CY1122251T1 - Αιμοστατικες συνθεσεις - Google Patents

Αιμοστατικες συνθεσεις

Info

Publication number
CY1122251T1
CY1122251T1 CY20191100862T CY191100862T CY1122251T1 CY 1122251 T1 CY1122251 T1 CY 1122251T1 CY 20191100862 T CY20191100862 T CY 20191100862T CY 191100862 T CY191100862 T CY 191100862T CY 1122251 T1 CY1122251 T1 CY 1122251T1
Authority
CY
Cyprus
Prior art keywords
collagen
composition
fibrillar
hemostatic compositions
relates
Prior art date
Application number
CY20191100862T
Other languages
English (en)
Inventor
Christian Gagnieu
Patricia Forest
Sylvain Picot
Original Assignee
Biom'up
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biom'up filed Critical Biom'up
Publication of CY1122251T1 publication Critical patent/CY1122251T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Abstract

Η εφεύρεση αναφέρεται σε μία αιμοστατική σύνθεση σε μορφή σκόνης που περιλαμβάνει κολλαγόνο του ινιδιακού τύπου που περιλαμβάνει μία περιεκτικότητα ινώδους κολλαγόνου και/ή ινιδιακού κολλαγόνου τουλάχιστον 70% κατά βάρος σε σχέση με το συνολικό βάρος του κολλαγόνου, και τουλάχιστον έναν μονοσακχαρίτη, και προαιρετικά, τουλάχιστον μία χημική ένωση που επιλέγεται από παράγοντες θρόμβωσης και γλυκοζαμινογλυκάνες. Η εφεύρεση περαιτέρω αναφέρεται σε μία μέθοδο για την παρασκευή τέτοιας σύνθεσης, και σε μία μονάδα που περιλαμβάνει τέτοια σύνθεση και μία συσκευή ψεκασμού.
CY20191100862T 2011-04-27 2019-08-12 Αιμοστατικες συνθεσεις CY1122251T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161517973P 2011-04-27 2011-04-27
EP11305492 2011-04-27
PCT/EP2012/057647 WO2012146655A1 (en) 2011-04-27 2012-04-26 Hemostatic compositions
EP12717682.4A EP2701729B1 (en) 2011-04-27 2012-04-26 Hemostatic compositions

Publications (1)

Publication Number Publication Date
CY1122251T1 true CY1122251T1 (el) 2020-11-25

Family

ID=46022222

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100862T CY1122251T1 (el) 2011-04-27 2019-08-12 Αιμοστατικες συνθεσεις

Country Status (14)

Country Link
US (6) US9283187B2 (el)
EP (3) EP3922261A1 (el)
JP (2) JP6050320B2 (el)
CN (2) CN106390186B (el)
AU (4) AU2012247480B2 (el)
BR (2) BR112013027567B1 (el)
CA (2) CA3108894A1 (el)
CY (1) CY1122251T1 (el)
DK (1) DK3513803T3 (el)
ES (1) ES2882911T3 (el)
PL (2) PL3513803T3 (el)
RS (1) RS59243B1 (el)
SI (1) SI2701729T1 (el)
WO (1) WO2012146655A1 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
CA3108894A1 (en) * 2011-04-27 2012-11-01 Biom'up Hemostatic compositions
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
BR112014030962A2 (pt) 2012-06-12 2017-06-27 Ferrosan Medical Devices As métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3470094B1 (en) * 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
RU2546006C1 (ru) 2014-03-07 2015-04-10 Римма Ильинична Ашкинази Противовирусное средство
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
WO2016102446A1 (en) 2014-12-24 2016-06-30 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
WO2016112026A1 (en) * 2015-01-06 2016-07-14 St. Teresa Medical, Inc. Hemostatic products
WO2016118043A1 (ru) * 2015-01-20 2016-07-28 Виктор Вениаминович ТЕЦ Гемостатическое средство
WO2017005590A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US10828387B2 (en) 2015-11-12 2020-11-10 St. Teresa Medical, Inc. Method of sealing a durotomy
PL3496770T3 (pl) 2016-08-12 2021-09-27 Biom'up France SAS Hemostatyczny płynny materiał
WO2018217743A1 (en) 2017-05-24 2018-11-29 Viktor Veniaminovich Tets Fractionated antimicrobial compositions and use thereof
WO2019089717A1 (en) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Fibrin sealant products
BR112020016593B1 (pt) * 2018-02-15 2023-11-14 Biom'up France SAS Produto hemostático impresso, uso de fluido hemostático e método de fabricação de produtos hemostáticos
EP4321182A2 (en) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
CN110652648B (zh) * 2018-08-01 2021-05-28 浙江探针生物科技有限公司 输送药剂的器件及其装置和组件
US11027041B2 (en) * 2019-06-30 2021-06-08 James Drake Stable and robust blended hemostatic composition
JP2021176422A (ja) 2020-05-08 2021-11-11 国立大学法人 東京大学 止血用ポリマー材料キット

