EA201400401A1 - Биокомпозит для регенерации поврежденных тканей и органов, набор для изготовления биокомпозита и способ лечения - Google Patents
Биокомпозит для регенерации поврежденных тканей и органов, набор для изготовления биокомпозита и способ леченияInfo
- Publication number
- EA201400401A1 EA201400401A1 EA201400401A EA201400401A EA201400401A1 EA 201400401 A1 EA201400401 A1 EA 201400401A1 EA 201400401 A EA201400401 A EA 201400401A EA 201400401 A EA201400401 A EA 201400401A EA 201400401 A1 EA201400401 A1 EA 201400401A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- recipient
- cells
- reparative
- regeneration
- organs
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
Предложен способ восстановления тканей органов млекопитающих с использований изделия, содержащего совмещенные с носителем клетки и генетические конструкции (нуклеиновые кислоты), взаимодействие которых обеспечивает комплексное воздействие на процессы репаративной регенерации. Изобретение относится к способам введения генно-клеточных терапевтических конструкций в организм реципиента и может быть использовано в медицине и ветеринарии для обеспечения репаративных процессов. После введения в организм реципиента из структуры носителя пролонгировано высвобождаются нуклеиновые кислоты, которые поступают в клетки реципиентного ложа и в клетки трансплантированного изделия, экспрессируются в них, что приводит к повышению концентрации целевых продуктов, ответственных за обеспечение репаративных процессов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2011153873/15A RU2519326C2 (ru) | 2011-12-29 | 2011-12-29 | Биокомпозит для обеспечения восстановительных процессов после повреждения у млекопитающего, способ его получения (варианты) и применения |
PCT/RU2012/001103 WO2013100818A2 (en) | 2011-12-29 | 2012-12-24 | A biocomposite for regeneration of injured tissue and organs, a kit for making the biocomposite, a method of making the biocomposite and a method of treating inquiries. |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201400401A1 true EA201400401A1 (ru) | 2014-07-30 |
EA031108B1 EA031108B1 (ru) | 2018-11-30 |
Family
ID=48698765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400401A EA031108B1 (ru) | 2011-12-29 | 2012-12-24 | Биокомпозит для обеспечения восстановительных процессов костных тканей у млекопитающего, способы получения и применения биокомпозита |
Country Status (9)
Country | Link |
---|---|
US (1) | US9730959B2 (ru) |
EP (1) | EP2797633B1 (ru) |
CN (1) | CN104203285A (ru) |
CA (1) | CA2866483C (ru) |
EA (1) | EA031108B1 (ru) |
ES (1) | ES2617338T3 (ru) |
RU (1) | RU2519326C2 (ru) |
UA (1) | UA112450C2 (ru) |
WO (1) | WO2013100818A2 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
RU2597786C2 (ru) * | 2015-02-10 | 2016-09-20 | Общество с ограниченной ответственностью "НекстГен" | Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани |
ES2584107B2 (es) * | 2016-05-02 | 2017-04-06 | Universidade De Santiago De Compostela | Andamio biodegradable que comprende ARN mensajero |
KR101710615B1 (ko) | 2016-09-07 | 2017-02-27 | 주식회사 파마리서치프로덕트 | 생착률을 증가시킨 이식용 진피층 및 이의 제조 방법 |
RU2623171C1 (ru) * | 2016-10-07 | 2017-06-22 | Общество с ограниченной ответственностью "ГИСТОГРАФТ" | Способ получения оптимизированного твердого ген-активированного материала, способ получения твердого матрикса носителя, оптимизированный твердый ген-активированный материал для регенерации тканей |
RU2634576C1 (ru) * | 2016-10-24 | 2017-10-31 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ стимуляции регенерации тканей |
CN106943624B (zh) * | 2017-05-08 | 2019-12-10 | 佛山今兰生物科技有限公司 | 一种具有基因调控功能的硬组织工程支架的制备方法 |
CN109663149A (zh) * | 2017-10-17 | 2019-04-23 | 天津大学 | 非病毒类载体投递MicroRNA与骨粉的复合材料及其制备方法 |
CN110393822A (zh) * | 2018-04-23 | 2019-11-01 | 香港賽寧生物工程技術有限公司 | 胶原蛋白-羟基磷灰石复合小分子骨材料的制备方法 |
CN112386744B (zh) * | 2020-10-14 | 2022-04-26 | 中山大学附属第六医院 | 一种药物缓释水凝胶半嵌入式复合支架及其制备方法 |
