JP2015536667A5 - - Google Patents
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- JP2015536667A5 JP2015536667A5 JP2015544542A JP2015544542A JP2015536667A5 JP 2015536667 A5 JP2015536667 A5 JP 2015536667A5 JP 2015544542 A JP2015544542 A JP 2015544542A JP 2015544542 A JP2015544542 A JP 2015544542A JP 2015536667 A5 JP2015536667 A5 JP 2015536667A5
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- 239000000090 biomarker Substances 0.000 claims 59
- 239000000523 sample Substances 0.000 claims 35
- 238000000034 method Methods 0.000 claims 33
- 230000001772 anti-angiogenic effect Effects 0.000 claims 25
- 239000003814 drug Substances 0.000 claims 23
- 229940124597 therapeutic agent Drugs 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 11
- 238000004393 prognosis Methods 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 238000002493 microarray Methods 0.000 claims 5
- 102100039435 C-X-C motif chemokine 17 Human genes 0.000 claims 4
- -1 CXCR2P1 Proteins 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 101000889048 Homo sapiens C-X-C motif chemokine 17 Proteins 0.000 claims 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 4
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims 4
- 101000575378 Homo sapiens Microfibrillar-associated protein 2 Proteins 0.000 claims 4
- 101000635777 Homo sapiens Receptor-transporting protein 4 Proteins 0.000 claims 4
- 101000825086 Homo sapiens Transcription factor SOX-11 Proteins 0.000 claims 4
- 101000831866 Homo sapiens Transmembrane protein 45A Proteins 0.000 claims 4
- 102100023915 Insulin Human genes 0.000 claims 4
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims 4
- 108010072582 Matrilin Proteins Proteins 0.000 claims 4
- 102100033670 Matrilin-3 Human genes 0.000 claims 4
- 102100025599 Microfibrillar-associated protein 2 Human genes 0.000 claims 4
- 102100030854 Receptor-transporting protein 4 Human genes 0.000 claims 4
- 108091006277 SLC5A1 Proteins 0.000 claims 4
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 claims 4
- 102100022415 Transcription factor SOX-11 Human genes 0.000 claims 4
- 102100024186 Transmembrane protein 45A Human genes 0.000 claims 4
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 238000010837 poor prognosis Methods 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 238000003018 immunoassay Methods 0.000 claims 3
- 238000003753 real-time PCR Methods 0.000 claims 3
- 230000004043 responsiveness Effects 0.000 claims 3
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 2
- ZHBXLZQQVCDGPA-UHFFFAOYSA-N 5-[(1,3-dioxo-2-benzofuran-5-yl)sulfonyl]-2-benzofuran-1,3-dione Chemical compound C1=C2C(=O)OC(=O)C2=CC(S(=O)(=O)C=2C=C3C(=O)OC(C3=CC=2)=O)=C1 ZHBXLZQQVCDGPA-UHFFFAOYSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 2
- 239000005536 L01XE08 - Nilotinib Substances 0.000 claims 2
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 230000031018 biological processes and functions Effects 0.000 claims 2
- 229960002412 cediranib Drugs 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 2
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 2
- JRMGHBVACUJCRP-BTJKTKAUSA-N (z)-but-2-enedioic acid;4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline Chemical compound OC(=O)\C=C/C(O)=O.COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 JRMGHBVACUJCRP-BTJKTKAUSA-N 0.000 claims 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 claims 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 102000009840 Angiopoietins Human genes 0.000 claims 1
- 108010009906 Angiopoietins Proteins 0.000 claims 1
- 102400000068 Angiostatin Human genes 0.000 claims 1
- 108010079709 Angiostatins Proteins 0.000 claims 1
- 102000003916 Arrestin Human genes 0.000 claims 1
