JP2012211150A5 - - Google Patents
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- Publication number
- JP2012211150A5 JP2012211150A5 JP2012128597A JP2012128597A JP2012211150A5 JP 2012211150 A5 JP2012211150 A5 JP 2012211150A5 JP 2012128597 A JP2012128597 A JP 2012128597A JP 2012128597 A JP2012128597 A JP 2012128597A JP 2012211150 A5 JP2012211150 A5 JP 2012211150A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- liquid pharmaceutical
- botulinum neurotoxin
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0415491A GB2416122A (en) | 2004-07-12 | 2004-07-12 | Botulinum neurotoxin composition |
| GB0415491.0 | 2004-07-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520876A Division JP5301830B2 (ja) | 2004-07-12 | 2005-07-06 | ボツリヌス神経毒を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012211150A JP2012211150A (ja) | 2012-11-01 |
| JP2012211150A5 true JP2012211150A5 (enExample) | 2014-08-21 |
| JP5662379B2 JP5662379B2 (ja) | 2015-01-28 |
Family
ID=32865775
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520876A Expired - Lifetime JP5301830B2 (ja) | 2004-07-12 | 2005-07-06 | ボツリヌス神経毒を含む医薬組成物 |
| JP2012128597A Expired - Lifetime JP5662379B2 (ja) | 2004-07-12 | 2012-06-06 | ボツリヌス神経毒を含む医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520876A Expired - Lifetime JP5301830B2 (ja) | 2004-07-12 | 2005-07-06 | ボツリヌス神経毒を含む医薬組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9125804B2 (enExample) |
| EP (4) | EP1817051B2 (enExample) |
| JP (2) | JP5301830B2 (enExample) |
| CN (2) | CN1984675B (enExample) |
| AR (2) | AR049978A1 (enExample) |
| BR (1) | BRPI0513327B8 (enExample) |
| CA (1) | CA2572915C (enExample) |
| DK (3) | DK1817051T4 (enExample) |
| ES (3) | ES2725908T3 (enExample) |
| FI (1) | FI1817051T4 (enExample) |
| GB (1) | GB2416122A (enExample) |
| HU (2) | HUE025434T2 (enExample) |
| IL (1) | IL180380A (enExample) |
| MX (1) | MX2007000409A (enExample) |
| PL (3) | PL2269631T5 (enExample) |
| PT (3) | PT1817051E (enExample) |
| RU (1) | RU2407541C2 (enExample) |
| TR (1) | TR201906275T4 (enExample) |
| WO (1) | WO2006005910A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763663B2 (en) | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
| KR101284710B1 (ko) | 2004-03-03 | 2013-07-23 | 레반스 테라퓨틱스, 아이엔씨. | 국소 진단제 및 치료제의 수송을 위한 조성물 및 방법 |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| DE102004043009A1 (de) | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| CA2599017C (en) | 2005-03-03 | 2014-08-12 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| DE102005019302A1 (de) | 2005-04-26 | 2006-11-16 | Toxogen Gmbh | Carrier zum Targeting von Nervenzellen |
| BRPI0613631A8 (pt) | 2005-07-18 | 2017-12-26 | Univ Massachusetts Lowell | nanoemulsão e método, |
| FR2889936B1 (fr) | 2005-09-01 | 2007-12-21 | Sod Conseils Rech Applic | Methode pour quantifier une neurotoxine cholinergique dans un echantillon |
| US8168206B1 (en) | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
| AU2016204034B2 (en) * | 2005-10-06 | 2017-12-21 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
| US8137677B2 (en) * | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| PL1959994T3 (pl) | 2005-12-01 | 2018-02-28 | University Of Massachusetts Lowell | Nanoemulsje botulinowe |
| FR2902341B1 (fr) * | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| JP2010528981A (ja) | 2006-12-01 | 2010-08-26 | アンテリオス, インコーポレイテッド | 両親媒性実体ナノ粒子 |
| US20100172943A1 (en) | 2006-12-01 | 2010-07-08 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
| FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
| KR20100050443A (ko) | 2007-05-31 | 2010-05-13 | 안테리오스, 인코퍼레이티드 | 핵산 나노입자 및 이의 용도 |
| ES2391798T3 (es) | 2007-07-10 | 2012-11-30 | Medy-Tox, Inc. | Composición líquida farmacéutica de toxina botulínica con estabilidad mejorada |
| FR2930447B1 (fr) | 2008-04-25 | 2010-07-30 | Sod Conseils Rech Applic | Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique |
| WO2009158687A1 (en) * | 2008-06-26 | 2009-12-30 | Anterios, Inc. | Dermal delivery |
| ES2356883B1 (es) * | 2008-07-24 | 2012-02-22 | Bcn Peptides, S.A. | Composición para el tratamiento del dolor y/o la inflamación. |
| CN101386648B (zh) * | 2008-09-25 | 2012-05-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途 |
