JP2014516552A5 - - Google Patents

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JP2014516552A5
JP2014516552A5 JP2014513800A JP2014513800A JP2014516552A5 JP 2014516552 A5 JP2014516552 A5 JP 2014516552A5 JP 2014513800 A JP2014513800 A JP 2014513800A JP 2014513800 A JP2014513800 A JP 2014513800A JP 2014516552 A5 JP2014516552 A5 JP 2014516552A5
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expression
cancer
biomarkers
biomarker
sample
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JP2014513800A
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JP2014516552A (ja
JP6067686B2 (ja
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Priority claimed from PCT/US2012/040805 external-priority patent/WO2012167278A1/en
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JP2014513800A 2011-06-02 2012-06-04 癌の分子的診断検査 Expired - Fee Related JP6067686B2 (ja)

Applications Claiming Priority (3)

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US201161492488P 2011-06-02 2011-06-02
US61/492,488 2011-06-02
PCT/US2012/040805 WO2012167278A1 (en) 2011-06-02 2012-06-04 Molecular diagnostic test for cancer

Related Child Applications (1)

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JP2016248061A Division JP2017079772A (ja) 2011-06-02 2016-12-21 癌の分子的診断検査

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JP2014516552A JP2014516552A (ja) 2014-07-17
JP2014516552A5 true JP2014516552A5 (enExample) 2016-02-25
JP6067686B2 JP6067686B2 (ja) 2017-01-25

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JP2014513800A Expired - Fee Related JP6067686B2 (ja) 2011-06-02 2012-06-04 癌の分子的診断検査
JP2016248061A Withdrawn JP2017079772A (ja) 2011-06-02 2016-12-21 癌の分子的診断検査

