EA029577B1 - Клетки-предшественники мезодермальной линии - Google Patents

Клетки-предшественники мезодермальной линии Download PDF

Info

Publication number
EA029577B1
EA029577B1 EA201391773A EA201391773A EA029577B1 EA 029577 B1 EA029577 B1 EA 029577B1 EA 201391773 A EA201391773 A EA 201391773A EA 201391773 A EA201391773 A EA 201391773A EA 029577 B1 EA029577 B1 EA 029577B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cells
tissue
patient
bone
present
Prior art date
Application number
EA201391773A
Other languages
English (en)
Russian (ru)
Other versions
EA201391773A1 (ru
Inventor
Томас Эверилл Хауз
Мартин Джон Эванс
Аджан Реджинальд
Ина Лаура Пипер
Брайан Ли Перкинс
Original Assignee
Селл Терапи Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1111503.7A external-priority patent/GB201111503D0/en
Priority claimed from GBGB1111500.3A external-priority patent/GB201111500D0/en
Priority claimed from GBGB1111509.4A external-priority patent/GB201111509D0/en
Priority claimed from GBGB1111505.2A external-priority patent/GB201111505D0/en
Application filed by Селл Терапи Лимитед filed Critical Селл Терапи Лимитед
Publication of EA201391773A1 publication Critical patent/EA201391773A1/ru
Publication of EA029577B1 publication Critical patent/EA029577B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0665Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0645Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115Platelets, megakaryocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
EA201391773A 2011-07-06 2012-07-06 Клетки-предшественники мезодермальной линии EA029577B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1111503.7A GB201111503D0 (en) 2011-07-06 2011-07-06 Heart failure (HF) MSC subtype
GBGB1111500.3A GB201111500D0 (en) 2011-07-06 2011-07-06 Wet age-related macular degeneration MSC subtype
GBGB1111509.4A GB201111509D0 (en) 2011-07-06 2011-07-06 Orthopedic MSC subtype
GBGB1111505.2A GB201111505D0 (en) 2011-07-06 2011-07-06 MI MSC subtype
PCT/GB2012/051600 WO2013005053A2 (en) 2011-07-06 2012-07-06 Progenitor cells of mesodermal lineage

Publications (2)

Publication Number Publication Date
EA201391773A1 EA201391773A1 (ru) 2014-11-28
EA029577B1 true EA029577B1 (ru) 2018-04-30

Family

ID=46513785

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391773A EA029577B1 (ru) 2011-07-06 2012-07-06 Клетки-предшественники мезодермальной линии

Country Status (19)

