HRP20150767T1 - Pripravak koristan za lijeäśenje poremeä†aja metabolizma lipida - Google Patents

Pripravak koristan za lijeäśenje poremeä†aja metabolizma lipida Download PDF

Info

Publication number
HRP20150767T1
HRP20150767T1 HRP20150767TT HRP20150767T HRP20150767T1 HR P20150767 T1 HRP20150767 T1 HR P20150767T1 HR P20150767T T HRP20150767T T HR P20150767TT HR P20150767 T HRP20150767 T HR P20150767T HR P20150767 T1 HRP20150767 T1 HR P20150767T1
Authority
HR
Croatia
Prior art keywords
dose
preparation according
preferred
acid
resveratrol
Prior art date
Application number
HRP20150767TT
Other languages
English (en)
Inventor
Aleardo Koverech
Ashraf Virmani
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of HRP20150767T1 publication Critical patent/HRP20150767T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (14)

1. Pripravak, naznačen time što kao aktivne sastojke sadrži: (a) ekstrakt riže fermentirane s gljivicom Monascus purpureus; (b) najmanje jednu ω-3 masnu kiselinu; (c) l-karnitin, ili njegovu sol; i jedan ili više sljedećih aktivnih sastojaka: (d) najmanje jedan polikozanol, ili prirodni ekstrakt koji sadrži polikozanole; (e) rezveratrol, ili prirodni ekstrakt koji sadrži rezveratrol; (f) koenzim Q10; i (g) najmanje jedan vitamin.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što kao aktivne sastojke sadrži: (a) ekstrakt riže fermentirane s gljivicom Monascus purpureus; (b) najmanje jednu ω-3 masnu kiselinu; (c) l-karnitin, ili njegovu sol; (d) najmanje jedan polikozanol, ili prirodni ekstrakt koji sadrži polikozanole; (e) rezveratrol, ili prirodni ekstrakt koji sadrži rezveratrol; (f) koenzim Q10; i izborno (g) najmanje jedan vitamin.
3. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što kao aktivne sastojke sadrži: (a) ekstrakt riže fermentirane s gljivicom Monascus purpureus u dozi od 1 mg do 3000 mg, gdje se poželjne doze se kreću od 10 mg do 2000 mg, a najpoželjnija doza je 200 mg; (b) najmanje jednu ω-3 masnu kiselinu u dozi od 1 mg do 2000 mg, gdje se poželjne doze se kreću od 10 mg do 1000 mg, a najpoželjnija doza je 600 mg; (c) l-karnitin, ili njegovu sol, u dozi od 1 mg do 3000 mg, gdje se poželjne doze se kreću od 10 mg do 1000 mg, a najpoželjnija doza je 100 mg u obliku unutarnje soli; (d) najmanje jedan polikozanol, ili prirodni ekstrakt koji sadrži polikozanole, u dozi od 0,1 mg do 1000 mg, gdje se poželjne doze se kreću od 1 mg do 100 mg, a najpoželjnija doza je 10 mg; (e) rezveratrol, ili prirodni ekstrakt koji sadrži rezveratrol, u dozi od 0,1 mg do 1000 mg, gdje se poželjne doze se kreću od 1 mg do 100 mg, a najpoželjnija doza je 10 mg; (f) koenzim Q10 u dozi od 0,1 mg do 1000 mg, gdje se poželjne doze se kreću od 1 mg do 100 mg, a najpoželjnija doza je 10 mg; (g) vitamin B6 u dozi od 0,03 mg do 300 mg, gdje se poželjne doze se kreću od 0,3 mg do 30 mg, a najpoželjnija doza je 3 mg; i (h) vitamin B12 u dozi od 0,025 µg do 250 µg, gdje se poželjne doze se kreću od 0,25 µg do 25 µg, a najpoželjnija doza je 2,5 µg.
4. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što kao aktivne sastojke sadrži: (a) ekstrakt riže fermentirane s gljivicom Monascus purpureus u dozi od 200 mg koja sadrži 3 mg monakolina K; (b) riblje ulje u dozi od 600 mg koja sadrži 120 mg DHA i 165 mg EPA; (c) l-karnitin-tartarat u dozi od 147 mg, koja odgovara 100 mg unutarnje soli l-karnitina; (d) ekstrakt šećerne trske koji sadrži polikozanole u dozi od 10 mg; (e) rezveratrol u dozi od 10 mg; (f) koenzim Q10 u dozi od 10 mg; (g) vitamin B6 u dozi od 3 mg; i (h) vitamin B12 u dozi od 2,5 µg.
5. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je namijenjen upotrebi kao antikolesterolemična i antitrigliceridemična sredstva, te za povećavanje razine HDL kolesterola.
6. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je namijenjen upotrebi u sprječavanju ili liječenju promijenjenog metabolizma lipida i njegovih komplikacija, gdje se navedene komplikacije biraju iz skupine koju čine kardiovaskularne, aterosklerotične i/ili tromboembolične bolesti.
7. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je namijenjen upotrebi kao medikament.
8. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je namijenjen upotrebi kao dodatak prehrani.
9. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što dodatno sadrži druge vitamine, koenzime, mineralne tvari i antioksidanse ili aktivne sastojke korisne u liječenju poremećaja lipida.
10. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što dodatno sadrži najmanje jedan farmaceutski prihvatljiv nosač i/ili ekscipijent.
11. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što se može primijeniti oralno, u tekućem, polutekućem ili krutom obliku; u vrećicama, pilulama, ampulama, balzamima, gelovima, ili liposomima.
12. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što se sol l-karnitina koju sadrži bira iz skupine koju čine klorid, bromid, orotat, aspartat, kiseli aspartat, kiseli citrat, magnezijev citrat, fosfat, kiseli fosfat, fumarat i kiseli fumarat, magnezijev fumarat, laktat, maleat i kiseli maleat, oksalat, kiseli oksalat, pamoat, kiseli pamoat, sulfat, kiseli sulfat, glucose fosfat, tartarat i kiseli tartarat, glicerofosfat, mukat, magnezijev tartarat, 2-aminoetansulfonat, magnezijev 2-aminoetansulfonat, metansulfonat, kolin-tartarat, trikloracetat i trifluoracetat.
13. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što se polikozanol koji sadrži bira iz skupine koju čine triakontanol, heksakozanol, heksakontanol, ekokontanol, tetrakozanol, dotriakontanol i tetrakontanol.
14. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je polikozanol koji sadrži u obliku ekstrakta iz prirodnih proizvoda koje se bira iz skupine koju čine: pšenične klice, rižine klice, šećerna trska ili lišće biljke Ginkgo biloba.
HRP20150767TT 2011-05-03 2015-07-13 Pripravak koristan za lijeäśenje poremeä†aja metabolizma lipida HRP20150767T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11164526 2011-05-03
PCT/EP2012/057428 WO2012150146A1 (en) 2011-05-03 2012-04-24 Composition useful for the treatment of lipid metabolism disorders
EP12716038.0A EP2704734B1 (en) 2011-05-03 2012-04-24 Composition useful for the treatment of lipid metabolism disorders

