WO2008120801A1 - アンチトロンビン組成物の製造方法 - Google Patents

アンチトロンビン組成物の製造方法 Download PDF

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Publication number
WO2008120801A1
WO2008120801A1 PCT/JP2008/056600 JP2008056600W WO2008120801A1 WO 2008120801 A1 WO2008120801 A1 WO 2008120801A1 JP 2008056600 W JP2008056600 W JP 2008056600W WO 2008120801 A1 WO2008120801 A1 WO 2008120801A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound content
antithrombin
antithrombin composition
composition
producing
Prior art date
Application number
PCT/JP2008/056600
Other languages
English (en)
French (fr)
Inventor
Tsutomu Sugihara
Setsuko Onodera
Tomonari Urakubo
Toshiyuki Suzawa
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Priority to EP08739710A priority Critical patent/EP2141178A4/en
Priority to US12/594,423 priority patent/US8076462B2/en
Priority to JP2009507556A priority patent/JP4772905B2/ja
Publication of WO2008120801A1 publication Critical patent/WO2008120801A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　所望のα体含有率またはβ体含有率を有するアンチトロンビン組成物の提供が求められている。本発明により、アンチトロンビン含有水溶液をセルファインサルフェイトクロマトグラフィ担体に接触させることにより、所望のα体またはβ体含有率を有するアンチトロンビン組成物を調製する、アンチトロンビンの製造方法が提供される。
PCT/JP2008/056600 2007-04-02 2008-04-02 アンチトロンビン組成物の製造方法 WO2008120801A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08739710A EP2141178A4 (en) 2007-04-02 2008-04-02 PROCESS FOR PRODUCING ANTITHROMBIN COMPOSITION
US12/594,423 US8076462B2 (en) 2007-04-02 2008-04-02 Method for producing antithrombin composition
JP2009507556A JP4772905B2 (ja) 2007-04-02 2008-04-02 アンチトロンビン組成物の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007096179 2007-04-02
JP2007-096179 2007-04-02

Publications (1)

Publication Number Publication Date
WO2008120801A1 true WO2008120801A1 (ja) 2008-10-09

Family

ID=39808382

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056600 WO2008120801A1 (ja) 2007-04-02 2008-04-02 アンチトロンビン組成物の製造方法

Country Status (4)

Country Link
US (1) US8076462B2 (ja)
EP (1) EP2141178A4 (ja)
JP (1) JP4772905B2 (ja)
WO (1) WO2008120801A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014503495A (ja) * 2010-11-15 2014-02-13 バイオジェン アイデック インコーポレイテッド 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮
JPWO2013002330A1 (ja) * 2011-06-29 2015-02-23 協和発酵キリン株式会社 たん白質の精製方法
JP2017222641A (ja) * 2016-06-09 2017-12-21 静岡県公立大学法人 シアリダーゼ阻害活性を有する化合物を含むインスリン分泌促進剤、血糖値上昇抑制剤及び糖尿病治療剤、並びにそれらの剤のスクリーニング方法
EP3643722A1 (en) 2012-08-07 2020-04-29 Kyowa Kirin Co., Ltd. Method of purifying protein
WO2020166557A1 (ja) 2019-02-11 2020-08-20 協和キリン株式会社 妊娠高血圧腎症の治療方法
WO2022239704A1 (ja) 2021-05-10 2022-11-17 株式会社カイオム・バイオサイエンス 抗体組成物の精製方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008120801A1 (ja) * 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
TW201307563A (zh) * 2011-05-19 2013-02-16 Shire Human Genetic Therapies 純化乙醯肝素－ｎ－硫酸酯酶之方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339919A2 (en) * 1988-04-28 1989-11-02 The Green Cross Corporation Method for purifying antithrombin-III and antithrombin-III preparation containing said antithrombin-III
US5510261A (en) 1991-11-21 1996-04-23 The Board Of Trustees Of The Leland Stanford Juniot University Method of controlling the degradation of glycoprotein oligosaccharides produced by cultured Chinese hamster ovary cells
JPH08510133A (ja) 1993-05-17 1996-10-29 ジェネンテク，インコーポレイテッド 組み替えｄｎａ技術によるｃｈｏ細胞シアリダーゼ
JP2678249B2 (ja) 1988-06-22 1997-11-17 株式会社ミドリ十字 アンチトロンビン−▲ｉｉｉ▼製剤
JP2852307B2 (ja) 1989-02-09 1999-02-03 吉富製薬株式会社 ウイルスの除去された蛋白質製剤の製造法
WO2001053328A1 (en) * 2000-01-21 2001-07-26 Biovitrum Ab Process for the purification of antothrombin-iii
WO2001053329A1 (en) * 2000-01-21 2001-07-26 Biovitrum Ab Process for the purification of antithrombin-iii
JP2002196004A (ja) 2000-05-08 2002-07-10 Aventis Behring Gmbh シクロデキストリン改変ミセルエレクトロキネティッククロマトグラフィーによる抗トロンビンｉｉｉ変種の分離
US6528286B1 (en) 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
WO2007108464A1 (ja) 2006-03-20 2007-09-27 Kyowa Hakko Kogyo Co., Ltd. 哺乳動物由来細胞質シアリダーゼに対する抗体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008120801A1 (ja) * 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339919A2 (en) * 1988-04-28 1989-11-02 The Green Cross Corporation Method for purifying antithrombin-III and antithrombin-III preparation containing said antithrombin-III
JP2678249B2 (ja) 1988-06-22 1997-11-17 株式会社ミドリ十字 アンチトロンビン−▲ｉｉｉ▼製剤
JP2852307B2 (ja) 1989-02-09 1999-02-03 吉富製薬株式会社 ウイルスの除去された蛋白質製剤の製造法
US5510261A (en) 1991-11-21 1996-04-23 The Board Of Trustees Of The Leland Stanford Juniot University Method of controlling the degradation of glycoprotein oligosaccharides produced by cultured Chinese hamster ovary cells
JPH08510133A (ja) 1993-05-17 1996-10-29 ジェネンテク，インコーポレイテッド 組み替えｄｎａ技術によるｃｈｏ細胞シアリダーゼ
US6528286B1 (en) 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
WO2001053328A1 (en) * 2000-01-21 2001-07-26 Biovitrum Ab Process for the purification of antothrombin-iii
WO2001053329A1 (en) * 2000-01-21 2001-07-26 Biovitrum Ab Process for the purification of antithrombin-iii
JP2003520805A (ja) 2000-01-21 2003-07-08 オクタファルマ・アーゲー 抗トロンビンｉｉｉの精製の方法
JP2003520806A (ja) 2000-01-21 2003-07-08 オクタファルマ・アーゲー 抗トロンビンｉｉｉの精製の方法
JP2002196004A (ja) 2000-05-08 2002-07-10 Aventis Behring Gmbh シクロデキストリン改変ミセルエレクトロキネティッククロマトグラフィーによる抗トロンビンｉｉｉ変種の分離
WO2007108464A1 (ja) 2006-03-20 2007-09-27 Kyowa Hakko Kogyo Co., Ltd. 哺乳動物由来細胞質シアリダーゼに対する抗体

