 229960002747 betacarotene Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 108010001545 phytoene dehydrogenase Proteins 0.000 claims 2
- WMHJCSAICLADIN-WYWSWGBSSA-N picrocrocin Chemical compound C1C(C)=C(C=O)C(C)(C)C[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 WMHJCSAICLADIN-WYWSWGBSSA-N 0.000 claims 2
- SGAWOGXMMPSZPB-UHFFFAOYSA-N safranal Chemical compound CC1=C(C=O)C(C)(C)CC=C1 SGAWOGXMMPSZPB-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 2
- YHCIKUXPWFLCFN-MTGLMCJBSA-N Crocetin dialdehyde Natural products CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=O)/C)C=O YHCIKUXPWFLCFN-MTGLMCJBSA-N 0.000 claims 1
- 244000124209 Crocus sativus Species 0.000 claims 1
- 235000015655 Crocus sativus Nutrition 0.000 claims 1
- 101100433159 Crocus sativus ZCD gene Proteins 0.000 claims 1
- 102000016680 Dioxygenases Human genes 0.000 claims 1
- 108010028143 Dioxygenases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 101100262416 Stevia rebaudiana UGT76G1 gene Proteins 0.000 claims 1
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- YHCIKUXPWFLCFN-QHUUTLAPSA-N crocetin dialdehyde Chemical compound O=CC(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C=O YHCIKUXPWFLCFN-QHUUTLAPSA-N 0.000 claims 1
- -1 crocetin ester Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 235000017509 safranal Nutrition 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521171P | 2011-08-08 | 2011-08-08 | |
| US61/521,171 | 2011-08-08 | ||
| US201161576460P | 2011-12-16 | 2011-12-16 | |
| US61/576,460 | 2011-12-16 | ||
| US201261595450P | 2012-02-06 | 2012-02-06 | |
| US61/595,450 | 2012-02-06 | ||
| PCT/IB2012/001513 WO2013021261A2 (en) | 2011-08-08 | 2012-08-07 | Methods and materials for recombinant production of saffron compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524246A JP2014524246A (ja) | 2014-09-22 |
| JP2014524246A5 true JP2014524246A5 (https=) | 2015-10-01 |
| JP6126597B2 JP6126597B2 (ja) | 2017-05-10 |
Family
ID=46970359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524458A Active JP6126597B2 (ja) | 2011-08-08 | 2012-08-07 | サフラン化合物の組換え生成のための方法および材料 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140248668A1 (https=) |
| EP (1) | EP2742131B1 (https=) |
| JP (1) | JP6126597B2 (https=) |
| KR (2) | KR101815063B1 (https=) |
| CN (1) | CN103764818B (https=) |
| AU (1) | AU2012293402B2 (https=) |
| BR (1) | BR112014002924A2 (https=) |
| CA (1) | CA2843549A1 (https=) |
| HK (1) | HK1199286A1 (https=) |
| IN (1) | IN2014CN01129A (https=) |
| RU (1) | RU2676730C2 (https=) |
| WO (1) | WO2013021261A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| EP3114210A2 (en) * | 2014-03-07 | 2017-01-11 | Evolva SA | Methods for recombinant production of saffron compounds |
| US20170044552A1 (en) * | 2014-04-25 | 2017-02-16 | Evolva Sa | Methods for Recombinant Production of Saffron Compounds |
| JP2017515512A (ja) * | 2014-05-16 | 2017-06-15 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | アスタキサンチンを生産するための組換えポリヌクレオチド配列及びその使用 |
| EP3194580A1 (en) * | 2014-07-23 | 2017-07-26 | ENEA-Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile | A carotenoid dioxygenase and methods for the biotechnological production in microorganisms and plants of compounds derived from saffron |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) * | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA3010716A1 (en) | 2016-01-07 | 2017-07-13 | Conagen Inc. | Methods of making capsinoids by biosynthetic processes |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN105950580B (zh) * | 2016-05-25 | 2019-03-08 | 新疆农业科学院经济作物研究所 | 一种制备蛋白质UGTCs4的方法 |
| CN105779406B (zh) * | 2016-05-25 | 2019-06-18 | 新疆农业科学院经济作物研究所 | 一种藏红花酸糖基转移酶及其编码基因与应用 |
