JP2014523880A - 金属酵素化合物 - Google Patents

金属酵素化合物 Download PDF

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JP2014523880A
JP2014523880A JP2014517113A JP2014517113A JP2014523880A JP 2014523880 A JP2014523880 A JP 2014523880A JP 2014517113 A JP2014517113 A JP 2014517113A JP 2014517113 A JP2014517113 A JP 2014517113A JP 2014523880 A JP2014523880 A JP 2014523880A
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difluoro
difluorophenyl
tetrazol
propan
compound
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JP2014523880A5 (OSRAM
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フックストラ，ウィリアム，ジェー．
ショットジンガー，ロバート，ジェー．
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ヴィアメット ファーマスーティカルズ，インコーポレイテッド
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Publication of JP2014523880A publication Critical patent/JP2014523880A/ja
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014517069A (ja) * 2011-06-23 2014-07-17 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物
JP2015505538A (ja) * 2012-01-20 2015-02-23 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害剤化合物
JP2016069380A (ja) * 2014-09-29 2016-05-09 国立研究開発法人理化学研究所 植物の耐塩性向上剤
JP2023501549A (ja) * 2019-11-14 2023-01-18 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 雑草防除方法におけるフッ素化フェニル酢酸誘導体

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101945869B (zh) 2007-12-19 2014-06-18 癌症研究技术有限公司 吡啶并[2,3-b]吡嗪-8-取代化合物及其用途
WO2011092469A1 (en) 2010-02-01 2011-08-04 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
WO2012177608A1 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US9309273B2 (en) * 2011-12-11 2016-04-12 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
AU2013209516A1 (en) 2012-01-20 2014-08-28 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
WO2013135674A1 (en) * 2012-03-12 2013-09-19 Syngenta Participations Ag Insecticidal 2-aryl-acetamide compounds
CN105102443B (zh) * 2013-02-04 2017-07-28 先正达参股股份有限公司 新颖的杀微生物剂
MX2015014268A (es) 2013-04-12 2016-06-02 Bayer Cropscience Ag Derivados de triazol novedosos.
EP2984080B1 (en) 2013-04-12 2017-08-30 Bayer CropScience Aktiengesellschaft Novel triazolinthione derivatives
KR20150142014A (ko) 2013-04-12 2015-12-21 바이엘 크롭사이언스 악티엔게젤샤프트 신규 트리아졸 유도체
JP6387401B2 (ja) * 2013-05-28 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 殺真菌組成物
CN105431418B (zh) * 2013-06-12 2019-02-05 北卡罗来纳维亚梅特制药公司 金属酶抑制剂化合物
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
AR099120A1 (es) 2014-01-20 2016-06-29 Bayer Cropscience Ag Derivados de quinolina como insecticidas y acaricidas
BR112016021257B1 (pt) 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
WO2015143137A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
WO2015143142A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119756B9 (en) 2014-03-19 2021-08-25 Dow AgroSciences LLC 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
CA2942932A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119771B1 (en) 2014-03-19 2020-05-06 Mycovia Pharmaceuticals, Inc. Antifungal compound process
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
US10399943B2 (en) 2014-03-19 2019-09-03 Mycovia Pharmaceuticals, Inc. Antifungal compound process
AU2015231226B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US9663491B2 (en) * 2014-04-15 2017-05-30 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
US20170303540A1 (en) 2014-10-02 2017-10-26 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
CN104844652A (zh) * 2015-02-10 2015-08-19 扬子江药业集团南京海陵药业有限公司 艾沙康唑磷酸酯及其制备方法和用途
JP2018511608A (ja) 2015-04-02 2018-04-26 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺真菌剤としてのトリアゾール誘導体
AU2016265932B2 (en) 2015-05-18 2020-10-08 Viamet Pharmaceuticals (NC), Inc. Antifungal compounds
KR20180052755A (ko) 2015-09-18 2018-05-18 브이피에스-3, 인크. 항진균 화합물 및 이의 제조방법
KR20180101342A (ko) 2015-11-17 2018-09-12 다우 아그로사이언시즈 엘엘씨 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법
JP6987070B2 (ja) 2015-11-17 2021-12-22 コルテバ アグリサイエンス エルエルシー ４−（（６−（２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−２−オキソエチル）ピリジン−３−イル）オキシ）ベンゾニトリル及び製造方法
CN105801571A (zh) * 2016-04-14 2016-07-27 上海大学 杂环二氟甲基化的环氧乙烷化合物及其制备方法
PL3559009T3 (pl) 2016-12-22 2021-10-25 Calithera Biosciences, Inc. Kompozycje i sposoby hamowania aktywności arginazy
CN106905273B (zh) * 2017-01-18 2019-05-14 中山大学 4-氧杂-4,5,6,7-四氢苯并[b]呋喃-3-羧酸类化合物及其应用
MA48994A (fr) 2017-03-30 2020-02-05 Hoffmann La Roche Isoquinoléines utilisées en tant qu'inhibiteurs de hpk1
BR112020009446A2 (pt) 2017-11-13 2020-11-03 Bayer Aktiengesellschaft derivados de tetrazólio propila e seu uso como fungicida
JP7386841B2 (ja) 2018-07-24 2023-11-27 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト イソキノリン化合物及びその使用
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
CN110672753B (zh) * 2019-11-04 2022-05-20 青海省农林科学院 一种氟咯草酮异构体的拆分和检测方法
GB202001564D0 (en) * 2020-02-05 2020-03-18 Kings College Compounds
CN114686450B (zh) * 2020-12-28 2024-04-16 苏州引航生物科技有限公司 经修饰的维生素d羟化酶突变体及其应用
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
CN115322151A (zh) * 2022-08-23 2022-11-11 河南师范大学 铜催化合成手性多立体中心吡唑烷类化合物的方法

