JP2017534609A5 - - Google Patents
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- Publication number
- JP2017534609A5 JP2017534609A5 JP2017519291A JP2017519291A JP2017534609A5 JP 2017534609 A5 JP2017534609 A5 JP 2017534609A5 JP 2017519291 A JP2017519291 A JP 2017519291A JP 2017519291 A JP2017519291 A JP 2017519291A JP 2017534609 A5 JP2017534609 A5 JP 2017534609A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- vaccine composition
- acid
- virus
- sugar alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 127
- 229960005486 vaccine Drugs 0.000 claims description 66
- 150000005846 sugar alcohols Chemical group 0.000 claims description 32
- 239000000427 antigen Substances 0.000 claims description 23
- 102000036639 antigens Human genes 0.000 claims description 23
- 108091007433 antigens Proteins 0.000 claims description 23
- 239000003085 diluting agent Substances 0.000 claims description 19
- 238000005187 foaming Methods 0.000 claims description 13
- 241000700605 Viruses Species 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 9
- 229930195725 Mannitol Natural products 0.000 claims description 9
- 239000006260 foam Substances 0.000 claims description 9
- 239000000594 mannitol Substances 0.000 claims description 9
- 235000010355 mannitol Nutrition 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 235000010356 sorbitol Nutrition 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 49
- 239000004088 foaming agent Substances 0.000 claims 16
- 239000007787 solid Substances 0.000 claims 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 11
- 241000711450 Infectious bronchitis virus Species 0.000 claims 10
- 241000711404 Avian avulavirus 1 Species 0.000 claims 9
- 238000011065 in-situ storage Methods 0.000 claims 8
- 239000003381 stabilizer Substances 0.000 claims 8
- 239000002253 acid Substances 0.000 claims 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000002378 acidificating effect Effects 0.000 claims 5
- 235000015165 citric acid Nutrition 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- 241000700662 Fowlpox virus Species 0.000 claims 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 4
- 241000233866 Fungi Species 0.000 claims 4
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 claims 4
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 claims 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 4
- 241001223089 Tremovirus A Species 0.000 claims 4
- 241000223238 Trichophyton Species 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- 241000700635 Orf virus Species 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 3
- 239000001361 adipic acid Substances 0.000 claims 3
- 235000011037 adipic acid Nutrition 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000011975 tartaric acid Substances 0.000 claims 3
- 235000002906 tartaric acid Nutrition 0.000 claims 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 125000005587 carbonate group Chemical group 0.000 claims 2
- 239000001530 fumaric acid Substances 0.000 claims 2
- 235000011087 fumaric acid Nutrition 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000001630 malic acid Substances 0.000 claims 2
- 235000011090 malic acid Nutrition 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 229940071207 sesquicarbonate Drugs 0.000 claims 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 2
- RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 claims 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims 1
- RQALKBLYTUKBFV-UHFFFAOYSA-N 1,4-dioxa-7-thiaspiro[4.4]nonane Chemical compound O1CCOC11CSCC1 RQALKBLYTUKBFV-UHFFFAOYSA-N 0.000 claims 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- JUAGNSFMKLTCCT-UHFFFAOYSA-N 2-aminoacetic acid;carbonic acid Chemical compound OC(O)=O.NCC(O)=O JUAGNSFMKLTCCT-UHFFFAOYSA-N 0.000 claims 1
