JP2014515041A5 - - Google Patents
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- Publication number
- JP2014515041A5 JP2014515041A5 JP2014510942A JP2014510942A JP2014515041A5 JP 2014515041 A5 JP2014515041 A5 JP 2014515041A5 JP 2014510942 A JP2014510942 A JP 2014510942A JP 2014510942 A JP2014510942 A JP 2014510942A JP 2014515041 A5 JP2014515041 A5 JP 2014515041A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- diaza
- bicyclo
- trans
- hydrazinocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 N ′-[(S) -pyrrolidine-2-carbonyl] -hydrazinocarbonyl Chemical group 0.000 claims 37
- 150000002148 esters Chemical class 0.000 claims 28
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 25
- 239000003242 anti bacterial agent Substances 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 208000035143 Bacterial infection Diseases 0.000 claims 16
- 208000022362 bacterial infectious disease Diseases 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims 11
- 229960005256 sulbactam Drugs 0.000 claims 11
- 241000894006 Bacteria Species 0.000 claims 8
- 229930186147 Cephalosporin Natural products 0.000 claims 8
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 8
- 102000006635 beta-lactamase Human genes 0.000 claims 8
- 229940124587 cephalosporin Drugs 0.000 claims 8
- 150000001780 cephalosporins Chemical class 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 229930182555 Penicillin Natural products 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 5
- 229960003324 clavulanic acid Drugs 0.000 claims 5
- 159000000000 sodium salts Chemical class 0.000 claims 5
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 claims 5
- 229960003865 tazobactam Drugs 0.000 claims 5
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 4
- 108010028921 Lipopeptides Proteins 0.000 claims 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 4
- 239000004098 Tetracycline Substances 0.000 claims 4
- 229940126575 aminoglycoside Drugs 0.000 claims 4
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 4
- 229960003644 aztreonam Drugs 0.000 claims 4
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 4
- JSVCEVCSANKFDY-SFYZADRCSA-N carbacephem Chemical compound C1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)C)[C@H]21 JSVCEVCSANKFDY-SFYZADRCSA-N 0.000 claims 4
- 229960002100 cefepime Drugs 0.000 claims 4
- HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 claims 4
- 229960000484 ceftazidime Drugs 0.000 claims 4
- ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 claims 4
- UCKZMPLVLCKKMO-LHLIQPBNSA-N cephamycin Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](C)[C@]21OC UCKZMPLVLCKKMO-LHLIQPBNSA-N 0.000 claims 4
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 4
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims 4
- 229960001907 nitrofurazone Drugs 0.000 claims 4
- 229940049954 penicillin Drugs 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 4
- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 claims 4
- 229960000885 rifabutin Drugs 0.000 claims 4
- 229940124530 sulfonamide Drugs 0.000 claims 4
- 150000003456 sulfonamides Chemical class 0.000 claims 4
- 229960002180 tetracycline Drugs 0.000 claims 4
- 229930101283 tetracycline Natural products 0.000 claims 4
- 235000019364 tetracycline Nutrition 0.000 claims 4
- 150000003522 tetracyclines Chemical class 0.000 claims 4