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137470A (ja) * 1983-01-21 1984-08-07 ファイザ−・コ−ポレ−ション トリアゾ−ル系抗真菌剤
JPS59163374A (ja) * 1983-02-16 1984-09-14 フアイザ−・コ−ポレ−シヨン トリアゾ−ル抗真菌剤
JPS59193877A (ja) * 1983-02-25 1984-11-02 フアイザ−・コ−ポレ−シヨン トリアゾ−ル抗真菌剤
JPS59196867A (ja) * 1983-04-12 1984-11-08 バイエル・アクチエンゲゼルシヤフト １−アゾリル−３−ピラゾリル−２−プロパノ−ル誘導体、その製法ならびに利用
US4483863A (en) * 1984-01-20 1984-11-20 Pfizer Inc. Triazole antifungal agents
JPS61215390A (ja) * 1985-03-14 1986-09-25 フアイザー・コーポレーシヨン トリアゾール抗真菌剤
JPH02104583A (ja) * 1988-08-13 1990-04-17 Pfizer Inc トリアゾール抗真菌剤
WO1992017474A1 (en) * 1991-04-04 1992-10-15 Pfizer Limited Triazole antifungal agents
JPH0649033A (ja) * 1991-11-25 1994-02-22 Takeda Chem Ind Ltd 光学活性アゾール化合物およびその用途
JPH0820578A (ja) * 1994-07-05 1996-01-23 Eisai Co Ltd 抗真菌剤及びその製造方法
JPH09501690A (ja) * 1993-08-23 1997-02-18 藤沢薬品工業株式会社 抗菌活性を有するキノリニル−（１ｈ−１，２，４−トリアゾール−１−イル）アルカノール誘導体
JPH10506652A (ja) * 1995-06-26 1998-06-30 ファイザー・インコーポレーテッド トリアゾール系抗真菌薬
JP2000344744A (ja) * 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
JP2010510248A (ja) * 2006-11-21 2010-04-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分をターゲティング部分と組み合わせて使用する金属酸化還元酵素阻害剤
JP2014517112A (ja) * 2011-12-30 2014-07-17 テトラ・ラヴァル・ホールディングス・アンド・ファイナンス・ソシエテ・アノニム 改善された近赤外吸収体

