JP2014517308A5 - - Google Patents
Info
- Publication number
- JP2014517308A5 JP2014517308A5 JP2014513942A JP2014513942A JP2014517308A5 JP 2014517308 A5 JP2014517308 A5 JP 2014517308A5 JP 2014513942 A JP2014513942 A JP 2014513942A JP 2014513942 A JP2014513942 A JP 2014513942A JP 2014517308 A5 JP2014517308 A5 JP 2014517308A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarker
- subject
- level
- determining
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000090 biomarker Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 28
- 208000015872 Gaucher disease Diseases 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 6
- 102100023701 C-C motif chemokine 18 Human genes 0.000 claims description 2
- 102100037328 Chitotriosidase-1 Human genes 0.000 claims description 2
- 238000000018 DNA microarray Methods 0.000 claims description 2
- 101000978371 Homo sapiens C-C motif chemokine 18 Proteins 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 108010057052 chitotriosidase Proteins 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11004597.8 | 2011-06-06 | ||
| EP11004597A EP2533051A1 (en) | 2011-06-06 | 2011-06-06 | Method for the diagnosis of Gaucher's disease |
| PCT/EP2012/002409 WO2012167925A1 (en) | 2011-06-06 | 2012-06-06 | Method for the diagnosis of gaucher's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017062025A Division JP6514256B2 (ja) | 2011-06-06 | 2017-03-28 | ゴーシェ病の診断のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517308A JP2014517308A (ja) | 2014-07-17 |
| JP2014517308A5 true JP2014517308A5 (https=) | 2015-07-23 |
| JP6120832B2 JP6120832B2 (ja) | 2017-04-26 |
Family
ID=44652046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513942A Expired - Fee Related JP6120832B2 (ja) | 2011-06-06 | 2012-06-06 | ゴーシェ病の診断のための方法 |
| JP2017062025A Expired - Fee Related JP6514256B2 (ja) | 2011-06-06 | 2017-03-28 | ゴーシェ病の診断のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017062025A Expired - Fee Related JP6514256B2 (ja) | 2011-06-06 | 2017-03-28 | ゴーシェ病の診断のための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10859580B2 (https=) |
| EP (4) | EP2533051A1 (https=) |
| JP (2) | JP6120832B2 (https=) |
| CN (1) | CN103582818B (https=) |
| AU (2) | AU2012266768B2 (https=) |
| BR (1) | BR112013031431B1 (https=) |
| CA (1) | CA2837609C (https=) |
| DK (2) | DK3318881T3 (https=) |
| ES (2) | ES2659753T3 (https=) |
| IL (2) | IL229607B (https=) |
| NO (1) | NO2718725T3 (https=) |
| PL (2) | PL3318881T3 (https=) |
| PT (2) | PT3318881T (https=) |
| RU (1) | RU2666952C2 (https=) |
| WO (1) | WO2012167925A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2893609A1 (en) * | 2012-12-11 | 2014-06-19 | Centogene Ag | Method for the diagnosis of metachromatic leukodystrophy |
| EP3105588A1 (en) * | 2014-02-11 | 2016-12-21 | Yeda Research and Development Co., Ltd. | Marker of neuropathic gaucher's disease and methods of use thereof |
| CN105463085A (zh) * | 2015-12-11 | 2016-04-06 | 上海新培晶医学检验所有限公司 | 一种检测戈谢病gba基因突变的试剂盒及其检测方法 |
| EP3264092A1 (en) | 2016-07-01 | 2018-01-03 | Centogene AG | Use of lyso-gb1 as druggable target |
| RU2629626C1 (ru) * | 2016-10-05 | 2017-08-30 | Федеральное государственное автономное учреждение "Научный центр здоровья детей" Министерства здравоохранения Российской Федерации (ФГАУ "НЦЗД" Минздрава России) | Способ оценки эффективности лечения болезни Гоше у детей |
| US12246037B2 (en) | 2020-12-08 | 2025-03-11 | Todd Frank Ovokaitys | Methods and systems for increased production of stem cells |
