BR112016015285A8 - pirimidina imidazol aminas como moduladores da atividade de quinase, seus usos e seu processo de preparação, composição farmacêutica, e kit - Google Patents

pirimidina imidazol aminas como moduladores da atividade de quinase, seus usos e seu processo de preparação, composição farmacêutica, e kit Download PDF

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Publication number
BR112016015285A8
BR112016015285A8 BR112016015285A BR112016015285A BR112016015285A8 BR 112016015285 A8 BR112016015285 A8 BR 112016015285A8 BR 112016015285 A BR112016015285 A BR 112016015285A BR 112016015285 A BR112016015285 A BR 112016015285A BR 112016015285 A8 BR112016015285 A8 BR 112016015285A8
Authority
BR
Brazil
Prior art keywords
modulators
kit
pharmaceutical composition
preparation process
kinase activity
Prior art date
Application number
BR112016015285A
Other languages
English (en)
Other versions
BR112016015285A2 (pt
Inventor
Ruoxi Lan
Xiaoling Chen
Yufang Xiao
Bayard R Huck
Andreas Goutopoulos
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112016015285A2 publication Critical patent/BR112016015285A2/pt
Publication of BR112016015285A8 publication Critical patent/BR112016015285A8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se a novos compostos do tipo imidazol amina de acordo com (i), e sua produção e uso para o tratamento de doenças hiperproliferativas, tais como câncer.
BR112016015285A 2014-02-11 2015-02-10 pirimidina imidazol aminas como moduladores da atividade de quinase, seus usos e seu processo de preparação, composição farmacêutica, e kit BR112016015285A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938343P 2014-02-11 2014-02-11
PCT/US2015/015136 WO2015123174A1 (en) 2014-02-11 2015-02-10 Pyrimidine imidazole amines as modulators of kinase activity

Publications (2)

Publication Number Publication Date
BR112016015285A2 BR112016015285A2 (pt) 2017-08-08
BR112016015285A8 true BR112016015285A8 (pt) 2020-06-09

Family

ID=52589790

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016015285A BR112016015285A8 (pt) 2014-02-11 2015-02-10 pirimidina imidazol aminas como moduladores da atividade de quinase, seus usos e seu processo de preparação, composição farmacêutica, e kit

Country Status (14)

Country Link
US (1) US9434714B2 (pt)
EP (1) EP3105224A1 (pt)
JP (1) JP6560243B2 (pt)
KR (1) KR20160110953A (pt)
CN (1) CN105980375A (pt)
AU (1) AU2015217397B2 (pt)
BR (1) BR112016015285A8 (pt)
CA (1) CA2935600A1 (pt)
IL (1) IL246973A0 (pt)
MX (1) MX2016010268A (pt)
RU (1) RU2690679C2 (pt)
SG (1) SG11201605121VA (pt)
WO (1) WO2015123174A1 (pt)
ZA (1) ZA201604613B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101992505B1 (ko) * 2011-09-12 2019-06-24 메르크 파텐트 게엠베하 키나아제 활성의 조절제로서 용도를 위한 아미노피리미딘 유도체
MX370448B (es) * 2013-03-11 2019-12-13 Merck Patent Gmbh Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP3272A (en) * 2008-09-22 2015-05-31 Cayman Chem Co Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prosaglandin D2 mediated diseases
AR074072A1 (es) * 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
EP2627650A2 (en) * 2010-05-26 2013-08-21 Merck Sharp & Dohme Corp. N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
CN104080782B (zh) * 2011-09-12 2016-06-01 默克专利有限公司 用作激酶活性调节剂的咪唑胺
KR101992505B1 (ko) * 2011-09-12 2019-06-24 메르크 파텐트 게엠베하 키나아제 활성의 조절제로서 용도를 위한 아미노피리미딘 유도체
MX370448B (es) * 2013-03-11 2019-12-13 Merck Patent Gmbh Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.

Also Published As

Publication number Publication date
RU2016135420A (ru) 2018-03-15
US20150225371A1 (en) 2015-08-13
EP3105224A1 (en) 2016-12-21
WO2015123174A1 (en) 2015-08-20
BR112016015285A2 (pt) 2017-08-08
IL246973A0 (en) 2016-09-29
US9434714B2 (en) 2016-09-06
AU2015217397A1 (en) 2016-07-07
MX2016010268A (es) 2016-10-13
JP2017505799A (ja) 2017-02-23
SG11201605121VA (en) 2016-07-28
RU2016135420A3 (pt) 2018-09-27
ZA201604613B (en) 2018-11-28
CA2935600A1 (en) 2015-08-20
CN105980375A (zh) 2016-09-28
RU2690679C2 (ru) 2019-06-05
JP6560243B2 (ja) 2019-08-14
KR20160110953A (ko) 2016-09-23
AU2015217397B2 (en) 2019-01-17

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements