MX2016010268A - Pirimidinimidazolaminas como modulares de actividad de cinasa. - Google Patents

Pirimidinimidazolaminas como modulares de actividad de cinasa.

Info

Publication number
MX2016010268A
MX2016010268A MX2016010268A MX2016010268A MX2016010268A MX 2016010268 A MX2016010268 A MX 2016010268A MX 2016010268 A MX2016010268 A MX 2016010268A MX 2016010268 A MX2016010268 A MX 2016010268A MX 2016010268 A MX2016010268 A MX 2016010268A
Authority
MX
Mexico
Prior art keywords
modulators
kinase activity
pyrimidine
imidazole amines
amines
Prior art date
Application number
MX2016010268A
Other languages
English (en)
Inventor
Goutopoulos Andreas
R Huck Bayard
Chen Xiaoling
Xiao Yufang
Lan Ruoxi
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2016010268A publication Critical patent/MX2016010268A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona compuestos de imidazolamina novedosos de acuerdo con la fórmula (I), su elaboración y uso para el tratamiento de enfermedades hiperproliferativas, como por ejemplo cáncer.
MX2016010268A 2014-02-11 2015-02-10 Pirimidinimidazolaminas como modulares de actividad de cinasa. MX2016010268A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938343P 2014-02-11 2014-02-11
PCT/US2015/015136 WO2015123174A1 (en) 2014-02-11 2015-02-10 Pyrimidine imidazole amines as modulators of kinase activity

Publications (1)

Publication Number Publication Date
MX2016010268A true MX2016010268A (es) 2016-10-13

Family

ID=52589790

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010268A MX2016010268A (es) 2014-02-11 2015-02-10 Pirimidinimidazolaminas como modulares de actividad de cinasa.

Country Status (14)

Country Link
US (1) US9434714B2 (es)
EP (1) EP3105224A1 (es)
JP (1) JP6560243B2 (es)
KR (1) KR20160110953A (es)
CN (1) CN105980375A (es)
AU (1) AU2015217397B2 (es)
BR (1) BR112016015285A8 (es)
CA (1) CA2935600A1 (es)
IL (1) IL246973A0 (es)
MX (1) MX2016010268A (es)
RU (1) RU2690679C2 (es)
SG (1) SG11201605121VA (es)
WO (1) WO2015123174A1 (es)
ZA (1) ZA201604613B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA028057B1 (ru) * 2011-09-12 2017-10-31 Мерк Патент Гмбх Производные аминопиримидина для применения в качестве модуляторов киназной активности
KR20150124957A (ko) * 2013-03-11 2015-11-06 메르크 파텐트 게엠베하 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP3272A (en) * 2008-09-22 2015-05-31 Cayman Chem Co Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prosaglandin D2 mediated diseases
AR074072A1 (es) * 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
EP2627650A2 (en) * 2010-05-26 2013-08-21 Merck Sharp & Dohme Corp. N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
RS56534B1 (sr) * 2011-09-12 2018-02-28 Merck Patent Gmbh Novi imidazol akmini kao modulatori aktivnosti kinaza
EA028057B1 (ru) * 2011-09-12 2017-10-31 Мерк Патент Гмбх Производные аминопиримидина для применения в качестве модуляторов киназной активности
KR20150124957A (ko) * 2013-03-11 2015-11-06 메르크 파텐트 게엠베하 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체

Also Published As

Publication number Publication date
RU2016135420A (ru) 2018-03-15
RU2016135420A3 (es) 2018-09-27
AU2015217397B2 (en) 2019-01-17
AU2015217397A1 (en) 2016-07-07
KR20160110953A (ko) 2016-09-23
US20150225371A1 (en) 2015-08-13
BR112016015285A8 (pt) 2020-06-09
SG11201605121VA (en) 2016-07-28
JP6560243B2 (ja) 2019-08-14
BR112016015285A2 (pt) 2017-08-08
ZA201604613B (en) 2018-11-28
EP3105224A1 (en) 2016-12-21
CN105980375A (zh) 2016-09-28
RU2690679C2 (ru) 2019-06-05
US9434714B2 (en) 2016-09-06
JP2017505799A (ja) 2017-02-23
WO2015123174A1 (en) 2015-08-20
IL246973A0 (en) 2016-09-29
CA2935600A1 (en) 2015-08-20

Similar Documents

Publication Publication Date Title
PH12018502102A1 (en) Pyrrolotriazine compounds as tam inhibitors
TW201613886A (en) 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones
PH12016501898A1 (en) Quinoxaline derivatives useful as fgfr kinase modulators
MX2015000129A (es) Derivados de pirimidin pirazolilo.
SG10201806849WA (en) Cyclopropylamines as lsd1 inhibitors
EA201792205A1 (ru) Гетероциклические соединения как ингибиторы lsd1
PH12016501192A1 (en) Tetrahydropyridopyrazines modulators of gpr6
MX2016010571A (es) Pirazolil-ureas como inhibidores de quinasas.
MX346095B (es) Nuevas imidazol-aminas como moduladores de la actividad de cinasas.
TN2014000138A1 (en) Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases.
EA201691594A1 (ru) Циклопропиламины в качестве ингибиторов lsd1
MX2014002836A (es) Derivados de aminopirimidina para usarse como moduladores de la actividad de cinasa.
PH12018502497A1 (en) Adenosine derivatives for use in the treatment of cancer
MY195000A (en) Method for the treatment of neurological disease
PH12016501613B1 (en) Pyrazines modulators of gpr6
SG10201900954SA (en) Heterocycles as Modulators of Kinase Activity
GEAP201814286A (en) Halogenated quinazolinthf-amines as pde1 inhibitors
MX353062B (es) Nuevas carboxamidas heterociclicas como moduladores de la activadad de cinasas.
MX2016010268A (es) Pirimidinimidazolaminas como modulares de actividad de cinasa.
MX2019008375A (es) Tiobenzoimidazol como fungicidas.
PH12017501063A1 (en) Compounds for the treatment of cancer
MX2016009448A (es) (hetero)aril-imidazoles/pirazoles para el tratamiento de trastornos neurologicos.
EA201691620A1 (ru) Циклопропиламины в качестве ингибиторов lsd1