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MOCHIZUKI S. ET AL.: "PURIFICATION AND CHARACTERIZATION OF RECOMBINANT HUMAN ANTITHROMBIN CONTAINING THE PRELATENT FORM IN CHINESE HAMSTER OVARY CELLS", EXPRESSION & PURIFICATION, vol. 41, 2005, pages 323 - 331, XP004875121 *
PETERSON C.B. AND BLACKBURN M.N.: "ISOLATION AND CHARACTERIZATION OF AN ANTITHROMBIN III VARIANT THE REDUCED CARBOHYDRATE CONTENT AND ENHANCED HEPARIN BINDING", J. BIOL. CHEM., vol. 260, no. 1, 1985, pages 610 - 615, XP000876939 *
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014503495A (ja) * 2010-11-15 2014-02-13 バイオジェン アイデック インコーポレイテッド 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮
JPWO2013002330A1 (ja) * 2011-06-29 2015-02-23 協和発酵キリン株式会社 たん白質の精製方法
EP3643722A1 (en) 2012-08-07 2020-04-29 Kyowa Kirin Co., Ltd. Method of purifying protein
JP2017222641A (ja) * 2016-06-09 2017-12-21 静岡県公立大学法人 シアリダーゼ阻害活性を有する化合物を含むインスリン分泌促進剤、血糖値上昇抑制剤及び糖尿病治療剤、並びにそれらの剤のスクリーニング方法
JP6990903B2 (ja) 2016-06-09 2022-02-15 静岡県公立大学法人 シアリダーゼ阻害活性を有する化合物を含むインスリン分泌促進剤、血糖値上昇抑制剤及び糖尿病治療剤、並びにそれらの剤のスクリーニング方法
WO2020166557A1 (ja) 2019-02-11 2020-08-20 協和キリン株式会社 妊娠高血圧腎症の治療方法
WO2022239704A1 (ja) 2021-05-10 2022-11-17 株式会社カイオム・バイオサイエンス 抗体組成物の精製方法
KR20240005771A (ko) 2021-05-10 2024-01-12 치오메 바이오사이언스 가부시키가이샤 항체 조성물의 정제 방법

Also Published As

Publication number Publication date
EP2141178A4 (en) 2010-05-19
US20100113754A1 (en) 2010-05-06
JP4772905B2 (ja) 2011-09-14
EP2141178A1 (en) 2010-01-06
US8076462B2 (en) 2011-12-13
JPWO2008120801A1 (ja) 2010-07-15

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