JP2014518199A5 - - Google Patents
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- JP2014518199A5 JP2014518199A5 JP2014513214A JP2014513214A JP2014518199A5 JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5 JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5
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- Prior art keywords
- formula
- compound
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- 150000001875 compounds Chemical class 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 6
- -1 alkylsilyl chloride Chemical compound 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- YJVFFLUZDVXJQI-UHFFFAOYSA-L Palladium(II) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- AJIPIJNNOJSSQC-NYLIRDPKSA-N Estetrol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 AJIPIJNNOJSSQC-NYLIRDPKSA-N 0.000 claims 2
- 229950009589 Estetrol Drugs 0.000 claims 2
- 229910052987 metal hydride Inorganic materials 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000003638 reducing agent Substances 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- PZABZCASVQXUET-UHFFFAOYSA-N FC(F)(F)S(=O)(=O)O[SiH2]C1=CC=CC=C1 Chemical compound FC(F)(F)S(=O)(=O)O[SiH2]C1=CC=CC=C1 PZABZCASVQXUET-UHFFFAOYSA-N 0.000 claims 1
- 229910010082 LiAlH Inorganic materials 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N Trifluoromethanesulfonic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 1
- 230000003197 catalytic Effects 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- NBWIIOQJUKRLKW-UHFFFAOYSA-N chloro(phenyl)silane Chemical compound Cl[SiH2]C1=CC=CC=C1 NBWIIOQJUKRLKW-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161492300P | 2011-06-01 | 2011-06-01 | |
EP11168561.6 | 2011-06-01 | ||
US61/492,300 | 2011-06-01 | ||
EP11168561 | 2011-06-01 | ||
PCT/EP2012/060447 WO2012164096A1 (en) | 2011-06-01 | 2012-06-01 | Process for the production of estetrol intermediates |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017155801A Division JP6479912B2 (ja) | 2011-06-01 | 2017-08-10 | エステトロール中間体を製造するための方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014518199A JP2014518199A (ja) | 2014-07-28 |
JP2014518199A5 true JP2014518199A5 (US07714131-20100511-C00001.png) | 2016-02-12 |
JP6425540B2 JP6425540B2 (ja) | 2018-11-21 |
Family
ID=45003353
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014513214A Active JP6425540B2 (ja) | 2011-06-01 | 2012-06-01 | エステトロール中間体を製造するための方法 |
JP2017155801A Active JP6479912B2 (ja) | 2011-06-01 | 2017-08-10 | エステトロール中間体を製造するための方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017155801A Active JP6479912B2 (ja) | 2011-06-01 | 2017-08-10 | エステトロール中間体を製造するための方法 |
Country Status (24)
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107266514A (zh) | 2011-06-01 | 2017-10-20 | 埃斯特拉私人有限责任公司 | 用于产生雌四醇中间体的方法 |
EA025511B1 (ru) | 2011-06-01 | 2016-12-30 | Эстетра С.П.Р.Л. | Способ получения промежуточных соединений эстетрола |
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
US8987484B2 (en) | 2011-10-07 | 2015-03-24 | Estetra S.P.R.L. | Process for the production of estetrol |
EA035687B1 (ru) | 2015-06-18 | 2020-07-27 | Эстетра Спрл | Диспергируемая в полости рта единица дозирования, содержащая эстетрольный компонент |
DK3310345T3 (da) | 2015-06-18 | 2021-05-25 | Estetra Sprl | Orodispersibel tablet indeholdende estetrol |
EP3310346B1 (en) | 2015-06-18 | 2021-03-24 | Estetra SPRL | Orodispersible tablet containing estetrol |
UA123098C2 (uk) | 2015-06-18 | 2021-02-17 | Естетра Спрл | Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент |
