JP2014520886A5 - - Google Patents

Download PDF

Info

Publication number
JP2014520886A5
JP2014520886A5 JP2014521705A JP2014521705A JP2014520886A5 JP 2014520886 A5 JP2014520886 A5 JP 2014520886A5 JP 2014521705 A JP2014521705 A JP 2014521705A JP 2014521705 A JP2014521705 A JP 2014521705A JP 2014520886 A5 JP2014520886 A5 JP 2014520886A5
Authority
JP
Japan
Prior art keywords
het
atoms
physiologically acceptable
compound according
hal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014521705A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014520886A (ja
JP6162694B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/047038 external-priority patent/WO2013012848A1/en
Publication of JP2014520886A publication Critical patent/JP2014520886A/ja
Publication of JP2014520886A5 publication Critical patent/JP2014520886A5/ja
Application granted granted Critical
Publication of JP6162694B2 publication Critical patent/JP6162694B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014521705A 2011-07-18 2012-07-17 ベンズアミド類 Expired - Fee Related JP6162694B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161508861P 2011-07-18 2011-07-18
US61/508,861 2011-07-18
US201161526342P 2011-08-23 2011-08-23
US61/526,342 2011-08-23
PCT/US2012/047038 WO2013012848A1 (en) 2011-07-18 2012-07-17 Benzamides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017043934A Division JP6254730B2 (ja) 2011-07-18 2017-03-08 ベンズアミド類

Publications (3)

Publication Number Publication Date
JP2014520886A JP2014520886A (ja) 2014-08-25
JP2014520886A5 true JP2014520886A5 (enExample) 2017-06-15
JP6162694B2 JP6162694B2 (ja) 2017-07-12

Family

ID=46551951

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014521705A Expired - Fee Related JP6162694B2 (ja) 2011-07-18 2012-07-17 ベンズアミド類
JP2017043934A Expired - Fee Related JP6254730B2 (ja) 2011-07-18 2017-03-08 ベンズアミド類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017043934A Expired - Fee Related JP6254730B2 (ja) 2011-07-18 2017-03-08 ベンズアミド類

Country Status (9)

Country Link
US (3) US9181226B2 (enExample)
EP (2) EP2734517B1 (enExample)
JP (2) JP6162694B2 (enExample)
CN (1) CN103702993B (enExample)
AU (2) AU2012284184B2 (enExample)
CA (1) CA2834199C (enExample)
ES (2) ES2899000T3 (enExample)
IL (1) IL230463A (enExample)
WO (1) WO2013012848A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013012848A1 (en) * 2011-07-18 2013-01-24 Merck Patent Gmbh Benzamides
ES2663972T3 (es) 2012-01-10 2018-04-17 Merck Patent Gmbh Derivados de benzamida como moduladores de la hormona folículo estimulante
WO2014107622A1 (en) 2013-01-07 2014-07-10 University Of Southern California Deoxyuridine triphosphatase inhibitors
MX370448B (es) 2013-03-11 2019-12-13 Merck Patent Gmbh Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.
CN104717415B (zh) * 2013-12-12 2019-03-01 华为技术有限公司 一种摄像装置
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
WO2016087880A1 (en) * 2014-12-05 2016-06-09 Pulmocide Limited Antimycotic compound
US10577321B2 (en) 2015-07-08 2020-03-03 University Of Southern California Deoxyuridine triphosphatase inhibitors
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
US10544105B2 (en) 2015-07-08 2020-01-28 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
DK3319939T3 (da) * 2015-07-08 2025-02-24 Cv6 Therapeutics Ni Ltd Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer
CA3000022A1 (en) 2015-10-22 2017-04-27 The Procter & Gamble Company Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US11174271B2 (en) 2016-11-23 2021-11-16 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US11247984B2 (en) 2017-01-05 2022-02-15 Cv6 Therapeutics (Ni) Limited Uracil containing compounds