- 239000004599 antimicrobial Substances 0.000 claims 3
- 229940036735 ceftaroline Drugs 0.000 claims 3
- ZCCUWMICIWSJIX-NQJJCJBVSA-N ceftaroline fosamil Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OCC)C=2N=C(NP(O)(O)=O)SN=2)CC=1SC(SC=1)=NC=1C1=CC=[N+](C)C=C1 ZCCUWMICIWSJIX-NQJJCJBVSA-N 0.000 claims 3
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 3
- QYQDKDWGWDOFFU-IUODEOHRSA-N Cefotiam Chemical compound CN(C)CCN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CC=3N=C(N)SC=3)[C@H]2SC1 QYQDKDWGWDOFFU-IUODEOHRSA-N 0.000 claims 2
- GNWUOVJNSFPWDD-XMZRARIVSA-M Cefoxitin sodium Chemical compound [Na+].N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)CC1=CC=CS1 GNWUOVJNSFPWDD-XMZRARIVSA-M 0.000 claims 2
- KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 claims 2
- JWCSIUVGFCSJCK-CAVRMKNVSA-N Disodium Moxalactam Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CO[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C1=CC=C(O)C=C1 JWCSIUVGFCSJCK-CAVRMKNVSA-N 0.000 claims 2
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 229940041011 carbapenems Drugs 0.000 claims 2
- RRYMAQUWDLIUPV-BXKDBHETSA-N cefacetrile Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CC#N)[C@@H]12 RRYMAQUWDLIUPV-BXKDBHETSA-N 0.000 claims 2
- 229960003972 cefacetrile Drugs 0.000 claims 2
- 229960005361 cefaclor Drugs 0.000 claims 2
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 claims 2
- CZTQZXZIADLWOZ-CRAIPNDOSA-N cefaloridine Chemical compound O=C([C@@H](NC(=O)CC=1SC=CC=1)[C@H]1SC2)N1C(C(=O)[O-])=C2C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-CRAIPNDOSA-N 0.000 claims 2
- 229960003866 cefaloridine Drugs 0.000 claims 2
- XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 claims 2
- 229960000603 cefalotin Drugs 0.000 claims 2
- 229960003012 cefamandole Drugs 0.000 claims 2
- OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 claims 2
- 229960001139 cefazolin Drugs 0.000 claims 2
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 claims 2
- 229960001817 cefbuperazone Drugs 0.000 claims 2
- SMSRCGPDNDCXFR-CYWZMYCQSA-N cefbuperazone Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H]([C@H](C)O)C(=O)N[C@]1(OC)C(=O)N2C(C(O)=O)=C(CSC=3N(N=NN=3)C)CS[C@@H]21 SMSRCGPDNDCXFR-CYWZMYCQSA-N 0.000 claims 2
- JUVHVMCKLDZLGN-TVNFHGJBSA-N cefclidin Chemical compound N([C@@H]1C(N2C(=C(C[N+]34CCC(CC3)(CC4)C(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=NSC(N)=N1 JUVHVMCKLDZLGN-TVNFHGJBSA-N 0.000 claims 2
- 229960003719 cefdinir Drugs 0.000 claims 2
- RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 claims 2
- 229960002142 cefditoren pivoxil Drugs 0.000 claims 2
- AFZFFLVORLEPPO-UVYJNCLZSA-N cefditoren pivoxil Chemical compound S([C@@H]1[C@@H](C(N1C=1C(=O)OCOC(=O)C(C)(C)C)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1\C=C/C=1SC=NC=1C AFZFFLVORLEPPO-UVYJNCLZSA-N 0.000 claims 2
- DASYMCLQENWCJG-XUKDPADISA-N cefetamet pivoxil Chemical compound N([C@@H]1C(N2C(=C(C)CS[C@@H]21)C(=O)OCOC(=O)C(C)(C)C)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 DASYMCLQENWCJG-XUKDPADISA-N 0.000 claims 2
- 229950000726 cefetamet pivoxil Drugs 0.000 claims 2
- 229960002129 cefixime Drugs 0.000 claims 2
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 claims 2
- XAKKNLNAJBNLPC-MAYKBZFQSA-N cefluprenam Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)/C=C/C[N+](C)(CC)CC(N)=O)C([O-])=O)C(=O)C(=N/OCF)\C1=NSC(N)=N1 XAKKNLNAJBNLPC-MAYKBZFQSA-N 0.000 claims 2
