JP2017528479A5 - - Google Patents
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- Publication number
- JP2017528479A5 JP2017528479A5 JP2017514346A JP2017514346A JP2017528479A5 JP 2017528479 A5 JP2017528479 A5 JP 2017528479A5 JP 2017514346 A JP2017514346 A JP 2017514346A JP 2017514346 A JP2017514346 A JP 2017514346A JP 2017528479 A5 JP2017528479 A5 JP 2017528479A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- liquid pharmaceutical
- concentration
- composition according
- rpl554
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 239000002245 particle Substances 0.000 claims 10
- -1 2,4,6-trimethylphenylimino Chemical group 0.000 claims 8
- CSOBIBXVIYAXFM-BYNJWEBRSA-N ensifentrine Chemical compound c-12cc(OC)c(OC)cc2CCn(c(n2CCNC(N)=O)=O)c-1c\c2=N/c1c(C)cc(C)cc1C CSOBIBXVIYAXFM-BYNJWEBRSA-N 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000008363 phosphate buffer Substances 0.000 claims 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
- PVKCAQKXTLCSBC-UHFFFAOYSA-N 1h-isoquinolin-4-one Chemical compound C1=CC=C2C(=O)C=NCC2=C1 PVKCAQKXTLCSBC-UHFFFAOYSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000012929 tonicity agent Substances 0.000 claims 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- OCAQSCOTLKDCIJ-UHFFFAOYSA-N C1CNC(N2C1=C1C=CC=CC1CC2)=O Chemical compound C1CNC(N2C1=C1C=CC=CC1CC2)=O OCAQSCOTLKDCIJ-UHFFFAOYSA-N 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000029771 childhood onset asthma Diseases 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1416274.7 | 2014-09-15 | ||
| GBGB1416274.7A GB201416274D0 (en) | 2014-09-15 | 2014-09-15 | Formulation |
| GB1504662.6 | 2015-03-19 | ||
| GBGB1504662.6A GB201504662D0 (en) | 2015-03-19 | 2015-03-19 | Formulation |
| PCT/GB2015/052668 WO2016042313A1 (en) | 2014-09-15 | 2015-09-15 | Liquid inhalation formulation comprising rpl554 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018238014A Division JP6795574B2 (ja) | 2014-09-15 | 2018-12-20 | Ｒｐｌ５５４を含む液体吸入製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528479A JP2017528479A (ja) | 2017-09-28 |
| JP2017528479A5 true JP2017528479A5 (enExample) | 2018-10-25 |
| JP6860477B2 JP6860477B2 (ja) | 2021-04-14 |
Family
ID=54196992
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514346A Active JP6860477B2 (ja) | 2014-09-15 | 2015-09-15 | Ｒｐｌ５５４を含む液体吸入製剤 |
| JP2018238014A Active JP6795574B2 (ja) | 2014-09-15 | 2018-12-20 | Ｒｐｌ５５４を含む液体吸入製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018238014A Active JP6795574B2 (ja) | 2014-09-15 | 2018-12-20 | Ｒｐｌ５５４を含む液体吸入製剤 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9956171B2 (enExample) |
| EP (3) | EP3332767B1 (enExample) |
| JP (2) | JP6860477B2 (enExample) |
| KR (1) | KR102379309B1 (enExample) |
| CN (3) | CN111249260B (enExample) |
| AU (3) | AU2015316592B2 (enExample) |
| CA (1) | CA2959943C (enExample) |
| CY (3) | CY1120264T1 (enExample) |
| DK (3) | DK3332767T3 (enExample) |
| ES (3) | ES2875584T3 (enExample) |
| HK (1) | HK1249415B (enExample) |
| HR (3) | HRP20180833T1 (enExample) |
| HU (3) | HUE045303T2 (enExample) |
| IL (1) | IL250895B (enExample) |
| LT (3) | LT3193835T (enExample) |
| MX (1) | MX2017003102A (enExample) |
| MY (1) | MY196072A (enExample) |
| NO (1) | NO3193835T3 (enExample) |
| PH (1) | PH12017500479B1 (enExample) |
| PL (3) | PL3332767T3 (enExample) |
| PT (3) | PT3494962T (enExample) |
| RS (3) | RS57227B1 (enExample) |
| RU (1) | RU2699995C2 (enExample) |
| SG (1) | SG11201701854WA (enExample) |
| SI (3) | SI3193835T1 (enExample) |
| SM (3) | SMT202100479T1 (enExample) |
| WO (1) | WO2016042313A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2688191C2 (ru) | 2014-05-12 | 2019-05-21 | ВЕРОНА ФАРМА ПиэЛСи | Новое лечение |
| PL3332767T3 (pl) * | 2014-09-15 | 2019-10-31 | Verona Pharma Plc | Płynna formulacja wziewna zawierająca RPL554 |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
| US10947272B2 (en) | 2015-07-24 | 2021-03-16 | Hoffmann-La Roche Inc. | BACE1 inhibitor peptides |
