JP2014524246A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014524246A5 JP2014524246A5 JP2014524458A JP2014524458A JP2014524246A5 JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5 JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524458 A JP2014524458 A JP 2014524458A JP 2014524246 A5 JP2014524246 A5 JP 2014524246A5
- Authority
- JP
- Japan
- Prior art keywords
- host
- crocetin
- seq
- set forth
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- PANKHBYNKQNAHN-JTBLXSOISA-N Crocetin Natural products OC(=O)C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)C(O)=O PANKHBYNKQNAHN-JTBLXSOISA-N 0.000 claims 9
- PANKHBYNKQNAHN-JUMCEFIXSA-N carotenoid dicarboxylic acid Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)O)C=CC=C(/C)C(=O)O PANKHBYNKQNAHN-JUMCEFIXSA-N 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- PANKHBYNKQNAHN-MQQNZMFNSA-N crocetin Chemical compound OC(=O)C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C(O)=O PANKHBYNKQNAHN-MQQNZMFNSA-N 0.000 claims 7
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 3
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 3
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 claims 3
- SEBIKDIMAPSUBY-JAUCNNNOSA-N Crocin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C=CC=C(/C)C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O SEBIKDIMAPSUBY-JAUCNNNOSA-N 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 3
- 102000007317 Farnesyltranstransferase Human genes 0.000 claims 3
- 108010007508 Farnesyltranstransferase Proteins 0.000 claims 3
- 108010091656 beta-carotene hydroxylase Proteins 0.000 claims 3
- 102000000340 Glucosyltransferases Human genes 0.000 claims 2
- 108010055629 Glucosyltransferases Proteins 0.000 claims 2
- 101710173432 Phytoene synthase Proteins 0.000 claims 2
- WMHJCSAICLADIN-MVVLZTAMSA-N Picrocrocin Natural products O=CC=1C(C)(C)C[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)CC=1C WMHJCSAICLADIN-MVVLZTAMSA-N 0.000 claims 2
- 241000235342 Saccharomycetes Species 0.000 claims 2
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 2
- 235000013734 beta-carotene Nutrition 0.000 claims 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 2
- 239000011648 beta-carotene Substances 0.000 claims 2
- 229960002747 betacarotene Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 108010001545 phytoene dehydrogenase Proteins 0.000 claims 2
- WMHJCSAICLADIN-WYWSWGBSSA-N picrocrocin Chemical compound C1C(C)=C(C=O)C(C)(C)C[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 WMHJCSAICLADIN-WYWSWGBSSA-N 0.000 claims 2
- SGAWOGXMMPSZPB-UHFFFAOYSA-N safranal Chemical compound CC1=C(C=O)C(C)(C)CC=C1 SGAWOGXMMPSZPB-UHFFFAOYSA-N 0.000 claims 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 2
- YHCIKUXPWFLCFN-MTGLMCJBSA-N Crocetin dialdehyde Natural products CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=O)/C)C=O YHCIKUXPWFLCFN-MTGLMCJBSA-N 0.000 claims 1
- 244000124209 Crocus sativus Species 0.000 claims 1
- 235000015655 Crocus sativus Nutrition 0.000 claims 1
- 101100433159 Crocus sativus ZCD gene Proteins 0.000 claims 1
- 102000016680 Dioxygenases Human genes 0.000 claims 1
- 108010028143 Dioxygenases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 101100262416 Stevia rebaudiana UGT76G1 gene Proteins 0.000 claims 1
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- YHCIKUXPWFLCFN-QHUUTLAPSA-N crocetin dialdehyde Chemical compound O=CC(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)C=O YHCIKUXPWFLCFN-QHUUTLAPSA-N 0.000 claims 1
- -1 crocetin ester Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 235000017509 safranal Nutrition 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521171P | 2011-08-08 | 2011-08-08 | |
| US61/521,171 | 2011-08-08 | ||
| US201161576460P | 2011-12-16 | 2011-12-16 | |
| US61/576,460 | 2011-12-16 | ||
