JP2014519506A5 - - Google Patents
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- Publication number
- JP2014519506A5 JP2014519506A5 JP2014513796A JP2014513796A JP2014519506A5 JP 2014519506 A5 JP2014519506 A5 JP 2014519506A5 JP 2014513796 A JP2014513796 A JP 2014513796A JP 2014513796 A JP2014513796 A JP 2014513796A JP 2014519506 A5 JP2014519506 A5 JP 2014519506A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- rfurin
- ppm
- sugar
- nonionic surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 86
- 239000002736 nonionic surfactant Substances 0.000 claims description 20
- 235000000346 sugar Nutrition 0.000 claims description 16
- 239000000872 buffer Substances 0.000 claims description 14
- 150000005846 sugar alcohols Chemical class 0.000 claims description 14
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 9
- 239000007995 HEPES buffer Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 239000011575 calcium Substances 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 102000004961 Furin Human genes 0.000 claims description 6
- 108090001126 Furin Proteins 0.000 claims description 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 5
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 229940068968 polysorbate 80 Drugs 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 239000006172 buffering agent Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 150000001242 acetic acid derivatives Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 11
- 239000013024 dilution buffer Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 239000000178 monomer Substances 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 150000001735 carboxylic acids Chemical class 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492712P | 2011-06-02 | 2011-06-02 | |
| US61/492,712 | 2011-06-02 | ||
| PCT/US2012/040790 WO2012167271A1 (en) | 2011-06-02 | 2012-06-04 | Formulations of recombinant furin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015161719A Division JP6064007B2 (ja) | 2011-06-02 | 2015-08-19 | 組換えフューリン製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519506A JP2014519506A (ja) | 2014-08-14 |
| JP2014519506A5 true JP2014519506A5 (enExample) | 2015-07-30 |
| JP5797837B2 JP5797837B2 (ja) | 2015-10-21 |
Family
ID=46705014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513796A Expired - Fee Related JP5797837B2 (ja) | 2011-06-02 | 2012-06-04 | 組換えフューリン製剤 |
| JP2015161719A Expired - Fee Related JP6064007B2 (ja) | 2011-06-02 | 2015-08-19 | 組換えフューリン製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015161719A Expired - Fee Related JP6064007B2 (ja) | 2011-06-02 | 2015-08-19 | 組換えフューリン製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8877473B2 (enExample) |
| EP (1) | EP2714087B1 (enExample) |
| JP (2) | JP5797837B2 (enExample) |
| KR (1) | KR102050609B1 (enExample) |
| CN (1) | CN103889454B (enExample) |
| AR (1) | AR086672A1 (enExample) |
| AU (2) | AU2012261813B2 (enExample) |
| BR (1) | BR112013030880B1 (enExample) |
| CA (1) | CA2837948C (enExample) |
| ES (1) | ES2715289T3 (enExample) |
| RU (1) | RU2610436C2 (enExample) |
| SG (2) | SG195261A1 (enExample) |
| TW (1) | TWI586802B (enExample) |
| WO (1) | WO2012167271A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4443135A3 (en) * | 2013-08-20 | 2024-12-18 | Yokogawa Fluence Analytics, Inc. | Characterization of polymer and colloid solutions |
| TWI743023B (zh) * | 2014-05-21 | 2021-10-21 | 日商Ｋｍ生物醫藥股份有限公司 | 基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法 |
| TWI666319B (zh) | 2014-08-12 | 2019-07-21 | 美商巴克斯歐塔公司 | 在分泌ｆｕｒｉｎ之哺乳動物表現系統中生產經完全加工且具功能性之因子Ｘ |
| CA3068121A1 (en) | 2017-06-23 | 2018-12-27 | Baxalta Incorporated | Purification of factor viii subspecies |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9000917A (nl) | 1989-10-25 | 1991-05-16 | Holland Biotechnology | Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. |
| ATE158816T1 (de) | 1990-11-26 | 1997-10-15 | Genetics Inst | Expression von pace in wirtszellen und verfahren zu dessen verwendung |
| ZA965368B (en) * | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
| AT404838B (de) | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| US5876992A (en) * | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| US6596526B1 (en) | 2000-06-09 | 2003-07-22 | Baxter Aktiengesellschaft | Furin polypeptides with improved characteristics |
| US7033991B2 (en) * | 2001-07-16 | 2006-04-25 | Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College | Inhibiting furin with polybasic peptides |
| ATE507822T1 (de) * | 2003-12-19 | 2011-05-15 | Novo Nordisk Healthcare Ag | Stabilisierte zusammensetzungen von faktor-vii- polypeptiden |
| DE102006008613A1 (de) * | 2006-02-24 | 2007-08-30 | Dade Behring Marburg Gmbh | Stabilisierte Zubereitungen von Serin-Endopeptidasen, deren Herstellung und Verwendung |
| US8343748B2 (en) * | 2007-05-22 | 2013-01-01 | Baxter International Inc. | Preparative purification process for human furin |
| SG10201805749QA (en) | 2007-12-31 | 2018-08-30 | Baxalta Inc | Substantially animal protein-free recombinant furin and methods for producing same |
-
2012
- 2012-06-04 WO PCT/US2012/040790 patent/WO2012167271A1/en not_active Ceased
- 2012-06-04 AR ARP120101976A patent/AR086672A1/es not_active Application Discontinuation
- 2012-06-04 US US13/488,324 patent/US8877473B2/en active Active
- 2012-06-04 BR BR112013030880-0A patent/BR112013030880B1/pt active IP Right Grant
- 2012-06-04 CN CN201280038218.5A patent/CN103889454B/zh active Active
- 2012-06-04 CA CA2837948A patent/CA2837948C/en active Active
- 2012-06-04 RU RU2013157927A patent/RU2610436C2/ru active
- 2012-06-04 AU AU2012261813A patent/AU2012261813B2/en not_active Ceased
- 2012-06-04 TW TW101119927A patent/TWI586802B/zh active
- 2012-06-04 ES ES12748588T patent/ES2715289T3/es active Active
- 2012-06-04 JP JP2014513796A patent/JP5797837B2/ja not_active Expired - Fee Related
- 2012-06-04 EP EP12748588.6A patent/EP2714087B1/en active Active
- 2012-06-04 KR KR1020147000019A patent/KR102050609B1/ko not_active Expired - Fee Related
- 2012-06-04 SG SG2013089115A patent/SG195261A1/en unknown
- 2012-06-04 SG SG10201604488TA patent/SG10201604488TA/en unknown
-
2014
- 2014-09-25 US US14/497,202 patent/US9662376B2/en not_active Expired - Fee Related
-
2015
- 2015-08-19 JP JP2015161719A patent/JP6064007B2/ja not_active Expired - Fee Related
-
2017
- 2017-03-28 AU AU2017202050A patent/AU2017202050A1/en not_active Abandoned
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