JP2014518199A5 - - Google Patents

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JP2014518199A5
JP2014518199A5 JP2014513214A JP2014513214A JP2014518199A5 JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5 JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014513214 A JP2014513214 A JP 2014513214A JP 2014518199 A5 JP2014518199 A5 JP 2014518199A5
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JP
Japan
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formula
compound
group
alkyl
reacting
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JP2014513214A
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English (en)
Japanese (ja)
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JP6425540B2 (ja
JP2014518199A (ja
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Priority claimed from PCT/EP2012/060447 external-priority patent/WO2012164096A1/en
Publication of JP2014518199A publication Critical patent/JP2014518199A/ja
Publication of JP2014518199A5 publication Critical patent/JP2014518199A5/ja
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JP2014513214A 2011-06-01 2012-06-01 エステトロール中間体を製造するための方法 Active JP6425540B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161492300P 2011-06-01 2011-06-01
EP11168561.6 2011-06-01
EP11168561 2011-06-01
US61/492,300 2011-06-01
PCT/EP2012/060447 WO2012164096A1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017155801A Division JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Publications (3)

Publication Number Publication Date
JP2014518199A JP2014518199A (ja) 2014-07-28
JP2014518199A5 true JP2014518199A5 (OSRAM) 2016-02-12
JP6425540B2 JP6425540B2 (ja) 2018-11-21

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ID=45003353

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JP2014513214A Active JP6425540B2 (ja) 2011-06-01 2012-06-01 エステトロール中間体を製造するための方法
JP2017155801A Active JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Family Applications After (1)

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JP2017155801A Active JP6479912B2 (ja) 2011-06-01 2017-08-10 エステトロール中間体を製造するための方法

Country Status (24)

