JP2014514927A5 - - Google Patents
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- JP2014514927A5 JP2014514927A5 JP2014504319A JP2014504319A JP2014514927A5 JP 2014514927 A5 JP2014514927 A5 JP 2014514927A5 JP 2014504319 A JP2014504319 A JP 2014504319A JP 2014504319 A JP2014504319 A JP 2014504319A JP 2014514927 A5 JP2014514927 A5 JP 2014514927A5
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- Japan
- Prior art keywords
- cells
- antigen
- specific
- administered
- dendritic cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 210000004443 dendritic cell Anatomy 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 230000000735 allogeneic effect Effects 0.000 claims 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 5
- 210000004698 lymphocyte Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 3
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000037452 priming Effects 0.000 claims 3
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 229940124614 TLR 8 agonist Drugs 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229940022511 therapeutic cancer vaccine Drugs 0.000 claims 2
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- -1 IL-1β Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000005975 antitumor immune response Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474904P | 2011-04-13 | 2011-04-13 | |
| US61/474,904 | 2011-04-13 | ||
| PCT/EP2012/056661 WO2012140130A1 (en) | 2011-04-13 | 2012-04-12 | Method for proliferation of antigen-specific t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017049576A Division JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014514927A JP2014514927A (ja) | 2014-06-26 |
| JP2014514927A5 true JP2014514927A5 (enExample) | 2015-05-07 |
Family
ID=45937382
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504319A Pending JP2014514927A (ja) | 2011-04-13 | 2012-04-12 | 抗原特異的ｔ細胞の増殖のための方法 |
| JP2017049576A Expired - Fee Related JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017049576A Expired - Fee Related JP6207783B2 (ja) | 2011-04-13 | 2017-03-15 | 抗原特異的ｔ細胞の増殖のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9476028B2 (enExample) |
| EP (1) | EP2697367B1 (enExample) |
| JP (2) | JP2014514927A (enExample) |
| KR (1) | KR102028340B1 (enExample) |
| CN (1) | CN103502439B (enExample) |
| WO (1) | WO2012140130A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5825966B2 (ja) * | 2011-10-11 | 2015-12-02 | 株式会社日本バイオセラピー研究所 | Ｃｄ５６陽性ｔ細胞増強方法 |
| ES2591230T3 (es) * | 2012-12-18 | 2016-11-25 | Immunicum Ab | Co-diferenciación y activación de monocitos procedentes de donantes alogénicos para producir células dendríticas pro-inflamatorias |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| KR102238226B1 (ko) * | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용 |
| CN106103711A (zh) | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用 |
| US20170044496A1 (en) | 2014-04-10 | 2017-02-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy |
| SG11201608393TA (en) * | 2014-04-10 | 2016-11-29 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Transgene genetic tags and methods of use |
| SI3689899T1 (sl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | MND promotor kimeričnih antigenskih receptorjev |
| EP3738597A1 (en) * | 2014-04-25 | 2020-11-18 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| NZ726989A (en) | 2014-06-06 | 2020-08-28 | Bluebird Bio Inc | Improved t cell compositions |
| SG10201900455YA (en) | 2014-07-24 | 2019-02-27 | Bluebird Bio Inc | Bcma chimeric antigen receptors |
| CN107106611B (zh) * | 2014-10-27 | 2021-11-23 | 弗雷德哈钦森癌症研究中心 | 用于提高过继细胞免疫疗法效力的组合物和方法 |
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| NZ733025A (en) | 2014-12-12 | 2022-01-28 | 2Seventy Bio Inc | Bcma chimeric antigen receptors |
| WO2016179006A1 (en) | 2015-05-01 | 2016-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
| AU2016259020B2 (en) * | 2015-05-07 | 2021-12-09 | Baylor College Of Medicine | Dendritic cell immunotherapy |
| CN114107197A (zh) * | 2015-05-13 | 2022-03-01 | 泰尔茂比司特公司 | 细胞扩增 |
| EP4286511A3 (en) * | 2015-06-12 | 2024-03-06 | Lentigen Technology, Inc. | Method to treat cancer with engineered t-cells |
| WO2017024006A1 (en) * | 2015-08-03 | 2017-02-09 | The Johns Hopkins University | Personalized, allogeneic cell therapy of cancer |
| US11458167B2 (en) | 2015-08-07 | 2022-10-04 | Seattle Children's Hospital | Bispecific CAR T-cells for solid tumor targeting |