- 108090000328 Arrestin Proteins 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 102100024155 Cadherin-11 Human genes 0.000 claims 1
- 102400000730 Canstatin Human genes 0.000 claims 1
- 101800000626 Canstatin Proteins 0.000 claims 1
- 102100031186 Chromogranin-A Human genes 0.000 claims 1
- 102100023708 Coiled-coil domain-containing protein 80 Human genes 0.000 claims 1
- 102100024337 Collagen alpha-1(VIII) chain Human genes 0.000 claims 1
- 102100033825 Collagen alpha-1(XI) chain Human genes 0.000 claims 1
- 102100027995 Collagenase 3 Human genes 0.000 claims 1
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 1
- 102400001047 Endostatin Human genes 0.000 claims 1
- 108010079505 Endostatins Proteins 0.000 claims 1
- 102100037362 Fibronectin Human genes 0.000 claims 1
- 102100037156 Gap junction beta-2 protein Human genes 0.000 claims 1
- 101710088083 Glomulin Proteins 0.000 claims 1
- 102100033424 Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Human genes 0.000 claims 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 1
- 101000762236 Homo sapiens Cadherin-11 Proteins 0.000 claims 1
- 101000978383 Homo sapiens Coiled-coil domain-containing protein 80 Proteins 0.000 claims 1
- 101000909492 Homo sapiens Collagen alpha-1(VIII) chain Proteins 0.000 claims 1
- 101000710623 Homo sapiens Collagen alpha-1(XI) chain Proteins 0.000 claims 1
- 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 claims 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 claims 1
- 101000954092 Homo sapiens Gap junction beta-2 protein Proteins 0.000 claims 1
- 101000997966 Homo sapiens Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 2 Proteins 0.000 claims 1
- 101000852489 Homo sapiens Inositol 1,4,5-triphosphate receptor associated 1 Proteins 0.000 claims 1
- 101001095308 Homo sapiens Periostin Proteins 0.000 claims 1
- 101001000631 Homo sapiens Peripheral myelin protein 22 Proteins 0.000 claims 1
- 101001082860 Homo sapiens Peroxisomal membrane protein 2 Proteins 0.000 claims 1
- 101000873646 Homo sapiens Protein bicaudal C homolog 1 Proteins 0.000 claims 1
- 101001060862 Homo sapiens Ras-related protein Rab-31 Proteins 0.000 claims 1
- 101000864786 Homo sapiens Secreted frizzled-related protein 2 Proteins 0.000 claims 1
- 101000633605 Homo sapiens Thrombospondin-2 Proteins 0.000 claims 1
- 101000787917 Homo sapiens Transmembrane protein 200A Proteins 0.000 claims 1
- 101000638886 Homo sapiens Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 102100027004 Inhibin beta A chain Human genes 0.000 claims 1
- 102100036344 Inositol 1,4,5-triphosphate receptor associated 1 Human genes 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 1
- 102100037765 Periostin Human genes 0.000 claims 1
- 102100030564 Peroxisomal membrane protein 2 Human genes 0.000 claims 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 1
- 102100035896 Protein bicaudal C homolog 1 Human genes 0.000 claims 1
- 102100027838 Ras-related protein Rab-31 Human genes 0.000 claims 1
- 102100030054 Secreted frizzled-related protein 2 Human genes 0.000 claims 1
- 102000002938 Thrombospondin Human genes 0.000 claims 1
- 108060008245 Thrombospondin Proteins 0.000 claims 1
- 102100029529 Thrombospondin-2 Human genes 0.000 claims 1
- 102100025940 Transmembrane protein 200A Human genes 0.000 claims 1
- 102400000731 Tumstatin Human genes 0.000 claims 1
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 229960002833 aflibercept Drugs 0.000 claims 1
- 108010081667 aflibercept Proteins 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000003527 anti-angiogenesis Effects 0.000 claims 1
- 238000011122 anti-angiogenic therapy Methods 0.000 claims 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 1
