JP2014514340A - 脂質代謝障害の治療に有用な組成物 - Google Patents

脂質代謝障害の治療に有用な組成物 Download PDF

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Publication number
JP2014514340A
JP2014514340A JP2014508740A JP2014508740A JP2014514340A JP 2014514340 A JP2014514340 A JP 2014514340A JP 2014508740 A JP2014508740 A JP 2014508740A JP 2014508740 A JP2014508740 A JP 2014508740A JP 2014514340 A JP2014514340 A JP 2014514340A
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JP
Japan
Prior art keywords
dose
policosanol
composition
preferred dose
resveratrol
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Pending
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JP2014508740A
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English (en)
Japanese (ja)
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JP2014514340A5 (enExample
Inventor
アレアルド・コヴェレク
アシュラフ・ヴィルマーニ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of JP2014514340A publication Critical patent/JP2014514340A/ja
Publication of JP2014514340A5 publication Critical patent/JP2014514340A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014508740A 2011-05-03 2012-04-24 脂質代謝障害の治療に有用な組成物 Pending JP2014514340A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11164526.3 2011-05-03
EP11164526 2011-05-03
PCT/EP2012/057428 WO2012150146A1 (en) 2011-05-03 2012-04-24 Composition useful for the treatment of lipid metabolism disorders

Publications (2)

Publication Number Publication Date
JP2014514340A true JP2014514340A (ja) 2014-06-19
JP2014514340A5 JP2014514340A5 (enExample) 2015-06-11

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ID=44645300

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Application Number Title Priority Date Filing Date
JP2014508740A Pending JP2014514340A (ja) 2011-05-03 2012-04-24 脂質代謝障害の治療に有用な組成物

Country Status (29)

Country Link
US (1) US9125903B2 (enExample)
EP (1) EP2704734B1 (enExample)
JP (1) JP2014514340A (enExample)
KR (1) KR101840082B1 (enExample)
CN (1) CN103517711B (enExample)
AR (1) AR086231A1 (enExample)
AU (1) AU2012251818B2 (enExample)
CA (1) CA2834173A1 (enExample)
CL (1) CL2013003144A1 (enExample)
CY (1) CY1116612T1 (enExample)
DK (1) DK2704734T3 (enExample)
EA (1) EA025256B1 (enExample)
ES (1) ES2542412T3 (enExample)
HR (1) HRP20150767T1 (enExample)
IL (1) IL229205A (enExample)
ME (1) ME02180B (enExample)
MX (1) MX361038B (enExample)
MY (1) MY176018A (enExample)
NZ (1) NZ617641A (enExample)
PH (1) PH12013502229A1 (enExample)
PL (1) PL2704734T3 (enExample)
PT (1) PT2704734E (enExample)
RS (1) RS54100B1 (enExample)
SG (1) SG194679A1 (enExample)
SI (1) SI2704734T1 (enExample)
SM (1) SMT201500173B (enExample)
UA (1) UA112182C2 (enExample)
WO (1) WO2012150146A1 (enExample)
ZA (1) ZA201309205B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
CN103202471B (zh) * 2013-04-25 2014-06-11 福建永生活力生物工程有限公司 一种辅助降血脂的保健食品及其制备方法
WO2016193096A1 (en) 2015-05-29 2016-12-08 Givaudan Sa Spray drying
CN105395925A (zh) * 2015-11-27 2016-03-16 杭州海王生物工程有限公司 一种以降血脂为基础的具有降血压和减肥功效的组合物
CN105475580A (zh) * 2016-01-19 2016-04-13 苟春虎 黑青稞降血脂茶（奶茶）
CN105853347A (zh) * 2016-04-01 2016-08-17 海南合瑞制药股份有限公司 一种左卡尼汀的组合物及其制备方法
IT201600075378A1 (it) * 2016-07-19 2018-01-19 Farm Legnani Del Dottor De Zanetti Andrea Integratore alimentare a base di riso rosso fermentato
IT201600078969A1 (it) * 2016-07-27 2018-01-27 Buonamici Gugliemo Integratore alimentare
WO2019018937A1 (en) 2017-07-26 2019-01-31 Yacyshyn Vincent REMOVAL OF CONTAMINANT POLYPHENOLS FROM START LOAD POLYPHENOLS
EP3735296A4 (en) 2018-01-04 2021-09-08 Pure Care Pro Llc NATURAL COMBINED PRODUCTS AND TOTAL BLOOD CHOLESTEROL REGULATION METHODS
US11173187B2 (en) 2018-11-13 2021-11-16 Immortazyme Company Ltd. Concentrated oil-based polyphenol composition and a method of producing the oil-based polyphenol composition
IT201900007002A1 (it) * 2019-05-20 2020-11-20 Angelo Montecuollo Integratore alimentare a base di caffè
CN112056563A (zh) * 2020-09-15 2020-12-11 王胜林 用于修复脂质代谢障碍的营养素组合物及其应用
KR102418383B1 (ko) * 2020-11-19 2022-07-07 한국식품산업클러스터진흥원 천연 복합물을 포함하는 비만 예방 또는 치료용 조성물
IT202200003191A1 (it) * 2022-02-21 2023-08-21 Inpha Res S R L Composizione per il controllo delle iperlipidemie
CN119424573B (zh) * 2024-02-05 2025-09-26 天津铭瑞医药科技有限公司 用于治疗高脂血症的中西药物组合

