CN104519891B - 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 - Google Patents

用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 Download PDF

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CN104519891B
CN104519891B CN201380025599.8A CN201380025599A CN104519891B CN 104519891 B CN104519891 B CN 104519891B CN 201380025599 A CN201380025599 A CN 201380025599A CN 104519891 B CN104519891 B CN 104519891B
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cell
tbi
animal
cells
brain
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CN104519891A (zh
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C·V·博兰干
C·C·凯斯
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Sanbio Inc
University of South Florida St Petersburg
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Sanbio Inc
University of South Florida St Petersburg
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0618—Cells of the nervous system
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380025599.8A 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 Active CN104519891B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202211044392.2A CN115381855A (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
CN201910165600.6A CN109718250B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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US201261647893P 2012-05-16 2012-05-16
US61/647,893 2012-05-16
PCT/US2013/030895 WO2013172944A1 (en) 2012-05-16 2013-03-13 Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells

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CN201910165600.6A Division CN109718250B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
CN202211044392.2A Division CN115381855A (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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CN104519891B true CN104519891B (zh) 2019-03-22

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CN201910165600.6A Active CN109718250B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
CN202211044392.2A Pending CN115381855A (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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CN202211044392.2A Pending CN115381855A (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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US (4) US9828593B2 (https=)
EP (1) EP2849766B1 (https=)
JP (6) JP6134783B2 (https=)
CN (3) CN104519891B (https=)
AU (2) AU2013263417B2 (https=)
CA (1) CA2872188C (https=)
WO (1) WO2013172944A1 (https=)

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CN104519891B (zh) * 2012-05-16 2019-03-22 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
HK1208371A1 (en) 2012-10-09 2016-03-04 桑比欧公司 Methods and compositions for treatment of retinal degeneration
US20170065638A1 (en) * 2014-02-10 2017-03-09 Cytori Therapeutics, Inc. Regenerative cell therapy for central nervous system (cns) disorders and ptsd
CA2981523A1 (en) * 2015-04-01 2016-10-06 Sanbio, Inc. Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms
US10555972B2 (en) * 2016-02-26 2020-02-11 Innopeutics Corporation Therapeutic effects of NURR1 and FOXA2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells
WO2017152035A1 (en) * 2016-03-03 2017-09-08 Henry Ford Health System 3-d collagen scaffold-generated exosomes and uses thereof
JP7220149B2 (ja) 2016-12-28 2023-02-09 サンバイオ，インコーポレイティド 細胞送達システム及びその動作方法

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CN101008033A (zh) * 2006-01-27 2007-08-01 陈云 功能性中枢神经损伤诊断检测用基因芯片及其制造方法
CN100497621C (zh) * 2002-02-06 2009-06-10 桑比欧公司 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法
CN101801396A (zh) * 2007-08-15 2010-08-11 桑比欧公司 治疗神经变性的方法和组合物

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US20200354709A1 (en) 2020-11-12
US20150197741A1 (en) 2015-07-16
JP2015517520A (ja) 2015-06-22
JP2023099213A (ja) 2023-07-11
CA2872188C (en) 2018-08-14
EP2849766A1 (en) 2015-03-25
US9828593B2 (en) 2017-11-28
US20190185839A1 (en) 2019-06-20
JP2018111733A (ja) 2018-07-19
WO2013172944A1 (en) 2013-11-21
HK1206631A1 (en) 2016-01-15
JP2016220694A (ja) 2016-12-28
JP2021098738A (ja) 2021-07-01
CA2872188A1 (en) 2013-11-21
AU2016204910B2 (en) 2017-07-20
AU2016204910A1 (en) 2016-08-04
JP6134783B2 (ja) 2017-05-24
CN115381855A (zh) 2022-11-25
CN104519891A (zh) 2015-04-15
AU2013263417A1 (en) 2014-11-20
US10626389B2 (en) 2020-04-21
JP2025098021A (ja) 2025-07-01
EP2849766B1 (en) 2019-03-06
US20140186316A1 (en) 2014-07-03
CN109718250B (zh) 2022-08-30
AU2013263417B2 (en) 2016-05-26
CN109718250A (zh) 2019-05-07

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