| US201261595450P | 2012-02-06 | 2012-02-06 | |
| US61/595,450 | 2012-02-06 | ||
| PCT/IB2012/001513 WO2013021261A2 (en) | 2011-08-08 | 2012-08-07 | Methods and materials for recombinant production of saffron compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524246A JP2014524246A (ja) | 2014-09-22 |
| JP2014524246A5 true JP2014524246A5 (https=) | 2015-10-01 |
| JP6126597B2 JP6126597B2 (ja) | 2017-05-10 |
Family
ID=46970359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524458A Active JP6126597B2 (ja) | 2011-08-08 | 2012-08-07 | サフラン化合物の組換え生成のための方法および材料 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140248668A1 (https=) |
| EP (1) | EP2742131B1 (https=) |
| JP (1) | JP6126597B2 (https=) |
| KR (2) | KR101815063B1 (https=) |
| CN (1) | CN103764818B (https=) |
| AU (1) | AU2012293402B2 (https=) |
| BR (1) | BR112014002924A2 (https=) |
| CA (1) | CA2843549A1 (https=) |
| HK (1) | HK1199286A1 (https=) |
| IN (1) | IN2014CN01129A (https=) |
| RU (1) | RU2676730C2 (https=) |
| WO (1) | WO2013021261A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| MY199452A (en) | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| SG10201807693YA (en) * | 2014-03-07 | 2018-10-30 | Evolva Sa | Methods for recombinant production of saffron compounds |
| EP3134539A1 (en) * | 2014-04-25 | 2017-03-01 | Evolva SA | Methods for recombinant production of saffron compounds |
| CN106795477A (zh) * | 2014-05-16 | 2017-05-31 | 中央研究院 | 用以制备虾红素的重组多核苷酸序列及其应用 |
| CN107075522A (zh) * | 2014-07-23 | 2017-08-18 | 国家新技术、能源和可持续经济发展局(Enea) | 类胡萝卜素双加氧酶和在微生物和植物中以生物技术制备衍生自藏红花的化合物的方法 |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2960693A1 (en) * | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
| MX2018008351A (es) | 2016-01-07 | 2018-12-06 | Conagen Inc | Metodos para preparar capsinoides por procesos biosinteticos. |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN105779406B (zh) * | 2016-05-25 | 2019-06-18 | 新疆农业科学院经济作物研究所 | 一种藏红花酸糖基转移酶及其编码基因与应用 |
| CN105950493B (zh) * | 2016-05-25 | 2019-12-27 | 天津大学 | 一种工程菌及其构建方法与在制备藏红花酸中的应用 |
| CN105950580B (zh) * | 2016-05-25 | 2019-03-08 | 新疆农业科学院经济作物研究所 | 一种制备蛋白质UGTCs4的方法 |
| CN109790513B (zh) * | 2016-07-19 | 2023-04-18 | 科纳根公司 | 用于特定天然辣椒素的微生物产生的方法 |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| IT201700089843A1 (it) * | 2017-08-03 | 2019-02-03 | Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile | Geni e metodi per la produzione e compartimentazione biotecnologica di apocarotenoidi ad elevato valore aggiunto |
| CN110791510A (zh) * | 2018-08-02 | 2020-02-14 | 中国医学科学院药用植物研究所 | 一种参与西红花酸合成的乙醛脱氢酶编码基因的筛选鉴定及应用 |
| EP3878954A4 (en) * | 2018-11-07 | 2022-10-26 | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences | ENZYME FOR THE BIOSYNTHESIS OF CROCIN AND USE THEREOF |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN109943493B (zh) * | 2019-04-17 | 2021-05-18 | 天津大学 | 实现通用酶催化功能多样性的突变体菌株及其构建方法 |
| KR102335035B1 (ko) * | 2019-09-17 | 2021-12-06 | 아주대학교 산학협력단 | 효소반응을 이용한 크로신-4의 생산방법 |
| EP4151732A1 (en) * | 2021-09-15 | 2023-03-22 | Universidad de Castilla-La Mancha | Transgenic plants producing high levels of apocarotenoids compounds and uses thereof |
| CN116083288B (zh) * | 2022-11-11 | 2025-02-18 | 泸州品创科技有限公司 | 产2,3-二氢-2,2,6-三甲基苯甲醛的肠膜明串珠菌及其应用 |
| KR20250075325A (ko) * | 2023-11-21 | 2025-05-28 | 아주대학교산학협력단 | 크로신 및 전구체 생산용 재조합 효모 |
| CN118546994B (zh) * | 2024-06-18 | 2025-01-28 | 华南农业大学 | 一种在种子胚乳生产藏红花素的转基因育种方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| DE69631924T2 (de) * | 1995-06-09 | 2004-08-12 | Dsm Ip Assets B.V. | Fermentative Herstellung von Carotenoiden |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| DE69722766T2 (de) * | 1996-12-02 | 2004-04-22 | Dsm Ip Assets B.V. | Verbesserte fermentative Herstellung von Carotenoide |
| DE19916140A1 (de) * | 1999-04-09 | 2000-10-12 | Basf Ag | Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten |
