JP2014512403A5 - - Google Patents

Info

Publication number

JP2014512403A5

JP2014512403A5 JP2014506862A JP2014506862A JP2014512403A5 JP 2014512403 A5 JP2014512403 A5 JP 2014512403A5 JP 2014506862 A JP2014506862 A JP 2014506862A JP 2014506862 A JP2014506862 A JP 2014506862A JP 2014512403 A5 JP2014512403 A5 JP 2014512403A5

Authority

JP

Japan

Prior art keywords

composition

collagen

weight

total weight

monosaccharide

Prior art date

2012-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000203 mixture Substances 0.000 claims 33
• 102000008186 Collagen Human genes 0.000 claims 13
• 108010035532 Collagen Proteins 0.000 claims 13
• 229920001436 collagen Polymers 0.000 claims 13
• 150000002772 monosaccharides Chemical class 0.000 claims 7
• 238000000034 method Methods 0.000 claims 6
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 5
• 102000013373 fibrillar collagen Human genes 0.000 claims 5
• 108060002894 fibrillar collagen Proteins 0.000 claims 5
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
• 108090000190 Thrombin Proteins 0.000 claims 3
• 229940059329 chondroitin sulfate Drugs 0.000 claims 3
• 239000000047 product Substances 0.000 claims 3
• 229960004072 thrombin Drugs 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• 108010039209 Blood Coagulation Factors Proteins 0.000 claims 2
• 102000015081 Blood Coagulation Factors Human genes 0.000 claims 2
• 229920000045 Dermatan sulfate Polymers 0.000 claims 2
• 239000003114 blood coagulation factor Substances 0.000 claims 2
• -1 carbohydrate compound Chemical class 0.000 claims 2
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 2
• 229940051593 dermatan sulfate Drugs 0.000 claims 2
• 230000002439 hemostatic effect Effects 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 229940030225 antihemorrhagics Drugs 0.000 claims 1
• 239000007900 aqueous suspension Substances 0.000 claims 1
• 238000005119 centrifugation Methods 0.000 claims 1
• 238000010908 decantation Methods 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 238000000605 extraction Methods 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 238000000227 grinding Methods 0.000 claims 1
• 239000002874 hemostatic agent Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000002244 precipitate Substances 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1