JP2015517520A5 - - Google Patents
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- JP2015517520A5 JP2015517520A5 JP2015512636A JP2015512636A JP2015517520A5 JP 2015517520 A5 JP2015517520 A5 JP 2015517520A5 JP 2015512636 A JP2015512636 A JP 2015512636A JP 2015512636 A JP2015512636 A JP 2015512636A JP 2015517520 A5 JP2015517520 A5 JP 2015517520A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- cells
- cell
- brain injury
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 33
- 102000040430 polynucleotide Human genes 0.000 claims description 21
- 108091033319 polynucleotide Proteins 0.000 claims description 21
- 239000002157 polynucleotide Substances 0.000 claims description 21
- 230000001272 neurogenic effect Effects 0.000 claims description 15
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 13
- 208000029028 brain injury Diseases 0.000 claims description 13
- 230000009529 traumatic brain injury Effects 0.000 claims description 13
- 210000004556 brain Anatomy 0.000 claims description 12
- 102400000552 Notch 1 intracellular domain Human genes 0.000 claims description 11
- 101800001628 Notch 1 intracellular domain Proteins 0.000 claims description 11
- 102000005650 Notch Receptors Human genes 0.000 claims description 7
- 108010070047 Notch Receptors Proteins 0.000 claims description 7
- 238000004113 cell culture Methods 0.000 claims description 7
- 238000012258 culturing Methods 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 5
- 230000005012 migration Effects 0.000 claims description 3
- 238000013508 migration Methods 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 238000002054 transplantation Methods 0.000 claims description 3
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 38
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 12
- 230000035755 proliferation Effects 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261647893P | 2012-05-16 | 2012-05-16 | |
| US61/647,893 | 2012-05-16 | ||
| PCT/US2013/030895 WO2013172944A1 (en) | 2012-05-16 | 2013-03-13 | Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016184086A Division JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517520A JP2015517520A (ja) | 2015-06-22 |
| JP2015517520A5 true JP2015517520A5 (https=) | 2015-10-29 |
| JP6134783B2 JP6134783B2 (ja) | 2017-05-24 |
Family
ID=48040424
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512636A Active JP6134783B2 (ja) | 2012-05-16 | 2013-03-13 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2016184086A Pending JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2018082259A Pending JP2018111733A (ja) | 2012-05-16 | 2018-04-23 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2021038508A Pending JP2021098738A (ja) | 2012-05-16 | 2021-03-10 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2023078339A Pending JP2023099213A (ja) | 2012-05-16 | 2023-05-11 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2025030492A Pending JP2025098021A (ja) | 2012-05-16 | 2025-02-27 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016184086A Pending JP2016220694A (ja) | 2012-05-16 | 2016-09-21 | 外傷性脳損傷の処置のため、および神経因性細胞の移動の調節のための方法および組成物 |
| JP2018082259A Pending JP2018111733A (ja) | 2012-05-16 | 2018-04-23 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2021038508A Pending JP2021098738A (ja) | 2012-05-16 | 2021-03-10 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2023078339A Pending JP2023099213A (ja) | 2012-05-16 | 2023-05-11 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
| JP2025030492A Pending JP2025098021A (ja) | 2012-05-16 | 2025-02-27 | 外傷性脳損傷後のバイオブリッジ形成時に発現する組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9828593B2 (https=) |
| EP (1) | EP2849766B1 (https=) |
| JP (6) | JP6134783B2 (https=) |
| CN (3) | CN104519891B (https=) |
| AU (2) | AU2013263417B2 (https=) |
| CA (1) | CA2872188C (https=) |
| WO (1) | WO2013172944A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104519891B (zh) * | 2012-05-16 | 2019-03-22 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
