CA2836599A1 - Process for purifying heparan-n-sulfatase - Google Patents
Process for purifying heparan-n-sulfatase Download PDFInfo
- Publication number
- CA2836599A1 CA2836599A1 CA2836599A CA2836599A CA2836599A1 CA 2836599 A1 CA2836599 A1 CA 2836599A1 CA 2836599 A CA2836599 A CA 2836599A CA 2836599 A CA2836599 A CA 2836599A CA 2836599 A1 CA2836599 A1 CA 2836599A1
- Authority
- CA
- Canada
- Prior art keywords
- hns
- process according
- heparan
- sulfatase
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010089932 heparan sulfate sulfatase Proteins 0.000 title claims abstract description 232
- 238000000034 method Methods 0.000 title claims description 76
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 74
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- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
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- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488090P | 2011-05-19 | 2011-05-19 | |
| US61/488,090 | 2011-05-19 | ||
| PCT/US2012/038630 WO2012159053A1 (en) | 2011-05-19 | 2012-05-18 | Process for purifying heparan-n-sulfatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2836599A1 true CA2836599A1 (en) | 2012-11-22 |
Family
ID=47177365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2836599A Abandoned CA2836599A1 (en) | 2011-05-19 | 2012-05-18 | Process for purifying heparan-n-sulfatase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120329133A1 (https=) |
| EP (2) | EP2929892B1 (https=) |
| JP (2) | JP2014517692A (https=) |
| AR (1) | AR086445A1 (https=) |
| CA (1) | CA2836599A1 (https=) |
| HK (1) | HK1214960A1 (https=) |
| TW (1) | TW201307563A (https=) |
| WO (1) | WO2012159053A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11584777B2 (en) | 2017-08-31 | 2023-02-21 | Green Cross Corporation | Method for purifying a sulfatase protein |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100581574B1 (ko) * | 2000-03-22 | 2006-05-22 | 옥타게네 게엠베하 | 인간 세포주 내 재조합 혈액 응고 인자의 제조 |
| CA2478925C (en) * | 2002-04-26 | 2016-06-07 | Robert Lee Fahrner | Non-affinity purification of proteins |
| ATE494367T1 (de) * | 2002-12-18 | 2011-01-15 | Hoffmann La Roche | Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität |
| CA2556245A1 (en) * | 2004-02-06 | 2005-08-25 | Biomarin Pharmaceutical Inc. | Manufacture of highly phosphorylated lysosomal enzymes and uses thereof |
| DK1828239T3 (da) * | 2004-12-10 | 2011-12-19 | Zymogenetics Inc | FGF18-produktion i prokaryote værter |
| WO2008120801A1 (ja) * | 2007-04-02 | 2008-10-09 | Kyowa Hakko Kirin Co., Ltd. | アンチトロンビン組成物の製造方法 |
| CN105274072A (zh) | 2008-01-18 | 2016-01-27 | 生物马林药物股份有限公司 | 制备活性高度磷酸化人溶酶体硫酸酯酶及其应用 |
| NZ605874A (en) * | 2010-06-25 | 2015-02-27 | Shire Human Genetic Therapies | Methods and compositions for cns delivery of heparan n-sulfatase |
-
2012
- 2012-05-17 TW TW101117561A patent/TW201307563A/zh unknown
- 2012-05-18 CA CA2836599A patent/CA2836599A1/en not_active Abandoned
- 2012-05-18 EP EP15166651.8A patent/EP2929892B1/en active Active
- 2012-05-18 AR ARP120101760A patent/AR086445A1/es unknown
- 2012-05-18 WO PCT/US2012/038630 patent/WO2012159053A1/en not_active Ceased
- 2012-05-18 EP EP12785579.9A patent/EP2709654A4/en not_active Withdrawn
- 2012-05-18 JP JP2014511591A patent/JP2014517692A/ja not_active Ceased
- 2012-05-18 US US13/475,568 patent/US20120329133A1/en not_active Abandoned
-
2016
- 2016-03-15 HK HK16102969.5A patent/HK1214960A1/en unknown
- 2016-11-01 JP JP2016214041A patent/JP2017029170A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AR086445A1 (es) | 2013-12-11 |
| JP2014517692A (ja) | 2014-07-24 |
| EP2709654A4 (en) | 2014-11-12 |
| EP2929892A1 (en) | 2015-10-14 |
| US20120329133A1 (en) | 2012-12-27 |
| TW201307563A (zh) | 2013-02-16 |
| EP2929892B1 (en) | 2018-07-04 |
| EP2709654A1 (en) | 2014-03-26 |
| HK1214960A1 (en) | 2016-08-12 |
| WO2012159053A1 (en) | 2012-11-22 |
| JP2017029170A (ja) | 2017-02-09 |
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| FZDE | Discontinued |
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