Publications (1)

Publication Number Publication Date
HRP20150767T1 true HRP20150767T1 (hr) 2015-08-28

Family

ID=44645300

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20150767TT HRP20150767T1 (hr) 2011-05-03 2015-07-13 Pripravak koristan za lijeäśenje poremeä†aja metabolizma lipida

Country Status (28)

Country Link
US (1) US9125903B2 (hr)
EP (1) EP2704734B1 (hr)
JP (1) JP2014514340A (hr)
KR (1) KR101840082B1 (hr)
CN (1) CN103517711B (hr)
AR (1) AR086231A1 (hr)
AU (1) AU2012251818B2 (hr)
CA (1) CA2834173A1 (hr)
CL (1) CL2013003144A1 (hr)
CY (1) CY1116612T1 (hr)
DK (1) DK2704734T3 (hr)
EA (1) EA025256B1 (hr)
ES (1) ES2542412T3 (hr)
HR (1) HRP20150767T1 (hr)
IL (1) IL229205A (hr)
ME (1) ME02180B (hr)
MX (1) MX361038B (hr)
MY (1) MY176018A (hr)
NZ (1) NZ617641A (hr)
PL (1) PL2704734T3 (hr)
PT (1) PT2704734E (hr)
RS (1) RS54100B1 (hr)
SG (1) SG194679A1 (hr)
SI (1) SI2704734T1 (hr)
SM (1) SMT201500173B (hr)
UA (1) UA112182C2 (hr)
WO (1) WO2012150146A1 (hr)
ZA (1) ZA201309205B (hr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103202471B (zh) * 2013-04-25 2014-06-11 福建永生活力生物工程有限公司 一种辅助降血脂的保健食品及其制备方法
WO2016193096A1 (en) 2015-05-29 2016-12-08 Givaudan Sa Spray drying
CN105395925A (zh) * 2015-11-27 2016-03-16 杭州海王生物工程有限公司 一种以降血脂为基础的具有降血压和减肥功效的组合物
CN105475580A (zh) * 2016-01-19 2016-04-13 苟春虎 黑青稞降血脂茶（奶茶）
CN105853347A (zh) * 2016-04-01 2016-08-17 海南合瑞制药股份有限公司 一种左卡尼汀的组合物及其制备方法
IT201600075378A1 (it) * 2016-07-19 2018-01-19 Farm Legnani Del Dottor De Zanetti Andrea Integratore alimentare a base di riso rosso fermentato
IT201600078969A1 (it) * 2016-07-27 2018-01-27 Buonamici Gugliemo Integratore alimentare
US11441161B2 (en) 2017-07-26 2022-09-13 Immortazyme Company Ltd. Removing polyphenol contaminants from feedstock-based polyphenols
CN111629784A (zh) * 2018-01-04 2020-09-04 纯护理专业有限责任公司 用于调节总血液胆固醇的天然组合产品和方法
US11173187B2 (en) 2018-11-13 2021-11-16 Immortazyme Company Ltd. Concentrated oil-based polyphenol composition and a method of producing the oil-based polyphenol composition
IT201900007002A1 (it) * 2019-05-20 2020-11-20 Angelo Montecuollo Integratore alimentare a base di caffè
CN112056563A (zh) * 2020-09-15 2020-12-11 王胜林 用于修复脂质代谢障碍的营养素组合物及其应用
KR102418383B1 (ko) * 2020-11-19 2022-07-07 한국식품산업클러스터진흥원 천연 복합물을 포함하는 비만 예방 또는 치료용 조성물
IT202200003191A1 (it) * 2022-02-21 2023-08-21 Inpha Res S R L Composizione per il controllo delle iperlipidemie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2903558C2 (de) * 1978-02-03 1994-09-01 Sigma Tau Ind Farmaceuti Verwendung von L-Carnitin
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
JP3926888B2 (ja) * 1997-05-27 2007-06-06 株式会社カネカ コレステロール低下剤
ITRM20030178A1 (it) 2003-04-17 2004-10-18 Sigma Tau Ind Farmaceuti Uso della l-carnitina per il trattamento di patologie cardiovascolari.
TR201909238T4 (tr) * 2004-03-29 2019-07-22 Wyeth Llc Multi-vitamin ve mineral besin takviyeleri.
US20100119600A1 (en) * 2007-06-01 2010-05-13 Joar Opheim Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof