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3461637D1 (en) * 1983-02-16 1987-01-22 Pfizer Ltd Triazole antifungal agents
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US4616206A (en) * 1984-09-07 1986-10-07 Eaton Corporation Circuit breaker and shunt trip apparatus combined within single pole device
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
PT96059B (pt) 1989-12-04 1998-07-31 Searle & Co Sistema de camada unica para a administracao de um medicamento por via transdermica
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
TW212798B (OSRAM) * 1991-11-25 1993-09-11 Takeda Pharm Industry Co Ltd
DE69228827T2 (de) 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul Mehrschichtige sperrstrukturen
EP0553769B1 (de) 1992-01-29 1996-01-03 FRANZ VÖLKL GmbH &amp; CO. SKI UND TENNIS SPORTARTIKELFABRIK KG Ballspielschläger, insbesondere Tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
ES2450567T3 (es) * 2008-10-15 2014-03-25 Amgen, Inc Moduladores de GPR40 espirocíclicos
BR112012027308B1 (pt) * 2010-04-24 2021-07-06 Mycovia Pharmaceuticals, Inc. compostos inibidores de metaloenzima e composições compreendendo os mesmos
IN2014DN00288A (OSRAM) * 2011-06-19 2015-06-05 Viamet Pharmaceuticals Inc
WO2012177608A1 (en) 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
AU2012273007A1 (en) * 2011-06-23 2014-01-30 Viamet Pharmaceuticals (NC), Inc. Metalloenzyme inhibitor compounds
US9309273B2 (en) 2011-12-11 2016-04-12 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US9414596B2 (en) * 2012-01-20 2016-08-16 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137470A (ja) * 1983-01-21 1984-08-07 ファイザ−・コ−ポレ−ション トリアゾ−ル系抗真菌剤
JPS59163374A (ja) * 1983-02-16 1984-09-14 フアイザ−・コ−ポレ−シヨン トリアゾ−ル抗真菌剤
JPS59193877A (ja) * 1983-02-25 1984-11-02 フアイザ−・コ−ポレ−シヨン トリアゾ−ル抗真菌剤
JPS59196867A (ja) * 1983-04-12 1984-11-08 バイエル・アクチエンゲゼルシヤフト １−アゾリル−３−ピラゾリル−２−プロパノ−ル誘導体、その製法ならびに利用
US4483863A (en) * 1984-01-20 1984-11-20 Pfizer Inc. Triazole antifungal agents
JPS61215390A (ja) * 1985-03-14 1986-09-25 フアイザー・コーポレーシヨン トリアゾール抗真菌剤
US5364938A (en) * 1988-08-13 1994-11-15 Pfizer Inc. Triazole antifungal agents
JPH02104583A (ja) * 1988-08-13 1990-04-17 Pfizer Inc トリアゾール抗真菌剤
WO1992017474A1 (en) * 1991-04-04 1992-10-15 Pfizer Limited Triazole antifungal agents
JPH0649033A (ja) * 1991-11-25 1994-02-22 Takeda Chem Ind Ltd 光学活性アゾール化合物およびその用途
JPH09501690A (ja) * 1993-08-23 1997-02-18 藤沢薬品工業株式会社 抗菌活性を有するキノリニル−（１ｈ−１，２，４−トリアゾール−１−イル）アルカノール誘導体
JPH0820578A (ja) * 1994-07-05 1996-01-23 Eisai Co Ltd 抗真菌剤及びその製造方法
JPH10506652A (ja) * 1995-06-26 1998-06-30 ファイザー・インコーポレーテッド トリアゾール系抗真菌薬
JP2000344744A (ja) * 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
JP2010510248A (ja) * 2006-11-21 2010-04-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分をターゲティング部分と組み合わせて使用する金属酸化還元酵素阻害剤
JP2014517112A (ja) * 2011-12-30 2014-07-17 テトラ・ラヴァル・ホールディングス・アンド・ファイナンス・ソシエテ・アノニム 改善された近赤外吸収体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEVREUIL, FRANCIS; LANDREAU, ANNE; SERAPHIN, DENIS; LARCHER, GERALD; BOUCHARA, JEAN-PHILIPPE; RICHO: "Synthesis and antifungal activity of new thienyl and aryl conazoles", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 21(3), JPN6016010270, 2006, pages 293 - 303, ISSN: 0003368391 *
RAM SHANKAR UPADHAYAYA ET AL.: "Synthesis of novel substituted tetrazoles having antifungal activity", EUROPEAN JOURANAL OF MEDICINAL CHEMISTRY, vol. 39, JPN6016028958, 28 May 2004 (2004-05-28), pages 579 - 592, ISSN: 0003368392 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014517069A (ja) * 2011-06-23 2014-07-17 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物
JP2015505538A (ja) * 2012-01-20 2015-02-23 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害剤化合物
JP2016069380A (ja) * 2014-09-29 2016-05-09 国立研究開発法人理化学研究所 植物の耐塩性向上剤
JP2023501549A (ja) * 2019-11-14 2023-01-18 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 雑草防除方法におけるフッ素化フェニル酢酸誘導体
JP7711056B2 (ja) 2019-11-14 2025-07-22 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 雑草防除方法におけるフッ素化フェニル酢酸誘導体

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