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US (1) US10260097B2 (enExample)
EP (1) EP2715348B1 (enExample)
JP (2) JP6067686B2 (enExample)
KR (1) KR20140044341A (enExample)
CN (1) CN103733065B (enExample)
AU (1) AU2012261820B2 (enExample)
BR (1) BR112013031019A2 (enExample)
CA (1) CA2838086A1 (enExample)
EA (2) EA025926B1 (enExample)
IL (1) IL229681A0 (enExample)
MX (1) MX2013014065A (enExample)
SG (2) SG10201604497UA (enExample)
WO (1) WO2012167278A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10260097B2 (en) 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
EP2667193A1 (en) * 2012-05-23 2013-11-27 Université d'Aix-Marseille MMP2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients
WO2014055398A1 (en) * 2012-10-05 2014-04-10 Siemens Healthcare Diagnostics Inc. Method for detecting an increased risk or incidence of colorectal cancer
HK1214633A1 (zh) * 2012-12-03 2016-07-29 Almac Diagnostics Limited 癌症的分子诊断测试
GB201313342D0 (en) * 2013-07-26 2013-09-11 Cancer Rec Tech Ltd Biomarkers
US10617755B2 (en) 2013-08-30 2020-04-14 Genentech, Inc. Combination therapy for the treatment of glioblastoma
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
GB201409479D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
GB201409476D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular subtype for use in prognosis
GB201409478D0 (en) * 2014-05-28 2014-07-09 Almac Diagnostics Ltd Pro-angiogenic signature
JP2017523776A (ja) * 2014-07-14 2017-08-24 ジェネンテック, インコーポレイテッド 膠芽腫の診断方法及びその治療用組成物
WO2016028638A1 (en) * 2014-08-18 2016-02-25 Drexel University Methods, computer-readable media, and systems for assessing samples and wounds, predicting whether a wound will heal, and monitoring effectiveness of a treatment
KR20160101706A (ko) * 2015-02-17 2016-08-25 싸이퍼롬, 인코퍼레이티드 자궁수축억제제 부작용 방지를 위한 개인별 단백질 손상 정보 기반의 자궁수축억제제 선택 방법
CN105160208A (zh) * 2015-05-29 2015-12-16 杭州奥视图像技术有限公司 用于疾病亚型问题的基于网络的聚类方法
IL308735A (en) 2015-07-01 2024-01-01 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
US10650325B2 (en) * 2015-07-31 2020-05-12 Microsoft Technology Licensing, Llc Deterministic message distribution
CA2996426A1 (en) 2015-10-05 2017-04-13 Cedars-Sinai Medical Center Method of classifying and diagnosing cancer
AU2017211247B2 (en) * 2016-01-25 2023-03-09 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer by measuring the level of a plasma biomarker
US20190127805A1 (en) * 2016-03-15 2019-05-02 Almac Diagnostics Limited Gene signatures for cancer detection and treatment
WO2018124153A1 (ja) 2016-12-28 2018-07-05 公益財団法人がん研究会 抗vegfr-2抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット
CN107037210A (zh) * 2017-04-05 2017-08-11 北京蛋白质组研究中心 Thbs2蛋白检测物在制备肝细胞癌诊断试剂盒中的应用
WO2018213331A1 (en) * 2017-05-16 2018-11-22 Lankenau Institute For Medical Research Compositions comprising ligands to rhob protein and the uses thereof
CN111033631B (zh) * 2017-06-13 2024-03-12 波士顿基因公司 用于生成分子功能谱、对其进行可视化和分类的系统和方法
US20180365372A1 (en) * 2017-06-19 2018-12-20 Jungla Inc. Systems and Methods for the Interpretation of Genetic and Genomic Variants via an Integrated Computational and Experimental Deep Mutational Learning Framework
EP3461916A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3461915A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
WO2019165366A1 (en) * 2018-02-23 2019-08-29 Beth Israel Deaconess Medical Center Drug efficacy evaluations
WO2019200410A1 (en) * 2018-04-13 2019-10-17 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay of biological samples
TWI787523B (zh) 2018-06-15 2022-12-21 漢達生技醫藥股份有限公司 達沙替尼十二烷基硫酸鹽之結晶
CN112955260A (zh) * 2018-06-27 2021-06-11 定量癌症诊断有限责任公司 生物样品保持器和处理器
CN109585011A (zh) * 2018-10-26 2019-04-05 朱海燕 胸痛患者的病症诊断方法及机器可读存储介质
AU2019378779A1 (en) * 2018-11-14 2021-06-03 Beyondspring Pharmaceuticals, Inc. Methods of treating cancer using tubulin binding agents
EP4004927A4 (en) * 2019-07-22 2023-08-02 Mission Bio, Inc. USING MACHINE LEARNING TO OPTIMIZE ASSAYS FOR UNICELLULAR TARGETED DNA SEQUENCING
KR102289533B1 (ko) * 2019-08-19 2021-08-17 주식회사 테라젠바이오 특정 약물의 타겟 유전자와 관련된 시그니처를 기초로 타겟 유전자와 관련된 유전자들을 판단하는 전자 장치, 방법 및 상기 방법을 실행하기 위한 컴퓨터 프로그램
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
TW202208355A (zh) * 2020-05-04 2022-03-01 美商安進公司 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法
CN116322696A (zh) * 2020-05-04 2023-06-23 安进公司 作为髓样细胞上表达的触发受体2激动剂的杂环化合物和使用方法
CN112489800B (zh) * 2020-12-03 2024-05-28 安徽医科大学第一附属医院 一种前列腺癌患者的预后评估系统及其应用
CN116312814B (zh) * 2021-12-02 2024-09-27 复旦大学 一种肺腺癌分子分型模型的构建方法、设备、装置以及试剂盒
CN114624441B (zh) * 2022-03-04 2025-07-18 中国人民解放军空军军医大学 跨膜蛋白43作为胰腺癌肿瘤诊断标志物的应用
CN115902223B (zh) * 2022-11-15 2025-08-26 中国人民解放军空军军医大学 蛋白生物标志物在胃癌诊断中的应用
CN116863995B (zh) * 2023-08-29 2024-05-14 北京大学第一医院 Alpk2,itga11,esyt1,cdh17在预测药物出血中的应用
CN118393140B (zh) * 2024-04-24 2025-04-11 英科众康(厦门)科技有限公司 基于适配体/抗体新型夹心式介导的检测技术在泛癌标志物c1qc诊断中的应用