| GB201613054D0 (en) | 2016-07-28 | 2016-09-14 | Verona Pharma Plc | New compound and process |
| GB2578093B (en) | 2018-10-09 | 2020-11-18 | Verona Pharma Plc | Liquid pharmaceutical composition comprising RPL554 and HFA-134A |
| JP6994061B2 (ja) * | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
| GB201911517D0 (en) | 2019-08-12 | 2019-09-25 | Verona Pharma Plc | Pharmaceutical composition |
| CA3167378A1 (en) * | 2020-01-15 | 2021-07-22 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd | Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound |
| GB202002786D0 (en) * | 2020-02-27 | 2020-04-15 | Verona Pharma Plc | Liquid pharmaceutical composition |
| GB202202297D0 (en) | 2022-02-21 | 2022-04-06 | Verona Pharma Plc | Formulation production process |
| KR20250040090A (ko) * | 2022-08-08 | 2025-03-21 | 베로나 파마 피엘씨 | 액상 약제학적 조성물 |
| EP4568676A1 (en) * | 2022-08-08 | 2025-06-18 | Verona Pharma PLC | Ensifentrine (rpl-554) for the treatment of moderate chronic obstructive pulmonary disease (copd) |
| EP4609864A1 (en) * | 2022-10-28 | 2025-09-03 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing isoquinolinone compound, and preparation method therefor |
| EP4378942A1 (en) | 2022-12-02 | 2024-06-05 | Sandoz AG | Crystal form of a pde3/4 inhibitor |
| WO2025003643A1 (en) * | 2023-06-26 | 2025-01-02 | Verona Pharma Plc | Particulate composition comprising ensifetrine |
| US12194045B1 (en) | 2023-06-26 | 2025-01-14 | Verona Pharma Plc | Particulate composition |
| WO2025052119A1 (en) * | 2023-09-06 | 2025-03-13 | Verona Pharma Plc | Ensifentrine for use in treating chronic obstructive pulmonary disease (copd) |
| US20250249006A1 (en) * | 2024-02-05 | 2025-08-07 | Verona Pharma Plc | Treatment |
| WO2025168708A1 (en) * | 2024-02-07 | 2025-08-14 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
| US20250249007A1 (en) * | 2024-02-07 | 2025-08-07 | Verona Pharma Plc | Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9410222D0 (en) * | 1994-05-21 | 1994-07-06 | Glaxo Wellcome Australia Ltd | Medicaments |
| EP1033991B1 (en) * | 1997-10-09 | 2002-04-17 | Schering Corporation | Mometasone furoate suspensions for nebulization |
| SE9704186D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| CA2368413C (en) | 1999-03-31 | 2008-07-29 | Vernalis Limited | Derivatives of pyrimido[6,1-a]isoquinolin-4-one |
| US6630169B1 (en) * | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
| GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0122031D0 (en) * | 2001-09-12 | 2001-10-31 | Pfizer Ltd | Use of pde4 inhibitors in a dry powder inhaler |
| RU2440972C2 (ru) * | 2004-12-17 | 2012-01-27 | Сипла Лимитед | Кристаллический сульфат левосальбутамола, способ его получения и фармацевтическая композиция, содержащая его |
| ITMI20051999A1 (it) | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| BR112012032332A2 (pt) | 2010-06-22 | 2016-11-08 | Chiesi Farma Spa | composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo |
| DK2603509T3 (da) * | 2010-08-09 | 2014-09-08 | Verona Pharma Plc | KRYSTALLINSK FORM AF PYRIMIDIO [6,1- a] ISOQUINOLIN-4-ON-FORBINDELSE |
| US8778383B2 (en) * | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2647627A1 (en) * | 2012-04-02 | 2013-10-09 | Almirall, S.A. | Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one. |
| WO2014037727A1 (en) * | 2012-09-06 | 2014-03-13 | Verona Pharma Plc | Carcainium salts |
| JP6560986B2 (ja) * | 2013-03-15 | 2019-08-14 | ヴェローナ ファーマ ピーエルシー | 複合製剤 |
| US10897787B2 (en) * | 2014-03-11 | 2021-01-19 | Lg Electronics Inc. | Method and apparatus for device-to-device user equipment to transmit discovery signal in wireless communication system |
| RU2688191C2 (ru) | 2014-05-12 | 2019-05-21 | ВЕРОНА ФАРМА ПиэЛСи | Новое лечение |
| PL3332767T3 (pl) * | 2014-09-15 | 2019-10-31 | Verona Pharma Plc | Płynna formulacja wziewna zawierająca RPL554 |
| GB201502260D0 (en) * | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