| HK1208371A1 (en) | 2012-10-09 | 2016-03-04 | 桑比欧公司 | Methods and compositions for treatment of retinal degeneration |
| US20170065638A1 (en) * | 2014-02-10 | 2017-03-09 | Cytori Therapeutics, Inc. | Regenerative cell therapy for central nervous system (cns) disorders and ptsd |
| CA2981523A1 (en) * | 2015-04-01 | 2016-10-06 | Sanbio, Inc. | Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms |
| US10555972B2 (en) * | 2016-02-26 | 2020-02-11 | Innopeutics Corporation | Therapeutic effects of NURR1 and FOXA2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells |
| WO2017152035A1 (en) * | 2016-03-03 | 2017-09-08 | Henry Ford Health System | 3-d collagen scaffold-generated exosomes and uses thereof |
| JP7220149B2 (ja) | 2016-12-28 | 2023-02-09 | サンバイオ，インコーポレイティド | 細胞送達システム及びその動作方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
| JP3886346B2 (ja) | 2001-06-22 | 2007-02-28 | サンバイオ，インコーポレイティド | 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物 |
| CN101584869B (zh) * | 2002-02-06 | 2013-03-27 | 桑比欧公司 | 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法 |
| EP1644026A4 (en) * | 2003-06-12 | 2007-10-24 | Ms Science Corp | SIGMA LIGANDS FOR NEURONAL REGENERATION AND FUNCTIONAL RECREATION |
| CA2929754A1 (en) | 2004-04-12 | 2005-10-27 | Sanbio Inc. | Cells exhibiting neuronal progenitor cell characteristics |
| AU2006220696B2 (en) | 2005-03-07 | 2010-08-19 | Sanbio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
| CN101008033A (zh) * | 2006-01-27 | 2007-08-01 | 陈云 | 功能性中枢神经损伤诊断检测用基因芯片及其制造方法 |
| WO2008102460A1 (en) | 2007-02-23 | 2008-08-28 | Sanbio Inc. | Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury |
| JP5662147B2 (ja) * | 2007-08-15 | 2015-01-28 | サンバイオ，インコーポレイティド | 神経変性を治療するための方法及び組成物 |
| WO2009073178A1 (en) | 2007-12-03 | 2009-06-11 | Sanbio, Inc. | Extracellular matrix from pluripotent cells |
| ES2787513T3 (es) | 2007-12-03 | 2020-10-16 | Sanbio Inc | Métodos y composiciones para modular la diferenciación de células pluripotenciales |
| JP5746016B2 (ja) | 2008-04-30 | 2015-07-08 | サンバイオ，インコーポレイティド | Ｄｎａメチル化における改変を伴う神経再生細胞連邦政府の援助に関する申告適用なし |
| CA2832356C (en) | 2011-04-06 | 2017-12-19 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| US20120263681A1 (en) | 2011-04-12 | 2012-10-18 | Fujifilm Corporation | Composition comprising cell and biocompatible polymer |
| EP2744891B1 (en) | 2011-08-19 | 2018-12-12 | SanBio, Inc. | Neurogenic and gliogenic factors and assays therefor |
| EP2806881A1 (en) | 2012-01-27 | 2014-12-03 | SanBio, Inc. | Methods and compositions for modulating angiogenesis and vasculogenesis |
| CN104519891B (zh) * | 2012-05-16 | 2019-03-22 | 桑比欧公司 | 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 |
-
2013
- 2013-03-13 CN CN201380025599.8A patent/CN104519891B/zh active Active
- 2013-03-13 US US13/800,585 patent/US9828593B2/en active Active
- 2013-03-13 AU AU2013263417A patent/AU2013263417B2/en active Active
- 2013-03-13 JP JP2015512636A patent/JP6134783B2/ja active Active
- 2013-03-13 EP EP13713286.6A patent/EP2849766B1/en active Active
- 2013-03-13 WO PCT/US2013/030895 patent/WO2013172944A1/en not_active Ceased
- 2013-03-13 CA CA2872188A patent/CA2872188C/en active Active
- 2013-03-13 CN CN201910165600.6A patent/CN109718250B/zh active Active
- 2013-03-13 CN CN202211044392.2A patent/CN115381855A/zh active Pending
-
2014
- 2014-09-18 US US14/489,934 patent/US20150197741A1/en not_active Abandoned
-
2016
- 2016-07-13 AU AU2016204910A patent/AU2016204910B2/en active Active
- 2016-09-21 JP JP2016184086A patent/JP2016220694A/ja active Pending
-
2018
- 2018-04-23 JP JP2018082259A patent/JP2018111733A/ja active Pending
-
2019
- 2019-02-26 US US16/285,700 patent/US10626389B2/en active Active
-
2020
- 2020-03-05 US US16/809,852 patent/US20200354709A1/en active Pending
-
2021
- 2021-03-10 JP JP2021038508A patent/JP2021098738A/ja active Pending
-
2023
- 2023-05-11 JP JP2023078339A patent/JP2023099213A/ja active Pending
-
2025
- 2025-02-27 JP JP2025030492A patent/JP2025098021A/ja active Pending
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