- 229950001334 cefluprenam Drugs 0.000 claims 2
- 229960004261 cefotaxime Drugs 0.000 claims 2
- AZZMGZXNTDTSME-JUZDKLSSSA-M cefotaxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 AZZMGZXNTDTSME-JUZDKLSSSA-M 0.000 claims 2
- 229960001242 cefotiam Drugs 0.000 claims 2
- 229960002682 cefoxitin Drugs 0.000 claims 2
- QDUIJCOKQCCXQY-WHJQOFBOSA-N cefozopran Chemical compound N([C@@H]1C(N2C(=C(CN3C4=CC=CN=[N+]4C=C3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=NSC(N)=N1 QDUIJCOKQCCXQY-WHJQOFBOSA-N 0.000 claims 2
- 229960002642 cefozopran Drugs 0.000 claims 2
- LNZMRLHZGOBKAN-KAWPREARSA-N cefpimizole Chemical compound N1=CNC(C(=O)N[C@@H](C(=O)N[C@@H]2C(N3C(=C(C[N+]=4C=CC(CCS(O)(=O)=O)=CC=4)CS[C@@H]32)C([O-])=O)=O)C=2C=CC=CC=2)=C1C(=O)O LNZMRLHZGOBKAN-KAWPREARSA-N 0.000 claims 2
- 229950004036 cefpimizole Drugs 0.000 claims 2
- 229960003202 cefsulodin Drugs 0.000 claims 2
- SYLKGLMBLAAGSC-QLVMHMETSA-N cefsulodin Chemical compound C1=CC(C(=O)N)=CC=[N+]1CC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)[C@@H](C=3C=CC=CC=3)S(O)(=O)=O)[C@H]2SC1 SYLKGLMBLAAGSC-QLVMHMETSA-N 0.000 claims 2
- UNJFKXSSGBWRBZ-BJCIPQKHSA-N ceftibuten Chemical compound S1C(N)=NC(C(=C\CC(O)=O)\C(=O)N[C@@H]2C(N3C(=CCS[C@@H]32)C(O)=O)=O)=C1 UNJFKXSSGBWRBZ-BJCIPQKHSA-N 0.000 claims 2
- 229960001991 ceftizoxime Drugs 0.000 claims 2
- NNULBSISHYWZJU-LLKWHZGFSA-N ceftizoxime Chemical compound N([C@@H]1C(N2C(=CCS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 NNULBSISHYWZJU-LLKWHZGFSA-N 0.000 claims 2
- 229960004755 ceftriaxone Drugs 0.000 claims 2
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims 2
- 229960001668 cefuroxime Drugs 0.000 claims 2
- JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 claims 2
- 229960002620 cefuroxime axetil Drugs 0.000 claims 2
- 229940106164 cephalexin Drugs 0.000 claims 2
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 claims 2
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 claims 2
- 229960000895 doripenem Drugs 0.000 claims 2
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims 2
- 229960002182 imipenem Drugs 0.000 claims 2
- 229960000433 latamoxef Drugs 0.000 claims 2
- 229960002260 meropenem Drugs 0.000 claims 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 claims 2
- 229940041009 monobactams Drugs 0.000 claims 2
- 150000002961 penems Chemical class 0.000 claims 2
- 150000002960 penicillins Chemical class 0.000 claims 2
- 229960002292 piperacillin Drugs 0.000 claims 2
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 claims 2
- 229940124586 β-lactam antibiotics Drugs 0.000 claims 2
- HYDTWJWCBMFIQL-GMTAPVOTSA-N 2-[[(2r,5r)-7-oxo-2-[[[(3r)-piperidine-3-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl]oxy]acetic acid Chemical compound O=C([C@@H]1N2C[C@@](CC1)(N(C2=O)OCC(O)=O)[H])NNC(=O)[C@@H]1CCCNC1 HYDTWJWCBMFIQL-GMTAPVOTSA-N 0.000 claims 1
- MBMIFCNAWJUXOY-HBNTYKKESA-N C1C[C@H](NC1)CCC(=O)NNC(=O)[C@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O Chemical compound C1C[C@H](NC1)CCC(=O)NNC(=O)[C@H]2CC[C@@H]3CN2C(=O)N3OS(=O)(=O)O MBMIFCNAWJUXOY-HBNTYKKESA-N 0.000 claims 1
- NUSJTKGZIBQZGQ-SCLLHFNJSA-M CC(C)(C(NNC([C@@H](CC[C@H](C1)N2OS([O-])(=O)=O)N1C2=O)=O)=O)C#N.[Na+] Chemical compound CC(C)(C(NNC([C@@H](CC[C@H](C1)N2OS([O-])(=O)=O)N1C2=O)=O)=O)C#N.[Na+] NUSJTKGZIBQZGQ-SCLLHFNJSA-M 0.000 claims 1
- 229940123930 Lactamase inhibitor Drugs 0.000 claims 1
