CN103649069B - 闪光和辉光1,2-二氧杂环丁烷类 - Google Patents

闪光和辉光1,2-二氧杂环丁烷类 Download PDF

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Publication number
CN103649069B
CN103649069B CN201280021603.9A CN201280021603A CN103649069B CN 103649069 B CN103649069 B CN 103649069B CN 201280021603 A CN201280021603 A CN 201280021603A CN 103649069 B CN103649069 B CN 103649069B
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enzyme
carbon atoms
group
light
compound
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CN103649069A (zh
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A.米哈利
B.爱德华兹
Z.王
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Life Technologies Corp
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Life Technologies Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
    • H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
    • H01L21/02104—Forming layers
    • H01L21/02365—Forming inorganic semiconducting materials on a substrate
    • H01L21/02436—Intermediate layers between substrates and deposited layers
    • H01L21/02439—Materials
    • H01L21/02491—Conductive materials

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Power Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280021603.9A 2011-05-03 2012-04-30 闪光和辉光1,2-二氧杂环丁烷类 Active CN103649069B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161482134P 2011-05-03 2011-05-03
US61/482134 2011-05-03
US61/482,134 2011-05-03
PCT/US2012/035732 WO2012151142A2 (en) 2011-05-03 2012-04-30 Flash and glow 1,2-dioxetanes

Publications (2)

Publication Number Publication Date
CN103649069A CN103649069A (zh) 2014-03-19
CN103649069B true CN103649069B (zh) 2016-09-14

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Country Link
US (4) US20140154675A1 (enExample)
EP (1) EP2705031B1 (enExample)
JP (2) JP2014516947A (enExample)
KR (1) KR101960113B1 (enExample)
CN (1) CN103649069B (enExample)
WO (1) WO2012151142A2 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3211050A1 (en) * 2016-02-26 2017-08-30 Trinseo Europe GmbH Molded structures of polycarbonate based substrates over molded with silicone rubbers
JP7125144B2 (ja) 2016-09-09 2022-08-24 キャリセラ バイオサイエンシーズ， インコーポレイテッド エクトヌクレオチダーゼ阻害剤およびその使用方法
US10570167B2 (en) 2016-12-22 2020-02-25 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
US11078228B2 (en) 2018-06-21 2021-08-03 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
WO2021086977A1 (en) * 2019-10-28 2021-05-06 Beckman Coulter, Inc. Rapid, high-intensity chemiluminescent dioxetanes
WO2025160017A1 (en) * 2024-01-26 2025-07-31 Beckman Coulter, Inc. Assay methods using chemiluminescent dioxetane compounds

Citations (1)

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US5780649A (en) * 1995-09-08 1998-07-14 Takasago International Corporation Process for preparing optically active cyclic compounds

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CA1340590C (en) 1986-07-24 1999-06-08 John C. Voyta Chemiluminescence enhancement
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
US5326882A (en) * 1989-07-17 1994-07-05 Tropix, Inc. Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
US5994073A (en) 1990-08-30 1999-11-30 Tropix, Inc. Enhancement of chemiluminescent assays
US5547836A (en) 1990-08-30 1996-08-20 Tropix, Inc. Enhancement of chemiluminescent assays
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
US5773628A (en) * 1994-11-14 1998-06-30 Tropix, Inc. 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use
JPH11500222A (ja) * 1995-02-13 1999-01-06 トロピックス・インコーポレーテッド 化学ルミネセンスエネルギー移動アッセイ
JPH08245615A (ja) * 1995-03-11 1996-09-24 Masakatsu Matsumoto １，２−ジオキセタン誘導体
US5679803A (en) * 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
ATE221061T1 (de) * 1995-10-17 2002-08-15 Tropix Inc Chemilumineszente 1,2-dioxetane mit verbesserter leistung
JP4519320B2 (ja) * 1998-07-28 2010-08-04 アプライド バイオシステムズ， エルエルシー ベンゾチアゾールジオキセタン類
US6660529B2 (en) * 1998-07-28 2003-12-09 Pe Corporation Heteroaryl substituted benzothiazole dioxetanes
DE69941786D1 (de) * 1998-09-08 2010-01-21 Brij P Giri Chemolumineszente 1,2-dioxetane
US7416898B2 (en) * 2002-10-04 2008-08-26 Giri Brij P Chemiluminescent 1,2-dioxetanes
US7781229B2 (en) * 2004-04-14 2010-08-24 Michigan Diagnostics, Llc Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
US20060079699A1 (en) * 2004-08-27 2006-04-13 Brooks Edwards Intermediate compounds and methods for synthesizing chemiluminescent dioxetane substrates
EP1787365A4 (en) * 2004-09-09 2009-10-21 Applera Corp DIOXETANNANOPARTICLE ARRANGEMENTS FOR ENERGY TRANSMISSION DETECTION SYSTEMS, METHOD FOR MANUFACTURING THE ARRANGEMENTS, AND METHOD FOR USING THE ORGANIZATIONS IN BIOTESTS
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US5780649A (en) * 1995-09-08 1998-07-14 Takasago International Corporation Process for preparing optically active cyclic compounds

Non-Patent Citations (1)

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Title
A Novel Substitution Process for the Preparation of Alkoxy-, Aryloxy-, and Acyloxy-Substituted 1,2-Dioxetanes;Hashem Akhavan-Tafti et al.;《J. Am. Chem. Soc.》;19971231;第119卷(第1期);第245-246页 *

Also Published As

Publication number Publication date
WO2012151142A3 (en) 2013-01-10
US20200056222A1 (en) 2020-02-20
HK1193608A1 (zh) 2014-09-26
EP2705031B1 (en) 2018-04-11
JP2017039743A (ja) 2017-02-23
JP2014516947A (ja) 2014-07-17
KR20140039213A (ko) 2014-04-01
US20220010356A1 (en) 2022-01-13
US20140154675A1 (en) 2014-06-05
US20170321245A1 (en) 2017-11-09
JP6440265B2 (ja) 2018-12-19
EP2705031A2 (en) 2014-03-12
KR101960113B1 (ko) 2019-03-19
WO2012151142A2 (en) 2012-11-08
CN103649069A (zh) 2014-03-19

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