| IL317112A (en) * | 2022-06-01 | 2025-01-01 | Univ Antwerpen | Method for detecting biomarkers of lysosomal storage disease and kits for performing the method |
| WO2024211616A1 (en) * | 2023-04-04 | 2024-10-10 | Ovokaitys Todd Frank | Methods and systems for improved therapies of genetic diseases using photo-activated allogenic stem cells |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
| UA63743A (en) * | 2003-06-09 | 2004-01-15 | Kyiv P Shupyk Medical Academy | Method for diagnosing gaucher disease |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| AU2006254796B2 (en) | 2005-06-08 | 2012-08-16 | Amicus Therapeutics, Inc. | Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes |
| WO2007150064A2 (en) * | 2006-06-23 | 2007-12-27 | Amicus Therapeutics, Inc. | METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF β-GLUCOCEREBROSIDASE |
| JP5586453B2 (ja) * | 2007-04-13 | 2014-09-10 | アミカス セラピューティックス インコーポレイテッド | 特異的薬理シャペロンによるゴーシェ病の治療および代理マーカーを用いた治療の監視 |
| MX2009011473A (es) * | 2007-04-26 | 2010-01-18 | Amicus Therapeutics Inc | Regimenes de dosificacion para el tratamiento de enfermedades por almacenamiento lisosomal que utilizan chaperonas farmacologicas. |
| EP2154969B1 (en) * | 2007-05-16 | 2015-11-18 | The Brigham and Women's Hospital, Inc. | Treatment of synucleinopathies |
| GB2480159A (en) * | 2008-11-14 | 2011-11-09 | Parkinson S Inst | Compositions and methods for the treatment of altered a-synuclein function |
-
2011
- 2011-06-06 EP EP11004597A patent/EP2533051A1/en not_active Withdrawn
-
2012
- 2012-06-06 DK DK17206796.9T patent/DK3318881T3/da active
- 2012-06-06 RU RU2013158667A patent/RU2666952C2/ru active
- 2012-06-06 EP EP17206796.9A patent/EP3318881B1/en not_active Revoked
- 2012-06-06 PT PT172067969T patent/PT3318881T/pt unknown
- 2012-06-06 ES ES12728976.7T patent/ES2659753T3/es active Active
- 2012-06-06 BR BR112013031431-1A patent/BR112013031431B1/pt not_active IP Right Cessation
- 2012-06-06 JP JP2014513942A patent/JP6120832B2/ja not_active Expired - Fee Related
- 2012-06-06 PL PL17206796T patent/PL3318881T3/pl unknown
- 2012-06-06 PL PL12728976T patent/PL2718725T3/pl unknown
- 2012-06-06 DK DK12728976.7T patent/DK2718725T3/en active
- 2012-06-06 EP EP20185233.2A patent/EP3742168A1/en not_active Withdrawn
- 2012-06-06 CA CA2837609A patent/CA2837609C/en active Active
- 2012-06-06 AU AU2012266768A patent/AU2012266768B2/en not_active Ceased
- 2012-06-06 EP EP12728976.7A patent/EP2718725B1/en not_active Revoked
- 2012-06-06 CN CN201280027860.3A patent/CN103582818B/zh not_active Expired - Fee Related
- 2012-06-06 ES ES17206796T patent/ES2820361T3/es active Active
- 2012-06-06 US US14/124,375 patent/US10859580B2/en not_active Expired - Fee Related
- 2012-06-06 NO NO12728976A patent/NO2718725T3/no unknown
- 2012-06-06 WO PCT/EP2012/002409 patent/WO2012167925A1/en not_active Ceased
- 2012-06-06 PT PT127289767T patent/PT2718725T/pt unknown
-
2013
- 2013-11-25 IL IL229607A patent/IL229607B/en active IP Right Grant
-
2017
- 2017-03-28 JP JP2017062025A patent/JP6514256B2/ja not_active Expired - Fee Related
- 2017-09-25 AU AU2017232226A patent/AU2017232226B2/en not_active Ceased
-
2018
- 2018-04-30 US US15/966,734 patent/US11092609B2/en not_active Expired - Fee Related
- 2018-06-17 IL IL260078A patent/IL260078B/en active IP Right Grant
-
2021
- 2021-07-20 US US17/380,257 patent/US20220011321A1/en not_active Abandoned
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