Country Link
US (1) US11053274B2 (OSRAM)
EP (1) EP2714710B1 (OSRAM)
JP (2) JP6425540B2 (OSRAM)
KR (1) KR101994805B1 (OSRAM)
CN (2) CN107266514A (OSRAM)
AU (1) AU2012264602B2 (OSRAM)
BR (1) BR112013030830B1 (OSRAM)
CA (1) CA2835981C (OSRAM)
CY (1) CY1118150T1 (OSRAM)
DK (1) DK2714710T3 (OSRAM)
EA (1) EA023991B1 (OSRAM)
ES (1) ES2579175T3 (OSRAM)
HR (1) HRP20160692T2 (OSRAM)
HU (1) HUE029252T2 (OSRAM)
ME (1) ME02454B (OSRAM)
MX (1) MX341561B (OSRAM)
PL (1) PL2714710T3 (OSRAM)
PT (1) PT2714710T (OSRAM)
RS (1) RS54880B1 (OSRAM)
SG (1) SG195118A1 (OSRAM)
SI (1) SI2714710T1 (OSRAM)
SM (1) SMT201600206B (OSRAM)
WO (1) WO2012164096A1 (OSRAM)
ZA (1) ZA201308446B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012264601C1 (en) 2011-06-01 2018-01-25 Estetra Srl Process for the production of estetrol intermediates
PT2714710T (pt) 2011-06-01 2016-07-12 Estetra Sprl Processo para a produção de intermediários de estetrol
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
EP2764008B1 (en) 2011-10-07 2016-08-17 Estetra S.P.R.L. Process for the production of estetrol
HUE054589T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Szájban diszpergálódó esztetrol tartalmú tabletta
MY195019A (en) 2015-06-18 2023-01-03 Estetra Sprl Orodispersible dosage unit containing an estetrol component
MD3310346T2 (ro) 2015-06-18 2021-06-30 Estetra Sprl Comprimată orodispersabilă ce conține estetrol
JP6866560B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
CN105837424A (zh) * 2016-03-31 2016-08-10 常州大学 一种1-氯-3-甲基-3-丁烯-2-酮的合成方法
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
JP6935766B2 (ja) 2018-02-15 2021-09-15 日本精工株式会社 スピンドル装置
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
ES2948324R1 (es) 2019-09-27 2025-09-11 Ind Chimica Srl Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato)
IT201900021879A1 (it) 2019-11-22 2021-05-22 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO
IT201900017414A1 (it) 2019-09-27 2021-03-27 Ind Chimica Srl Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol
ES2976651B2 (es) 2021-10-01 2025-12-05 Ind Chimica Srl PROCESO PARA PREPARAR (15alfa,16alfa,17beta)-ESTRA-1,3,5(10)-TRIENO-3,15,16,17-TETROL (ESTETROL) Y ESTETROL MONOHIDRATO
AU2023428138A1 (en) 2023-02-02 2025-09-04 Industriale Chimica S.R.L. PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE144266C (OSRAM)
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3177206A (en) 1963-03-07 1965-04-06 American Home Prod Selective bromination of a-ring aromatic 17-ketalized steroids
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3673180A (en) 1970-06-18 1972-06-27 Merck & Co Inc 19-nor-6,6-ethylene-20-spiroxenes
US4792620A (en) 1983-10-14 1988-12-20 Bp Chemicals Limited Carbonylation catalysts
US4739078A (en) 1984-02-17 1988-04-19 The Upjohn Company Use of borohydride-salt lanthanide salt reagents for stereo selective reduction of C-15-keto prostaglandin precursors
IE60780B1 (en) 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3710728A1 (de) 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
US8048869B2 (en) 2001-05-18 2011-11-01 Pantarhei Bioscience B.V. Pharmaceutical composition for use in hormone replacement therapy
DK1390042T3 (da) 2001-05-23 2008-03-31 Pantarhei Bioscience Bv System for administration af et lægemiddel omfattende tetrahydroxyleret östrogen til anvendelse i hormonal svangerskabsforebyggelse
EP1390041B1 (en) 2001-05-23 2009-11-25 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
CA2467222C (en) 2001-11-15 2010-06-08 Herman Jan Tijmen Coelingh Bennink Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
CA2476940C (en) 2002-02-21 2011-11-01 Herman Jan Tijmen Coelingh Bennink Pharmaceutical compositions comprising one or more steroids, one or more tetrahydrofolate components and vitamin b12
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
US7943604B2 (en) 2002-06-11 2011-05-17 Pantarhei Bioscience B.V. Method of treating human skin and a skin care composition for use in such a method
CN1691947B (zh) 2002-06-11 2011-11-23 潘塔希生物科学股份有限公司 雌激素成分在制备用于治疗或预防免疫介导的疾病中的应用以及包含所述雌激素成分的药物组合物
CA2492287C (en) 2002-07-12 2011-12-13 Pantarhei Bioscience B.V. Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy
CN100528167C (zh) 2002-10-23 2009-08-19 潘塔希生物科学股份有限公司 用于治疗癌症的包含雌四醇衍生物的药物组合物
ATE469165T1 (de) * 2002-11-08 2010-06-15 Pantarhei Bioscience Bv Synthese von oestetrol aus von oestron abgeleiteten steroiden
DK1624878T3 (da) 2003-05-22 2007-01-08 Pantarhei Bioscience Bv Anvendelse af præparater som omfatter en östrogen komponent til behandling og forebyggelse af muskel-skelet-smerte
JP5268635B2 (ja) 2005-05-26 2013-08-21 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 17β−HSD1及びSTSインヒビター
EP2077322B1 (de) 2005-07-25 2010-08-25 RiboxX GmbH Verfahren und Kit zur Amplifikation von heteropolymerer oder poly(C)- RNA
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
CA2636638C (en) 2006-01-09 2014-02-18 Pantarhei Bioscience B.V. A method of treating an acute vascular disorder
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
ES2659316T3 (es) 2006-06-08 2018-03-14 Allergan Pharmaceuticals International Limited Procedimientos para administrar formas de dosificación sólidas de etinilestradiol y profármacos del mismo con biodisponibilidad mejorada
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
GB0621926D0 (en) 2006-11-03 2006-12-13 Medlock Medical Ltd Multi directional stretch tubular bandages
CA2670544A1 (en) 2006-11-29 2008-06-05 Wyeth Estrogen/ serm and estrogen/ progestin bi-layer tablets
CA2674776A1 (en) 2006-12-20 2008-07-03 Duramed Pharmaceuticals, Inc. Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof
US8236785B2 (en) 2007-01-08 2012-08-07 Pantarhei Bioscience B.V. Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method
PE20081632A1 (es) 2007-01-12 2008-12-10 Wyeth Corp Composiciones de tableta en tableta
CN102014924B (zh) 2007-06-21 2012-07-18 潘塔希生物科学股份有限公司 用雌激素治疗胎粪吸入综合征
WO2009011576A1 (en) 2007-07-19 2009-01-22 Pantarhei Bioscience B.V. Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation
EP2085373B8 (en) 2007-08-31 2013-06-26 National University Corporation Nagoya University Method for producing carbonyl compound and pro-oxidant used for production of carbonyl compound
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
EP2077273B1 (en) 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Methods for separating casein from soluble proteins in a composition
US20110250274A1 (en) 2008-09-19 2011-10-13 Shaked Ze Ev Estriol formulations
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AU2012264601C1 (en) 2011-06-01 2018-01-25 Estetra Srl Process for the production of estetrol intermediates
PT2714710T (pt) 2011-06-01 2016-07-12 Estetra Sprl Processo para a produção de intermediários de estetrol
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
WO2013012326A1 (en) 2011-07-19 2013-01-24 Pantarhei Bioscience B.V. Tablet containing dehydroepiandrosterone (dhea)
HRP20170797T1 (hr) 2011-08-11 2017-08-11 Estetra S.P.R.L. Primjena estetrola kao hitnog kontraceptiva
NZ620897A (en) 2011-09-16 2016-07-29 Ferring Bv A fast dissolving pharmaceutical composition
EP2764008B1 (en) 2011-10-07 2016-08-17 Estetra S.P.R.L. Process for the production of estetrol
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
US9808470B2 (en) 2012-04-19 2017-11-07 Universite De Liege Estrogenic components for use in the treatment of neurological disorders
WO2014159377A1 (en) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
CA2924255C (en) 2013-09-18 2022-11-22 Crystal Pharma, S.A.U. Process for the preparation of estetrol
KR102265150B1 (ko) 2013-12-12 2021-06-16 에스테트라 에스.피.알.엘. 에스테트롤 성분을 함유하는 구강 붕해성 고체 투여 단위
MY195019A (en) 2015-06-18 2023-01-03 Estetra Sprl Orodispersible dosage unit containing an estetrol component
MD3310346T2 (ro) 2015-06-18 2021-06-30 Estetra Sprl Comprimată orodispersabilă ce conține estetrol
HUE054589T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Szájban diszpergálódó esztetrol tartalmú tabletta
JP6866560B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位

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