|
WO2012088446A1
(en)
|
2010-12-22 |
2012-06-28 |
Board Of Trustees Of The Leland Stanford Junior University |
Superagonists and antagonists of interleukin-2
|
|
MX340498B
(es)
|
2011-06-30 |
2016-07-11 |
Chugai Pharmaceutical Co Ltd |
Polipeptido heterodimerizado.
|
|
WO2014149067A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Momenta Pharmaceuticals, Inc. |
Methods related to ctla4-fc fusion proteins
|
|
US10464996B2
(en)
|
2013-05-13 |
2019-11-05 |
Momenta Pharmaceuticals, Inc. |
Methods for the treatment of neurodegeneration
|
|
US11273204B2
(en)
|
2013-08-08 |
2022-03-15 |
Cytune Pharma |
IL-15 and IL-15RAPLHA sushi domain based immunocytokines
|
|
EP3030262B1
(en)
|
2013-08-08 |
2019-10-09 |
Cytune Pharma |
Combined pharmaceutical composition
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
US20160257754A1
(en)
|
2013-10-16 |
2016-09-08 |
Momenta Pharmaceuticals Inc. |
Sialylated glycoproteins
|
|
KR20160102314A
(ko)
*
|
2014-01-02 |
2016-08-29 |
메모리얼 슬로안-케터링 캔서 센터 |
면역 치료요법에 대한 암 반응의 결정인자
|
|
JP6592505B2
(ja)
|
2014-04-24 |
2019-10-16 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト
|
|
CN105296433B
(zh)
*
|
2014-08-01 |
2018-02-09 |
中山康方生物医药有限公司 |
一种ctla4抗体、其药物组合物及其用途
|
|
WO2016025647A1
(en)
|
2014-08-12 |
2016-02-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine
|
|
AU2015301753B2
(en)
|
2014-08-12 |
2021-04-08 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with IL-2 and integrin-binding-Fc-fusion protein
|
|
MX391478B
(es)
|
2014-10-10 |
2025-03-21 |
Idera Pharmaceuticals Inc |
Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer.
|
|
US10983128B2
(en)
|
2015-02-05 |
2021-04-20 |
Bristol-Myers Squibb Company |
CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
|
|
CN108271359B
(zh)
*
|
2015-02-13 |
2021-11-09 |
索伦托药业有限公司 |
结合ctla4的抗体治疗剂
|
|
US10806787B2
(en)
|
2015-02-16 |
2020-10-20 |
Pharma Foods International Co., Ltd. |
Anticancer agents or antimetastatic agents using FSTL1 and combination drug thereof
|
|
CN107849144B
(zh)
*
|
2015-05-29 |
2021-09-17 |
艾吉纳斯公司 |
抗-ctla-4抗体及其使用方法
|
|
NL2014935B1
(en)
*
|
2015-06-08 |
2017-02-03 |
Applied Immune Tech Ltd |
T cell receptor like antibodies having fine specificity.
|
|
HK1248115A1
(zh)
|
2015-07-16 |
2018-10-12 |
Bioxcel Therapeutics, Inc. |
一种使用免疫调节治疗癌症的新颖方法
|
|
HK1257840A1
(zh)
|
2015-09-01 |
2019-11-01 |
Agenus Inc. |
抗-pd-1抗体及其使用方法
|
|
US11208483B2
(en)
|
2015-11-19 |
2021-12-28 |
Shanghai Kanda Biotechnology Co, Ltd. |
CTLA-4 antibodies and uses thereof
|
|
TW202208440A
(zh)
|
2015-12-14 |
2022-03-01 |
美商宏觀基因股份有限公司 |
對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法
|
|
DK3389699T5
(da)
*
|
2015-12-15 |
2024-09-23 |
Oncoc4 Inc |
Kimæriske og humaniserede anti-humane CTLA4-monoklonale antistoffer og anvendelser deraf
|
|
US20190241658A1
(en)
|
2016-01-10 |
2019-08-08 |
Modernatx, Inc. |
Therapeutic mRNAs encoding anti CTLA-4 antibodies
|
|
CA3016474A1
(en)
|
2016-03-15 |
2017-09-21 |
Mersana Therapeutics, Inc. |
Napi2b-targeted antibody-drug conjugates and methods of use thereof
|
|
TW201735949A
(zh)
|
2016-03-24 |
2017-10-16 |
千禧製藥公司 |
治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法
|
|
JP7069032B2
(ja)
|
2016-03-24 |
2022-05-17 |
ミレニアム ファーマシューティカルズ, インコーポレイテッド |
がん免疫治療における胃腸の免疫関連有害事象の治療方法
|
|
US11542332B2
(en)
|
2016-03-26 |
2023-01-03 |
Bioatla, Inc. |
Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
|
|
EA039322B1
(ru)
*
|
2016-04-15 |
2022-01-13 |
Эйдженус Инк. |