Country Link
US (3) US10472609B2 (enExample)
EP (1) EP2729562B1 (enExample)
JP (2) JP6607675B2 (enExample)
CN (2) CN104508124B (enExample)
AU (2) AU2012279995C1 (enExample)
CA (1) CA2840307C (enExample)
CY (1) CY1120646T1 (enExample)
DK (1) DK2729562T3 (enExample)
EA (1) EA029577B1 (enExample)
ES (1) ES2675693T3 (enExample)
HR (1) HRP20181152T1 (enExample)
HU (1) HUE039236T2 (enExample)
IL (2) IL230071B (enExample)
LT (1) LT2729562T (enExample)
MY (1) MY185016A (enExample)
PL (1) PL2729562T3 (enExample)
PT (1) PT2729562T (enExample)
SG (1) SG10201605518XA (enExample)
WO (1) WO2013005053A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
PL2782555T3 (pl) * 2011-11-23 2019-09-30 Cell Therapy Limited Żel z lizatem płytek krwi
JP6615753B2 (ja) * 2013-10-04 2019-12-04 レジニアス リミテッド 細胞療法のためのバイオマーカー
GB201408712D0 (en) * 2014-05-16 2014-07-02 Univ Leuven Kath Mesodermal progenitor cells
GB201410504D0 (en) 2014-06-12 2014-07-30 Cell Therapy Ltd Immuno-modulaltory progenitor (IMP) cell
CN107076745A (zh) * 2014-08-29 2017-08-18 贝克顿·迪金森公司 在受试者中获得结核病评价的方法和组合物
JP2018512061A (ja) * 2015-02-20 2018-05-10 ナショナル ヤン−ミン ユニバーシティ 骨関節炎処置のための間葉幹細胞の使用
EP3091084A1 (en) * 2015-05-08 2016-11-09 Université Catholique De Louvain Methods for assessing the purity of a mesenchymal stem cells preparation
GB201513996D0 (en) 2015-08-07 2015-09-23 Cell Therapy Ltd Immuno-oncology mesodermal progenitor (IOMP) cell
JP6830893B2 (ja) 2015-09-11 2021-02-17 アステラス製薬株式会社 腎前駆細胞を製造する方法
GB201518263D0 (en) 2015-10-15 2015-12-02 Oxford Bioelectronics Ltd Method
CN105483206B (zh) * 2016-01-06 2019-09-13 北京汉氏联合生物技术股份有限公司 一种用vcam-1检测msc促内皮细胞增殖能力的方法
US11066648B2 (en) * 2016-08-29 2021-07-20 Hackensack University Medical Center Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans
CA3033750A1 (en) * 2016-08-29 2018-03-08 Hackensack University Medical Center Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells
CN112004923A (zh) 2017-11-22 2020-11-27 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
JP7009977B2 (ja) * 2017-12-25 2022-01-26 国立大学法人東海国立大学機構 被検体の血中vegf-aに関する測定値を用いた心疾患の重症度及び予後予測を行うための方法、装置及びコンピュータプログラム
CN108715833B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种负载血小板裂解液的微球制备方法
CN108715834B (zh) * 2018-06-01 2021-09-14 天晴干细胞股份有限公司 一种富含cd41+、cd81+微囊的血小板裂解液制备方法
US12310989B2 (en) * 2018-11-14 2025-05-27 Onderzoeks- En Ontwikkelingsfonds Rode Kruis-Vlaanderen Methods for preparing platelet releasate
CN109329270A (zh) * 2018-11-19 2019-02-15 成都清科生物科技有限公司 一种静脉回输用间充质干细胞保存液及其制备方法
GB201900554D0 (en) 2019-01-15 2019-03-06 Cell Therapy Ltd Mesodermal killer (mk) cell
US20230047325A1 (en) * 2019-01-15 2023-02-16 Cell Therapy Limited Mesodermal killer (mk) cell
WO2020157660A1 (en) * 2019-01-28 2020-08-06 Mesoblast International Sárl Method for treating or preventing gastrointestinal bleeding
EP3968992A4 (en) * 2019-05-15 2023-06-21 Stemcyte, Inc. PACKAGING AND SHIPPING HIGH CONCENTRATION CELLS
CN110237094B (zh) * 2019-07-30 2023-10-03 天晴干细胞股份有限公司 一种底层血小板因子贴及sPL血小板因子凝胶贴膜的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058404A1 (en) * 2005-11-16 2007-05-24 Rnl Bio Co., Ltd. Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
WO2009069991A2 (en) * 2007-11-30 2009-06-04 Rnl Bio Co., Ltd. Cellular therapeutic agent for incontinence of urine comprising stem cells originated from decidua or adipose
