JP2014517692A - ヘパラン−ｎ−スルファターゼを精製するためのプロセス - Google Patents

ヘパラン−ｎ−スルファターゼを精製するためのプロセス Download PDF

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Publication number
JP2014517692A
JP2014517692A JP2014511591A JP2014511591A JP2014517692A JP 2014517692 A JP2014517692 A JP 2014517692A JP 2014511591 A JP2014511591 A JP 2014511591A JP 2014511591 A JP2014511591 A JP 2014511591A JP 2014517692 A JP2014517692 A JP 2014517692A
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Prior art keywords
hns
heparan
sulfatase
column
resin
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JP2014511591A
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Japanese (ja)
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JP2014517692A5 (https=
Inventor
デイビッド ニコルス，
Original Assignee
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド
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Publication of JP2014517692A publication Critical patent/JP2014517692A/ja
Publication of JP2014517692A5 publication Critical patent/JP2014517692A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2014511591A 2011-05-19 2012-05-18 ヘパラン−ｎ−スルファターゼを精製するためのプロセス Ceased JP2014517692A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488090P 2011-05-19 2011-05-19
US61/488,090 2011-05-19
PCT/US2012/038630 WO2012159053A1 (en) 2011-05-19 2012-05-18 Process for purifying heparan-n-sulfatase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016214041A Division JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Publications (2)

Publication Number Publication Date
JP2014517692A true JP2014517692A (ja) 2014-07-24
JP2014517692A5 JP2014517692A5 (https=) 2015-07-02

Family

ID=47177365

Family Applications (2)

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JP2014511591A Ceased JP2014517692A (ja) 2011-05-19 2012-05-18 ヘパラン−ｎ−スルファターゼを精製するためのプロセス
JP2016214041A Pending JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016214041A Pending JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Country Status (8)

Country Link
US (1) US20120329133A1 (https=)
EP (2) EP2929892B1 (https=)
JP (2) JP2014517692A (https=)
AR (1) AR086445A1 (https=)
CA (1) CA2836599A1 (https=)
HK (1) HK1214960A1 (https=)
TW (1) TW201307563A (https=)
WO (1) WO2012159053A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524092A (ja) * 2002-04-26 2005-08-11 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
JP2011509674A (ja) * 2008-01-18 2011-03-31 バイオマリン ファーマシューティカル インコーポレイテッド 高度にリン酸化された活性なヒトリソソームスルファターゼ酵素の製造およびそれの使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100581574B1 (ko) * 2000-03-22 2006-05-22 옥타게네 게엠베하 인간 세포주 내 재조합 혈액 응고 인자의 제조
ATE494367T1 (de) * 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
CA2556245A1 (en) * 2004-02-06 2005-08-25 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
DK1828239T3 (da) * 2004-12-10 2011-12-19 Zymogenetics Inc FGF18-produktion i prokaryote værter
WO2008120801A1 (ja) * 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
NZ605874A (en) * 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of heparan n-sulfatase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524092A (ja) * 2002-04-26 2005-08-11 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
JP2011509674A (ja) * 2008-01-18 2011-03-31 バイオマリン ファーマシューティカル インコーポレイテッド 高度にリン酸化された活性なヒトリソソームスルファターゼ酵素の製造およびそれの使用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J., 1978, VOL. 181, PP. 677-684, JPN6016016509, ISSN: 0003308882 *
BIOCHEM. J., 1998, VOL. 329, PP. 145-150, JPN6016016506, ISSN: 0003308880 *
MOL. GENET. METAB., 2004, VOL. 83, PP. 239-245, JPN6016016505, ISSN: 0003308879 *
MOL. GENET. METAB., 2007, VOL. 90, PP. 313-328, JPN6016016508, ISSN: 0003308881 *

Also Published As

Publication number Publication date
AR086445A1 (es) 2013-12-11
CA2836599A1 (en) 2012-11-22
EP2709654A4 (en) 2014-11-12
EP2929892A1 (en) 2015-10-14
US20120329133A1 (en) 2012-12-27
TW201307563A (zh) 2013-02-16
EP2929892B1 (en) 2018-07-04
EP2709654A1 (en) 2014-03-26
HK1214960A1 (en) 2016-08-12
WO2012159053A1 (en) 2012-11-22
JP2017029170A (ja) 2017-02-09

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