MX370448B - Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. - Google Patents

Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.

Info

Publication number
MX370448B
MX370448B MX2015011660A MX2015011660A MX370448B MX 370448 B MX370448 B MX 370448B MX 2015011660 A MX2015011660 A MX 2015011660A MX 2015011660 A MX2015011660 A MX 2015011660A MX 370448 B MX370448 B MX 370448B
Authority
MX
Mexico
Prior art keywords
imidazol
pyrimidin
piperidin
modulators
kinase activity
Prior art date
Application number
MX2015011660A
Other languages
English (en)
Other versions
MX2015011660A (es
Inventor
Goutopoulos Andreas
R Huck Bayard
Chen Xiaoling
Xiao Yufang
Lan Ruoxi
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2015011660A publication Critical patent/MX2015011660A/es
Publication of MX370448B publication Critical patent/MX370448B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona nuevas aminas heterocíclicas de acuerdo con la fórmula (I), su fabricación y uso para el tratamiento de enfermedades hiperproliferativas, tales como cáncer.
MX2015011660A 2013-03-11 2014-03-10 Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. MX370448B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776440P 2013-03-11 2013-03-11
PCT/US2014/022479 WO2014143612A1 (en) 2013-03-11 2014-03-10 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity

Publications (2)

Publication Number Publication Date
MX2015011660A MX2015011660A (es) 2015-12-16
MX370448B true MX370448B (es) 2019-12-13

Family

ID=50440836

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011660A MX370448B (es) 2013-03-11 2014-03-10 Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.

Country Status (17)

Country Link
US (2) US9458134B2 (es)
EP (1) EP2970201B1 (es)
JP (1) JP6483656B2 (es)
KR (1) KR20150124957A (es)
CN (1) CN105209454A (es)
AR (1) AR095202A1 (es)
AU (1) AU2014228385B2 (es)
BR (1) BR112015021324A2 (es)
CA (1) CA2902755C (es)
ES (1) ES2746756T3 (es)
HK (1) HK1218756A1 (es)
IL (1) IL240875B (es)
MX (1) MX370448B (es)
RU (1) RU2674261C2 (es)
SG (2) SG10201900954SA (es)
WO (1) WO2014143612A1 (es)
ZA (1) ZA201505749B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095202A1 (es) * 2013-03-11 2015-09-30 Merck Patent Gmbh Heterociclos como moduladores de la actividad quinasa
WO2015123174A1 (en) * 2014-02-11 2015-08-20 Merck Patent Gmbh Pyrimidine imidazole amines as modulators of kinase activity
CA2944573C (en) * 2014-04-03 2022-10-25 Merck Patent Gmbh Combinations of cancer therapeutics
MY185962A (en) * 2016-05-20 2021-06-14 Taiho Pharmaceutical Co Ltd Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative
CN110922354B (zh) * 2019-12-12 2023-05-02 丽水绿氟科技有限公司 一种1-r-3-氟哌啶-4-羧酸的化学拆分制备方法及其产物
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

Family Cites Families (32)

* Cited by examiner, † Cited by third party
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TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
EP1542993B1 (en) * 2002-09-20 2012-12-19 Merck Serono SA Piperazine derivatives and methods of use
JP2006522124A (ja) 2003-04-03 2006-09-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用な組成物
CA2539339A1 (en) 2003-09-30 2005-04-14 Irm Llc Compounds and compositions as protein kinase inhibitors
JP4800216B2 (ja) 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
MXPA06005702A (es) 2003-11-21 2006-08-17 Novartis Ag Derivados de 1h-imidazoquinolina como inhibidores de quinasa de proteina.
ATE447957T1 (de) 2003-12-09 2009-11-15 Us Gov Health & Human Serv Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen
GB0403606D0 (en) * 2004-02-18 2004-03-24 Novartis Ag Organic compounds
JP5213229B2 (ja) 2004-04-23 2013-06-19 エグゼリクシス， インコーポレイテッド キナーゼ調節因子および使用方法
ATE543821T1 (de) 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
US8343953B2 (en) 2005-06-22 2013-01-01 Astex Therapeutics Limited Pharmaceutical compounds
AR064416A1 (es) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
AR074072A1 (es) * 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
CA2743295A1 (en) * 2008-11-11 2010-05-20 Eli Lilly And Company P70 s6 kinase inhibitor and egfr inhibitor combination therapy
EP2355820A1 (en) * 2008-11-11 2011-08-17 Eli Lilly and Company P70 s6 kinase inhibitor and mtor inhibitor combination therapy
AU2010214095B2 (en) 2009-02-11 2015-12-24 Merck Patent Gmbh Novel amino azaheterocyclic carboxamides
AU2010310786B2 (en) * 2009-10-23 2014-03-27 Eli Lilly And Company AKT inhibitors
BR112013002212A2 (pt) 2010-07-29 2017-09-26 Merck Patent Gmbh carboxamidas aza-heterocíclicas de aminas cíclicas
UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
MX355325B (es) 2010-11-24 2018-04-16 Merck Patent Gmbh Quinazolincarboxamida azetidinas.
BR112013030442B1 (pt) * 2011-06-10 2021-11-09 Merck Patent Gmbh Compostos de pirimidina e piridina com atividade inibidora de btk, seus usos, composição, e kit
EP2734517B1 (en) * 2011-07-18 2017-08-30 Merck Patent GmbH Benzamides
EP2755965B1 (en) * 2011-09-12 2017-07-26 Merck Patent GmbH Novel imidazole amines as modulators of kinase activity
CA2844704C (en) * 2011-09-12 2020-04-28 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity
AU2012355494B2 (en) * 2011-12-22 2017-07-13 Merck Patent Gmbh Novel heterocyclic carboxamides as modulators of kinase activity
CN104981247A (zh) * 2012-09-06 2015-10-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
AR093511A1 (es) * 2012-11-16 2015-06-10 Merck Patent Gmbh Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas
AR095202A1 (es) * 2013-03-11 2015-09-30 Merck Patent Gmbh Heterociclos como moduladores de la actividad quinasa
WO2015123174A1 (en) * 2014-02-11 2015-08-20 Merck Patent Gmbh Pyrimidine imidazole amines as modulators of kinase activity
US9771369B2 (en) * 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

Also Published As

Publication number Publication date
WO2014143612A1 (en) 2014-09-18
US20160361316A1 (en) 2016-12-15
CA2902755C (en) 2021-02-16
JP2016512509A (ja) 2016-04-28
SG10201900954SA (en) 2019-02-27
RU2674261C2 (ru) 2018-12-06
IL240875B (en) 2020-08-31
RU2015143160A (ru) 2017-04-18
AR095202A1 (es) 2015-09-30
HK1218756A1 (zh) 2017-03-10
US20160016936A1 (en) 2016-01-21
MX2015011660A (es) 2015-12-16
EP2970201A1 (en) 2016-01-20
AU2014228385B2 (en) 2018-08-09
BR112015021324A2 (pt) 2017-07-18
US9458134B2 (en) 2016-10-04
KR20150124957A (ko) 2015-11-06
ES2746756T3 (es) 2020-03-06
IL240875A0 (en) 2015-10-29
CA2902755A1 (en) 2014-09-18
JP6483656B2 (ja) 2019-03-13
ZA201505749B (en) 2017-01-25
CN105209454A (zh) 2015-12-30
EP2970201B1 (en) 2019-06-19
RU2015143160A3 (es) 2018-03-01
US9867826B2 (en) 2018-01-16
AU2014228385A1 (en) 2015-08-20
SG11201505999VA (en) 2015-08-28

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