JP2014517830A5 - - Google Patents
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- Publication number
- JP2014517830A5 JP2014517830A5 JP2014509383A JP2014509383A JP2014517830A5 JP 2014517830 A5 JP2014517830 A5 JP 2014517830A5 JP 2014509383 A JP2014509383 A JP 2014509383A JP 2014509383 A JP2014509383 A JP 2014509383A JP 2014517830 A5 JP2014517830 A5 JP 2014517830A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- living cells
- activated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 80
- 238000000034 method Methods 0.000 claims 33
- 239000000872 buffer Substances 0.000 claims 27
- 230000000050 nutritive effect Effects 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 23
- 210000000447 Th1 cell Anatomy 0.000 claims 17
- 238000002360 preparation method Methods 0.000 claims 13
- 229960000074 biopharmaceutical Drugs 0.000 claims 7
- 238000009169 immunotherapy Methods 0.000 claims 7
- 108010029697 CD40 Ligand Proteins 0.000 claims 6
- 102100032937 CD40 ligand Human genes 0.000 claims 6
- 230000028327 secretion Effects 0.000 claims 5
- 102100037850 Interferon gamma Human genes 0.000 claims 4
- 108010074328 Interferon-gamma Proteins 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 108010039471 Fas Ligand Protein Proteins 0.000 claims 2
- 102000001398 Granzyme Human genes 0.000 claims 2
- 108060005986 Granzyme Proteins 0.000 claims 2
- 102000004503 Perforin Human genes 0.000 claims 2
- 108010056995 Perforin Proteins 0.000 claims 2
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 235000015097 nutrients Nutrition 0.000 claims 2
- 229930192851 perforin Natural products 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000032258 transport Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161481991P | 2011-05-03 | 2011-05-03 | |
| US61/481,991 | 2011-05-03 | ||
| US201161528493P | 2011-08-29 | 2011-08-29 | |
| US61/528,493 | 2011-08-29 | ||
| US201161565225P | 2011-11-30 | 2011-11-30 | |
| US61/565,225 | 2011-11-30 | ||
| US201261582878P | 2012-01-04 | 2012-01-04 | |
| US61/582,878 | 2012-01-04 | ||
| PCT/US2012/036103 WO2012151266A1 (en) | 2011-05-03 | 2012-05-02 | Methods for handling biological drugs containing living cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014266252A Division JP6006288B2 (ja) | 2011-05-03 | 2014-12-26 | 柔軟性のある容器あるいは注射器 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517830A JP2014517830A (ja) | 2014-07-24 |
| JP2014517830A5 true JP2014517830A5 (https=) | 2015-02-19 |
| JP5934783B2 JP5934783B2 (ja) | 2016-06-15 |
Family
ID=47108026
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509383A Active JP5934783B2 (ja) | 2011-05-03 | 2012-05-02 | 生細胞を含む生物学的薬剤の取り扱い方法 |
| JP2014266252A Active JP6006288B2 (ja) | 2011-05-03 | 2014-12-26 | 柔軟性のある容器あるいは注射器 |
| JP2016174984A Active JP6359059B2 (ja) | 2011-05-03 | 2016-09-07 | 生細胞を含む生物学的薬剤の取り扱い方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014266252A Active JP6006288B2 (ja) | 2011-05-03 | 2014-12-26 | 柔軟性のある容器あるいは注射器 |
| JP2016174984A Active JP6359059B2 (ja) | 2011-05-03 | 2016-09-07 | 生細胞を含む生物学的薬剤の取り扱い方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10350242B2 (https=) |
| EP (1) | EP2704741B1 (https=) |
| JP (3) | JP5934783B2 (https=) |
| KR (3) | KR102229108B1 (https=) |
| CN (2) | CN103732247A (https=) |
| AU (1) | AU2012250794B2 (https=) |
| BR (1) | BR112013028257B1 (https=) |
| CA (1) | CA2838041C (https=) |
| DK (1) | DK2704741T3 (https=) |
| ES (1) | ES2648136T3 (https=) |
| HU (1) | HUE034995T2 (https=) |
| IL (1) | IL229176B (https=) |
| PH (1) | PH12013502253A1 (https=) |
| PL (1) | PL2704741T3 (https=) |
| PT (1) | PT2704741T (https=) |