WO2010021412A1 (ja) * 2008-08-22 2010-02-25 財団法人ヒューマンサイエンス振興財団 脳梗塞治療材及び脳組織再生方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801537D0 (sv) 1988-04-26 1988-04-26 Ellco Food Ab Cellodlingsmedium samt forfarande for dess framstellning
RU2138162C1 (ru) 1997-04-17 1999-09-27 Суханов Владимир Александрович Способ криоконсервации богатой тромбоцитами плазмы
EP1028737B1 (en) 1997-07-03 2007-04-04 Osiris Therapeutics, Inc. Human mesenchymal stem cells from peripheral blood
WO1999011287A1 (en) 1997-09-04 1999-03-11 Osiris Therapeutics, Inc. Ligands that modulate differentiation of mesenchymal stem cells
EP1082410B1 (en) 1998-05-29 2007-08-01 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
DK1226233T3 (da) 1999-08-05 2011-10-03 Abt Holding Co Multipotente voksne stamceller og fremgangsmåder til isolering heraf
AUPR703601A0 (en) 2001-08-15 2001-09-06 Peter Maccallum Cancer Institute, The Identification and isolation of somatic stem cells and uses thereof
JP2003055237A (ja) * 2001-08-15 2003-02-26 Japan Science & Technology Corp 骨再生促進剤
DE60314602T2 (de) 2002-02-19 2008-02-28 Medipost, Co., Ltd. Verfahren zur isolierung und kulturexpansion mesenchymaler stamm-/vorläuferzellen aus nabelschnurblut sowie verfahren zur differenzierung von aus nabelschnurblut stammenden mesenchymalen stamm-/vorläuferzellen in unterschiedliche mesenchymgewebe
KR100534215B1 (ko) 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
DE102005011568A1 (de) 2004-04-13 2005-11-17 Man Roland Druckmaschinen Ag Produktionsverfahren für eine Prägeeinrichtung in einer Bogendruckmaschine
US20090047257A1 (en) 2004-07-20 2009-02-19 Case Western Reserve University Novel cell populations and uses thereof
AU2005287855B2 (en) 2004-09-24 2011-06-16 Mesoblast, Inc. Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC)
US20080260694A1 (en) 2004-09-24 2008-10-23 Angioblast Systems, Inc. Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof
KR101617319B1 (ko) 2005-04-12 2016-05-02 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
ES2415855T3 (es) 2006-01-13 2013-07-29 Osiris Therapeutics, Inc. Células troncales mesenquimatosas que expresan el receptor de TNF
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
US20100111910A1 (en) 2006-07-12 2010-05-06 Angioblast Systems, Inc. Treatment of excessive neovascularization
US20090253151A1 (en) 2006-09-01 2009-10-08 Stempeutics Research Private Limited Self-Renewing Master Adult Pluripotent Stem Cells
WO2008097828A2 (en) 2007-02-02 2008-08-14 St. Jude Children's Research Hospital Method for isolating mesenchymal stromal cells
WO2008129563A2 (en) 2007-04-23 2008-10-30 Stempeutics Research Private Limited, Human mesenchymal stem cells and preparation thereof
US20090053182A1 (en) 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
US9095562B2 (en) * 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
EP2014294A1 (en) 2007-07-13 2009-01-14 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of CD200 as a mesenchymal stem cells marker
WO2009044943A1 (en) 2007-10-01 2009-04-09 Seoul National University Industry Foundation Various human dental stem cells having a mineralization ability and the method for culturing them
WO2009061024A1 (en) 2007-11-09 2009-05-14 Rnl Bio Co., Ltd Method for isolating and culturing adult stem cells derived from human amniotic epithelium