- 229940120638 avastin Drugs 0.000 claims 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- AEULIVPVIDOLIN-UHFFFAOYSA-N cep-11981 Chemical compound C1=C2C3=C4CNC(=O)C4=C4C5=CN(C)N=C5CCC4=C3N(CC(C)C)C2=CC=C1NC1=NC=CC=N1 AEULIVPVIDOLIN-UHFFFAOYSA-N 0.000 claims 1
- PIQCTGMSNWUMAF-UHFFFAOYSA-N chembl522892 Chemical compound C1CN(C)CCN1C1=CC=C(NC(=N2)C=3C(NC4=CC=CC(F)=C4C=3N)=O)C2=C1 PIQCTGMSNWUMAF-UHFFFAOYSA-N 0.000 claims 1
- 229960002448 dasatinib Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 229940022353 herceptin Drugs 0.000 claims 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 108010019691 inhibin beta A subunit Proteins 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims 1
- 229960001346 nilotinib Drugs 0.000 claims 1
- 229960004378 nintedanib Drugs 0.000 claims 1
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 1
- 229960000639 pazopanib Drugs 0.000 claims 1
- 229960002633 ramucirumab Drugs 0.000 claims 1
- 229960001796 sunitinib Drugs 0.000 claims 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 1
- 229940034785 sutent Drugs 0.000 claims 1
- 229940069905 tasigna Drugs 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 108010075758 trebananib Proteins 0.000 claims 1
- 108010012374 type IV collagen alpha3 chain Proteins 0.000 claims 1
- 108010060757 vasostatin Proteins 0.000 claims 1
- 229940069559 votrient Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732761P | 2012-12-03 | 2012-12-03 | |
| US61/732,761 | 2012-12-03 | ||
| PCT/GB2013/053202 WO2014087156A1 (en) | 2012-12-03 | 2013-12-03 | Molecular diagnostic test for cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015536667A JP2015536667A (ja) | 2015-12-24 |
| JP2015536667A5 true JP2015536667A5 (enExample) | 2017-01-19 |
Family
ID=49780086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015544542A Pending JP2015536667A (ja) | 2012-12-03 | 2013-12-03 | 癌のための分子診断検査 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11091809B2 (enExample) |
| EP (1) | EP2925885B1 (enExample) |
| JP (1) | JP2015536667A (enExample) |
| KR (1) | KR20150090246A (enExample) |
| CN (1) | CN105102631A (enExample) |
| AU (1) | AU2013353839A1 (enExample) |
| CA (1) | CA2893033A1 (enExample) |
| HK (1) | HK1214633A1 (enExample) |
| IL (1) | IL239196A0 (enExample) |
| MX (1) | MX2015006955A (enExample) |
| SG (1) | SG11201504023SA (enExample) |
| WO (1) | WO2014087156A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA025926B1 (ru) | 2011-06-02 | 2017-02-28 | Олмак Дайэгностикс Лимитед | Молекулярно-диагностический тест на рак |
| AU2013353839A1 (en) | 2012-12-03 | 2015-06-18 | Almac Diagnostics Limited | Molecular diagnostic test for cancer |
| US10456470B2 (en) | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| GB201409479D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| GB201409476D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular subtype for use in prognosis |
| GB201409478D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Pro-angiogenic signature |
| WO2016011052A1 (en) * | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| CN104212440B (zh) * | 2014-09-03 | 2016-03-30 | 无锡艾德美特生物科技有限公司 | 一类喹唑啉类荧光探针及其制备和应用 |
| MX2017006864A (es) * | 2014-12-23 | 2017-08-28 | Genentech Inc | Composiciones y métodos para tratar y diagnosticar cánceres resistentes a la quimioterapia. |
| ES2908848T3 (es) * | 2016-01-25 | 2022-05-04 | Sanofi Sa | Método de predicción del resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer midiendo el nivel de un biomarcador de plasma |
| EP3443120A2 (en) * | 2016-04-15 | 2019-02-20 | H. Hoffnabb-La Roche Ag | Methods for monitoring and treating cancer |
| JP7359547B2 (ja) * | 2016-05-17 | 2023-10-11 | ジェネンテック， インコーポレイテッド | 免疫療法における診断及び使用のための間質遺伝子シグネチャー |
| JP6899848B2 (ja) | 2016-12-28 | 2021-07-07 | 公益財団法人がん研究会 | 抗ｖｅｇｆｒ−２抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット |