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- -1 carbonate compound Chemical class 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 235000011167 hydrochloric acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 229960002510 mandelic acid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- ILUJQPXNXACGAN-UHFFFAOYSA-N ortho-methoxybenzoic acid Natural products COC1=CC=CC=C1C(O)=O ILUJQPXNXACGAN-UHFFFAOYSA-N 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 239000011736 potassium bicarbonate Substances 0.000 claims 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims 1
- 235000015497 potassium bicarbonate Nutrition 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 235000011181 potassium carbonates Nutrition 0.000 claims 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062180P | 2014-10-10 | 2014-10-10 | |
| US62/062,180 | 2014-10-10 | ||
| PCT/US2015/055027 WO2016057978A1 (en) | 2014-10-10 | 2015-10-09 | Reduced foaming vaccine compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020152793A Division JP2021004246A (ja) | 2014-10-10 | 2020-09-11 | 発泡低減ワクチン組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017534609A JP2017534609A (ja) | 2017-11-24 |
| JP2017534609A5 true JP2017534609A5 (enExample) | 2019-08-15 |
Family
ID=55653887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519291A Pending JP2017534609A (ja) | 2014-10-10 | 2015-10-09 | 発泡低減ワクチン組成物 |
| JP2020152793A Pending JP2021004246A (ja) | 2014-10-10 | 2020-09-11 | 発泡低減ワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020152793A Pending JP2021004246A (ja) | 2014-10-10 | 2020-09-11 | 発泡低減ワクチン組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US10188734B2 (enExample) |
| EP (1) | EP3203988B1 (enExample) |
| JP (2) | JP2017534609A (enExample) |
| KR (1) | KR102652509B1 (enExample) |
| CN (1) | CN107106667B (enExample) |
| AR (1) | AR102250A1 (enExample) |
| AU (2) | AU2015330716B2 (enExample) |
| BR (1) | BR112017007422A8 (enExample) |
| CA (1) | CA2964171C (enExample) |
| CO (1) | CO2017004271A2 (enExample) |
| ES (1) | ES2895494T3 (enExample) |
| HK (1) | HK1243341A1 (enExample) |
| MX (1) | MX390873B (enExample) |
| MY (1) | MY198730A (enExample) |
| NZ (1) | NZ731296A (enExample) |
| PH (1) | PH12017500661A1 (enExample) |
| PL (1) | PL3203988T3 (enExample) |
| RU (1) | RU2731534C2 (enExample) |
| TW (1) | TWI745278B (enExample) |
| UA (1) | UA126057C2 (enExample) |
| WO (1) | WO2016057978A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018102586A1 (en) | 2016-11-30 | 2018-06-07 | Merial, Inc. | Attenuated swine influenza vaccines and methods of making and use thereof |
| CN110308145A (zh) * | 2019-07-10 | 2019-10-08 | 迪瑞医疗科技股份有限公司 | 一种沙眼衣原体糖原检测试剂、沙眼衣原体糖原检测试纸条及其制备方法 |
| WO2021113206A1 (en) * | 2019-12-02 | 2021-06-10 | University Of Georgia Research Foundation, Inc. | Attenuated avian reovirus strains 94826 c140 and 96139 c140 |
| US11814653B2 (en) * | 2020-09-22 | 2023-11-14 | University Of Georgia Research Foundation, Inc. | Attenuated isolate of infectious bronchitis virus strain DMV1639 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3184384A (en) * | 1961-09-07 | 1965-05-18 | Dow Chemical Co | Method of producing brucella abortus vaccine |
| IL46189A (en) | 1974-12-05 | 1979-01-31 | Vineland Lab Ltd | Color coded poultry vaccines |
| JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| US5178862A (en) | 1989-12-01 | 1993-01-12 | Parhelion Corporation | Canine distemper virus vaccine and method of preparation |
| FR2662942B1 (fr) | 1990-06-06 | 1992-09-18 | Neway Tsehay | Medicament immunostimulant a base de glycopeptidolipides polaires de mycobacterium chelonae. |
| US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
| US5338543A (en) | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| DK0683816T3 (da) | 1993-02-08 | 2001-01-08 | Bayer Ag | Fremgangsmåde til dyrkning af porcinreproduktions- og respirationssygdom-virus og dets anvendelse i vacciner |
