JP2014516947A - フラッシュ・グロー型の１，２−ジオキセタン - Google Patents

フラッシュ・グロー型の１，２−ジオキセタン Download PDF

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JP2014516947A
JP2014516947A JP2014509331A JP2014509331A JP2014516947A JP 2014516947 A JP2014516947 A JP 2014516947A JP 2014509331 A JP2014509331 A JP 2014509331A JP 2014509331 A JP2014509331 A JP 2014509331A JP 2014516947 A JP2014516947 A JP 2014516947A
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carbon atoms
enzyme
compound
light
group
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JP2014516947A5 (enExample
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アルバーナ ミハイ
ブルックス エドワーズ
チーシアン ワン
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ライフ テクノロジーズ コーポレーション
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
    • H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
    • H01L21/02104—Forming layers
    • H01L21/02365—Forming inorganic semiconducting materials on a substrate
    • H01L21/02436—Intermediate layers between substrates and deposited layers
    • H01L21/02439—Materials
    • H01L21/02491—Conductive materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Power Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014509331A 2011-05-03 2012-04-30 フラッシュ・グロー型の１，２−ジオキセタン Pending JP2014516947A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161482134P 2011-05-03 2011-05-03
US61/482,134 2011-05-03
PCT/US2012/035732 WO2012151142A2 (en) 2011-05-03 2012-04-30 Flash and glow 1,2-dioxetanes

Related Child Applications (1)

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JP2016192667A Division JP6440265B2 (ja) 2011-05-03 2016-09-30 フラッシュ・グロー型の１，２−ジオキセタン

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JP2014516947A true JP2014516947A (ja) 2014-07-17
JP2014516947A5 JP2014516947A5 (enExample) 2015-05-07

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JP2016192667A Active JP6440265B2 (ja) 2011-05-03 2016-09-30 フラッシュ・グロー型の１，２−ジオキセタン

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US (4) US20140154675A1 (enExample)
EP (1) EP2705031B1 (enExample)
JP (2) JP2014516947A (enExample)
KR (1) KR101960113B1 (enExample)
CN (1) CN103649069B (enExample)
WO (1) WO2012151142A2 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3211050A1 (en) * 2016-02-26 2017-08-30 Trinseo Europe GmbH Molded structures of polycarbonate based substrates over molded with silicone rubbers
JP7125144B2 (ja) 2016-09-09 2022-08-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド エクトヌクレオチダーゼ阻害剤およびその使用方法
US10570167B2 (en) 2016-12-22 2020-02-25 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
US11078228B2 (en) 2018-06-21 2021-08-03 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
WO2021086977A1 (en) * 2019-10-28 2021-05-06 Beckman Coulter, Inc. Rapid, high-intensity chemiluminescent dioxetanes
WO2025160017A1 (en) * 2024-01-26 2025-07-31 Beckman Coulter, Inc. Assay methods using chemiluminescent dioxetane compounds

Citations (11)

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JPH02131478A (ja) * 1988-06-30 1990-05-21 Tropix Inc 新規な化学発光性１，２―ジオキセタン化合物，発光方法および検定方法
JPH07509736A (ja) * 1993-05-07 1995-10-26 トロピックス・インコーポレーテッド 改良された化学発光性１，２−ジオキセタン類
JPH08502968A (ja) * 1992-10-30 1996-04-02 アボツト・ラボラトリーズ 電子数の多い化学発光性アリール置換１，２−ジオキセタン
JPH08245615A (ja) * 1995-03-11 1996-09-24 Masakatsu Matsumoto １，２−ジオキセタン誘導体
JPH10508846A (ja) * 1994-11-14 1998-09-02 トロピックス・インコーポレーテッド ハロアルコキシ基を有する新規な１，２−ジオキセタン化合物、その調製方法及びその用途
JPH11500222A (ja) * 1995-02-13 1999-01-06 トロピックス・インコーポレーテッド 化学ルミネセンスエネルギー移動アッセイ
JPH11515004A (ja) * 1995-10-24 1999-12-21 トロピックス・インコーポレーテッド 改良された性能を有する１，２化学発光性ジオキセタン類
WO2000014092A1 (en) * 1998-09-08 2000-03-16 Giri Brij P Chemiluminescent 1,2-dioxetanes
JP2002521447A (ja) * 1998-07-28 2002-07-16 トロピックス・インコーポレーテッド ベンゾチアゾールジオキセタン類
JP2005502688A (ja) * 2001-09-05 2005-01-27 アプレーラ コーポレイション ヘテロアリール置換ベンゾチアゾールジオキセタン
WO2009139811A2 (en) * 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection

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CA1340590C (en) 1986-07-24 1999-06-08 John C. Voyta Chemiluminescence enhancement
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5326882A (en) * 1989-07-17 1994-07-05 Tropix, Inc. Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
US5994073A (en) 1990-08-30 1999-11-30 Tropix, Inc. Enhancement of chemiluminescent assays
US5547836A (en) 1990-08-30 1996-08-20 Tropix, Inc. Enhancement of chemiluminescent assays
JP3855033B2 (ja) * 1995-09-08 2006-12-06 高砂香料工業株式会社 光学活性３−ヒドロキシ−γ−ブチロラクトンの製造方法
US5679803A (en) * 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
ATE221061T1 (de) * 1995-10-17 2002-08-15 Tropix Inc Chemilumineszente 1,2-dioxetane mit verbesserter leistung
US7416898B2 (en) * 2002-10-04 2008-08-26 Giri Brij P Chemiluminescent 1,2-dioxetanes
US7781229B2 (en) * 2004-04-14 2010-08-24 Michigan Diagnostics, Llc Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
US20060079699A1 (en) * 2004-08-27 2006-04-13 Brooks Edwards Intermediate compounds and methods for synthesizing chemiluminescent dioxetane substrates
EP1787365A4 (en) * 2004-09-09 2009-10-21 Applera Corp DIOXETANNANOPARTICLE ARRANGEMENTS FOR ENERGY TRANSMISSION DETECTION SYSTEMS, METHOD FOR MANUFACTURING THE ARRANGEMENTS, AND METHOD FOR USING THE ORGANIZATIONS IN BIOTESTS
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WO2010101839A2 (en) * 2009-03-02 2010-09-10 Life Technologies Corporation Chemiluminescent compositions, methods, assays and kits for oxidative enzymes

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02131478A (ja) * 1988-06-30 1990-05-21 Tropix Inc 新規な化学発光性１，２―ジオキセタン化合物，発光方法および検定方法
JPH08502968A (ja) * 1992-10-30 1996-04-02 アボツト・ラボラトリーズ 電子数の多い化学発光性アリール置換１，２−ジオキセタン
JP2008164600A (ja) * 1992-10-30 2008-07-17 Abbott Lab 電子数の多い化学発光性アリール置換１，２−ジオキセタン
JPH07509736A (ja) * 1993-05-07 1995-10-26 トロピックス・インコーポレーテッド 改良された化学発光性１，２−ジオキセタン類
JPH10508846A (ja) * 1994-11-14 1998-09-02 トロピックス・インコーポレーテッド ハロアルコキシ基を有する新規な１，２−ジオキセタン化合物、その調製方法及びその用途
JPH11500222A (ja) * 1995-02-13 1999-01-06 トロピックス・インコーポレーテッド 化学ルミネセンスエネルギー移動アッセイ
JPH08245615A (ja) * 1995-03-11 1996-09-24 Masakatsu Matsumoto １，２−ジオキセタン誘導体
JPH11515004A (ja) * 1995-10-24 1999-12-21 トロピックス・インコーポレーテッド 改良された性能を有する１，２化学発光性ジオキセタン類
JP2002521447A (ja) * 1998-07-28 2002-07-16 トロピックス・インコーポレーテッド ベンゾチアゾールジオキセタン類
WO2000014092A1 (en) * 1998-09-08 2000-03-16 Giri Brij P Chemiluminescent 1,2-dioxetanes
JP2005502688A (ja) * 2001-09-05 2005-01-27 アプレーラ コーポレイション ヘテロアリール置換ベンゾチアゾールジオキセタン
WO2009139811A2 (en) * 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection

Also Published As

Publication number Publication date
WO2012151142A3 (en) 2013-01-10
US20200056222A1 (en) 2020-02-20
HK1193608A1 (zh) 2014-09-26
EP2705031B1 (en) 2018-04-11
JP2017039743A (ja) 2017-02-23
KR20140039213A (ko) 2014-04-01
US20220010356A1 (en) 2022-01-13
US20140154675A1 (en) 2014-06-05
CN103649069B (zh) 2016-09-14
US20170321245A1 (en) 2017-11-09
JP6440265B2 (ja) 2018-12-19
EP2705031A2 (en) 2014-03-12
KR101960113B1 (ko) 2019-03-19
WO2012151142A2 (en) 2012-11-08
CN103649069A (zh) 2014-03-19

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