- UYLDIIWDUDIANL-RFZPGFLSSA-N [(2R,5R)-2-(hydrazinecarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N(N)C(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O UYLDIIWDUDIANL-RFZPGFLSSA-N 0.000 claims 1
- XBQYSOJNZSCBNF-RNFRBKRXSA-N [(2R,5R)-2-[(3-aminopropanoylamino)carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound NCCC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O XBQYSOJNZSCBNF-RNFRBKRXSA-N 0.000 claims 1
- DKQYIDUFCOSIGB-HTQZYQBOSA-N [(2R,5R)-2-[(4-aminobutanoylamino)carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound NCCCC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O DKQYIDUFCOSIGB-HTQZYQBOSA-N 0.000 claims 1
- OGLYOHMUJKXRIO-RKDXNWHRSA-N [(2R,5R)-2-[(5-aminopentanoylamino)carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound NCCCCC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O OGLYOHMUJKXRIO-RKDXNWHRSA-N 0.000 claims 1
- XYTWGTZSUPIYFZ-HTQZYQBOSA-N [(2R,5R)-2-[(azetidine-3-carbonylamino)carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1CC(C1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O XYTWGTZSUPIYFZ-HTQZYQBOSA-N 0.000 claims 1
- APBHTOUFSZXYCV-PHDIDXHHSA-N [(2R,5R)-2-[[(2-aminoacetyl)amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound NCC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O APBHTOUFSZXYCV-PHDIDXHHSA-N 0.000 claims 1
- QEJZBLVKSRUUKM-DSYKOEDSSA-N [(2R,5R)-2-[[[(2S)-2-amino-3-hydroxypropanoyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N[C@H](C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O)CO QEJZBLVKSRUUKM-DSYKOEDSSA-N 0.000 claims 1
- HGDFYIWSKIRGEH-LURQLKTLSA-N [(2R,5R)-2-[[[(2S,4R)-4-hydroxypyrrolidine-2-carbonyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound O[C@@H]1C[C@H](NC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O HGDFYIWSKIRGEH-LURQLKTLSA-N 0.000 claims 1
- BSIPLMLCLGSFOX-DOLQZWNJSA-N [(2R,5R)-2-[[[(2S,4R)-4-methoxypyrrolidine-2-carbonyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound CO[C@@H]1C[C@H](NC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O BSIPLMLCLGSFOX-DOLQZWNJSA-N 0.000 claims 1
- UDWBQLXRVRBWLL-UYXSQOIJSA-N [(2R,5R)-2-[[[(2S,4S)-4-(diaminomethylideneamino)pyrrolidine-2-carbonyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N(C(=N)N)[C@H]1C[C@H](NC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O UDWBQLXRVRBWLL-UYXSQOIJSA-N 0.000 claims 1
- CIIXHNAIHMNPNA-UYXSQOIJSA-N [(2R,5R)-2-[[[(2S,4S)-4-aminopyrrolidine-2-carbonyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N[C@H]1C[C@H](NC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O CIIXHNAIHMNPNA-UYXSQOIJSA-N 0.000 claims 1
- HHIXMUSUBFKSRV-UYXSQOIJSA-N [(2R,5R)-2-[[[(2S,4S)-4-fluoropyrrolidine-2-carbonyl]amino]carbamoyl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound F[C@H]1C[C@H](NC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O HHIXMUSUBFKSRV-UYXSQOIJSA-N 0.000 claims 1
- CJDXSFPMLHXKPP-PQDIPPBSSA-N [(2R,5R)-7-oxo-2-[(3-piperidin-2-ylpropanoylamino)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1C(CCCC1)CCC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O CJDXSFPMLHXKPP-PQDIPPBSSA-N 0.000 claims 1
- KXTJXSAKJFXLEI-RCAUJQPQSA-N [(2R,5R)-7-oxo-2-[(piperidine-2-carbonylamino)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1C(CCCC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O KXTJXSAKJFXLEI-RCAUJQPQSA-N 0.000 claims 1