CN105837424A (zh) * | 2016-03-31 | 2016-08-10 | 常州大学 | 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法 |
CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
JP6935766B2 (ja) | 2018-02-15 | 2021-09-15 | 日本精工株式会社 | スピンドル装置 |
TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
IT201900021879A1 (it) | 2019-11-22 | 2021-05-22 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO |
IT201900017414A1 (it) | 2019-09-27 | 2021-03-27 | Ind Chimica Srl | Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo |
FR3101348B1 (fr) | 2019-09-27 | 2024-01-19 | Ind Chimica Srl | PROCÉDÉ DE PRÉPARATION DE (15α,16α,17β)-OESTRA-1,3,5(10)-TRIÈNE-3,15,16,17-TÉTROL (OESTÉTROL) ET INTERMÉDIAIRES DUDIT PROCÉDÉ |
WO2023021026A1 (en) | 2021-08-17 | 2023-02-23 | Aspen Oss B.V. | A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol |
GB2626482A (en) | 2021-10-01 | 2024-07-24 | Ind Chimica Srl | Process for preparing (15alpha,16alpha,17eta)-estra-1,3,5-(10)-triene-3,15,16,17-tetrol(estetrol) monohydrate |
WO2024160373A1 (en) | 2023-02-02 | 2024-08-08 | Industriale Chimica S.R.L. | PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE |
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UA123098C2 (uk) | 2015-06-18 | 2021-02-17 | Естетра Спрл | Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент |
EP3310346B1 (en) | 2015-06-18 | 2021-03-24 | Estetra SPRL | Orodispersible tablet containing estetrol |
EA035687B1 (ru) | 2015-06-18 | 2020-07-27 | Эстетра Спрл | Диспергируемая в полости рта единица дозирования, содержащая эстетрольный компонент |
DK3310345T3 (da) | 2015-06-18 | 2021-05-25 | Estetra Sprl | Orodispersibel tablet indeholdende estetrol |
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2012
- 2012-06-01 CN CN201710354709.5A patent/CN107266514A/zh active Pending
- 2012-06-01 WO PCT/EP2012/060447 patent/WO2012164096A1/en active Application Filing
- 2012-06-01 DK DK12729054.2T patent/DK2714710T3/en active
- 2012-06-01 HU HUE12729054A patent/HUE029252T2/en unknown
- 2012-06-01 EP EP12729054.2A patent/EP2714710B1/en active Active
- 2012-06-01 PT PT127290542T patent/PT2714710T/pt unknown
- 2012-06-01 ME MEP-2016-130A patent/ME02454B/me unknown
- 2012-06-01 SI SI201230598A patent/SI2714710T1/sl unknown
- 2012-06-01 AU AU2012264602A patent/AU2012264602B2/en active Active
- 2012-06-01 ES ES12729054.2T patent/ES2579175T3/es active Active
- 2012-06-01 PL PL12729054T patent/PL2714710T3/pl unknown
- 2012-06-01 MX MX2013014045A patent/MX341561B/es active IP Right Grant
- 2012-06-01 EA EA201301316A patent/EA023991B1/ru unknown
- 2012-06-01 JP JP2014513214A patent/JP6425540B2/ja active Active
- 2012-06-01 SG SG2013086681A patent/SG195118A1/en unknown
- 2012-06-01 KR KR1020137031483A patent/KR101994805B1/ko active IP Right Grant
- 2012-06-01 CN CN201280026162.1A patent/CN103703014A/zh active Pending
- 2012-06-01 CA CA2835981A patent/CA2835981C/en active Active
- 2012-06-01 US US14/122,872 patent/US11053274B2/en active Active
- 2012-06-01 RS RS20160478A patent/RS54880B1/sr unknown
- 2012-06-01 BR BR112013030830A patent/BR112013030830B1/pt active IP Right Grant
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2013
- 2013-11-11 ZA ZA2013/08446A patent/ZA201308446B/en unknown
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2016
- 2016-06-15 CY CY20161100525T patent/CY1118150T1/el unknown
- 2016-06-17 HR HRP20160692TT patent/HRP20160692T2/hr unknown
- 2016-06-30 SM SM201600206T patent/SMT201600206B/it unknown
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2017
- 2017-08-10 JP JP2017155801A patent/JP6479912B2/ja active Active