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54113409A (en) * 1978-02-03 1979-09-05 Sigma Tau Ind Farmaceuti Treating agent for hyperlipoid disease
JPH09176005A (ja) * 1995-12-21 1997-07-08 Sigma Tau Ind Farmaceut Riunite Spa オメガ−３系のポリ不飽和脂肪酸を併用するｌ−カルニチンまたはアルカノイル ｌ−カルニチン含有医薬組成物
JPH10330251A (ja) * 1997-05-27 1998-12-15 Kanegafuchi Chem Ind Co Ltd コレステロール低下剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030178A1 (it) 2003-04-17 2004-10-18 Sigma Tau Ind Farmaceuti Uso della l-carnitina per il trattamento di patologie cardiovascolari.
KR101573316B1 (ko) * 2004-03-29 2015-12-01 와이어쓰 엘엘씨 종합비타민 및 무기물 영양 보충제
US20100119600A1 (en) * 2007-06-01 2010-05-13 Joar Opheim Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54113409A (en) * 1978-02-03 1979-09-05 Sigma Tau Ind Farmaceuti Treating agent for hyperlipoid disease
JPH09176005A (ja) * 1995-12-21 1997-07-08 Sigma Tau Ind Farmaceut Riunite Spa オメガ−３系のポリ不飽和脂肪酸を併用するｌ−カルニチンまたはアルカノイル ｌ−カルニチン含有医薬組成物
JPH10330251A (ja) * 1997-05-27 1998-12-15 Kanegafuchi Chem Ind Co Ltd コレステロール低下剤

Non-Patent Citations (5)

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Title
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 367, JPN6016011585, 2008, pages 190 - 194, ISSN: 0003285115 *
MAYO CLIN. PROC., vol. 83, no. 7, JPN6016011586, 2008, pages 758 - 764, ISSN: 0003285113 *
NEPHRON CLIN. PRACT., vol. 101, JPN6017017196, 2005, pages 174 - 179, ISSN: 0003558528 *
NUTR. REV., vol. 61, no. 11, JPN6016011584, 2003, pages 376 - 383, ISSN: 0003285114 *
中国中葯雑誌, vol. Vol.35 Iss.4, JPN6017017197, 2010, pages 504 - 507, ISSN: 0003558529 *

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Publication number Publication date
AU2012251818A1 (en) 2013-11-28
CL2013003144A1 (es) 2014-07-04
PH12013502229A1 (en) 2021-06-23
SI2704734T1 (sl) 2015-08-31
NZ617641A (en) 2015-12-24
EA025256B1 (ru) 2016-12-30
UA112182C2 (uk) 2016-08-10
CN103517711A (zh) 2014-01-15
HRP20150767T1 (hr) 2015-08-28
MY176018A (en) 2020-07-21
CA2834173A1 (en) 2012-11-08
SG194679A1 (en) 2013-12-30
IL229205A (en) 2017-01-31
EP2704734B1 (en) 2015-06-17
EA201391622A1 (ru) 2014-02-28
MX361038B (es) 2018-11-26
RS54100B1 (sr) 2015-10-30
ES2542412T3 (es) 2015-08-05
AU2012251818B2 (en) 2017-04-13
EP2704734A1 (en) 2014-03-12
PL2704734T3 (pl) 2015-10-30
AR086231A1 (es) 2013-11-27
KR20140036170A (ko) 2014-03-25
DK2704734T3 (en) 2015-07-20
US9125903B2 (en) 2015-09-08
CN103517711B (zh) 2016-07-27
IL229205A0 (en) 2014-01-30
PT2704734E (pt) 2015-09-07
CY1116612T1 (el) 2017-03-15
US20140086985A1 (en) 2014-03-27
SMT201500173B (it) 2015-10-30
WO2012150146A1 (en) 2012-11-08
MX2013012781A (es) 2013-12-06
ME02180B (me) 2015-10-20
ZA201309205B (en) 2015-04-29
KR101840082B1 (ko) 2018-03-19

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