Антитела против ctla-4 и способы их применения
|
|
WO2017201352A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
BR112018076260A2
(pt)
|
2016-06-20 |
2019-03-26 |
Kymab Limited |
anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
|
|
EP3478321A4
(en)
|
2016-06-30 |
2020-04-22 |
Oncorus, Inc. |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
WO2018035303A1
(en)
*
|
2016-08-17 |
2018-02-22 |
Orbis Health Solutions Llc |
Tumor-targeting bead vectors and methods of using the same
|
|
CN106977602B
(zh)
|
2016-08-23 |
2018-09-25 |
中山康方生物医药有限公司 |
一种抗pd1单克隆抗体、其药物组合物及其用途
|
|
CN106967172B
(zh)
*
|
2016-08-23 |
2019-01-08 |
康方药业有限公司 |
抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
|
|
WO2018035710A1
(en)
*
|
2016-08-23 |
2018-03-01 |
Akeso Biopharma, Inc. |
Anti-ctla4 antibodies
|
|
WO2018041121A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric ctla-4
|
|
CN107815468B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
CN107815467B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
CA3037380A1
(en)
|
2016-10-11 |
2018-04-19 |
Agenus Inc. |
Anti-lag-3 antibodies and methods of use thereof
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
FI3551660T3
(fi)
*
|
2016-12-07 |
2023-12-11 |
Agenus Inc |
Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
|
|
WO2018112266A1
(en)
|
2016-12-14 |
2018-06-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13 superkine: immune cell targeting constructs and methods of use thereof
|
|
JP2020505438A
(ja)
|
2017-01-10 |
2020-02-20 |
ノダス・セラピューティクスNodus Therapeutics |
インテグリン結合性ポリペプチド−Fc融合タンパク質および免疫調節物質を用いる併用がん治療法
|
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
|
WO2018156250A1
(en)
*
|
2017-02-21 |
2018-08-30 |
Remd Biotherapeutics, Inc. |
Cancer treatment using antibodies that bind cytotoxic t-lymphocyte antigen-4 (ctla-4)
|
|
US20180271996A1
(en)
|
2017-02-28 |
2018-09-27 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
BR112019017695A2
(pt)
*
|
2017-02-28 |
2020-04-07 |
Bristol-Myers Squibb Company |
uso de anticorpos anti-ctla-4 com adcc acentuada para acentuar a resposta imune a uma vacina
|
|
EP3597735A4
(en)
*
|
2017-03-15 |
2020-11-25 |
Suzhou Galaxy Biopharma, Co., Ltd. |
CTLA4 ANTIBODIES, PHARMACEUTICAL COMPOSITION AND USES THEREOF
|
|
CN108948194B
(zh)
*
|
2017-05-19 |
2023-02-17 |
上海药明生物技术有限公司 |
一种新的ctla-4单克隆抗体
|
|
MX2019013648A
(es)
*
|
2017-05-19 |
2021-01-08 |
Wuxi Biologics Shanghai Co Ltd |
Anticuerpos monoclonales novedosos para proteina 4 asociada con el linfocito t citotoxico (ctla-4).
|
|
EP3641814A4
(en)
|
2017-06-19 |
2021-06-23 |
Medicenna Therapeutics Inc. |
USES AND METHODS FOR IL-2 SUPERAGONISTS AND AGONISTS AND FUSIONS THEREOF
|
|
TWI799432B
(zh)
*
|
2017-07-27 |
2023-04-21 |
美商再生元醫藥公司 |
抗ctla-4抗體及其用途
|
|
WO2019020807A1
(en)
*
|
2017-07-28 |
2019-01-31 |
Gene Signal International Sa |
CD9P-1 TARGETING ANTIBODIES AND USES THEREOF
|
|
CN111542538A
(zh)
*
|
2017-07-28 |
2020-08-14 |
基因信号国际公司 |
Cd9p-1-靶向抗体及其用途
|
|
EP3684812A4
(en)
*
|
2017-09-21 |
2021-09-08 |
Eucure (Beijing) Biopharma Co., Ltd |
ANTI-CTLA4 ANTIBODIES AND USES THEREOF
|
|
EP3717021A1
(en)
|
2017-11-27 |
2020-10-07 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
RU2756100C1
(ru)
*
|
2017-12-20 |
2021-09-28 |
Харбор Байомед (Шанхай) Ко., Лтд |
Антитела, связывающие ctla-4, и их применение
|
|
EP3727463A1
(en)
|
2017-12-21 |
2020-10-28 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
EP3731850A4
(en)
|