- GYXFEMGIRUYDEP-NXEZZACHSA-N [(2R,5R)-7-oxo-2-[(piperidine-4-carbonylamino)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1CCC(CC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O GYXFEMGIRUYDEP-NXEZZACHSA-N 0.000 claims 1
- GSHJUFCGOVFWMM-RKDXNWHRSA-N [(2R,5R)-7-oxo-2-[(pyrrolidine-1-carbonylamino)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1(CCCC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O GSHJUFCGOVFWMM-RKDXNWHRSA-N 0.000 claims 1
- NRZLXMVYLARNKK-NXEZZACHSA-N [(2R,5R)-7-oxo-2-[[(2-piperazin-1-ylacetyl)amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1CCN(CC1)CC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O NRZLXMVYLARNKK-NXEZZACHSA-N 0.000 claims 1
- WXSCNWNDBSBAIG-NXEZZACHSA-N [(2R,5R)-7-oxo-2-[[(3-oxo-3-piperazin-1-ylpropanoyl)amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound O=C(CC(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O)N1CCNCC1 WXSCNWNDBSBAIG-NXEZZACHSA-N 0.000 claims 1
- KXTJXSAKJFXLEI-OPRDCNLKSA-N [(2R,5R)-7-oxo-2-[[[(2R)-piperidine-2-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1[C@H](CCCC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O KXTJXSAKJFXLEI-OPRDCNLKSA-N 0.000 claims 1
- KXTJXSAKJFXLEI-KXUCPTDWSA-N [(2R,5R)-7-oxo-2-[[[(2S)-piperidine-2-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1[C@@H](CCCC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O KXTJXSAKJFXLEI-KXUCPTDWSA-N 0.000 claims 1
- YCZPXRQPDCXTIO-OPRDCNLKSA-N [(2R,5R)-7-oxo-2-[[[(3R)-piperidine-3-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1C[C@@H](CCC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O YCZPXRQPDCXTIO-OPRDCNLKSA-N 0.000 claims 1
- NAURQUDBIPQVFZ-IWSPIJDZSA-N [(2R,5R)-7-oxo-2-[[[(3R)-pyrrolidine-3-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1C[C@@H](CC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O NAURQUDBIPQVFZ-IWSPIJDZSA-N 0.000 claims 1
- NAURQUDBIPQVFZ-DJLDLDEBSA-N [(2R,5R)-7-oxo-2-[[[(3S)-pyrrolidine-3-carbonyl]amino]carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N1C[C@H](CC1)C(=O)NNC(=O)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O NAURQUDBIPQVFZ-DJLDLDEBSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 1
- 0 CNNC(C(CCC(C1)N2O*)N1C2=O)=O Chemical compound CNNC(C(CCC(C1)N2O*)N1C2=O)=O 0.000 description 1
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| PCT/IB2012/054290 WO2013030733A1 (en) | 2011-08-27 | 2012-08-24 | 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections |
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Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6179588A (ja) * | 1984-09-28 | 1986-04-23 | 株式会社東芝 | 多関節ロボツト |
| CN105732745A (zh) | 2007-10-25 | 2016-07-06 | 森普拉制药公司 | 大环内酯类抗菌剂的制备方法 |
| AU2009308182B2 (en) | 2008-10-24 | 2016-05-19 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| MX348974B (es) * | 2011-08-27 | 2017-07-04 | Wockhardt Ltd | Derivados 1,6 - diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas. |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| MX2014011537A (es) | 2012-03-27 | 2015-02-10 | Cempra Pharmaceuticals Inc | Formulaciones parenterales para la administracion de antibioticos macrolidos. |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| UA111925C2 (uk) * | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| KR20150089086A (ko) * | 2013-01-14 | 2015-08-04 | 욱크하르트 리미티드 | 박테리아 감염을 치료하기 위한 조성물 및 방법 |