| PL3589754T3 (pl) | 2017-03-01 | 2023-10-09 | F. Hoffmann-La Roche Ag | Sposoby diagnostyczne i terapeutyczne w chorobach nowotworowych |
| US10311967B2 (en) * | 2017-06-13 | 2019-06-04 | Bostongene Corporation | Systems and methods for generating, visualizing and classifying molecular functional profiles |
| EP3652663A4 (en) * | 2017-07-14 | 2021-04-21 | Cofactor Genomics, Inc. | NEXT GENERATION IMMUNONCOLOGICAL APPLICATIONS BY SEQUENCING |
| US10636512B2 (en) * | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| CN107621545B (zh) * | 2017-07-26 | 2019-10-11 | 东南大学 | Bicc1蛋白对精神疾病诊断的新用途 |
| WO2019074920A1 (en) * | 2017-10-10 | 2019-04-18 | Oncocyte Corporation | METHODS AND COMPOSITIONS FOR THE DETECTION AND DIAGNOSIS OF BREAST CANCER |
| US20200294622A1 (en) * | 2017-12-04 | 2020-09-17 | Nantomics, Llc | Subtyping of TNBC And Methods |
| CN108524937B (zh) * | 2018-05-11 | 2020-05-05 | 中南大学湘雅三医院 | Mrvi1-as1作为靶位点在制备治疗鼻咽癌紫杉醇化疗增敏药物中的应用 |
| EP3843638A4 (en) * | 2018-08-31 | 2022-05-18 | Seno Medical Instruments, Inc. | METHODS AND SYSTEMS FOR DETERMINING MOLECULAR CANCER SUBTYPES BASED ON ULTRASOUND AND/OR OPTOACOUSTIC (OA/US) PROPERTIES |
| CN109585011A (zh) * | 2018-10-26 | 2019-04-05 | 朱海燕 | 胸痛患者的病症诊断方法及机器可读存储介质 |
| EP3963099A1 (en) * | 2019-04-30 | 2022-03-09 | Larimar Therapeutics, Inc. | Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy |
| CN110358827A (zh) * | 2019-07-09 | 2019-10-22 | 中国人民解放军第四军医大学 | Vmp1基因在病理诊断胶质母细胞瘤中的应用及其试剂盒的制备 |
| WO2021034091A1 (ko) * | 2019-08-19 | 2021-02-25 | 재단법인 아산사회복지재단 | 교모세포종의 진단 방법 |
| IT201900023946A1 (it) * | 2019-12-13 | 2021-06-13 | Complexdata S R L | Metodo per determinare una prognosi di sopravvivenza a lungo termine di pazienti di cancro al seno, sulla base di algoritmi che modellizzano reti biologiche |
| CN111105843B (zh) * | 2019-12-31 | 2023-07-21 | 杭州纽安津生物科技有限公司 | 一种hlai型分子与多肽的亲和力预测方法 |
| CN111735949B (zh) * | 2020-07-17 | 2023-07-21 | 北京信诺卫康科技有限公司 | Wnt7a和CA125联合用作早期卵巢癌生物标志物以及试剂盒 |
| CN112266961B (zh) * | 2020-10-29 | 2023-05-12 | 中山大学附属第六医院 | Tsg-6基因在预测结直肠癌转移及预后方面的应用 |
| CN112592397B (zh) * | 2020-12-31 | 2022-08-30 | 上海市胸科医院 | Ccdc80来源的多肽及其用途 |
| CN113035298B (zh) * | 2021-04-02 | 2023-06-20 | 南京信息工程大学 | 递归生成大阶数行限制覆盖阵列的药物临床试验设计方法 |
| KR102897399B1 (ko) * | 2021-04-12 | 2025-12-08 | 연세대학교 산학협력단 | 유방암 진단을 위한 신규 바이오마커 |
| CA3219979A1 (en) * | 2021-05-13 | 2022-11-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Method of targeted multi-panel approach and tiered a.i. use for differential diagnosis and prognosis |
| CN116243003B (zh) * | 2023-02-20 | 2025-12-09 | 东莞市滨海湾中心医院(东莞市太平人民医院、东莞市第五人民医院) | Smox在制备结直肠癌诊断或预后预测产品中的应用 |
| CN116482367A (zh) * | 2023-05-04 | 2023-07-25 | 中国中医科学院望京医院(中国中医科学院骨伤科研究所) | 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法 |
| CN116519954B (zh) * | 2023-06-28 | 2023-10-27 | 杭州广科安德生物科技有限公司 | 一种结直肠癌检测模型构建方法、系统及生物标志物 |
| CN117089621B (zh) * | 2023-09-28 | 2024-06-25 | 上海爱谱蒂康生物科技有限公司 | 生物标志物组合及其在预测结直肠癌疗效中的应用 |
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- 2013-12-03 WO PCT/GB2013/053202 patent/WO2014087156A1/en not_active Ceased
- 2013-12-03 CN CN201380071098.3A patent/CN105102631A/zh active Pending
- 2013-12-03 US US14/649,421 patent/US11091809B2/en not_active Expired - Fee Related
- 2013-12-03 EP EP13808178.1A patent/EP2925885B1/en active Active
- 2013-12-03 KR KR1020157017703A patent/KR20150090246A/ko not_active Withdrawn
- 2013-12-03 JP JP2015544542A patent/JP2015536667A/ja active Pending
- 2013-12-03 CA CA2893033A patent/CA2893033A1/en not_active Abandoned
- 2013-12-03 SG SG11201504023SA patent/SG11201504023SA/en unknown
- 2013-12-03 MX MX2015006955A patent/MX2015006955A/es unknown
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2015
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