| US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
| US11834675B2 (en) | 2015-12-30 | 2023-12-05 | Celgene Corporation | T lymphocyte production methods and t lymphocytes produced thereby |
| EP3400289A4 (en) * | 2016-01-08 | 2019-06-19 | Prospect Chartercare RWMC LLC D/B/A Roger Williams Medical Center | GERIATRIC CAR T CELLS AND USES THEREOF |
| KR102770425B1 (ko) * | 2016-02-08 | 2025-02-18 | 고쿠리츠다이가쿠호진 미에다이가쿠 | 면역체크포인트 저해제 저항성 종양에 대한 t세포 수주요법의 전처치약 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| PL3444334T3 (pl) | 2016-04-15 | 2022-01-10 | Kyoto University | Sposób indukowania limfocytów t cd8-dodatnich swoistych wobec antygenu |
| EP3452082A1 (en) | 2016-05-04 | 2019-03-13 | Fred Hutchinson Cancer Research Center | Cell-based neoantigen vaccines and uses thereof |
| CA3029813A1 (en) | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| MA45491A (fr) * | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
| CN107779433A (zh) * | 2016-08-30 | 2018-03-09 | 天津市康婷生物工程有限公司 | 便捷的刺激nk细胞增殖和分化的饲养层制备方法 |
| JP2018042481A (ja) * | 2016-09-13 | 2018-03-22 | テラ株式会社 | 抗原特異的ｔ細胞含有組成物及びその製造方法 |
| AU2017347851B2 (en) | 2016-10-26 | 2024-03-07 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| KR20240005168A (ko) | 2016-11-04 | 2024-01-11 | 2세븐티 바이오, 인코포레이티드 | 항-bcma car t 세포 조성물 |
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| RU2019120398A (ru) | 2016-12-03 | 2021-01-12 | Джуно Терапьютикс, Инк. | Способы определения дозировки cart-клеток |
| CN110249046A (zh) | 2016-12-05 | 2019-09-17 | 朱诺治疗学股份有限公司 | 用于过继细胞疗法的工程化细胞的产生 |
| CN110291200B (zh) | 2016-12-12 | 2024-05-14 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体 |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| CN107502589A (zh) * | 2017-08-04 | 2017-12-22 | 北京世纪劲得生物技术有限公司 | 一种肿瘤浸润淋巴细胞与单个核细胞共培养方法 |
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| JP2021509586A (ja) | 2018-01-08 | 2021-04-01 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍抗原特異的ｔ細胞について濃縮されたｔｉｌ製品を生成するためのプロセス |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| WO2019183924A1 (en) * | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CN108841792A (zh) * | 2018-06-14 | 2018-11-20 | 浙江大学 | 靶向cd19和ebna1基因修饰的t细胞及其制备方法与应用 |
| WO2020096988A2 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| CN109370987A (zh) * | 2018-11-23 | 2019-02-22 | 见多视光(北京)科技有限公司 | 外周血ctl细胞改良的培养方法 |
| WO2020243561A1 (en) * | 2019-05-31 | 2020-12-03 | Modernatx, Inc. | Expanded t cell assay |
| WO2021007180A1 (en) * | 2019-07-05 | 2021-01-14 | Case Western Reserve University | Priming media and methods for stem cell culture and therapy |
| WO2021191870A1 (en) * | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
| EP4171617A1 (en) | 2020-06-30 | 2023-05-03 | Mendus B.V. | Use of leukemia-derived cells in ovarian cancer vaccines |
| CN113234674B (zh) * | 2021-03-15 | 2023-02-07 | 青岛华赛伯曼医学细胞生物有限公司 | 一种t细胞活化扩增的方法及其应用 |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics Inc | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| CN115068598A (zh) * | 2022-04-25 | 2022-09-20 | 福建医科大学孟超肝胆医院(福州市传染病医院) | Tlr激动剂以及包含新生抗原的免疫原性组合物在制备药物中的应用 |
| WO2025212473A1 (en) * | 2024-04-01 | 2025-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to identify and selectively expand tumor antigen-specific t cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821778B1 (en) * | 1993-12-01 | 2004-11-23 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| ATE428769T1 (de) * | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
| JP2008521406A (ja) | 2004-11-24 | 2008-06-26 | フレッド ハッチンソン キャンサー リサーチ センター | 養子免疫療法のためのｉｌ−２１の使用法および腫瘍抗原の同定法 |
| CN102597222B (zh) * | 2009-10-27 | 2015-07-15 | 因缪尼卡姆股份公司 | 用于增殖抗原特异性t细胞的方法 |
-
2012
- 2012-04-12 CN CN201280018193.2A patent/CN103502439B/zh active Active
- 2012-04-12 JP JP2014504319A patent/JP2014514927A/ja active Pending
- 2012-04-12 EP EP12713167.0A patent/EP2697367B1/en active Active
- 2012-04-12 KR KR1020137029248A patent/KR102028340B1/ko not_active Expired - Fee Related
- 2012-04-12 WO PCT/EP2012/056661 patent/WO2012140130A1/en not_active Ceased
- 2012-04-12 US US14/110,901 patent/US9476028B2/en active Active
-
2016
- 2016-10-24 US US15/331,924 patent/US9789174B2/en active Active
-
2017
- 2017-03-15 JP JP2017049576A patent/JP6207783B2/ja not_active Expired - Fee Related
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