JP2014514927A5 - - Google Patents
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- JP2014514927A5 JP2014514927A5 JP2014504319A JP2014504319A JP2014514927A5 JP 2014514927 A5 JP2014514927 A5 JP 2014514927A5 JP 2014504319 A JP2014504319 A JP 2014504319A JP 2014504319 A JP2014504319 A JP 2014504319A JP 2014514927 A5 JP2014514927 A5 JP 2014514927A5
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- JP
- Japan
- Prior art keywords
- cells
- antigen
- specific
- administered
- dendritic cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 210000004443 dendritic cell Anatomy 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 230000000735 allogeneic effect Effects 0.000 claims 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 5
- 210000004698 lymphocyte Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 3
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000037452 priming Effects 0.000 claims 3
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 229940124614 TLR 8 agonist Drugs 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229940022511 therapeutic cancer vaccine Drugs 0.000 claims 2
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- -1 IL-1β Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000005975 antitumor immune response Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474904P | 2011-04-13 | 2011-04-13 | |
| US61/474,904 | 2011-04-13 | ||
| PCT/EP2012/056661 WO2012140130A1 (en) | 2011-04-13 | 2012-04-12 | Method for proliferation of antigen-specific t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017049576A Division JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014514927A JP2014514927A (ja) | 2014-06-26 |
| JP2014514927A5 true JP2014514927A5 (enExample) | 2015-05-07 |
Family
ID=45937382
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504319A Pending JP2014514927A (ja) | 2011-04-13 | 2012-04-12 | 抗原特異的ｔ細胞の増殖のための方法 |
| JP2017049576A Expired - Fee Related JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017049576A Expired - Fee Related JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9476028B2 (enExample) |
| EP (1) | EP2697367B1 (enExample) |
| JP (2) | JP2014514927A (enExample) |
| KR (1) | KR102028340B1 (enExample) |
| CN (1) | CN103502439B (enExample) |
| WO (1) | WO2012140130A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5825966B2 (ja) * | 2011-10-11 | 2015-12-02 | 株式会社日本バイオセラピー研究所 | Ｃｄ５６陽性ｔ細胞増強方法 |
| BR112015014270B1 (pt) * | 2012-12-18 | 2018-12-04 | Immunicum Ab | co-diferenciação de monócitos a partir de doadores alogênicos |
| WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| EP3783098A1 (en) | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| CN106103711A (zh) | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用 |
| PH12016502010B1 (en) | 2014-04-10 | 2023-08-16 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Drug related transgene expression |
| ES2980788T3 (es) | 2014-04-10 | 2024-10-03 | H Lee Moffitt Cancer Ct & Res | Expansión mejorada de linfocitos infiltrantes de tumores para terapia celular adoptiva |
| PL3134095T3 (pl) * | 2014-04-25 | 2020-10-19 | Bluebird Bio, Inc. | Ulepszone sposoby produkcji komórek do adoptywnych terapii komórkowych |
| SI3689899T1 (sl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | MND promotor kimeričnih antigenskih receptorjev |
| SG10201810723VA (en) | 2014-06-06 | 2018-12-28 | Bluebird Bio Inc | Improved t cell compositions |
| EP3172231B1 (en) | 2014-07-24 | 2021-05-05 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| CN107106611B (zh) * | 2014-10-27 | 2021-11-23 | 弗雷德哈钦森癌症研究中心 | 用于提高过继细胞免疫疗法效力的组合物和方法 |
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| EP3230321B1 (en) | 2014-12-12 | 2019-08-28 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| AU2016258845B2 (en) * | 2015-05-01 | 2022-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
| WO2016179475A1 (en) | 2015-05-07 | 2016-11-10 | Baylor College Of Medicine | Dendritic cell immunotherapy |
| CN107750271B (zh) * | 2015-05-13 | 2021-12-10 | 泰尔茂比司特公司 | 细胞扩增 |
| AU2016277121C1 (en) * | 2015-06-12 | 2022-07-14 | Lentigen Technology, Inc. | Method to treat cancer with engineered T-cells |
| WO2017024006A1 (en) * | 2015-08-03 | 2017-02-09 | The Johns Hopkins University | Personalized, allogeneic cell therapy of cancer |
| CA2994829A1 (en) | 2015-08-07 | 2017-02-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific car t-cells for solid tumor targeting |
| US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
| US11834675B2 (en) | 2015-12-30 | 2023-12-05 | Celgene Corporation | T lymphocyte production methods and t lymphocytes produced thereby |