Also Published As

Publication number Publication date
DK2704734T3 (en) 2015-07-20
KR20140036170A (ko) 2014-03-25
CY1116612T1 (el) 2017-03-15
MX2013012781A (es) 2013-12-06
CN103517711A (zh) 2014-01-15
RS54100B1 (en) 2015-10-30
CL2013003144A1 (es) 2014-07-04
NZ617641A (en) 2015-12-24
EP2704734B1 (en) 2015-06-17
EA201391622A1 (ru) 2014-02-28
MY176018A (en) 2020-07-21
AR086231A1 (es) 2013-11-27
AU2012251818B2 (en) 2017-04-13
PT2704734E (pt) 2015-09-07
AU2012251818A1 (en) 2013-11-28
ES2542412T3 (es) 2015-08-05
JP2014514340A (ja) 2014-06-19
EA025256B1 (ru) 2016-12-30
CA2834173A1 (en) 2012-11-08
EP2704734A1 (en) 2014-03-12
MX361038B (es) 2018-11-26
CN103517711B (zh) 2016-07-27
KR101840082B1 (ko) 2018-03-19
US20140086985A1 (en) 2014-03-27
SMT201500173B (it) 2015-10-30
SI2704734T1 (sl) 2015-08-31
IL229205A (en) 2017-01-31
IL229205A0 (en) 2014-01-30
WO2012150146A1 (en) 2012-11-08
ME02180B (me) 2015-10-20
UA112182C2 (uk) 2016-08-10
ZA201309205B (en) 2015-04-29
PL2704734T3 (pl) 2015-10-30
US9125903B2 (en) 2015-09-08
SG194679A1 (en) 2013-12-30

Similar Documents

Publication Publication Date Title
HRP20150767T1 (hr) Pripravak koristan za lijeäśenje poremeä†aja metabolizma lipida
JP2014514340A5 (hr)
US10512615B1 (en) Compositions and methods for delivering cannabidiol and ketone bodies
US20090099261A1 (en) Omega-3 mixtures
US10973792B2 (en) Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
US11903978B2 (en) Non-winterized, standardized marine source oil products and methods of making thereof
WO2020167690A1 (en) Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use
US20200170982A1 (en) S-beta-hydroxybutyrate compounds and compositions enriched with s-enantiomer
US11129802B2 (en) Compositions and methods for delivering cannabidiol and ketone bodies
JP2023166026A (ja) 非ラセミ体のベータ－ヒドロキシブチレート化合物およびｒ－エナンチオマー富化組成物およびキット
CA3166226C (en) Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions
US11419836B2 (en) Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions
JP2009155278A (ja) 高ホモシステイン血症改善剤
US20200061023A1 (en) Compositions and methods for delivering tetrahydrocannabinol and ketone bodies
CN114072137A (zh) S-β-羟基丁酸根化合物和富含S-对映体的组合物
JP2018168139A (ja) ｎ−３系不飽和脂肪酸を含む中性脂肪値の低減または上昇抑制用の組成物、並びに該組成物の製造におけるｎ−３系不飽和脂肪酸の使用
WO2015163091A1 (ja) 不飽和脂肪酸の吸収促進剤
TW201300119A (zh) 用於治療脂質代謝失調之組成物