| JP6285969B2 (ja) * | 2013-03-08 | 2018-02-28 | ウォックハート リミテッド | （２ｓ，５ｒ）−７−オキソ−６−スルホオキシ−２−［（（３ｒ）−ピペリジン−３−カルボニル）−ヒドラジノカルボニル］−１，６−ジアザ−ビシクロ［３．２．１］オクタンの調製のためのプロセス |
| AU2013380575B2 (en) * | 2013-03-08 | 2016-07-07 | Wockhardt Limited | A process for preparation of (2S, 5R)-7-oxo-6-sulphooxy-2-[((3R)-pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2.1]octane |
| KR101774132B1 (ko) * | 2013-03-08 | 2017-09-01 | 욱크하르트 리미티드 | (2s, 5r)-7-옥소-6-술포옥시-2-[((3r)-피페리딘-3-카보닐)-히드라지노 카보닐]-1,6-디아자-비사이클로[3.2.1]-옥탄의 제조 방법 |
| WO2014135931A1 (en) * | 2013-03-08 | 2014-09-12 | Wockhardt Limited | A process for preparation of (2s, 5r)-7-oxo-6-sulphooxy-2-[((3r)-piperidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo [3.2.1]- octane |
| HK1217665A1 (zh) | 2013-03-14 | 2017-01-20 | 森普拉制药公司 | 用於治療呼吸道疾病的方法及其製劑 |
| US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
| RU2015138797A (ru) | 2013-03-15 | 2017-04-24 | Семпра Фармасьютикалс, Инк. | Конвергентные способы получения макролидных антибактериальных агентов |
| JP6453222B2 (ja) | 2013-09-24 | 2019-01-16 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | ジアザビシクロオクタン誘導体の製造法とその中間体 |
| ES2901198T3 (es) | 2013-10-08 | 2022-03-21 | Meiji Seika Pharma Co Ltd | Formas cristalinas de derivado de diazabiciclooctano y procedimiento de producción de las mismas |
| NZ719215A (en) * | 2013-10-22 | 2020-04-24 | Wockhardt Ltd | Pharmaceutical compositions comprising antibacterial agents |
| US20160287571A1 (en) * | 2013-10-30 | 2016-10-06 | Wockhardt Limited | Pharmaceutical compositions comprising antibacterial agents |
| CA2934492A1 (en) * | 2014-01-21 | 2015-07-30 | Wockhardt Limited | Nitrogen containing compounds and their use |
| EP3105231A1 (en) * | 2014-01-21 | 2016-12-21 | Wockhardt Limited | A process for preparation of (2s,5r)-6-sulphooxy-7-oxo-2-[((3r)-piperidine-3-carbonyl)-hydrazinocarbonyl]-1,6-diaza-bicyclo[3.2.1] octane |
| NZ728036A (en) * | 2014-01-21 | 2019-12-20 | Wockhardt Ltd | Pharmaceutical compositions comprising antibacterial agents |
| KR20160130824A (ko) * | 2014-03-29 | 2016-11-14 | 욱크하르트 리미티드 | 세페파임 또는 술박탐을 포함하는 제약학적 조성물 |
| CN107980000A (zh) * | 2014-04-18 | 2018-05-01 | 沃克哈特有限公司 | 包含抗菌剂的药物组合物 |
| KR20170039689A (ko) * | 2014-08-05 | 2017-04-11 | 셈프라 파마슈티컬스, 인크. | 항균제의 분말 경구 현탁제 제형 |
| JP6764862B2 (ja) | 2014-11-17 | 2020-10-07 | エンタシス・セラピューティックス・リミテッド | 耐性細菌感染症の治療のための併用療法 |
| MY190283A (en) | 2014-12-05 | 2022-04-12 | Meiji Seika Pharma Co Ltd | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
| WO2016116788A1 (en) * | 2015-01-24 | 2016-07-28 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2016151543A1 (en) * | 2015-03-25 | 2016-09-29 | Wockhardt Limited | Pharmaceutical compositions comprising antibacterial agents |
| US10570131B2 (en) | 2015-03-31 | 2020-02-25 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EP3075734A1 (en) * | 2015-03-31 | 2016-10-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| WO2017002089A1 (en) | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2017002083A1 (en) * | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| WO2017002086A1 (en) * | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
| EP3281942A4 (en) * | 2015-09-16 | 2018-08-15 | Xuanzhu Pharma Co., Ltd. | B-lactamase inhibitor and application thereof |
| KR20180051559A (ko) | 2015-10-02 | 2018-05-16 | 주식회사 레고켐 바이오사이언스 | 베타-락타마제의 억제용 조성물 및 억제 방법 |
