JP2012211150A5 - - Google Patents

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Publication number
JP2012211150A5
JP2012211150A5 JP2012128597A JP2012128597A JP2012211150A5 JP 2012211150 A5 JP2012211150 A5 JP 2012211150A5 JP 2012128597 A JP2012128597 A JP 2012128597A JP 2012128597 A JP2012128597 A JP 2012128597A JP 2012211150 A5 JP2012211150 A5 JP 2012211150A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
liquid pharmaceutical
botulinum neurotoxin
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012128597A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012211150A (ja
JP5662379B2 (ja
Filing date
Publication date
Priority claimed from GB0415491A external-priority patent/GB2416122A/en
Application filed filed Critical
Publication of JP2012211150A publication Critical patent/JP2012211150A/ja
Publication of JP2012211150A5 publication Critical patent/JP2012211150A5/ja
Application granted granted Critical
Publication of JP5662379B2 publication Critical patent/JP5662379B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2012128597A 2004-07-12 2012-06-06 ボツリヌス神経毒を含む医薬組成物 Expired - Lifetime JP5662379B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0415491A GB2416122A (en) 2004-07-12 2004-07-12 Botulinum neurotoxin composition
GB0415491.0 2004-07-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007520876A Division JP5301830B2 (ja) 2004-07-12 2005-07-06 ボツリヌス神経毒を含む医薬組成物

Publications (3)

Publication Number Publication Date
JP2012211150A JP2012211150A (ja) 2012-11-01
JP2012211150A5 true JP2012211150A5 (enExample) 2014-08-21
JP5662379B2 JP5662379B2 (ja) 2015-01-28

Family

ID=32865775

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007520876A Expired - Lifetime JP5301830B2 (ja) 2004-07-12 2005-07-06 ボツリヌス神経毒を含む医薬組成物
JP2012128597A Expired - Lifetime JP5662379B2 (ja) 2004-07-12 2012-06-06 ボツリヌス神経毒を含む医薬組成物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2007520876A Expired - Lifetime JP5301830B2 (ja) 2004-07-12 2005-07-06 ボツリヌス神経毒を含む医薬組成物

Country Status (19)