2017-12-29 |
2021-12-01 |
Oncorus, Inc. |
ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES
|
|
WO2019232523A1
(en)
|
2018-06-01 |
2019-12-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof
|
|
KR20210035805A
(ko)
|
2018-06-15 |
2021-04-01 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
세포후 신호전달 인자의 조절을 통한 면역 활성의 증가
|
|
US12459980B2
(en)
|
2018-07-25 |
2025-11-04 |
AskGene Pharma, Inc. |
IL-21 prodrugs and methods of use thereof
|
|
CN110760002A
(zh)
*
|
2018-07-25 |
2020-02-07 |
南京金斯瑞生物科技有限公司 |
人源化抗人ctla4单克隆抗体及其制备方法和用途
|
|
CN112888445B
(zh)
|
2018-08-30 |
2025-06-10 |
免疫生物公司 |
治疗老年化相关病症的方法
|
|
CN120535649A
(zh)
|
2018-08-30 |
2025-08-26 |
免疫生物公司 |
单链嵌合多肽和其用途
|
|
NZ772550A
(en)
|
2018-08-30 |
2025-08-29 |
Immunitybio Inc |
Multi-chain chimeric polypeptides and uses thereof
|
|
AU2019346335B2
(en)
|
2018-09-28 |
2024-07-25 |
Massachusetts Institute Of Technology |
Collagen-localized immunomodulatory molecules and methods thereof
|
|
AU2019369340A1
(en)
|
2018-10-29 |
2021-05-20 |
Mersana Therapeutics, Inc. |
Cysteine engineered antibody-drug conjugates with peptide-containing linkers
|
|
AU2019371223B2
(en)
*
|
2018-10-31 |
2022-03-17 |
Bioatla, Inc. |
Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
|
|
CA3123338A1
(en)
|
2018-12-21 |
2020-06-25 |
Ose Immunotherapeutics |
Bifunctional anti-pd-1/il-7 molecule
|
|
BR112021012631A2
(pt)
|
2018-12-26 |
2021-12-14 |
Xilio Dev Inc |
Anticorpos anti-ctla4 e métodos de uso dos mesmos
|
|
CN119930820A
(zh)
*
|
2018-12-27 |
2025-05-06 |
吉加根公司 |
抗ctla-4结合蛋白及其使用方法
|
|
US11235032B2
(en)
|
2019-01-23 |
2022-02-01 |
Massachusetts Institute Of Technology |
Combination immunotherapy dosing regimen for immune checkpoint blockade
|
|
WO2020165374A1
(en)
|
2019-02-14 |
2020-08-20 |
Ose Immunotherapeutics |
Bifunctional molecule comprising il-15ra
|
|
MA55805A
(fr)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V Inc |
Métodes de modulation de l'activité immunitaire
|
|
TWI869398B
(zh)
*
|
2019-05-10 |
2025-01-11 |
英商拜西克爾德有限公司 |
治療癌症之方法
|
|
WO2020252264A1
(en)
|
2019-06-12 |
2020-12-17 |
AskGene Pharma, Inc. |
Novel il-15 prodrugs and methods of use thereof
|
|
KR20220035394A
(ko)
|
2019-06-21 |
2022-03-22 |
에이치씨더블유 바이올로직스, 인크. |
다중-사슬 키메라 폴리펩티드 및 이의 용도
|
|
EP3990491A1
(en)
|
2019-06-26 |
2022-05-04 |
Massachusetts Institute of Technology |
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
|
|
JP7695228B2
(ja)
*
|
2019-07-15 |
2025-06-18 |
インターベット インターナショナル ベー. フェー. |
ヒト及びイヌctla-4に対するイヌ化抗体
|
|
CA3145345A1
(en)
|
2019-07-15 |
2021-01-21 |
Intervet International B.V. |
Caninized antibodies against canine ctla-4
|
|
CN110467675B
(zh)
*
|
2019-09-19 |
2020-08-14 |
合源生物科技(天津)有限公司 |
一种ctla-4单克隆抗体6f1及其用于抗肿瘤的用途
|
|
US11459389B2
(en)
|
2019-10-24 |
2022-10-04 |
Massachusetts Institute Of Technology |
Monoclonal antibodies that bind human CD161
|
|
TW202136287A
(zh)
|
2019-12-17 |
2021-10-01 |
法商Ose免疫治療公司 |
包含il-7變體之雙官能分子
|
|
US20230114107A1
(en)
|
2019-12-17 |
2023-04-13 |
Flagship Pioneering Innovations V, Inc. |
Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
|
|
EP4082570A4
(en)
|
2019-12-27 |
2023-09-13 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-CTLA-4 ANTIBODIES AND USE THEREOF
|
|
KR20220140535A
(ko)
|
2020-02-11 |
2022-10-18 |
에이치씨더블유 바이올로직스, 인크. |
크로마토그래피 수지 및 이의 용도
|
|
WO2021163298A1
(en)
|
2020-02-11 |
2021-08-19 |
HCW Biologics, Inc. |
Methods of activating regulatory t cells
|
|
AU2021220870A1
(en)
|