| CN102307571A (zh) * | 2008-12-10 | 2012-01-04 | 阿勒根公司 | 梭菌毒素药物组合物 |
| EP3332805B1 (en) | 2008-12-31 | 2022-02-23 | ReVance Therapeutics, Inc. | Injectable botulinum toxin formulations |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| AU2010265888A1 (en) | 2009-06-25 | 2012-01-19 | Revance Therapeutics, Inc. | Albumin-free botulinum toxin formulations |
| AU2011316111B2 (en) | 2010-10-12 | 2015-05-28 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
| DK3241547T3 (da) * | 2011-03-31 | 2020-08-17 | Medy-Tox Inc | Lyofiliseret præparat af botulinumtoksin |
| US9498521B2 (en) * | 2011-09-28 | 2016-11-22 | Wisconsin Alumni Research Foundation | Purification, characterization, and use of Clostridium botulinum neurotoxin BoNT/A3 |
| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| JP2015534814A (ja) * | 2012-10-31 | 2015-12-07 | イプセン バイオイノベーション リミテッド | 組換えクロストリジウムボツリヌス神経毒 |
| WO2014145735A2 (en) | 2013-03-15 | 2014-09-18 | Orpro Therapeutics, Inc. | Product and process for mucus viscosity normalization |
| RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
| US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| RU2593344C2 (ru) * | 2014-03-05 | 2016-08-10 | Михаил Григорьевич Сойхер | Способ лечения бруксизма |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| KR102557798B1 (ko) | 2014-12-23 | 2023-07-19 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 독소 사전충전된 용기 |
| AR103244A1 (es) * | 2015-02-03 | 2017-04-26 | Merz Pharma Gmbh & Co Kgaa | Recipiente precargado con toxina botulínica |
| ES2907652T3 (es) | 2015-10-29 | 2022-04-25 | Revance Therapeutics Inc | Formulaciones inyectables de toxina botulínica y métodos de uso de las mismas que tienen un efecto terapéutico o cosmético de larga duración |
| WO2017177160A1 (en) | 2016-04-07 | 2017-10-12 | Nevakar Llc | Formulation for use in a method of treatment of pain |
| RU2741497C9 (ru) | 2016-05-27 | 2021-04-30 | Ипсен Биофарм Лимитед | Жидкая композиция нейротоксина, стабилизированная триптофаном или тирозином |
| RU2651044C2 (ru) * | 2016-08-22 | 2018-04-18 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ им. ак. Е.Н. Мешалкина" Минздрава России) | Способ лечения желудочковых нарушений ритма сердца (варианты) |
| WO2018038301A1 (en) * | 2016-08-26 | 2018-03-01 | Hugel Inc. | Stabilized liquid formulation of botulinum toxin and preparation method thereof |
| PL3432916T3 (pl) | 2016-09-13 | 2020-04-30 | Allergan, Inc. | Niebiałkowo stabilzowane kompozycje toksyny clostridium |
| BR112019010131A2 (pt) | 2016-11-21 | 2019-10-08 | Eirion Therapeutics Inc | entrega transdérmica de agentes grandes |
| KR101744900B1 (ko) * | 2017-01-20 | 2017-06-08 | 주식회사 대웅 | 보툴리눔 독소를 포함하는 안정한 액상 조성물 |
| BR112019017001A2 (pt) | 2017-02-16 | 2020-04-28 | Sonnet Bio Therapeutics | composição, proteína de fusão, ácido nucleico, célula hospedeira, e, métodos para produção de um domínio de aglutinação de albumina, para preparação de uma variante de il-15, para produção de uma proteína de fusão e para inibição ou redução de um tumor em um indivíduo em necessidade do mesmo. |
| WO2019070641A1 (en) * | 2017-10-03 | 2019-04-11 | Nevakar Inc. | COMBINATIONS OF ACETAMINOPHENE-PRÉGABALINE AND METHODS OF TREATING PAIN |
| WO2019113044A1 (en) * | 2017-12-07 | 2019-06-13 | Ps Therapies Ltd | Topical compositions and methods of use thereof |
| CN113573727A (zh) * | 2019-02-21 | 2021-10-29 | 梅尔兹制药公司 | 肉毒神经毒素用于治疗震颤的新用途 |
| RU2728102C1 (ru) * | 2019-12-19 | 2020-07-28 | Александр Александрович Ильин | Способ лечения гипертонуса латеральной крыловидной мышцы |
| KR102324855B1 (ko) * | 2020-05-20 | 2021-11-11 | 오스템임플란트 주식회사 | 보툴리눔 독소를 포함하는 약제학적 액상 조성물 |
| JP2024500416A (ja) * | 2020-12-18 | 2024-01-09 | エーティージーシー カンパニー、リミテッド | ボツリヌス毒素の液剤を長期保管するための薬学的組成物 |
| CN119258202A (zh) * | 2023-07-05 | 2025-01-07 | 重庆誉颜制药有限公司 | 一种肉毒毒素蛋白组合物及其应用 |
| US12134635B1 (en) | 2023-12-29 | 2024-11-05 | Sonnet BioTherapeutics, Inc. | Interleukin 18 (IL-18) variants and fusion proteins comprising same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457916A (en) | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
| WO1994007510A1 (en) * | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| US5756468A (en) * | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
| US20030095927A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
