TW201307563A - 純化乙醯肝素-n-硫酸酯酶之方法 - Google Patents

純化乙醯肝素-n-硫酸酯酶之方法 Download PDF

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Publication number
TW201307563A
TW201307563A TW101117561A TW101117561A TW201307563A TW 201307563 A TW201307563 A TW 201307563A TW 101117561 A TW101117561 A TW 101117561A TW 101117561 A TW101117561 A TW 101117561A TW 201307563 A TW201307563 A TW 201307563A
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TW
Taiwan
Prior art keywords
hns
sulfatase
heparin
column
composition
Prior art date
Application number
TW101117561A
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English (en)
Chinese (zh)
Inventor
David Nichols
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Publication of TW201307563A publication Critical patent/TW201307563A/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
TW101117561A 2011-05-19 2012-05-17 純化乙醯肝素-n-硫酸酯酶之方法 TW201307563A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161488090P 2011-05-19 2011-05-19

Publications (1)

Publication Number Publication Date
TW201307563A true TW201307563A (zh) 2013-02-16

Family

ID=47177365

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101117561A TW201307563A (zh) 2011-05-19 2012-05-17 純化乙醯肝素-n-硫酸酯酶之方法

Country Status (8)

Country Link
US (1) US20120329133A1 (https=)
EP (2) EP2929892B1 (https=)
JP (2) JP2014517692A (https=)
AR (1) AR086445A1 (https=)
CA (1) CA2836599A1 (https=)
HK (1) HK1214960A1 (https=)
TW (1) TW201307563A (https=)
WO (1) WO2012159053A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100581574B1 (ko) * 2000-03-22 2006-05-22 옥타게네 게엠베하 인간 세포주 내 재조합 혈액 응고 인자의 제조
CA2478925C (en) * 2002-04-26 2016-06-07 Robert Lee Fahrner Non-affinity purification of proteins
ATE494367T1 (de) * 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
CA2556245A1 (en) * 2004-02-06 2005-08-25 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
DK1828239T3 (da) * 2004-12-10 2011-12-19 Zymogenetics Inc FGF18-produktion i prokaryote værter
WO2008120801A1 (ja) * 2007-04-02 2008-10-09 Kyowa Hakko Kirin Co., Ltd. アンチトロンビン組成物の製造方法
CN105274072A (zh) 2008-01-18 2016-01-27 生物马林药物股份有限公司 制备活性高度磷酸化人溶酶体硫酸酯酶及其应用
NZ605874A (en) * 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of heparan n-sulfatase

Also Published As

Publication number Publication date
AR086445A1 (es) 2013-12-11
JP2014517692A (ja) 2014-07-24
CA2836599A1 (en) 2012-11-22
EP2709654A4 (en) 2014-11-12
EP2929892A1 (en) 2015-10-14
US20120329133A1 (en) 2012-12-27
EP2929892B1 (en) 2018-07-04
EP2709654A1 (en) 2014-03-26
HK1214960A1 (en) 2016-08-12
WO2012159053A1 (en) 2012-11-22
JP2017029170A (ja) 2017-02-09

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