Country Link
US (4) US9125804B2 (enExample)
EP (4) EP2939688B1 (enExample)
JP (2) JP5301830B2 (enExample)
CN (2) CN102327602B (enExample)
AR (2) AR049978A1 (enExample)
BR (1) BRPI0513327B8 (enExample)
CA (1) CA2572915C (enExample)
DK (3) DK2939688T3 (enExample)
ES (3) ES2725908T3 (enExample)
FI (1) FI1817051T4 (enExample)
GB (1) GB2416122A (enExample)
HU (2) HUE025434T2 (enExample)
IL (1) IL180380A (enExample)
MX (1) MX2007000409A (enExample)
PL (3) PL2939688T3 (enExample)
PT (3) PT2939688T (enExample)
RU (1) RU2407541C2 (enExample)
TR (1) TR201906275T4 (enExample)
WO (1) WO2006005910A2 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763663B2 (en) 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
WO2005120546A2 (en) 2004-03-03 2005-12-22 Essentia Biosystems, Inc. Compositions and methods for topical diagnostic and therapeutic transport
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
DE102004043009A1 (de) 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
US9180081B2 (en) 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
BRPI0613631A8 (pt) 2005-07-18 2017-12-26 Univ Massachusetts Lowell nanoemulsão e método,
FR2889936B1 (fr) 2005-09-01 2007-12-21 Sod Conseils Rech Applic Methode pour quantifier une neurotoxine cholinergique dans un echantillon
AU2016204034B2 (en) * 2005-10-06 2017-12-21 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
US8137677B2 (en) * 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
CN103919690B (zh) 2005-12-01 2020-07-31 麻萨诸塞州洛厄尔大学 肉毒杆菌纳米乳液
FR2902341B1 (fr) * 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
CA2671133C (en) 2006-12-01 2015-11-24 Anterios, Inc. Peptide nanoparticles and uses therefor
US20100150994A1 (en) 2006-12-01 2010-06-17 Anterios, Inc. Amphiphilic entity nanoparticles
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
ES2660906T3 (es) 2007-05-31 2018-03-26 Anterios, Inc. Nanopartículas de ácido nucleico y usos de las mismas
RU2440825C2 (ru) 2007-07-10 2012-01-27 Меди-Токс, Инк. Жидкая фармацевтическая композиция ботулинического токсина
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
CA3042777A1 (en) * 2008-06-26 2009-12-30 Anterios, Inc. Dermal delivery
ES2356883B1 (es) * 2008-07-24 2012-02-22 Bcn Peptides, S.A. Composición para el tratamiento del dolor y/o la inflamación.
CN101386648B (zh) * 2008-09-25 2012-05-30 中国人民解放军军事医学科学院微生物流行病研究所 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途
CN105833254A (zh) 2008-12-10 2016-08-10 阿勒根公司 梭菌毒素药物组合物
RU2011125775A (ru) 2008-12-31 2013-02-10 Реванс Терапьютикс, Инк. Составы на основе ботулотоксина для инъекции
EP2248518B1 (en) 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
KR101975051B1 (ko) 2009-06-25 2019-05-03 레반스 테라퓨틱스, 아이엔씨. 알부민­불포함 보툴리눔 독소 제제
US9173944B2 (en) 2010-10-12 2015-11-03 Merz Pharma Gmbh & Co. Kgaa Formulation suitable for stabilizing proteins, which is free of mammalian excipients
US8920795B2 (en) * 2011-03-31 2014-12-30 Medy-Tox Inc. Lyophilized preparation of botulinum toxin
WO2013049139A1 (en) * 2011-09-28 2013-04-04 Wisconsin Alumni Research Foundation Purification, characterization, and use of clostridium botulinum neurotoxin bont/a3
JP2015534814A (ja) * 2012-10-31 2015-12-07 イプセン バイオイノベーション リミテッド 組換えクロストリジウムボツリヌス神経毒
GB201219602D0 (en) * 2012-10-31 2012-12-12 Syntaxin Ltd Recombinant clostridium botulinum neurotoxins
CN105188738B (zh) 2013-03-15 2025-11-07 奥普罗治疗学股份有限公司 用于粘液粘稠度标准化的产品和方法
RU2535115C1 (ru) 2013-05-15 2014-12-10 Бости Трейдинг Лтд Фармацевтический состав, содержащий нейротоксин ботулина
US9480731B2 (en) 2013-12-12 2016-11-01 Medy-Tox, Inc. Long lasting effect of new botulinum toxin formulations
RU2593344C2 (ru) * 2014-03-05 2016-08-10 Михаил Григорьевич Сойхер Способ лечения бруксизма
GB201407525D0 (en) * 2014-04-29 2014-06-11 Syntaxin Ltd Manufacture of recombinant clostridium botulinum neurotoxins
KR102557798B1 (ko) 2014-12-23 2023-07-19 메르츠 파마 게엠베하 운트 코. 카가아 보툴리눔 독소 사전충전된 용기
CA2974450C (en) 2015-02-03 2024-01-09 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled container
EP3368071B1 (en) 2015-10-29 2022-01-26 ReVance Therapeutics, Inc. Injectable botulinum toxin formulations and methods of use thereof having long duration of therapeutic or cosmetic effect
US10052296B2 (en) 2016-04-07 2018-08-21 Nevakar Inc. Formulations for treating pain
PT3679946T (pt) 2016-05-27 2022-01-14 Ipsen Biopharm Ltd Formulação líquida de neurotoxina estabilizada com triptofano ou tirosina
RU2651044C2 (ru) * 2016-08-22 2018-04-18 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) Способ лечения желудочковых нарушений ритма сердца (варианты)
WO2018038301A1 (en) * 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
PT3432916T (pt) 2016-09-13 2019-11-20 Allergan Inc Composições de toxina clostrídica não-proteica estabilizadas
WO2018093465A1 (en) 2016-11-21 2018-05-24 Eirion Therapeutics, Inc. Transdermal delivery of large agents
KR101744900B1 (ko) * 2017-01-20 2017-06-08 주식회사 대웅 보툴리눔 독소를 포함하는 안정한 액상 조성물
JP7200138B2 (ja) 2017-02-16 2023-01-06 ソネット バイオセラピューティクス，インコーポレイテッド アルブミン結合ドメイン融合タンパク質
CA3075414A1 (en) * 2017-10-03 2019-04-11 Nevakar Inc. Acetaminophen-pregabalin combinations and methods of treating pain
US10918586B2 (en) * 2017-12-07 2021-02-16 Ps Therapy Ltd. Topical compositions and methods of use thereof
IL285634B2 (en) 2019-02-21 2025-06-01 Merz Pharma Gmbh Co Kgaa Novel uses of botulinum neurotoxin for the treatment of tremor
RU2728102C1 (ru) * 2019-12-19 2020-07-28 Александр Александрович Ильин Способ лечения гипертонуса латеральной крыловидной мышцы
KR102324855B1 (ko) * 2020-05-20 2021-11-11 오스템임플란트 주식회사 보툴리눔 독소를 포함하는 약제학적 액상 조성물
CA3202665A1 (en) * 2020-12-18 2022-06-23 Sung Su Jang Pharmaceutical composition for long-term storage of liquid formulation of botulinum toxin
CN119258202A (zh) * 2023-07-05 2025-01-07 重庆誉颜制药有限公司 一种肉毒毒素蛋白组合物及其应用
US12134635B1 (en) 2023-12-29 2024-11-05 Sonnet BioTherapeutics, Inc. Interleukin 18 (IL-18) variants and fusion proteins comprising same