| WO2017060826A1 (en) * | 2015-10-06 | 2017-04-13 | Wockhardt Limited | Difluoro-(2-substituted carbamoyl-1,6-diaza-bicyclo [3.2.1] oct-6-yloxy) acetic acid compounds and their use in treatment of bacterial infections |
| WO2017081615A1 (en) | 2015-11-09 | 2017-05-18 | Wockhardt Limited | 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections |
| DE102016005299A1 (de) * | 2016-05-02 | 2017-11-02 | Eisele Pneumatics Gmbh & Co. Kg | Verfahren zum Herstellen eines gebogenen rohrförmigen Verbindungselementes |
| WO2017216764A1 (en) * | 2016-06-17 | 2017-12-21 | Wockhardt Limited | N-(alkanoyl)-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carbonylhydrazide derivatives and their use as antibacterial agents |
| DK3512851T3 (en) * | 2016-09-16 | 2022-10-17 | Entasis Therapeutics Ltd | Beta-lactamase inhibitor compounds |
| CN110392684A (zh) * | 2017-02-06 | 2019-10-29 | 拜欧蒂姆公司 | 新型杂环化合物及其在预防或治疗细菌感染中的用途 |
| EA037916B1 (ru) * | 2017-02-08 | 2021-06-07 | Энтасис Терапеутикс Лимитед | Соединения-ингибиторы бета-лактамаз |
| US10500195B2 (en) * | 2017-03-02 | 2019-12-10 | Wockhardt Limited | Antibacterial compounds |
| WO2018208769A1 (en) | 2017-05-08 | 2018-11-15 | Entasis Therapeutics, Inc. | Compounds and methods for treating bacterial infections |
| WO2018234962A1 (en) | 2017-06-20 | 2018-12-27 | Wockhardt Limited | Process for o-sulfonation of 1,6-diazabicyclo[3.2.1]octane compounds |
| CN111417633B (zh) | 2017-12-01 | 2022-05-06 | 齐鲁制药有限公司 | 一种β-内酰胺酶抑制剂的晶型及其制备方法 |
| CN115151544B (zh) * | 2020-09-01 | 2024-08-16 | 宁夏农林科学院 | β-内酰胺酶抑制剂及其制备 |
| GB202306826D0 (en) | 2023-05-09 | 2023-06-21 | Adjutec Pharma As | Therapy |
| GB202306833D0 (en) | 2023-05-09 | 2023-06-21 | Adjutec Pharma As | Therapy |
| CN117700415B (zh) * | 2024-02-06 | 2024-04-30 | 成都四面体药物研究有限公司 | 含脲双环化合物、其用途、其制备的药物、其联合用药物及其复方制剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527808A (en) * | 1991-09-26 | 1996-06-18 | Pfizer Inc. | Fused tricyclic nitrogen containing heterocycles |
| CZ282567B6 (cs) * | 1993-12-29 | 1997-08-13 | Pfizer Inc. | Diazabicyklické sloučeniny a farmaceutické prostředky na jejich bázi |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| WO2009091856A2 (en) * | 2008-01-18 | 2009-07-23 | Merck & Co., Inc. | Beta-lactamase inhibitors |
| FR2937034B1 (fr) | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| FR2951171A1 (fr) * | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| MX348974B (es) * | 2011-08-27 | 2017-07-04 | Wockhardt Ltd | Derivados 1,6 - diazabiciclo [3,2,1] octan-7-ona y su uso en el tratamiento de infecciones bacterianas. |
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2012
- 2012-08-24 MX MX2013013887A patent/MX348974B/es active IP Right Grant
- 2012-08-24 AU AU2012303691A patent/AU2012303691B2/en active Active
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- 2012-08-24 JP JP2014510942A patent/JP5666743B2/ja active Active
- 2012-08-24 PL PL12772808T patent/PL2748165T3/pl unknown
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- 2012-08-24 RU RU2016106633A patent/RU2636147C1/ru active
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- 2012-08-24 CA CA2833241A patent/CA2833241C/en active Active
- 2012-08-24 WO PCT/IB2012/054290 patent/WO2013030733A1/en not_active Ceased
- 2012-08-24 CN CN201280025141.8A patent/CN103619843B/zh active Active
- 2012-08-24 KR KR1020137034052A patent/KR101512738B1/ko active Active
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