BR112014002924A2 - métodos e materiais para produção recombinante de compostos do açafrão - Google Patents
métodos e materiais para produção recombinante de compostos do açafrãoInfo
- Publication number
- BR112014002924A2 BR112014002924A2 BR112014002924A BR112014002924A BR112014002924A2 BR 112014002924 A2 BR112014002924 A2 BR 112014002924A2 BR 112014002924 A BR112014002924 A BR 112014002924A BR 112014002924 A BR112014002924 A BR 112014002924A BR 112014002924 A2 BR112014002924 A2 BR 112014002924A2
- Authority
- BR
- Brazil
- Prior art keywords
- materials
- methods
- recombinant production
- turmeric
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521171P | 2011-08-08 | 2011-08-08 | |
| US201161576460P | 2011-12-16 | 2011-12-16 | |
| US201261595450P | 2012-02-06 | 2012-02-06 | |
| PCT/IB2012/001513 WO2013021261A2 (en) | 2011-08-08 | 2012-08-07 | Methods and materials for recombinant production of saffron compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014002924A2 true BR112014002924A2 (pt) | 2018-10-09 |
Family
ID=46970359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014002924A BR112014002924A2 (pt) | 2011-08-08 | 2012-08-07 | métodos e materiais para produção recombinante de compostos do açafrão |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140248668A1 (https=) |
| EP (1) | EP2742131B1 (https=) |
| JP (1) | JP6126597B2 (https=) |
| KR (2) | KR101815063B1 (https=) |
| CN (1) | CN103764818B (https=) |
| AU (1) | AU2012293402B2 (https=) |
| BR (1) | BR112014002924A2 (https=) |
| CA (1) | CA2843549A1 (https=) |
| HK (1) | HK1199286A1 (https=) |
| IN (1) | IN2014CN01129A (https=) |
| RU (1) | RU2676730C2 (https=) |
| WO (1) | WO2013021261A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| MY199452A (en) | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| SG10201807693YA (en) * | 2014-03-07 | 2018-10-30 | Evolva Sa | Methods for recombinant production of saffron compounds |
| EP3134539A1 (en) * | 2014-04-25 | 2017-03-01 | Evolva SA | Methods for recombinant production of saffron compounds |
| CN106795477A (zh) * | 2014-05-16 | 2017-05-31 | 中央研究院 | 用以制备虾红素的重组多核苷酸序列及其应用 |
| CN107075522A (zh) * | 2014-07-23 | 2017-08-18 | 国家新技术、能源和可持续经济发展局(Enea) | 类胡萝卜素双加氧酶和在微生物和植物中以生物技术制备衍生自藏红花的化合物的方法 |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2960693A1 (en) * | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
| MX2018008351A (es) | 2016-01-07 | 2018-12-06 | Conagen Inc | Metodos para preparar capsinoides por procesos biosinteticos. |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CN105779406B (zh) * | 2016-05-25 | 2019-06-18 | 新疆农业科学院经济作物研究所 | 一种藏红花酸糖基转移酶及其编码基因与应用 |
| CN105950493B (zh) * | 2016-05-25 | 2019-12-27 | 天津大学 | 一种工程菌及其构建方法与在制备藏红花酸中的应用 |
| CN105950580B (zh) * | 2016-05-25 | 2019-03-08 | 新疆农业科学院经济作物研究所 | 一种制备蛋白质UGTCs4的方法 |
| CN109790513B (zh) * | 2016-07-19 | 2023-04-18 | 科纳根公司 | 用于特定天然辣椒素的微生物产生的方法 |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108728477B (zh) * | 2017-04-24 | 2022-02-22 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| IT201700089843A1 (it) * | 2017-08-03 | 2019-02-03 | Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile | Geni e metodi per la produzione e compartimentazione biotecnologica di apocarotenoidi ad elevato valore aggiunto |
| CN110791510A (zh) * | 2018-08-02 | 2020-02-14 | 中国医学科学院药用植物研究所 | 一种参与西红花酸合成的乙醛脱氢酶编码基因的筛选鉴定及应用 |
| EP3878954A4 (en) * | 2018-11-07 | 2022-10-26 | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences | ENZYME FOR THE BIOSYNTHESIS OF CROCIN AND USE THEREOF |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN109943493B (zh) * | 2019-04-17 | 2021-05-18 | 天津大学 | 实现通用酶催化功能多样性的突变体菌株及其构建方法 |
