JP2014511704A5 - - Google Patents
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- JP2014511704A5 JP2014511704A5 JP2014504317A JP2014504317A JP2014511704A5 JP 2014511704 A5 JP2014511704 A5 JP 2014511704A5 JP 2014504317 A JP2014504317 A JP 2014504317A JP 2014504317 A JP2014504317 A JP 2014504317A JP 2014511704 A5 JP2014511704 A5 JP 2014511704A5
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- JP
- Japan
- Prior art keywords
- cells
- antigen
- specific
- viral
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 208000036142 Viral infection Diseases 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000001616 monocyte Anatomy 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 3
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 3
- 108010067390 Viral Proteins Proteins 0.000 claims 3
- 230000000735 allogeneic effect Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 2
- 229940124614 TLR 8 agonist Drugs 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000037452 priming Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- -1 IL-1β Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 230000007416 antiviral immune response Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 229960004854 viral vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474892P | 2011-04-13 | 2011-04-13 | |
| US61/474,892 | 2011-04-13 | ||
| PCT/EP2012/056658 WO2012140127A2 (en) | 2011-04-13 | 2012-04-12 | Method for priming of t cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511704A JP2014511704A (ja) | 2014-05-19 |
| JP2014511704A5 true JP2014511704A5 (enExample) | 2015-05-28 |
Family
ID=45953145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504317A Withdrawn JP2014511704A (ja) | 2011-04-13 | 2012-04-12 | Ｔ細胞のプライミングのための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9492529B2 (enExample) |
| EP (1) | EP2696894B1 (enExample) |
| JP (1) | JP2014511704A (enExample) |
| KR (1) | KR20140043340A (enExample) |
| CN (1) | CN103533955A (enExample) |
| WO (1) | WO2012140127A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2668816C2 (ru) * | 2012-12-18 | 2018-10-02 | Иммуникум Аб | Совместная дифференцировка моноцитов от аллогенных доноров |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| JP6775515B2 (ja) | 2015-03-11 | 2020-10-28 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | トランスポザーゼポリペプチド及びその使用 |
| US20180171294A1 (en) * | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
| JP2018510644A (ja) * | 2015-03-26 | 2018-04-19 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 治療およびエピトープマッピング用Ｔ細胞の感作および増殖のためのｉｎ ｖｉｔｒｏ人工リンパ節 |
| PT3291821T (pt) | 2015-05-07 | 2026-03-18 | Baylor College Medicine | Imunoterapêutica com células dendríticas |
| CN108369226B (zh) * | 2015-12-16 | 2022-06-07 | Neogap治疗学公司 | T细胞反应性平台 |
| CN105543170A (zh) * | 2015-12-31 | 2016-05-04 | 中山大学 | 一种可刺激t细胞扩增的组合物 |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖワクチン接種および免疫療法 |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| CA3028982A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| AU2018219226B2 (en) | 2017-02-07 | 2024-12-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| CN110582288B (zh) | 2017-02-28 | 2024-09-20 | 恩多塞特公司 | 用于car t细胞疗法的组合物和方法 |
| US20200345800A1 (en) * | 2017-10-03 | 2020-11-05 | Tokyo Metropolitan Institute Of Medical Science | Medication for influenza |
| WO2019144095A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| AU2019218729B2 (en) | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| JP7568224B2 (ja) | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための配列決定法 |
| CN109370987A (zh) * | 2018-11-23 | 2019-02-22 | 见多视光(北京)科技有限公司 | 外周血ctl细胞改良的培养方法 |
| KR102234394B1 (ko) * | 2019-03-08 | 2021-03-31 | 신지섭 | 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제 |
| EP3959305A1 (en) | 2019-04-26 | 2022-03-02 | Allogene Therapeutics, Inc. | Methods of manufacturing allogeneic car t cells |
| WO2021006733A1 (en) * | 2019-07-08 | 2021-01-14 | Erasmus University Medical Center Rotterdam | Rapid in vitro t cell exhaustion |
| IL295063A (en) | 2020-02-04 | 2022-09-01 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Chimeric antigen receptors (car) against dinitrophenol |
| WO2022125746A2 (en) * | 2020-12-09 | 2022-06-16 | Tevogen Bio Inc. | Virus specific t-cells and methods of treating and preventing viral infections |
| CN115877017B (zh) * | 2023-03-01 | 2023-05-05 | 首都医科大学附属北京地坛医院 | 预测hiv/aids患者免疫重建的产品和系统 |
| CN116948966A (zh) * | 2023-07-07 | 2023-10-27 | 华南农业大学 | 单倍型spf鸡细胞免疫应答模型的建立方法、细胞应答测试方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821778B1 (en) | 1993-12-01 | 2004-11-23 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| ATE428769T1 (de) | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| EP1712634A1 (en) | 2005-04-13 | 2006-10-18 | Wittycell SAS | Selection of highly efficient antigen presenting cells for regulating immunity and uses thereof |
| PT2201100E (pt) * | 2007-09-14 | 2016-06-03 | Univ Brussel Vrije | Aperfeiçoamento da capacidade estimulatória de células t das células que apresentam antígeno humano e o seu uso na vacinação |
| US9211321B2 (en) | 2009-10-27 | 2015-12-15 | Immunicum Ab | Method for proliferation of antigen-specific T cells |
-
2012
- 2012-04-12 US US14/110,899 patent/US9492529B2/en not_active Expired - Fee Related
- 2012-04-12 CN CN201280018223.XA patent/CN103533955A/zh active Pending
- 2012-04-12 JP JP2014504317A patent/JP2014511704A/ja not_active Withdrawn
- 2012-04-12 KR KR1020137029247A patent/KR20140043340A/ko not_active Withdrawn
- 2012-04-12 EP EP12713992.1A patent/EP2696894B1/en not_active Not-in-force
- 2012-04-12 WO PCT/EP2012/056658 patent/WO2012140127A2/en not_active Ceased
-
2016
- 2016-11-14 US US15/350,124 patent/US10000736B2/en active Active
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