CN113351165B (zh) * | 2021-04-29 | 2023-04-14 | 中石化石油工程技术服务有限公司 | 矿区饮用水除氟工艺 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US5962427A (en) * | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
US20040266715A1 (en) | 1999-03-31 | 2004-12-30 | Wong Liang Fong | Neurite regeneration |
US7022522B2 (en) * | 1998-11-13 | 2006-04-04 | Limin Guan | Macroporous polymer scaffold containing calcium phosphate particles |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
EP1409647A4 (en) | 2001-04-30 | 2009-09-09 | Yissum Res Dev Co | COMPOSITE SKELETONS AND METHODS OF USE THEREOF FOR GENERATING COMPLEX TISSUE GRAFT |
US8623393B2 (en) | 2002-04-29 | 2014-01-07 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
US7211275B2 (en) | 2004-01-16 | 2007-05-01 | Massachusetts Institute Of Technology | Composite materials for controlled release of water soluble products |
US20050272153A1 (en) | 2004-01-27 | 2005-12-08 | Zou Xuenong | Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal |
RU2297848C2 (ru) | 2005-05-11 | 2007-04-27 | Александр Веньяминович Иткес | Генно-инженерная конструкция vegf-ибмед (vegf-ibmed) |
US20070212332A1 (en) | 2005-08-11 | 2007-09-13 | Department Of Veterans Affairs | Methods for accelerating bone repair |
CA2925688C (en) * | 2005-09-09 | 2019-10-22 | Farshid Guilak | Tissue engineering methods and compositions |
RU2343928C1 (ru) | 2007-04-03 | 2009-01-20 | Открытое акционерное общество "Институт стволовых клеток человека" | Способ получения ядросодержащих клеток из пуповинной крови |
CN101925675A (zh) | 2007-11-28 | 2010-12-22 | 器官发生有限公司 | 生物工程化组织构建物及其制备和使用方法 |
RU2359030C1 (ru) | 2008-03-19 | 2009-06-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты) |
RU2384618C2 (ru) | 2008-03-27 | 2010-03-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения фибробластоподобных клеток из пупочного канатика новорожденного |
RU2414916C2 (ru) | 2008-12-22 | 2011-03-27 | Российская академия наук. Учреждение Российской академии наук институт цитологии РАН (ИНЦ РАН) | Способ совмещения культивированных остеогенных клеток и трехмерного материала-носителя |
RU2407063C2 (ru) | 2009-03-02 | 2010-12-20 | Федеральное государственное учреждение "Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р.Вредена Федерального агентства по высокотехнологичной медицинской помощи" (ФГУ "РНИИТО им. Р.Р.Вредена Росмедтехнологий") | Способ моделирования злокачественных соединительнотканных опухолей (сарком) |
RU2399667C1 (ru) | 2009-04-10 | 2010-09-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения плюрипотентных клеток |
US20110229970A1 (en) * | 2010-03-05 | 2011-09-22 | Florida State University Research Foundation | Dual-chamber perfusion bioreactor for orthopedic tissue interfaces and methods of use |
-
2011
- 2011-12-29 RU RU2011153873/15A patent/RU2519326C2/ru active
-
2012
- 2012-12-24 CN CN201280064772.0A patent/CN104203285A/zh active Pending
- 2012-12-24 WO PCT/RU2012/001103 patent/WO2013100818A2/en active Application Filing
- 2012-12-24 EP EP12861904.6A patent/EP2797633B1/en active Active
- 2012-12-24 US US14/369,008 patent/US9730959B2/en active Active
- 2012-12-24 CA CA2866483A patent/CA2866483C/en active Active
- 2012-12-24 ES ES12861904.6T patent/ES2617338T3/es active Active
- 2012-12-24 EA EA201400401A patent/EA031108B1/ru active IP Right Revival
- 2012-12-24 UA UAA201405515A patent/UA112450C2/uk unknown
Also Published As
Publication number | Publication date |
---|---|
RU2011153873A (ru) | 2013-07-10 |
US9730959B2 (en) | 2017-08-15 |
ES2617338T3 (es) | 2017-06-16 |
WO2013100818A2 (en) | 2013-07-04 |
CA2866483A1 (en) | 2013-07-04 |
EP2797633B1 (en) | 2016-11-30 |
EA031108B1 (ru) | 2018-11-30 |
WO2013100818A3 (en) | 2013-09-06 |
EP2797633A4 (en) | 2015-01-14 |
RU2519326C2 (ru) | 2014-06-10 |
CN104203285A (zh) | 2014-12-10 |
EP2797633A2 (en) | 2014-11-05 |
UA112450C2 (uk) | 2016-09-12 |
US20140341870A1 (en) | 2014-11-20 |
CA2866483C (en) | 2019-01-29 |
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