| CN105950493B (zh) * | 2016-05-25 | 2019-12-27 | 天津大学 | 一种工程菌及其构建方法与在制备藏红花酸中的应用 |
| EP3487986B1 (en) | 2016-07-19 | 2021-06-30 | Conagen Inc. | Method for the microbial production of specific natural capsaicinoids |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| IT201700089843A1 (it) * | 2017-08-03 | 2019-02-03 | Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile | Geni e metodi per la produzione e compartimentazione biotecnologica di apocarotenoidi ad elevato valore aggiunto |
| CN110791510A (zh) * | 2018-08-02 | 2020-02-14 | 中国医学科学院药用植物研究所 | 一种参与西红花酸合成的乙醛脱氢酶编码基因的筛选鉴定及应用 |
| EP3878954A4 (en) * | 2018-11-07 | 2022-10-26 | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences | ENZYME FOR THE BIOSYNTHESIS OF CROCIN AND USE THEREOF |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| CN109943493B (zh) * | 2019-04-17 | 2021-05-18 | 天津大学 | 实现通用酶催化功能多样性的突变体菌株及其构建方法 |
| KR102335035B1 (ko) * | 2019-09-17 | 2021-12-06 | 아주대학교 산학협력단 | 효소반응을 이용한 크로신-4의 생산방법 |
| EP4151732A1 (en) * | 2021-09-15 | 2023-03-22 | Universidad de Castilla-La Mancha | Transgenic plants producing high levels of apocarotenoids compounds and uses thereof |
| CN116083288B (zh) * | 2022-11-11 | 2025-02-18 | 泸州品创科技有限公司 | 产2,3-二氢-2,2,6-三甲基苯甲醛的肠膜明串珠菌及其应用 |
| KR20250075325A (ko) * | 2023-11-21 | 2025-05-28 | 아주대학교산학협력단 | 크로신 및 전구체 생산용 재조합 효모 |
| CN118546994B (zh) * | 2024-06-18 | 2025-01-28 | 华南农业大学 | 一种在种子胚乳生产藏红花素的转基因育种方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| ES2216027T3 (es) * | 1995-06-09 | 2004-10-16 | Dsm Ip Assets B.V. | Produccion de carotenoides fermentativos. |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| ES2200110T3 (es) * | 1996-12-02 | 2004-03-01 | F. Hoffmann-La Roche Ag | Produccion fermentativa de caroteniodes mejorada. |
| DE19916140A1 (de) * | 1999-04-09 | 2000-10-12 | Basf Ag | Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten |
| JP2003527077A (ja) | 1999-04-15 | 2003-09-16 | カルジーン エルエルシー | トコフェロール合成に関与するタンパク質の核酸配列 |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| ATE484198T1 (de) * | 2002-08-20 | 2010-10-15 | Sungene Gmbh & Co Kgaa | Verwendung von astaxanthinhaltigen pflanzen oder pflanzenteilen der gattung tagetes als futtermittel |
| CN100510097C (zh) * | 2002-09-27 | 2009-07-08 | Dsmip资产公司 | 由Phaffia制备玉米黄素 |
| CN101023181A (zh) | 2004-05-21 | 2007-08-22 | 加利福尼亚大学董事会 | 提高类异戊二烯化合物的产生的方法 |
| EP1956077A4 (en) * | 2005-12-06 | 2009-02-11 | Tosoh Corp | NEW MICROORGANISM AND PROCESS FOR CAROTINOID PRODUCTION THEREWITH |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
-
2012
- 2012-08-07 IN IN1129CHN2014 patent/IN2014CN01129A/en unknown
- 2012-08-07 EP EP12768896.8A patent/EP2742131B1/en not_active Not-in-force
- 2012-08-07 RU RU2014109010A patent/RU2676730C2/ru not_active IP Right Cessation
- 2012-08-07 CN CN201280038874.5A patent/CN103764818B/zh not_active Expired - Fee Related
- 2012-08-07 HK HK14112719.9A patent/HK1199286A1/xx unknown
- 2012-08-07 JP JP2014524458A patent/JP6126597B2/ja active Active
- 2012-08-07 US US14/237,542 patent/US20140248668A1/en not_active Abandoned
- 2012-08-07 AU AU2012293402A patent/AU2012293402B2/en not_active Ceased
- 2012-08-07 KR KR1020147006130A patent/KR101815063B1/ko not_active Expired - Fee Related
- 2012-08-07 BR BR112014002924A patent/BR112014002924A2/pt not_active Application Discontinuation
- 2012-08-07 WO PCT/IB2012/001513 patent/WO2013021261A2/en not_active Ceased
- 2012-08-07 CA CA2843549A patent/CA2843549A1/en not_active Abandoned
- 2012-08-07 KR KR1020177037475A patent/KR101983115B1/ko not_active Expired - Fee Related
-
2017
- 2017-05-08 US US15/589,269 patent/US20170306376A1/en not_active Abandoned
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