| WO2017120481A1 (en) * | 2016-01-08 | 2017-07-13 | Prospect CharterCare RWMC, LLC d/b/a Roger Williams Medical Center | Geriatric car-t cells and uses thereof |
| CA3014027A1 (en) * | 2016-02-08 | 2017-08-17 | Mie University | Pretreatment drug for t cell infusion therapy for immune checkpoint inhibitor-resistant tumor |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| ES2886631T3 (es) | 2016-04-15 | 2021-12-20 | Univ Kyoto | Método para inducir células T positivas para CD8 específicas de antígeno |
| CA3022267A1 (en) | 2016-05-04 | 2017-11-09 | Fred Hutchinson Cancer Research Center | Cell-based neoantigen vaccines and uses thereof |
| EP3468581A1 (en) | 2016-06-13 | 2019-04-17 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| MA45491A (fr) * | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
| CN107779433A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 便捷的刺激nk细胞增殖和分化的饲养层制备方法 |
| JP2018042481A (ja) * | 2016-09-13 | 2018-03-22 | テラ株式会社 | 抗原特異的ｔ細胞含有組成物及びその製造方法 |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| AU2017355504C1 (en) | 2016-11-04 | 2024-06-20 | 2Seventy Bio, Inc. | Anti-BCMA CAR T cell compositions |
| US11401507B2 (en) | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| MA46963A (fr) | 2016-12-03 | 2019-10-09 | Juno Therapeutics Inc | Méthodes pour déterminer le dosage de céllules car-t |
| WO2018106732A1 (en) | 2016-12-05 | 2018-06-14 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| US11408005B2 (en) | 2016-12-12 | 2022-08-09 | Seattle Children's Hospital | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| WO2018129336A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院（Dba西雅图儿童研究所） | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| US11344578B2 (en) | 2017-04-19 | 2022-05-31 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| CN107502589A (zh) * | 2017-08-04 | 2017-12-22 | 北京世纪劲得生物技术有限公司 | 一种肿瘤浸润淋巴细胞与单个核细胞共培养方法 |
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
| US20210198372A1 (en) | 2017-12-01 | 2021-07-01 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| EP3749695A4 (en) | 2018-02-06 | 2021-12-29 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| WO2019183924A1 (en) * | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CN108841792A (zh) * | 2018-06-14 | 2018-11-20 | 浙江大学 | 靶向cd19和ebna1基因修饰的t细胞及其制备方法与应用 |
| KR20210091213A (ko) | 2018-11-05 | 2021-07-21 | 이오반스 바이오테라퓨틱스, 인크. | 종양 침윤 림프구의 생성 방법 및 면역치료법에서 이의 용도 |
| CN109370987A (zh) * | 2018-11-23 | 2019-02-22 | 见多视光(北京)科技有限公司 | 外周血ctl细胞改良的培养方法 |
| CA3142352A1 (en) * | 2019-05-31 | 2020-12-03 | Modernatx, Inc. | Expanded t cell assay |
| JP7668781B2 (ja) * | 2019-07-05 | 2025-04-25 | ケース ウェスタン リザーブ ユニバーシティ | 幹細胞培養及び幹細胞治療用プライム化培地及びプライム化方法 |
| AU2021243864A1 (en) * | 2020-03-27 | 2022-11-03 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| CA3182607A1 (en) | 2020-06-30 | 2022-01-06 | Erik Hans MANTING | Use of leukemia-derived cells in ovarian cancer vaccines |
| CN113234674B (zh) * | 2021-03-15 | 2023-02-07 | 青岛华赛伯曼医学细胞生物有限公司 | 一种t细胞活化扩增的方法及其应用 |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| CN114601923B (zh) * | 2022-04-25 | 2023-08-22 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种新生抗原组合物及在制备治疗肿瘤的药物中的应用 |
| WO2025212473A1 (en) * | 2024-04-01 | 2025-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to identify and selectively expand tumor antigen-specific t cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821778B1 (en) * | 1993-12-01 | 2004-11-23 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| EP0922758B1 (en) * | 1997-10-27 | 2009-04-15 | Rockefeller University | Methods and compositions for obtaining mature dendritic cells |
| PL1814580T3 (pl) * | 2004-11-24 | 2017-03-31 | Fred Hutchinson Cancer Research Center | Metody stosowania il-21 do adoptywnej immunoterapii i identyfikacji antygenów guza |
| EP2494038B1 (en) * | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
-
2012
- 2012-04-12 US US14/110,901 patent/US9476028B2/en active Active
- 2012-04-12 JP JP2014504319A patent/JP2014514927A/ja active Pending
- 2012-04-12 KR KR1020137029248A patent/KR102028340B1/ko not_active Expired - Fee Related
- 2012-04-12 WO PCT/EP2012/056661 patent/WO2012140130A1/en not_active Ceased
- 2012-04-12 CN CN201280018193.2A patent/CN103502439B/zh active Active
- 2012-04-12 EP EP12713167.0A patent/EP2697367B1/en active Active
-
2016
- 2016-10-24 US US15/331,924 patent/US9789174B2/en active Active
-
2017
- 2017-03-15 JP JP2017049576A patent/JP6207783B2/ja not_active Expired - Fee Related
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