| US5595761A (en) | 1994-01-27 | 1997-01-21 | The Board Of Regents Of The University Of Oklahoma | Particulate support matrix for making a rapidly dissolving tablet |
| FR2723740B1 (fr) | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
| US5866401A (en) | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
| US6391314B1 (en) | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
| GB9722682D0 (en) | 1997-10-27 | 1997-12-24 | Scherer Ltd R P | Pharmaceutical products |
| US6541001B1 (en) * | 1999-08-24 | 2003-04-01 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| US6592869B2 (en) * | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| CN1233418C (zh) * | 2001-12-21 | 2005-12-28 | 卫广森 | 鸡传染性支气管炎h120或h52与鸡新城疫二联冻干疫苗耐热冻干保护剂及制备工艺 |
| CN100381463C (zh) * | 2002-09-18 | 2008-04-16 | 中国人民解放军免疫学研究所 | 用于生产治疗用乙型肝炎疫苗或药物的免疫原及其制备方法和用途 |
| AU2002951692A0 (en) | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
| CN1284601C (zh) * | 2003-05-22 | 2006-11-15 | 维奥（四川）生物技术有限公司 | 常温稳定的疫苗组合物及其制备方法 |
| CN1261161C (zh) * | 2003-11-10 | 2006-06-28 | 钱汶光 | 复方干扰素诱生剂口含片 |
| AU2006272804B2 (en) | 2005-07-22 | 2011-02-24 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
| WO2007132480A2 (en) * | 2006-05-12 | 2007-11-22 | Bharat Biotech International Limited | A composition useful as a vaccine |
| UA46896U (ru) * | 2009-07-13 | 2010-01-11 | Владимир Николаевич Дзюба | Способ изготовления вакцины живой споровой концентрированной против сибирской язвы животных |
| KR101751964B1 (ko) | 2010-10-08 | 2017-06-28 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 전분을 이용한 경구 백신 급속 용해성 투여 형태 |
| CN102160856A (zh) | 2011-03-28 | 2011-08-24 | 南京易海生物科技有限公司 | 鸡传染性法氏囊病防漏型饮水免疫片及其制备方法 |
| AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
-
2015
- 2015-10-08 TW TW104133291A patent/TWI745278B/zh active
- 2015-10-09 HK HK18102910.3A patent/HK1243341A1/zh unknown
- 2015-10-09 RU RU2017115776A patent/RU2731534C2/ru active
- 2015-10-09 WO PCT/US2015/055027 patent/WO2016057978A1/en not_active Ceased
- 2015-10-09 BR BR112017007422A patent/BR112017007422A8/pt active Search and Examination
- 2015-10-09 CN CN201580061142.1A patent/CN107106667B/zh active Active
- 2015-10-09 EP EP15801958.8A patent/EP3203988B1/en active Active
- 2015-10-09 PL PL15801958T patent/PL3203988T3/pl unknown
- 2015-10-09 MX MX2017004679A patent/MX390873B/es unknown
- 2015-10-09 AU AU2015330716A patent/AU2015330716B2/en active Active
- 2015-10-09 ES ES15801958T patent/ES2895494T3/es active Active
- 2015-10-09 UA UAA201704437A patent/UA126057C2/uk unknown
- 2015-10-09 KR KR1020177011822A patent/KR102652509B1/ko active Active
- 2015-10-09 MY MYPI2017000526A patent/MY198730A/en unknown
- 2015-10-09 JP JP2017519291A patent/JP2017534609A/ja active Pending
- 2015-10-09 CA CA2964171A patent/CA2964171C/en active Active
- 2015-10-09 NZ NZ731296A patent/NZ731296A/en unknown
- 2015-10-09 US US14/880,145 patent/US10188734B2/en active Active
- 2015-10-13 AR ARP150103298A patent/AR102250A1/es active IP Right Grant
-
2017
- 2017-04-07 PH PH12017500661A patent/PH12017500661A1/en unknown
- 2017-04-27 CO CONC2017/0004271A patent/CO2017004271A2/es unknown
-
2018
- 2018-09-10 US US16/125,911 patent/US10213509B2/en active Active
- 2018-11-30 AU AU2018271395A patent/AU2018271395B2/en active Active
-
2019
- 2019-01-24 US US16/256,463 patent/US10610596B2/en active Active
-
2020
- 2020-02-26 US US16/802,089 patent/US20200188519A1/en not_active Abandoned
- 2020-09-11 JP JP2020152793A patent/JP2021004246A/ja active Pending
-
2022
- 2022-01-21 US US17/580,896 patent/US20220241421A1/en not_active Abandoned
-
2023
- 2023-10-09 US US18/483,149 patent/US20240042037A1/en not_active Abandoned
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