| SG (1) | SG194774A1 (https=) |
| WO (1) | WO2012151266A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160095307A1 (en) | 2014-10-07 | 2016-04-07 | NuTech Medical, Inc. | Method and composition for hypothermic storage of placental tissue |
| WO2016075542A1 (en) * | 2014-11-11 | 2016-05-19 | Macrocure, Ltd. | Methods for extended storage of activated leukocyte compositions |
| JP6814593B2 (ja) * | 2016-10-14 | 2021-01-20 | 株式会社 バイオミメティクスシンパシーズ | 幹細胞及び投与システム |
| SG11202104524YA (en) | 2018-11-01 | 2021-05-28 | Gracell Biotechnologies Shanghai Co Ltd | Compositions and methods for t cell engineering |
| CN118931967A (zh) * | 2018-12-07 | 2024-11-12 | 亘喜生物科技（上海）有限公司 | 用于免疫疗法的组合物和方法 |
| TW202110463A (zh) * | 2019-05-15 | 2021-03-16 | 美商永生生技股份有限公司 | 高濃度細胞包裝和運送 |
| JP7722390B2 (ja) | 2020-12-10 | 2025-08-13 | Ａｇｃ株式会社 | オキシアルキレン重合体、その製造方法、硬化性組成物、硬化物 |
| WO2022191084A1 (ja) | 2021-03-12 | 2022-09-15 | Ａｇｃ株式会社 | 硬化性組成物及び硬化物 |
| WO2023282298A1 (ja) | 2021-07-07 | 2023-01-12 | Ａｇｃ株式会社 | 硬化性組成物、硬化物、接着剤、及びシーリング材 |
| JPWO2023190640A1 (https=) * | 2022-03-30 | 2023-10-05 | ||
| DE112023002011T5 (de) | 2022-04-22 | 2025-02-20 | AGC Inc. | Aushärtbare zusammensetzung und ausgehärtetes produkt |
| DE112023002002T5 (de) | 2022-04-22 | 2025-02-20 | AGC Inc. | Aushärtbare zusammensetzung und ausgehärtetes produkt davon |
| EP4516821A4 (en) | 2022-04-27 | 2026-04-29 | Agc Inc | Production method for reactive silicon group-containing organic polymer |
| CN119072501A (zh) | 2022-04-27 | 2024-12-03 | Ａｇｃ株式会社 | 含反应性硅基团的有机聚合物的制造方法 |
| CN119301211A (zh) | 2022-06-03 | 2025-01-10 | Ａｇｃ株式会社 | 粘接剂组合物及物品 |
| EP4729560A1 (en) | 2024-07-05 | 2026-04-22 | Agc Inc. | Composite metal cyanide complex catalyst, method for producing polyether compound, method for producing polyether compound having reactive silicon group, method for producing polyether compound having urethane bond, and method for producing polyether compound having polymerizable unsaturated group |
| WO2026009589A1 (ja) | 2024-07-05 | 2026-01-08 | Ａｇｃ株式会社 | 組成物、反応性ケイ素基を有するポリエーテル化合物の製造方法、ウレタン結合を有するポリエーテル化合物の製造方法、及び重合性不飽和基を有するポリエーテル化合物の製造方法 |
| WO2026014465A1 (ja) | 2024-07-12 | 2026-01-15 | Ａｇｃ株式会社 | ポリエーテル化合物の製造方法、反応性ケイ素基を有するポリエーテル化合物の製造方法、ウレタン結合を有するポリエーテル化合物の製造方法及び重合性不飽和基を有するポリエーテル化合物の製造方法 |
| WO2026014466A1 (ja) | 2024-07-12 | 2026-01-15 | Ａｇｃ株式会社 | ポリエーテル化合物の製造方法、反応性ケイ素基を有するポリエーテル化合物の製造方法、ウレタン結合を有するポリエーテル化合物の製造方法及び重合性不飽和基を有するポリエーテル化合物の製造方法 |
| EP4711399A1 (en) | 2024-07-12 | 2026-03-18 | Agc Inc. | Method for producing polyether compound, method for producing polyether compound having reactive silicon group, method for producing polyether compound having urethane bond, and method for producing polyether compound having polymerizable unsaturated group |
Family Cites Families (47)
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|---|---|---|---|---|
| FR2439003A1 (fr) | 1978-10-20 | 1980-05-16 | Anvar | Nouvelles pieces d'osteosynthese, leur preparation et leur application |
| US5766920A (en) | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| AU7873187A (en) | 1986-08-08 | 1988-02-24 | University Of Minnesota | Method of culturing leukocytes |
| PT89121A (pt) | 1987-12-04 | 1989-12-29 | Du Pont | Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
| US6204058B1 (en) | 1992-02-07 | 2001-03-20 | Vasogen Ireland Limited | Treatment of autoimmune diseases |
| AU5729294A (en) | 1992-11-25 | 1994-06-22 | Tanox Biosystems, Inc. | Conjugates and constructs including anti-cd28 and anti-cd3 binding molecules |
| DE69430315T2 (de) | 1993-08-06 | 2002-11-21 | Epimmune, Inc. | Methoden zur (ex vivo) therapie mittels peptid - bestueckten antigen - praesentierenden zellen zur aktivierung von ctl |