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457916A (en) 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
MX9306133A (es) 1992-10-02 1994-04-29 Kabi Pharmacia Ab Composicion que comprende una formulacion del factor de coagulacion viii, proceso para su preparacion y uso de un surfactante como estabilizador.
US5512547A (en) 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
US5756468A (en) * 1994-10-13 1998-05-26 Wisconsin Alumni Research Foundation Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation
US20030095927A1 (en) 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders
EP1053014A4 (en) † 1998-01-26 2004-11-10 Univ Massachusetts BIOLOGICALLY ACTIVE HEMAGGLUTININE TYPE A i (STRIDIUM BOTULINUM) AND METHOD FOR ITS USE
DE19925739A1 (de) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
IL149778A0 (en) † 1999-11-22 2002-11-10 Universal Preservation Technologies Inc Preservation of sensitive biological material
JP2003522154A (ja) * 2000-02-08 2003-07-22 アラーガン、インコーポレイテッド ボツリヌス毒素医薬組成物
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US6306423B1 (en) * 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
US20040033241A1 (en) * 2000-06-02 2004-02-19 Allergan, Inc. Controlled release botulinum toxin system
US7255865B2 (en) 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
WO2003000193A2 (en) * 2001-06-21 2003-01-03 Surromed, Inc. Covalent coupling of botulinum toxin with polyethylene glycol
US20030224020A1 (en) * 2002-05-31 2003-12-04 Zabudkin Alexander F. Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
US20040009180A1 (en) * 2002-07-11 2004-01-15 Allergan, Inc. Transdermal botulinum toxin compositions
RU2206337C1 (ru) * 2002-10-29 2003-06-20 Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" Лекарственный препарат для лечения мышечных дистоний и способ его получения
US20040086532A1 (en) * 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
DE10333317A1 (de) † 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
GB2416122A (en) 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
US20080102090A1 (en) * 2004-08-04 2008-05-01 Naveed Panjwani Pharmaceutical Compositon Containing Botulinum Neurotoxin A2
EP3210620A1 (en) * 2004-08-04 2017-08-30 Ipsen Biopharm Limited Pharmaceutical composition containing botulinum neurotoxin a2
US8137677B2 (en) 2005-10-06 2012-03-20 Allergan, Inc. Non-protein stabilized clostridial toxin pharmaceutical compositions

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