CN107106667B - 起泡减少的疫苗组合物 - Google Patents

起泡减少的疫苗组合物 Download PDF

Info

Publication number
CN107106667B
CN107106667B CN201580061142.1A CN201580061142A CN107106667B CN 107106667 B CN107106667 B CN 107106667B CN 201580061142 A CN201580061142 A CN 201580061142A CN 107106667 B CN107106667 B CN 107106667B
Authority
CN
China
Prior art keywords
composition
vaccine composition
virus
stable
stabilizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580061142.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN107106667A (zh
Inventor
N·Y·H·J·詹尼恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apic Biological Experiment Co ltd
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of CN107106667A publication Critical patent/CN107106667A/zh
Application granted granted Critical
Publication of CN107106667B publication Critical patent/CN107106667B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/255—Marek's disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN201580061142.1A 2014-10-10 2015-10-09 起泡减少的疫苗组合物 Active CN107106667B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462062180P 2014-10-10 2014-10-10
US62/062,180 2014-10-10
PCT/US2015/055027 WO2016057978A1 (en) 2014-10-10 2015-10-09 Reduced foaming vaccine compositions

Publications (2)

Publication Number Publication Date
CN107106667A CN107106667A (zh) 2017-08-29
CN107106667B true CN107106667B (zh) 2022-03-15

Family

ID=55653887

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580061142.1A Active CN107106667B (zh) 2014-10-10 2015-10-09 起泡减少的疫苗组合物

Country Status (21)

Country Link
US (6) US10188734B2 (enExample)
EP (1) EP3203988B1 (enExample)
JP (2) JP2017534609A (enExample)
KR (1) KR102652509B1 (enExample)
CN (1) CN107106667B (enExample)
AR (1) AR102250A1 (enExample)
AU (2) AU2015330716B2 (enExample)
BR (1) BR112017007422A8 (enExample)
CA (1) CA2964171C (enExample)
CO (1) CO2017004271A2 (enExample)
ES (1) ES2895494T3 (enExample)
HK (1) HK1243341A1 (enExample)
MX (1) MX390873B (enExample)
MY (1) MY198730A (enExample)
NZ (1) NZ731296A (enExample)
PH (1) PH12017500661A1 (enExample)
PL (1) PL3203988T3 (enExample)
RU (1) RU2731534C2 (enExample)
TW (1) TWI745278B (enExample)
UA (1) UA126057C2 (enExample)
WO (1) WO2016057978A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018102586A1 (en) 2016-11-30 2018-06-07 Merial, Inc. Attenuated swine influenza vaccines and methods of making and use thereof
CN110308145A (zh) * 2019-07-10 2019-10-08 迪瑞医疗科技股份有限公司 一种沙眼衣原体糖原检测试剂、沙眼衣原体糖原检测试纸条及其制备方法
WO2021113206A1 (en) * 2019-12-02 2021-06-10 University Of Georgia Research Foundation, Inc. Attenuated avian reovirus strains 94826 c140 and 96139 c140
US11814653B2 (en) * 2020-09-22 2023-11-14 University Of Georgia Research Foundation, Inc. Attenuated isolate of infectious bronchitis virus strain DMV1639

