JP2014520523A5 - - Google Patents
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- JP2014520523A5 JP2014520523A5 JP2014517958A JP2014517958A JP2014520523A5 JP 2014520523 A5 JP2014520523 A5 JP 2014520523A5 JP 2014517958 A JP2014517958 A JP 2014517958A JP 2014517958 A JP2014517958 A JP 2014517958A JP 2014520523 A5 JP2014520523 A5 JP 2014520523A5
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- 210000004027 cell Anatomy 0.000 claims 18
- 210000000130 stem cell Anatomy 0.000 claims 17
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- 210000000988 bone and bone Anatomy 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000014674 injury Diseases 0.000 claims 9
- 230000008733 trauma Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 7
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 7
- 210000005087 mononuclear cell Anatomy 0.000 claims 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 6
- 206010031252 Osteomyelitis Diseases 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
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- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 4
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 4
- 108010074328 Interferon-gamma Proteins 0.000 claims 4
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- 230000000747 cardiac effect Effects 0.000 claims 4
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
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- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 2
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
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- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
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- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1111500.3 | 2011-07-06 | ||
| GBGB1111503.7A GB201111503D0 (en) | 2011-07-06 | 2011-07-06 | Heart failure (HF) MSC subtype |
| GBGB1111500.3A GB201111500D0 (en) | 2011-07-06 | 2011-07-06 | Wet age-related macular degeneration MSC subtype |
| GB1111505.2 | 2011-07-06 | ||
| GB1111503.7 | 2011-07-06 | ||
| GB1111509.4 | 2011-07-06 | ||
| GBGB1111509.4A GB201111509D0 (en) | 2011-07-06 | 2011-07-06 | Orthopedic MSC subtype |
| GBGB1111505.2A GB201111505D0 (en) | 2011-07-06 | 2011-07-06 | MI MSC subtype |
| PCT/GB2012/051600 WO2013005053A2 (en) | 2011-07-06 | 2012-07-06 | Progenitor cells of mesodermal lineage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144116A Division JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520523A JP2014520523A (ja) | 2014-08-25 |
| JP2014520523A5 true JP2014520523A5 (enExample) | 2015-07-16 |
| JP6607675B2 JP6607675B2 (ja) | 2019-11-20 |
Family
ID=46513785
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517958A Active JP6607675B2 (ja) | 2011-07-06 | 2012-07-06 | 中胚葉系列の前駆細胞 |
| JP2017144116A Pending JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144116A Pending JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10472609B2 (enExample) |
| EP (1) | EP2729562B1 (enExample) |
| JP (2) | JP6607675B2 (enExample) |
| CN (2) | CN104508124B (enExample) |
| AU (2) | AU2012279995C1 (enExample) |
| CA (1) | CA2840307C (enExample) |
| CY (1) | CY1120646T1 (enExample) |
| DK (1) | DK2729562T3 (enExample) |
| EA (1) | EA029577B1 (enExample) |
| ES (1) | ES2675693T3 (enExample) |
| HR (1) | HRP20181152T1 (enExample) |
| HU (1) | HUE039236T2 (enExample) |
| IL (2) | IL230071B (enExample) |
| LT (1) | LT2729562T (enExample) |
| MY (1) | MY185016A (enExample) |
| PL (1) | PL2729562T3 (enExample) |
| PT (1) | PT2729562T (enExample) |
| SG (1) | SG10201605518XA (enExample) |
| WO (1) | WO2013005053A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
| PL2782555T3 (pl) * | 2011-11-23 | 2019-09-30 | Cell Therapy Limited | Żel z lizatem płytek krwi |
| JP6615753B2 (ja) * | 2013-10-04 | 2019-12-04 | レジニアス リミテッド | 細胞療法のためのバイオマーカー |
| GB201408712D0 (en) * | 2014-05-16 | 2014-07-02 | Univ Leuven Kath | Mesodermal progenitor cells |
| GB201410504D0 (en) | 2014-06-12 | 2014-07-30 | Cell Therapy Ltd | Immuno-modulaltory progenitor (IMP) cell |
| CN107076745A (zh) * | 2014-08-29 | 2017-08-18 | 贝克顿·迪金森公司 | 在受试者中获得结核病评价的方法和组合物 |
| JP2018512061A (ja) * | 2015-02-20 | 2018-05-10 | ナショナル ヤン−ミン ユニバーシティ | 骨関節炎処置のための間葉幹細胞の使用 |
| EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
| GB201513996D0 (en) | 2015-08-07 | 2015-09-23 | Cell Therapy Ltd | Immuno-oncology mesodermal progenitor (IOMP) cell |
| JP6830893B2 (ja) | 2015-09-11 | 2021-02-17 | アステラス製薬株式会社 | 腎前駆細胞を製造する方法 |
| GB201518263D0 (en) | 2015-10-15 | 2015-12-02 | Oxford Bioelectronics Ltd | Method |
| CN105483206B (zh) * | 2016-01-06 | 2019-09-13 | 北京汉氏联合生物技术股份有限公司 | 一种用vcam-1检测msc促内皮细胞增殖能力的方法 |
| US11066648B2 (en) * | 2016-08-29 | 2021-07-20 | Hackensack University Medical Center | Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans |
| CA3033750A1 (en) * | 2016-08-29 | 2018-03-08 | Hackensack University Medical Center | Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells |
| CN112004923A (zh) | 2017-11-22 | 2020-11-27 | 迈索布拉斯特国际有限公司 | 细胞组合物及治疗方法 |
| JP7009977B2 (ja) * | 2017-12-25 | 2022-01-26 | 国立大学法人東海国立大学機構 | 被検体の血中vegf-aに関する測定値を用いた心疾患の重症度及び予後予測を行うための方法、装置及びコンピュータプログラム |
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