EP2297305A4 (en) 2008-05-15 2013-03-13 Univ Miami ISOLATION OF STEM CELL PROCESSORS AND EXPANSION UNDER NON-TERMS OF CONDITION
WO2010005527A1 (en) 2008-06-30 2010-01-14 Angioblast Systems, Inc. Treatment of eye diseases and excessive neovascularization using a combined therapy
EP2321408A4 (en) 2008-08-04 2013-04-17 Allocure Inc MESENCHYMAL STROMAZELL POPULATIONS AND PROCESS FOR THEIR INSULATION AND USE
US9090678B2 (en) 2008-08-18 2015-07-28 Mesoblast, Inc. Monoclonal antibody STRO-4
EP2334785B2 (en) 2008-09-16 2019-08-14 Mayo Foundation For Medical Education And Research Compositions containing platelet contents
EP2186883A1 (en) 2008-11-04 2010-05-19 Fresenius Medical Care An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney
KR102011609B1 (ko) 2008-11-20 2019-08-16 메소블라스트, 아이엔씨. 췌장 기능장애를 치료 또는 예방하는 방법
US20120020937A1 (en) 2009-04-28 2012-01-26 Anterogen Co., Ltd. Autologous and allogenic adipose-derived stromal stem cell composition for treating fistulas
EP2488187A4 (en) 2009-10-13 2014-03-26 Allocure Inc ASSAY FOR PREDICTING THE THERAPEUTIC EFFECT OF MECHANICAL CYCLES AND METHOD OF USE THEREOF
ES2358146B1 (es) 2009-10-22 2012-03-23 Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud En Sevilla Uso de células mesenquimales nestina positivas para el mantenimiento de la hematopoyesis.
US20110123498A1 (en) 2009-10-30 2011-05-26 Christof Westenfelder Mesenchymal stromal cell populations and methods of using same
CN102048756B (zh) 2009-11-04 2014-02-19 中国医学科学院基础医学研究所 人脂肪来源的间充质干细胞在肾脏、眼底疾病中的用途
WO2011068792A2 (en) 2009-12-01 2011-06-09 The Regents Of The University Of California Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells
EP2506867B1 (en) * 2009-12-02 2014-10-08 Cardio3 Biosciences S.A. Pharmaceutical compositions for the stimulation of stem cells.
KR101871472B1 (ko) 2010-07-02 2018-06-27 메소블라스트, 아이엔씨. 이식편대숙주 질환의 치료 방법
JP6061345B2 (ja) 2010-08-27 2017-01-18 ユニヴァーシティ・オヴ・マイアミ 心臓修復のための骨髄由来cd271前駆細胞
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
ES2384790B1 (es) 2010-12-10 2013-05-20 Instituto De Salud Carlos Iii Células madre mesenquimales aisladas a partir de sangre periférica.
US20120288480A1 (en) 2011-02-22 2012-11-15 Taipei Medical University Cell population comprising orbital fat-derived stem cells (ofscs) and their isolation and applications
CN102078644A (zh) * 2011-03-08 2011-06-01 吉林大学 一种简便高效的自体富血小板血浆提取装置及提取方法
SG194930A1 (en) 2011-05-19 2013-12-30 Mesoblast Inc Methods for treating obesity and/or metabolic syndrome
CN103826646A (zh) 2011-06-03 2014-05-28 麦瑟布莱斯特公司 治疗中风的影响的方法
CN109276706A (zh) 2011-06-03 2019-01-29 麦瑟布莱斯特公司 治疗或预防神经性疾病的方法
WO2013003899A1 (en) 2011-07-04 2013-01-10 Mesoblast, Inc Methods of treating or preventing rheumatic disease
CN108635377B (zh) 2011-09-09 2022-06-24 麦瑟布莱斯特公司 增加成骨细胞功能的方法
JP6348848B2 (ja) 2012-02-13 2018-06-27 ガミダ セル リミテッド 間葉系幹細胞の増殖
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US20130273011A1 (en) 2012-04-17 2013-10-17 Medistem, Inc. Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007058404A1 (en) * 2005-11-16 2007-05-24 Rnl Bio Co., Ltd. Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
WO2009069991A2 (en) * 2007-11-30 2009-06-04 Rnl Bio Co., Ltd. Cellular therapeutic agent for incontinence of urine comprising stem cells originated from decidua or adipose
WO2010021412A1 (ja) * 2008-08-22 2010-02-25 財団法人ヒューマンサイエンス振興財団 脳梗塞治療材及び脳組織再生方法