| KR102335035B1 (ko) * | 2019-09-17 | 2021-12-06 | 아주대학교 산학협력단 | 효소반응을 이용한 크로신-4의 생산방법 |
| EP4151732A1 (en) * | 2021-09-15 | 2023-03-22 | Universidad de Castilla-La Mancha | Transgenic plants producing high levels of apocarotenoids compounds and uses thereof |
| CN116083288B (zh) * | 2022-11-11 | 2025-02-18 | 泸州品创科技有限公司 | 产2,3-二氢-2,2,6-三甲基苯甲醛的肠膜明串珠菌及其应用 |
| KR20250075325A (ko) * | 2023-11-21 | 2025-05-28 | 아주대학교산학협력단 | 크로신 및 전구체 생산용 재조합 효모 |
| CN118546994B (zh) * | 2024-06-18 | 2025-01-28 | 华南农业大学 | 一种在种子胚乳生产藏红花素的转基因育种方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| DE69631924T2 (de) * | 1995-06-09 | 2004-08-12 | Dsm Ip Assets B.V. | Fermentative Herstellung von Carotenoiden |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| DE69722766T2 (de) * | 1996-12-02 | 2004-04-22 | Dsm Ip Assets B.V. | Verbesserte fermentative Herstellung von Carotenoide |
| DE19916140A1 (de) * | 1999-04-09 | 2000-10-12 | Basf Ag | Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten |
| MXPA01010488A (es) | 1999-04-15 | 2003-07-21 | Calgene Llc | Secuencias de acidos nucleicos para proteinas que intervienen en sintesis isoprenoide. |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| EP1532265A2 (de) * | 2002-08-20 | 2005-05-25 | Sungene GmbH & Co. KGaA | Verfahren zur herstellung von ketocarotinoiden in genetisch veränderten organismen |
| ATE361372T1 (de) * | 2002-09-27 | 2007-05-15 | Dsm Ip Assets Bv | Produktion von zeaxanthin und beta-cryptoxanthin durch phaffia |
| ATE537269T1 (de) | 2004-05-21 | 2011-12-15 | Univ California | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
| WO2007066454A1 (ja) * | 2005-12-06 | 2007-06-14 | Tosoh Corporation | 新規微生物およびそれを用いたカロテノイド類の製造方法 |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
-
2012
- 2012-08-07 IN IN1129CHN2014 patent/IN2014CN01129A/en unknown
- 2012-08-07 CN CN201280038874.5A patent/CN103764818B/zh not_active Expired - Fee Related
- 2012-08-07 KR KR1020147006130A patent/KR101815063B1/ko not_active Expired - Fee Related
- 2012-08-07 AU AU2012293402A patent/AU2012293402B2/en not_active Ceased
- 2012-08-07 JP JP2014524458A patent/JP6126597B2/ja active Active
- 2012-08-07 BR BR112014002924A patent/BR112014002924A2/pt not_active Application Discontinuation
- 2012-08-07 RU RU2014109010A patent/RU2676730C2/ru not_active IP Right Cessation
- 2012-08-07 CA CA2843549A patent/CA2843549A1/en not_active Abandoned
- 2012-08-07 EP EP12768896.8A patent/EP2742131B1/en not_active Not-in-force
- 2012-08-07 US US14/237,542 patent/US20140248668A1/en not_active Abandoned
- 2012-08-07 KR KR1020177037475A patent/KR101983115B1/ko not_active Expired - Fee Related
- 2012-08-07 WO PCT/IB2012/001513 patent/WO2013021261A2/en not_active Ceased
- 2012-08-07 HK HK14112719.9A patent/HK1199286A1/xx unknown
-
2017
- 2017-05-08 US US15/589,269 patent/US20170306376A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012293402A2 (en) | 2014-03-13 |
| WO2013021261A2 (en) | 2013-02-14 |
| RU2014109010A (ru) | 2015-09-20 |
| CN103764818B (zh) | 2017-05-31 |
| WO2013021261A3 (en) | 2013-05-02 |
| EP2742131A2 (en) | 2014-06-18 |
| AU2012293402A1 (en) | 2014-02-06 |
| US20170306376A1 (en) | 2017-10-26 |
| JP6126597B2 (ja) | 2017-05-10 |
| IN2014CN01129A (https=) | 2015-04-10 |
| JP2014524246A (ja) | 2014-09-22 |
| CN103764818A (zh) | 2014-04-30 |
| US20140248668A1 (en) | 2014-09-04 |
| AU2012293402B2 (en) | 2017-08-03 |
| KR20180004306A (ko) | 2018-01-10 |
| EP2742131B1 (en) | 2018-11-28 |
| CA2843549A1 (en) | 2013-02-14 |
| KR20140057319A (ko) | 2014-05-12 |
| KR101815063B1 (ko) | 2018-01-05 |
| KR101983115B1 (ko) | 2019-05-29 |
| RU2676730C2 (ru) | 2019-01-10 |
| HK1199286A1 (en) | 2015-06-26 |
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