2020-02-11 |
2022-08-04 |
Immunitybio, Inc. |
Methods of treating age-related and inflammatory diseases
|
|
US20230149560A1
(en)
|
2020-04-20 |
2023-05-18 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
IL297442A
(en)
|
2020-04-22 |
2022-12-01 |
Iovance Biotherapeutics Inc |
Systems and methods for coordinating production of cells for patient-specific immunotherapy
|
|
CN115836087A
(zh)
|
2020-04-29 |
2023-03-21 |
Hcw生物科技公司 |
抗cd26蛋白及其用途
|
|
WO2021247003A1
(en)
|
2020-06-01 |
2021-12-09 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
KR20230031280A
(ko)
|
2020-06-01 |
2023-03-07 |
에이치씨더블유 바이올로직스, 인크. |
노화 관련 장애의 치료 방법
|
|
US12024545B2
(en)
|
2020-06-01 |
2024-07-02 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
JP7695272B2
(ja)
*
|
2020-06-11 |
2025-06-18 |
ナントバイオ,インコーポレイテッド |
抗ctla4モノクローナル抗体及びキメラ抗原受容体
|
|
US20230355804A1
(en)
|
2020-06-29 |
2023-11-09 |
Flagship Pioneering Innovations V, Inc. |
Viruses engineered to promote thanotransmission and their use in treating cancer
|
|
IL298825A
(en)
*
|
2020-07-02 |
2023-02-01 |
Gigagen Inc |
ANTI-CTLA-4 binding proteins and methods of using them
|
|
WO2022112198A1
(en)
|
2020-11-24 |
2022-06-02 |
Worldwide Innovative Network |
Method to select the optimal immune checkpoint therapies
|
|
EP4263600A1
(en)
|
2020-12-18 |
2023-10-25 |
Century Therapeutics, Inc. |
Chimeric antigen receptor systems with adaptable receptor specificity
|
|
WO2022169269A1
(ko)
*
|
2021-02-03 |
2022-08-11 |
주식회사 유틸렉스 |
항 ctla-4 항체 및 이의 용도
|
|
CA3214085A1
(en)
|
2021-03-31 |
2022-10-06 |
Darby Rye Schmidt |
Thanotransmission polypeptides and their use in treating cancer
|
|
US20240182571A1
(en)
|
2021-04-09 |
2024-06-06 |
Ose Immunotherapeutics |
New scaffold for bifunctional molecules with improved properties
|
|
WO2022214652A1
(en)
|
2021-04-09 |
2022-10-13 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
CA3220353A1
(en)
|
2021-06-25 |
2022-12-29 |
Chugai Seiyaku Kabushiki Kaisha |
Use of anti-ctla-4 antibody
|
|
US12448451B2
(en)
|
2021-06-25 |
2025-10-21 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-CTLA-4 antibody and use thereof
|
|
AR126220A1
(es)
|
2021-06-25 |
2023-09-27 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-ctla-4
|
|
KR20240026507A
(ko)
|
2021-06-29 |
2024-02-28 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
|
|
JP2025508939A
(ja)
|
2022-03-02 |
2025-04-10 |
イミュニティーバイオ インコーポレイテッド |
膵臓癌の治療方法
|
|
CA3248034A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics Inc |
METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
|
|
WO2024003360A1
(en)
|
2022-07-01 |
2024-01-04 |
Institut Curie |
Biomarkers and uses thereof for the treatment of neuroblastoma
|
|
JP2025525886A
(ja)
|
2022-08-02 |
2025-08-07 |
オーエスイー・イミュノセラピューティクス |
Cd28に対する多機能性分子
|
|
WO2024077191A1
(en)
|
2022-10-05 |
2024-04-11 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
|
|
IL320733A
(en)
|
2022-11-21 |
2025-07-01 |
Iovance Biotherapeutics Inc |
Two-dimensional processes for expanding tumor-infiltrating lymphocytes and treatments thereof
|
|
WO2024151687A1
(en)
|
2023-01-09 |
2024-07-18 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
|
WO2024200826A1
(en)
|
2023-03-30 |
2024-10-03 |
Ose Immunotherapeutics |
Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell inhibiting molecule and use thereof
|
|
WO2024200823A1
(en)
|
2023-03-30 |
2024-10-03 |
Ose Immunotherapeutics |
Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|