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
ABDALLAH B M, KASSEM M: "Human mesenchymal stem cells: from basic biology to clinical applications.", GENE THERAPY, NATURE PUBLISHING GROUP, GB, vol. 15, no. 2, 1 January 2008 (2008-01-01), GB, pages 109 - 116, XP002505627, ISSN: 0969-7128, DOI: 10.1038/SJ.GT.3303067 *
ADRIANA L�PEZ PONTE, MARAIS EMELINE, GALLAY NATHALIE, LANGONN� ALAIN, DELORME BRUNO, H�RAULT OLIVIER, CHARBORD PIERRE, DOMENECH JO: "The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities", STEM CELLS, ALPHAMED PRESS, vol. 25, no. 7, 1 July 2007 (2007-07-01), pages 1737 - 1745, XP055050706, ISSN: 10665099, DOI: 10.1634/stemcells.2007-0054 *
ANDRIELLE CASTILHO-FERNANDES; DANILO CANDIDO DE ALMEIDA; APARECIDA MARIA FONTES; FERNANDA URSOLI FERREIRA MELO; VIRGÍNIA PICANÇO-C: "Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells", EXPERIMENTAL AND MOLECULAR PATHOLOGY., ACADEMIC PRESS., US, vol. 91, no. 3, US, pages 664 - 672, XP028111727, ISSN: 0014-4800, DOI: 10.1016/j.yexmp.2011.09.002 *
BASEM M. ABDALLAH, KASSEM MOUSTAPHA: "The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: Current status and future perspectives", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., vol. 218, no. 1, 1 January 2009 (2009-01-01), pages 9 - 12, XP055056394, ISSN: 00219541, DOI: 10.1002/jcp.21572 *
BUEHRING HANS-JOERG; BATTULA VENKATA LOKESH; TREML SABRINA; SCHEWE BERNHARD; KANZ LOTHAR; VOGEL WICHARD: "Novel markers for the prospective isolation of human MSC", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES., US, 16 September 2006 (2006-09-16), US, pages 262 - 271, XP009109140, ISSN: 0077-8923 *
CARRANCIO, S. ; LOPEZ-HOLGADO, N. ; SANCHEZ-GUIJO, F.M. ; VILLARON, E. ; BARBADO, V. ; TABERA, S. ; DIEZ-CAMPELO, M. ; BLANCO, J. : "Optimization of mesenchymal stem cell expansion procedures by cell separation and culture conditions modification", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC., US, vol. 36, no. 8, 1 August 2008 (2008-08-01), US, pages 1014 - 1021, XP022940505, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2008.03.012 *
CATHERINE M KOLF, ELIZABETH CHO, ROCKY S TUAN: "Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 19 February 2007 (2007-02-19), GB, pages 204 - 204-10, XP008146968, ISSN: 1478-6354, DOI: 10.1186/ar2116 *
DANUTA JAROCHA, LUKASIEWICZ EWA, MAJKA MARCIN: "Adventage of mesenchymal stem cells (MSC) expansion directly from purified bone marrow CD105+ and CD271+ cells.", FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, vol. 46, no. 3, XP055052371, ISSN: 02398508, DOI: 10.2478/v10042-008-0046-z *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1 October 2010 (2010-10-01), LIU QUAN-HUA , GE JIAN, LIU KAI-YAN: "[Are CD133 and CD271 useful in positive selection to enrich umbilical cord blood mesenchymal stem cells?].", XP002693611 *
GISELLE CHAMBERLAIN, KARINA WRIGHT, ANTAL ROT, BRIAN ASHTON, JIM MIDDLETON: "Murine Mesenchymal Stem Cells Exhibit a Restricted Repertoire of Functional Chemokine Receptors: Comparison with Human", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 3, no. 8, 1 August 2008 (2008-08-01), US, pages e2934.1 - e2934.6, XP002622569, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0002934 *
HATIM HEMEDA, JAKOB MARK, LUDWIG ANNA-KRISTIN, GIEBEL BERND, LANG STEPHAN, BRANDAU SVEN: "Interferon-γ and Tumor Necrosis Factor-α Differentially Affect Cytokine Expression and Migration Properties of Mesenchymal Stem Cells", STEM CELLS AND DEVELOPMENT, vol. 19, no. 5, 1 May 2010 (2010-05-01), pages 693 - 706, XP055056178, ISSN: 15473287, DOI: 10.1089/scd.2009.0365 *
HOLZWARTH CHRISTINA; VAEGLER MARTIN; GIESEKE FRIEDERIKE; PFISTER STEFAN M; HANDGRETINGER RUPERT; KERST GUNTER; MÜLLER INGO: "Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells", BMC CELL BIOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 11, no. 1, 28 January 2010 (2010-01-28), GB, pages 11, XP021065781, ISSN: 1471-2121 *
LIU, H. ; XUE, W. ; GE, G. ; LUO, X. ; LI, Y. ; XIANG, H. ; DING, X. ; TIAN, P. ; TIAN, X.: "Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1@a in MSCs", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, AMSTERDAM, NL, vol. 401, no. 4, 29 October 2010 (2010-10-29), AMSTERDAM, NL, pages 509 - 515, XP027567795, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2010.09.076 *
MARIA ESTER BERNARDO, FRANCO LOCATELLI AND WILLEM E. FIBBE: "Mesenchymal stromal cells.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES., US, vol. 1176, 1 September 2009 (2009-09-01), US, pages 101 - 117, XP008156034, ISSN: 0077-8923, DOI: 10.1111/j.1749-6632.2009.04607.x *
NAGHMEH AHMADIAN KIA; AHMAD REZA BAHRAMI; MARZIEH EBRAHIMI; MARYAM M. MATIN; ZEINAB NESHATI; MAHMOOD RAIS ALMOHADDESIN; NASER AGHD: "Comparative Analysis of Chemokine Receptor's Expression in Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue", JOURNAL OF MOLECULAR NEUROSCIENCE, HUMANA PRESS INC, NEW YORK, vol. 44, no. 3, 12 October 2010 (2010-10-12), New York, pages 178 - 185, XP019912023, ISSN: 1559-1166, DOI: 10.1007/s12031-010-9446-6 *
WAGNER W, HO A D: "Mesenchymal stem cell preparations--comparing apples and oranges", STEM CELL REVIEWS, HUMANA PRESS INC., US, vol. 3, no. 4, 1 December 2007 (2007-12-01), US, pages 239 - 248, XP002545736, ISSN: 1550-8943, DOI: 10.1007/s12015-007-9001-1 *
YAOJIONG WU; ROBERT C. H. ZHAO: "The Role of Chemokines in Mesenchymal Stem Cell Homing to Myocardium", STEM CELL REVIEWS AND REPORTS, HUMANA PRESS INC, NEW YORK, vol. 8, no. 1, 25 June 2011 (2011-06-25), New York, pages 243 - 250, XP035019891, ISSN: 1558-6804, DOI: 10.1007/s12015-011-9293-z *