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710378A (en) * 1984-03-13 1987-12-01 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Lyophilized hepatitis B vaccine
CN1379663A (zh) * 1999-08-24 2002-11-13 特瓦制药工业有限公司 疫苗组合物及其使用方法
WO2004026336A1 (en) * 2002-09-23 2004-04-01 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
CN1261161C (zh) * 2003-11-10 2006-06-28 钱汶光 复方干扰素诱生剂口含片
WO2007132480A2 (en) * 2006-05-12 2007-11-22 Bharat Biotech International Limited A composition useful as a vaccine
CN102160856A (zh) * 2011-03-28 2011-08-24 南京易海生物科技有限公司 鸡传染性法氏囊病防漏型饮水免疫片及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184384A (en) * 1961-09-07 1965-05-18 Dow Chemical Co Method of producing brucella abortus vaccine
IL46189A (en) 1974-12-05 1979-01-31 Vineland Lab Ltd Color coded poultry vaccines
US5178862A (en) 1989-12-01 1993-01-12 Parhelion Corporation Canine distemper virus vaccine and method of preparation
FR2662942B1 (fr) 1990-06-06 1992-09-18 Neway Tsehay Medicament immunostimulant a base de glycopeptidolipides polaires de mycobacterium chelonae.
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
DK0683816T3 (da) 1993-02-08 2001-01-08 Bayer Ag Fremgangsmåde til dyrkning af porcinreproduktions- og respirationssygdom-virus og dets anvendelse i vacciner
US5595761A (en) 1994-01-27 1997-01-21 The Board Of Regents Of The University Of Oklahoma Particulate support matrix for making a rapidly dissolving tablet
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5866401A (en) 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
GB9722682D0 (en) 1997-10-27 1997-12-24 Scherer Ltd R P Pharmaceutical products
US6592869B2 (en) * 1999-08-24 2003-07-15 Teva Pharmaceutical Industries, Ltd. Vaccine composition and method of using the same
CN1233418C (zh) * 2001-12-21 2005-12-28 卫广森 鸡传染性支气管炎h120或h52与鸡新城疫二联冻干疫苗耐热冻干保护剂及制备工艺
CN100381463C (zh) * 2002-09-18 2008-04-16 中国人民解放军免疫学研究所 用于生产治疗用乙型肝炎疫苗或药物的免疫原及其制备方法和用途
CN1284601C (zh) * 2003-05-22 2006-11-15 维奥（四川）生物技术有限公司 常温稳定的疫苗组合物及其制备方法
AU2006272804B2 (en) 2005-07-22 2011-02-24 Amgen Inc. Concentrated protein lyophilates, methods, and uses
UA46896U (ru) * 2009-07-13 2010-01-11 Владимир Николаевич Дзюба Способ изготовления вакцины живой споровой концентрированной против сибирской язвы животных
KR101751964B1 (ko) 2010-10-08 2017-06-28 알.피.쉐러 테크놀러지즈 엘엘씨 전분을 이용한 경구 백신 급속 용해성 투여 형태
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710378A (en) * 1984-03-13 1987-12-01 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Lyophilized hepatitis B vaccine
CN1379663A (zh) * 1999-08-24 2002-11-13 特瓦制药工业有限公司 疫苗组合物及其使用方法
WO2004026336A1 (en) * 2002-09-23 2004-04-01 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
CN1261161C (zh) * 2003-11-10 2006-06-28 钱汶光 复方干扰素诱生剂口含片
WO2007132480A2 (en) * 2006-05-12 2007-11-22 Bharat Biotech International Limited A composition useful as a vaccine
CN102160856A (zh) * 2011-03-28 2011-08-24 南京易海生物科技有限公司 鸡传染性法氏囊病防漏型饮水免疫片及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Transmissibility of infectious bronchitis virus H120 vaccine strain among broilers under experimental conditions;Matthijs MG et al.;《Avian Diseases》;20081231;第52卷(第3期);第461-466页 *

Also Published As

Publication number Publication date
MY198730A (en) 2023-09-20
EP3203988A1 (en) 2017-08-16
RU2017115776A3 (enExample) 2019-04-11
US20200188519A1 (en) 2020-06-18
JP2021004246A (ja) 2021-01-14
AU2018271395A1 (en) 2018-12-20
AU2018271395B2 (en) 2020-05-14
TWI745278B (zh) 2021-11-11
MX2017004679A (es) 2017-08-08
CN107106667A (zh) 2017-08-29
JP2017534609A (ja) 2017-11-24
US20160256554A1 (en) 2016-09-08
WO2016057978A1 (en) 2016-04-14
MX390873B (es) 2025-03-21
US10188734B2 (en) 2019-01-29
US20220241421A1 (en) 2022-08-04
RU2731534C2 (ru) 2020-09-04
AR102250A1 (es) 2017-02-15
US10213509B2 (en) 2019-02-26
BR112017007422A2 (pt) 2018-01-16
CO2017004271A2 (es) 2017-09-29
BR112017007422A8 (pt) 2022-07-12
ES2895494T3 (es) 2022-02-21
EP3203988B1 (en) 2021-09-01
US20190000978A1 (en) 2019-01-03
AU2015330716B2 (en) 2018-12-06
TW201625296A (zh) 2016-07-16
AU2015330716A1 (en) 2017-05-18
CA2964171C (en) 2023-03-28
US10610596B2 (en) 2020-04-07
US20190151451A1 (en) 2019-05-23
NZ731296A (en) 2018-08-31
RU2017115776A (ru) 2018-11-12
CA2964171A1 (en) 2016-04-14
US20240042037A1 (en) 2024-02-08
HK1243341A1 (zh) 2018-07-13
KR20170066532A (ko) 2017-06-14
PH12017500661A1 (en) 2017-10-09
KR102652509B1 (ko) 2024-03-28
PL3203988T3 (pl) 2022-02-14
UA126057C2 (uk) 2022-08-10

Similar Documents

Publication Publication Date Title
US20240042037A1 (en) Reduced foaming vaccine compositions
ES2373238T3 (es) Estabilizadores para vacunas liofilizadas.
EP3566716B1 (en) Dry formulations of parvovirus vaccines that are room temperature stable
US10653627B2 (en) Method for vacuum-assisted preservation of biologics including vaccines
RU2826263C2 (ru) Сухие композиции вакцин, стабильные при комнатной температуре

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1243341

Country of ref document: HK

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20190715

Address after: Georgia

Applicant after: MERIAL, Inc.

Address before: Georgia

Applicant before: MERIAL, Inc.

GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20220823

Address after: Beit Beit, Israel

Patentee after: Apic Biological Experiment Co.,Ltd.

Address before: Georgia

Patentee before: MERIAL, Inc.