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07258224A (ja) * 1994-03-24 1995-10-09 Dai Ichi Seiyaku Co Ltd 二環性化合物
JPH0959236A (ja) * 1995-08-23 1997-03-04 Dai Ichi Seiyaku Co Ltd ベンズアミド化合物
US6017919A (en) 1996-02-06 2000-01-25 Japan Tobacco Inc. Compounds and pharmaceutical use thereof
FR2765221B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 4-[(1h-imidazol-4-yl)piperidin-1-yl]anilide, leur preparation et leur application en therapeutique
AR013693A1 (es) * 1997-10-23 2001-01-10 Uriach & Cia Sa J Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria
WO2000008015A2 (en) 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
US7101878B1 (en) * 1998-08-20 2006-09-05 Agouron Pharmaceuticals, Inc. Non-peptide GNRH agents, methods and intermediates for their preparation
DE60010448T2 (de) * 1999-03-17 2005-04-07 Astrazeneca Ab Amid-derivate
SE9904652D0 (sv) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
WO2002009706A1 (en) 2000-07-27 2002-02-07 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
US20040010033A1 (en) * 2001-02-20 2004-01-15 Pfizer Inc. Non-peptide GnRH agents, methods and intermediates for their preparation
SE0101387D0 (sv) * 2001-04-20 2001-04-20 Astrazeneca Ab Novel compounds
WO2003068769A1 (en) * 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
JP2005538064A (ja) * 2002-06-13 2005-12-15 ファイザー・インク 非ペプチドＧｎＲＨ剤、医薬組成物、およびそれらの使用方法
CA2499732A1 (en) * 2002-09-20 2004-04-15 Applied Research Systems Ars Holding N.V. Piperazine derivatives and methods of use
SE0203070D0 (en) * 2002-10-16 2002-10-16 Astrazeneca Ab Novel compounds
FR2851563B1 (fr) 2003-02-26 2005-04-22 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
US7700583B2 (en) * 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
FR2862971B1 (fr) 2003-11-28 2006-03-24 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
WO2005108370A1 (ja) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
JP4847459B2 (ja) * 2005-01-25 2011-12-28 田辺三菱製薬株式会社 ノルバリン誘導体及びその製造方法
AU2006261082B2 (en) 2005-06-22 2012-04-19 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
US20080312215A1 (en) * 2005-06-28 2008-12-18 Pharmacopeia Drug Discovery, Inc. Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders
WO2007008541A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
RU2405770C2 (ru) * 2005-09-27 2010-12-10 Сионоги Энд Ко., Лтд. Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2
CA2651898A1 (en) 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
US20110071130A1 (en) * 2006-05-08 2011-03-24 Pharmacopeia, Inc. 2-aminobenzimidazoles for treating neurodegenerative diseases
CN101679266B (zh) 2007-03-01 2015-05-06 诺华股份有限公司 Pim激酶抑制剂及其应用方法
US20140249135A1 (en) * 2007-03-01 2014-09-04 Novartis Ag Pim kinase inhibitors and methods of their use
GB0705656D0 (en) * 2007-03-23 2007-05-02 Addex Pharmaceuticals Sa Novel compounds E1
WO2008123469A1 (ja) * 2007-03-30 2008-10-16 Japan Tobacco Inc. ６員環アミド化合物およびその用途
CL2008000986A1 (es) * 2007-04-06 2008-10-17 Neurocrine Biosciences Inc COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
CA2706203A1 (en) * 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh Use of mnk inhibitors for the treatment of alzheimer's disease
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
PE20091576A1 (es) * 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
UY32138A (es) * 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
US20100137386A1 (en) * 2008-12-01 2010-06-03 Tesshi Yamada Tnik inhibitor and the use
US8969342B2 (en) * 2009-03-20 2015-03-03 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
TWI461426B (zh) 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
JP6170043B2 (ja) * 2011-07-01 2017-07-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ジヒドロピラゾール
WO2013012848A1 (en) * 2011-07-18 2013-01-24 Merck Patent Gmbh Benzamides
ES2663972T3 (es) * 2012-01-10 2018-04-17 Merck Patent Gmbh Derivados de benzamida como moduladores de la hormona folículo estimulante

Similar Documents

Publication Publication Date Title
JP6257326B2 (ja) 神経因性疼痛におけるマロノニトリルアミドの使用
JP2021527092A5 (enExample)
RU2762193C2 (ru) Применение антагонистов рецептора ep4 для лечения nash-ассоциированного рака печени
JP5767122B2 (ja) 特定の癌の治療のためのｒｄｅａ１１９／ｂａｙ８６９７６６を含む組み合わせ医薬
JP2015529229A5 (enExample)
RS53716B1 (sr) Kombinovana terapija kancera sa hsp90 inhibitornim jedinjenjima
CN109311832A (zh) 沃替西汀的帕莫酸盐及其晶型
JP2016507500A5 (enExample)
ES2333805T3 (es) Uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas sustituidas en el tratamiento de nauseas y vomitos.
RU2015134420A (ru) Кристаллические формы { [1-циано-5-(4-хлорофеноксид)-4-гидроксид-изохинолин-3-карбонил]-амино} -уксусной кислоты
WO2024041330A1 (zh) Ly2922470在制备预防或治疗脑血管疾病或组织缺血再灌注损伤药物中的应用
KR20200068659A (ko) 3-치환된 1,2,4-옥사다이아졸의 결정질 형태
JP2013500982A (ja) ＰＰＡＲγのベンズイミダゾール誘導体作動薬で神経因性疼痛を治療する方法
WO2018200357A1 (en) Methods and compositions of improving fertility
Liu et al. Protective effects of estrogen combined with sevoflurane in an experimental model of cerebral infarction and focal cerebral ischemia-reperfusion injury.
JP6642892B2 (ja) ジメチルアミノミケリオリドを含む肺線維化の治療薬
JP6960415B2 (ja) 三叉神経痛を予防又は治療する目的のためのカルバメート化合物の使用
ES3054693T3 (en) Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder
JP2015524460A5 (enExample)
FI3519050T3 (fi) Koostumuksia silmätautien hoitamiseksi
CA2876926C (en) Composition for treating or preventing vascular permeability-related disease containing imatinib or pharmaceutically acceptable salt thereof as active ingredient
CN105078944A (zh) Isopaucifloral F在制备抗骨质疏松药物中的用途
JP2012513443A5 (enExample)
CN107427508B (zh) 异喹啉衍生物用于糖尿病伤口愈合的用途
JP2013126971A (ja) 抗感冒剤