Also Published As

Publication number Publication date
US20150071886A1 (en) 2015-03-12
CN107746830A (zh) 2018-03-02
AU2012279995A1 (en) 2014-01-23
IL264455A (en) 2019-02-28
WO2013005053A3 (en) 2013-06-13
CN104508124B (zh) 2017-11-17
CN104508124A (zh) 2015-04-08
US10472609B2 (en) 2019-11-12
HRP20181152T1 (hr) 2018-09-21
CA2840307A1 (en) 2013-01-10
EA201391773A1 (ru) 2014-11-28
AU2012279995B2 (en) 2017-03-30
JP2014520523A (ja) 2014-08-25
WO2013005053A2 (en) 2013-01-10
SG10201605518XA (en) 2016-08-30
ES2675693T3 (es) 2018-07-11
DK2729562T3 (en) 2018-07-23
MY185016A (en) 2021-04-30
AU2012279995C1 (en) 2019-10-24
AU2017204559A1 (en) 2017-07-20
EP2729562A2 (en) 2014-05-14
JP2017225451A (ja) 2017-12-28
CY1120646T1 (el) 2019-12-11
US10829739B2 (en) 2020-11-10
PL2729562T3 (pl) 2018-10-31
PT2729562T (pt) 2018-07-18
NZ620283A (en) 2016-06-24
CA2840307C (en) 2021-10-19
HUE039236T2 (hu) 2018-12-28
US11873513B2 (en) 2024-01-16
EP2729562B1 (en) 2018-04-18
IL230071B (en) 2019-02-28
JP6607675B2 (ja) 2019-11-20
US20210032600A1 (en) 2021-02-04
LT2729562T (lt) 2018-07-25
US20200048613A1 (en) 2020-02-13

Similar Documents

Publication Publication Date Title
US11873513B2 (en) Progenitor cells of mesodermal lineage
JP6185657B2 (ja) 免疫調節前駆(imp)細胞
ES2432744T3 (es) Células del tejido adiposo extramedular y sus aplicaciones en la reconstitución del tejido cardiaco
EP3154599B1 (en) Hybrid composition
US20150246079A1 (en) Immune privileged and modulatory progenitor cells
KR20180057614A (ko) 면역-종양학 중배엽 전구체(iomp) 세포
CN113383069B (zh) 使用转化的t细胞培养脐带血来源的自然杀伤细胞的方法
WO2014193895A1 (en) Ex vivo perfusion of donor organs prior to transplantation using mesenchymal stem cells
CN120769904A (zh) 表达膜结合细胞因子的肿瘤浸润淋巴细胞
HK1198047A (en) Progenitor cells of mesodermal lineage
HK1198047B (en) Progenitor cells of mesodermal lineage
NZ620283B2 (en) Progenitor cells of mesodermal lineage
CN120866362A (zh) 过表达ifitm2基因的car-t细胞、构建方法及其在免疫细胞疗法中的应用

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM BY KZ KG TJ TM