| JP2002501033A (ja) | 1998-01-26 | 2002-01-15 | ユニバーシティー オブ マサチューセッツ | A型ボツリヌス菌の生物学的活性赤血球凝集素とその使用法 |
| DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| IL149778A0 (en) | 1999-11-22 | 2002-11-10 | Universal Preservation Technologies Inc | Preservation of sensitive biological material |
| CN1258379C (zh) | 2000-02-08 | 2006-06-07 | 阿勒根公司 | 肉毒杆菌毒素药物组合物 |
| US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
| US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
| US7255865B2 (en) | 2000-12-05 | 2007-08-14 | Allergan, Inc. | Methods of administering botulinum toxin |
| AU2002320127A1 (en) * | 2001-06-21 | 2003-01-08 | Surromed, Inc. | Covalent coupling of botulinum toxin with polyethylene glycol |
| US20030224020A1 (en) * | 2002-05-31 | 2003-12-04 | Zabudkin Alexander F. | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
| US20040009180A1 (en) * | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| RU2206337C1 (ru) * | 2002-10-29 | 2003-06-20 | Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" | Лекарственный препарат для лечения мышечных дистоний и способ его получения |
| US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| PT2813239T (pt) | 2004-08-04 | 2017-06-09 | Ipsen Biopharm Ltd | Composição farmacêutica contendo a neurotoxina botulínica a2 |
| WO2006013370A1 (en) * | 2004-08-04 | 2006-02-09 | Ipsen Limited | Pharmaceutical composition containing botulinum neurotoxin a2 |
| US8137677B2 (en) | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
-
2004
- 2004-07-12 GB GB0415491A patent/GB2416122A/en not_active Withdrawn
-
2005
- 2005-07-06 HU HUE05757842A patent/HUE025434T2/en unknown
- 2005-07-06 PL PL10010686T patent/PL2269631T5/pl unknown
- 2005-07-06 TR TR2019/06275T patent/TR201906275T4/tr unknown
- 2005-07-06 WO PCT/GB2005/002653 patent/WO2006005910A2/en not_active Ceased
- 2005-07-06 CN CN2005800234802A patent/CN1984675B/zh not_active Expired - Lifetime
- 2005-07-06 PT PT57578429T patent/PT1817051E/pt unknown
- 2005-07-06 EP EP05757842.9A patent/EP1817051B2/en not_active Expired - Lifetime
- 2005-07-06 FI FIEP05757842.9T patent/FI1817051T4/fi active
- 2005-07-06 PL PL15000178T patent/PL2939688T3/pl unknown
- 2005-07-06 EP EP15000178.2A patent/EP2939688B1/en not_active Expired - Lifetime
- 2005-07-06 EP EP10010686.3A patent/EP2269631B2/en not_active Expired - Lifetime
- 2005-07-06 DK DK05757842.9T patent/DK1817051T4/da active
- 2005-07-06 EP EP18185827.5A patent/EP3446701B1/en not_active Expired - Lifetime
- 2005-07-06 ES ES15000178T patent/ES2725908T3/es not_active Expired - Lifetime
- 2005-07-06 CN CN201110280992.4A patent/CN102327602B/zh not_active Expired - Lifetime
- 2005-07-06 CA CA2572915A patent/CA2572915C/en not_active Expired - Lifetime
- 2005-07-06 RU RU2007101307A patent/RU2407541C2/ru active
- 2005-07-06 DK DK15000178.2T patent/DK2939688T3/da active
- 2005-07-06 JP JP2007520876A patent/JP5301830B2/ja not_active Expired - Lifetime
- 2005-07-06 MX MX2007000409A patent/MX2007000409A/es active IP Right Grant
- 2005-07-06 ES ES10010686T patent/ES2438780T5/es not_active Expired - Lifetime
- 2005-07-06 DK DK10010686.3T patent/DK2269631T4/da active
- 2005-07-06 PL PL05757842.9T patent/PL1817051T5/pl unknown
- 2005-07-06 BR BRPI0513327A patent/BRPI0513327B8/pt active IP Right Grant
- 2005-07-06 US US11/632,156 patent/US9125804B2/en active Active
- 2005-07-06 PT PT10010686T patent/PT2269631E/pt unknown
- 2005-07-06 HU HUE15000178A patent/HUE043301T2/hu unknown
- 2005-07-06 PT PT15000178T patent/PT2939688T/pt unknown
- 2005-07-06 ES ES05757842T patent/ES2537312T5/es not_active Expired - Lifetime
- 2005-07-12 AR ARP050102876 patent/AR049978A1/es not_active Application Discontinuation
-
2006
- 2006-12-27 IL IL180380A patent/IL180380A/en active IP Right Grant
-
2012
- 2012-06-06 JP JP2012128597A patent/JP5662379B2/ja not_active Expired - Lifetime
-
2015
- 2015-07-28 US US14/810,975 patent/US9757329B2/en not_active Expired - Lifetime
-
2017
- 2017-07-07 AR ARP170101893A patent/AR108998A2/es not_active Application Discontinuation
- 2017-08-08 US US15/671,727 patent/US10561604B2/en not_active Expired - Lifetime
-
2020
- 2020-01-05 US US16/734,367 patent/US11534394B2/en active Active
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