-
2015
- 2015-09-15 PL PL17207623T patent/PL3332767T3/pl unknown
- 2015-09-15 JP JP2017514346A patent/JP6860477B2/ja active Active
- 2015-09-15 CN CN202010090019.5A patent/CN111249260B/zh active Active
- 2015-09-15 DK DK17207623.4T patent/DK3332767T3/da active
- 2015-09-15 ES ES19152629T patent/ES2875584T3/es active Active
- 2015-09-15 RS RS20180519A patent/RS57227B1/sr unknown
- 2015-09-15 PT PT191526292T patent/PT3494962T/pt unknown
- 2015-09-15 CA CA2959943A patent/CA2959943C/en active Active
- 2015-09-15 RU RU2017108432A patent/RU2699995C2/ru active
- 2015-09-15 CN CN201580053062.1A patent/CN106794157B/zh active Active
- 2015-09-15 DK DK15770593.0T patent/DK3193835T3/en active
- 2015-09-15 LT LTEP15770593.0T patent/LT3193835T/lt unknown
- 2015-09-15 SI SI201530213T patent/SI3193835T1/en unknown
- 2015-09-15 HU HUE17207623A patent/HUE045303T2/hu unknown
- 2015-09-15 PL PL19152629T patent/PL3494962T3/pl unknown
- 2015-09-15 SM SM20210479T patent/SMT202100479T1/it unknown
- 2015-09-15 LT LTEP19152629.2T patent/LT3494962T/lt unknown
- 2015-09-15 HU HUE15770593A patent/HUE038433T2/hu unknown
- 2015-09-15 DK DK19152629.2T patent/DK3494962T3/da active
- 2015-09-15 AU AU2015316592A patent/AU2015316592B2/en active Active
- 2015-09-15 KR KR1020177006862A patent/KR102379309B1/ko active Active
- 2015-09-15 SI SI201530774T patent/SI3332767T1/sl unknown
- 2015-09-15 WO PCT/GB2015/052668 patent/WO2016042313A1/en not_active Ceased
- 2015-09-15 HR HRP20180833TT patent/HRP20180833T1/hr unknown
- 2015-09-15 SG SG11201701854WA patent/SG11201701854WA/en unknown
- 2015-09-15 SI SI201531657T patent/SI3494962T1/sl unknown
- 2015-09-15 US US15/509,943 patent/US9956171B2/en active Active
- 2015-09-15 MY MYPI2017000391A patent/MY196072A/en unknown
- 2015-09-15 RS RS20190765A patent/RS58897B1/sr unknown
- 2015-09-15 ES ES17207623T patent/ES2730810T3/es active Active
- 2015-09-15 HU HUE19152629A patent/HUE055527T2/hu unknown
- 2015-09-15 LT LTEP17207623.4T patent/LT3332767T/lt unknown
- 2015-09-15 NO NO15770593A patent/NO3193835T3/no unknown
- 2015-09-15 SM SM20190340T patent/SMT201900340T1/it unknown
- 2015-09-15 PL PL15770593T patent/PL3193835T3/pl unknown
- 2015-09-15 PT PT17207623T patent/PT3332767T/pt unknown
- 2015-09-15 CN CN201811561721.4A patent/CN110051627A/zh active Pending
- 2015-09-15 SM SM20180242T patent/SMT201800242T1/it unknown
- 2015-09-15 PT PT157705930T patent/PT3193835T/pt unknown
- 2015-09-15 EP EP17207623.4A patent/EP3332767B1/en active Active
- 2015-09-15 RS RS20211044A patent/RS62252B1/sr unknown
- 2015-09-15 EP EP19152629.2A patent/EP3494962B1/en active Active
- 2015-09-15 EP EP15770593.0A patent/EP3193835B1/en active Active
- 2015-09-15 ES ES15770593.0T patent/ES2670025T3/es active Active
- 2015-09-15 MX MX2017003102A patent/MX2017003102A/es active IP Right Grant
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2017
- 2017-03-02 IL IL250895A patent/IL250895B/en active IP Right Grant
- 2017-03-14 PH PH12017500479A patent/PH12017500479B1/en unknown
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2018
- 2018-03-21 US US15/927,517 patent/US10945950B2/en active Active
- 2018-05-03 CY CY20181100455T patent/CY1120264T1/el unknown
- 2018-07-10 HK HK18108909.3A patent/HK1249415B/en unknown
- 2018-12-20 JP JP2018238014A patent/JP6795574B2/ja active Active
- 2018-12-24 AU AU2018286571A patent/AU2018286571B2/en active Active
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2019
- 2019-06-18 CY CY20191100622T patent/CY1121698T1/el unknown
- 2019-06-19 HR HRP20191122TT patent/HRP20191122T1/hr unknown
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2020
- 2020-05-11 AU AU2020203081A patent/AU2020203081B2/en active Active
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2021
- 2021-06-30 HR HRP20211035TT patent/HRP20211035T1/hr unknown
- 2021-08-10 CY CY20211100720T patent/CY1124546T1/el unknown
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