| IL107483A0 (en) | 1993-11-03 | 1994-02-27 | Yeda Res & Dev | Bone marrow transplantation |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| JP3926842B2 (ja) | 1995-03-08 | 2007-06-06 | ザ・スクリプス・リサーチ・インステイチユート | 抗原提示系およびｔ−細胞の活性化方法 |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| ATE347588T1 (de) | 1996-05-23 | 2006-12-15 | Scripps Research Inst | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| CN1237909A (zh) | 1996-10-11 | 1999-12-08 | 加利福尼亚大学董事会 | 联合使用肿瘤细胞与混合淋巴细胞的癌症免疫治疗 |
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| WO1998033891A1 (en) | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| US7282198B2 (en) | 1997-03-19 | 2007-10-16 | The University Of Arkansas For Medical Sciences | Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme |
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| CA2309206A1 (en) | 1997-11-10 | 1999-05-20 | Arch Development Corporation | Methods for treatment of tumors and tumor cells using ex vivo activated t cells |
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| HUE035726T2 (en) | 2004-03-01 | 2018-05-28 | Immunovative Therapies Ltd | Cell therapy formulation method and composition |
| EP1744794A2 (en) | 2004-03-05 | 2007-01-24 | The Trustees Of Columbia University In The City Of New York | Polymer-ceramic-hydrogel composite scaffold for osteochondral repair |
| TW200726474A (en) | 2005-07-15 | 2007-07-16 | Cognate Therapeutics Inc | The immunophenotype and immunogenicity of human adipose derived cells |
| EP1792979A1 (en) * | 2005-12-01 | 2007-06-06 | Stiftung Caesar Center of Advanced European Studies and Research | Cell culture system for the enrichment and expansion of stem cells |
| RU2496482C2 (ru) * | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Композиции и способы для доставки лекарственных средств |
-
2012
- 2012-05-02 WO PCT/US2012/036103 patent/WO2012151266A1/en not_active Ceased
- 2012-05-02 CN CN201280032760.XA patent/CN103732247A/zh active Pending
- 2012-05-02 JP JP2014509383A patent/JP5934783B2/ja active Active
- 2012-05-02 DK DK12779413.9T patent/DK2704741T3/da active
- 2012-05-02 KR KR1020137032016A patent/KR102229108B1/ko active Active
- 2012-05-02 PT PT127794139T patent/PT2704741T/pt unknown
- 2012-05-02 EP EP12779413.9A patent/EP2704741B1/en active Active
- 2012-05-02 BR BR112013028257-6A patent/BR112013028257B1/pt active IP Right Grant
- 2012-05-02 US US13/581,895 patent/US10350242B2/en active Active
- 2012-05-02 HU HUE12779413A patent/HUE034995T2/en unknown
- 2012-05-02 KR KR1020197020882A patent/KR102202460B1/ko active Active
- 2012-05-02 PH PH1/2013/502253A patent/PH12013502253A1/en unknown
- 2012-05-02 AU AU2012250794A patent/AU2012250794B2/en not_active Ceased
- 2012-05-02 KR KR1020147019539A patent/KR20140099328A/ko not_active Withdrawn
- 2012-05-02 ES ES12779413.9T patent/ES2648136T3/es active Active
- 2012-05-02 SG SG2013081617A patent/SG194774A1/en unknown
- 2012-05-02 PL PL12779413T patent/PL2704741T3/pl unknown
- 2012-05-02 CN CN201810178504.0A patent/CN108261423B/zh active Active
- 2012-05-02 CA CA2838041A patent/CA2838041C/en active Active
-
2013
- 2013-10-31 IL IL229176A patent/IL229176B/en active IP Right Grant
-
2014
- 2014-12-26 JP JP2014266252A patent/JP6006288B2/ja active Active
-
2016
- 2016-09-07 JP JP2016174984A patent/JP6359059B2/ja active Active
-
2019
- 2019-06-06 US US16/433,659 patent/US11648273B2/en active Active
-
2023
- 2023-03-21 US US18/124,525 patent/US20230226112A1/en active Pending
- 2023-03-22 US US18/124,987 patent/US20230218672A1/en active Pending
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