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
JP2775346B2 (ja) 1992-04-03 1998-07-16 アプライド バイオシステムズ,インコーポレイテッド プローブ構成物および方法
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US6946442B2 (en) 1994-11-30 2005-09-20 Asif Syed Ahmed Method of hastening cervical ripening
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
US6680175B2 (en) 1998-05-05 2004-01-20 Adherex Technologies, Inc. Methods for diagnosing and evaluating cancer
WO2004005883A2 (en) * 2002-07-02 2004-01-15 The Johns Hopkins University Secreted and cytoplasmic tumor endothelial markers
US6998234B2 (en) 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
WO2003096981A2 (en) 2002-05-15 2003-11-27 Seul, Kyung, Hwan Method of modulating angiogenesis
RS20150135A1 (sr) * 2003-05-30 2015-08-31 Genentech Inc. Tretman sa anti-vegf antitelima
WO2004108896A2 (en) 2003-06-03 2004-12-16 The Board Of Trustees Of The University Of Arkansas Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
JP4682152B2 (ja) * 2003-12-31 2011-05-11 ザ・ペン・ステート・リサーチ・ファンデーション 卵巣がんの化学療法に対する抵抗性を予測および克服するための方法ならびに結腸がんの発生を予測するための方法
US20080113874A1 (en) * 2004-01-23 2008-05-15 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
CA2563074C (en) 2004-04-09 2014-05-20 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
BRPI0511088A (pt) * 2004-05-14 2007-12-26 Monica Nister identificação e caracterização de um subconjunto de glioblastomas sensìveis ao tratamento com imatinib
AU2005263972A1 (en) * 2004-07-23 2006-01-26 Astrazeneca Ab Method of predicting the responsiveness of a tumor to erbB receptor drugs
JP2008518610A (ja) 2004-11-03 2008-06-05 アルマック ダイアグノスティックス リミテッド トランスクリプトームマイクロアレイ技法およびそれを使用する方法
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2006101925A2 (en) 2005-03-16 2006-09-28 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
US20080305962A1 (en) * 2005-07-29 2008-12-11 Ralph Markus Wirtz Methods and Kits for the Prediction of Therapeutic Success, Recurrence Free and Overall Survival in Cancer Therapies
AU2006292278B2 (en) 2005-09-20 2012-03-08 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
US8445198B2 (en) * 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US7919261B2 (en) 2005-12-05 2011-04-05 Merck Sharp & Dohme Corp. Methods for predicting treatment response based on the expression profiles of protein and transcription biomarkers
US20070128636A1 (en) 2005-12-05 2007-06-07 Baker Joffre B Predictors Of Patient Response To Treatment With EGFR Inhibitors
JP2009524438A (ja) 2006-01-27 2009-07-02 トライパス イメージング インコーポレイテッド 卵巣癌を有する可能性の高い患者を同定するための方法およびそのための組成物
CA2639070A1 (en) * 2006-04-13 2007-11-01 Oncomethylime Sciences S.A. Novel tumour suppressor
US8768629B2 (en) * 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
EP2074226A2 (en) 2006-09-19 2009-07-01 Novartis AG Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors
NZ582941A (en) 2007-08-13 2012-05-25 Almac Diagnostics Ltd A 3' -based sequencing approach for microarray manufacture
US20090092603A1 (en) 2007-09-25 2009-04-09 Bamdad Cynthia C Early diagnosis and treatment of drug resistance in muc1-positive cancer
NZ562237A (en) * 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
WO2009061800A2 (en) * 2007-11-09 2009-05-14 Genentech, Inc. Methods and compositions for diagnostic use in cancer patients
WO2009076229A2 (en) 2007-12-07 2009-06-18 Oregon Health & Science University Methods to determine if a subject will respond to a bcr-abl inhibitor
US8114593B2 (en) 2008-03-12 2012-02-14 University Of Medicine And Dentistry Of New Jersey Cancer biomarker genes and gene products and methods for using the same
WO2009149297A1 (en) * 2008-06-04 2009-12-10 The Arizona Board Regents, On Behalf Of The University Of Arizona Diffuse large b-cell lymphoma markers and uses therefor
ES2552937T3 (es) 2008-06-06 2015-12-03 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Factor de predicción de supervivencia para linfoma difuso de células B grandes
CA2730614A1 (en) 2008-07-16 2010-01-21 Dana-Farber Cancer Institute Signatures and pcdeterminants associated with prostate cancer and methods of use thereof
JP5606438B2 (ja) 2008-07-23 2014-10-15 エフ.ホフマン−ラ ロシュ アーゲー 抗血管新生療法を受容可能な被験体の同定
DK2368118T3 (da) 2008-12-23 2013-11-25 Merck Patent Gmbh Biomarkører til inhibitorer med anti-angiogen aktivitet
WO2010088688A2 (en) 2009-02-02 2010-08-05 Biotheranostics, Inc. Diagnosis of in situ and invasive breast cancer
EP2425020A4 (en) 2009-05-01 2016-04-20 Genomic Health Inc GENE EXPRESSION PROFILE GORITHM AND TEST OF PROBABILITY OF REPRODUCTION OF COLORECTAL CANCER AND RESPONSE TO CHEMOTHERAPY
US7615353B1 (en) 2009-07-06 2009-11-10 Aveo Pharmaceuticals, Inc. Tivozanib response prediction
KR101557545B1 (ko) 2009-09-17 2015-10-06 에프. 호프만-라 로슈 아게 암 환자에서 진단 용도를 위한 방법 및 조성물
EP2975399B1 (en) 2010-09-15 2022-05-11 Almac Diagnostic Services Limited Molecular diagnostic test for cancer
WO2012052757A1 (en) * 2010-10-20 2012-04-26 Astrazeneca Ab Tumour phenotype patient selection method
AU2011352167A1 (en) 2010-12-28 2013-07-11 Caris Mpi, Inc. Molecular profiling for cancer
US10260097B2 (en) 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
CA2862835A1 (en) 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists
EP2667193A1 (en) 2012-05-23 2013-11-27 Université d'Aix-Marseille MMP2 as a predictive biomarker of response to antiangiogenic therapy and survival after therapy in cancer patients
HK1214633A1 (zh) 2012-12-03 2016-07-29 Almac Diagnostics Limited 癌症的分子诊断测试

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