| MXPA01010488A (es) | 1999-04-15 | 2003-07-21 | Calgene Llc | Secuencias de acidos nucleicos para proteinas que intervienen en sintesis isoprenoide. |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| EP1532265A2 (de) * | 2002-08-20 | 2005-05-25 | Sungene GmbH & Co. KGaA | Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten organismen |
| ATE361372T1 (de) * | 2002-09-27 | 2007-05-15 | Dsm Ip Assets Bv | Produktion von zeaxanthin und beta-cryptoxanthin durch phaffia |
| ATE537269T1 (de) | 2004-05-21 | 2011-12-15 | Univ California | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
| WO2007066454A1 (ja) * | 2005-12-06 | 2007-06-14 | Tosoh Corporation | 新規微生物およびそれを用いたカロテノイド類の製造方法 |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
-
2012
- 2012-08-07 IN IN1129CHN2014 patent/IN2014CN01129A/en unknown
- 2012-08-07 CN CN201280038874.5A patent/CN103764818B/zh not_active Expired - Fee Related
- 2012-08-07 KR KR1020147006130A patent/KR101815063B1/ko not_active Expired - Fee Related
- 2012-08-07 AU AU2012293402A patent/AU2012293402B2/en not_active Ceased
- 2012-08-07 JP JP2014524458A patent/JP6126597B2/ja active Active
- 2012-08-07 BR BR112014002924A patent/BR112014002924A2/pt not_active Application Discontinuation
- 2012-08-07 RU RU2014109010A patent/RU2676730C2/ru not_active IP Right Cessation
- 2012-08-07 CA CA2843549A patent/CA2843549A1/en not_active Abandoned
- 2012-08-07 EP EP12768896.8A patent/EP2742131B1/en not_active Not-in-force
- 2012-08-07 US US14/237,542 patent/US20140248668A1/en not_active Abandoned
- 2012-08-07 KR KR1020177037475A patent/KR101983115B1/ko not_active Expired - Fee Related
- 2012-08-07 WO PCT/IB2012/001513 patent/WO2013021261A2/en not_active Ceased
- 2012-08-07 HK HK14112719.9A patent/HK1199286A1/xx unknown
-
2017
- 2017-05-08 US US15/589,269 patent/US20170306376A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014524246A5 (https=) | ||
| RU2014109010A (ru) | Способы и вещества для основанного на рекомбинации получения соединений шафрана | |
| US12098403B2 (en) | Metabolically engineered organisms for the production of added value bio-products | |
| Jung et al. | Enhanced production of 2’‐fucosyllactose from fucose by elimination of rhamnose isomerase and arabinose isomerase in engineered Escherichia coli | |
| JP2019524134A5 (https=) | ||
| Cintolesi et al. | Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coli | |
| PH12018550020A1 (en) | Production of human milk oligosaccharides in microbial hosts with engineered import/export | |
| JP2014524247A5 (https=) | ||
| WO2008094546A3 (en) | Genetically modified host cells for increased p450 activity levels and methods of use thereof | |
| WO2018114839A3 (en) | Production of manool | |
| Zhang et al. | Enhanced bioproduction of chitin in engineered Pichia pastoris | |
| WO2017193010A1 (en) | Microbial platform for production of glycosylated compounds | |
| JP7761754B2 (ja) | α１，２－フコシルトランスフェラーゼ活性を有する蛋白質及びラクト－Ｎ－フコペンタオースＩ（ＬＮＦＰＩ）の製造方法 | |
| CN116731941A (zh) | 一种改善2′-岩藻糖基乳糖生产性能的自主动态调控方法 | |
| JP4606419B2 (ja) | ウリジン５’−ジリン酸−ｎ−アセチルガラクトサミンの製造法 | |
| CN104017843B (zh) | 一种通过调控gln1基因表达提高S‑腺苷甲硫氨酸产量的方法 | |
| Wang et al. | Glycolysis and its metabolic engineering applications | |
| CN114672448A (zh) | 一种合成2’-岩藻糖基乳糖的大肠杆菌及其构建方法与应用 | |
| AU2015215937B2 (en) | Metabolically engineered organisms for the production of added value bio-products | |
| WO2026046344A1 (zh) | 岩藻糖基转移酶及其应用 | |
| Jiyun et al. | Development of Highly Characterized Genetic Bioparts for Efficient Gene Expression in CO₂-Fixing Eubacterium limosum | |
| WO2024253084A1 (ja) | α１，２－フコシルトランスフェラーゼ活性を有する蛋白質及びラクト－Ｎ－フコペンタオースＩ（ＬＮＦＰＩ）の製造方法 | |
| CN120718822A (zh) | 合成乳酰-n-岩藻糖基五糖ⅰ的无质粒工程化大肠杆菌及其构建方法、应用 | |
| AR133254A1 (es) | Aumento de la producción de acetil-coenzima a y productos derivados en levaduras | |
| CN120574748A (zh) | 一种半乳糖及半乳糖醇的重组大肠杆菌及制备方法、应用 |