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE13810T1 (de) 1981-06-25 1985-07-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung.
US4515637A (en) 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
US4942153A (en) 1987-02-03 1990-07-17 Fernandez Helen M Skin moisturizing product and process
US5263984A (en) * 1987-07-20 1993-11-23 Regen Biologics, Inc. Prosthetic ligaments
US5681353A (en) * 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
IT1263394B (it) 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
DE19520575A1 (de) 1995-06-06 1996-12-12 Permselect Ges Fuer Zellstrukt Hautwirksame Kombination von Mucopolysacchariden
AU7977298A (en) * 1997-06-18 1999-01-04 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
US7691829B2 (en) * 1998-03-24 2010-04-06 Petito George D Composition and method for healing tissues
US20050208114A1 (en) * 1998-03-24 2005-09-22 Petito George D Composition and method for healing tissues
HUP0104168A3 (en) 1998-08-20 2003-04-28 3M Innovative Properties Co Spray on bandage and drug delivery system
US6454787B1 (en) * 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
AT412445B (de) * 2000-06-20 2005-03-25 Biering Wolfgang Flüssiges collagen-hämostatikum
AT411326B (de) 2000-06-20 2003-12-29 Biering Wolfgang Hämostatische collagen-pellets
US20030003157A1 (en) 2001-06-06 2003-01-02 University Of Medicine & Dentistry Of New Jersey Collagen compositions and methods for making and using the same
JP3805654B2 (ja) 2001-08-29 2006-08-02 株式会社ネクスト 止血・癒着防止性のバイオポリマーの微細粒子
WO2003026709A1 (en) 2001-09-26 2003-04-03 Mbs Multination Business Services (G.B.) Ltd. Liquid mixture for use as a dressing spray
EP1501558A1 (de) 2002-05-08 2005-02-02 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Resorbierbare pharmazeutische formulierung zur kontinuierlichen thrombinfreisetzung
US8153591B2 (en) * 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
CN1554448A (zh) 2003-12-23 2004-12-15 张淑荣 壳聚糖明胶聚乙烯醇生物止血敷料
JP2007519450A (ja) * 2004-01-30 2007-07-19 フェロサン アー／エス 止血用のスプレーおよび組成物
WO2005087182A1 (ja) * 2004-03-17 2005-09-22 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo 機能性粉体
EP1580229A1 (en) 2004-03-22 2005-09-28 Warner-Lambert Company Llc Biopolymer compositons and products thereof
EP1745747A4 (en) 2004-05-13 2010-12-29 Next21 Kk DEVICE FOR HEMOSTASIS AND PREVENTION OF ADHESIONS FOR USE IN ENDOSCOPIC SURGERY
CA2571981C (en) * 2004-07-09 2014-12-30 Ferrosan A/S Haemostatic composition comprising hyaluronic acid
MY142987A (en) 2005-06-08 2011-02-14 Hayashibara Biochem Lab Solution for tissue adhesion prevention and method for tissue adhesion prevention
CN1709507A (zh) 2005-06-29 2005-12-21 肖春 外用复方止血镇痛消炎药
CN101272790A (zh) * 2005-09-22 2008-09-24 特罗比奥股份公司 稳定的蛋白酶组合物
JP5040234B2 (ja) 2006-09-26 2012-10-03 三菱電機株式会社 圧接型半導体装置
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
EP2219572A4 (en) 2007-12-06 2014-05-28 Nanosys Inc RESORBABLE HEMOSTATIC STRUCTURES ENHANCED BY NANOMATERIAL AND BANDING MATERIALS
AU2009220808B2 (en) * 2008-03-03 2014-01-16 Omrix Biopharmaceuticals Ltd. A gelatin sponge comprising an active ingredient, its preparation and use
FR2944706B1 (fr) 2009-04-28 2012-08-24 Biom Up Nouveaux materiaux en collagene et procedes d'obtention.
CN101757614B (zh) * 2010-02-22 2012-04-04 苏州汇涵医用科技发展有限公司 止血剂及其制备方法
CN101837143A (zh) * 2010-04-22 2010-09-22 胡堃 一种药物缓释止血组合物及制备方法
CA3108894A1 (en) * 2011-04-27 2012-11-01 Biom'up Hemostatic compositions

Also Published As

Publication number Publication date
DK3513803T3 (da) 2021-07-05
SI2701729T1 (sl) 2019-09-30
CN106390186B (zh) 2020-07-03
CN103635202B (zh) 2016-09-28
US10342856B2 (en) 2019-07-09
CA2830659A1 (en) 2012-11-01
US20140023714A1 (en) 2014-01-23
JP2014512403A (ja) 2014-05-22
EP2701729A1 (en) 2014-03-05
AU2021200468A1 (en) 2021-02-25
PL2701729T3 (pl) 2020-01-31
EP3513803A1 (en) 2019-07-24
CN103635202A (zh) 2014-03-12
ES2882911T3 (es) 2021-12-03
BR112013027567A2 (pt) 2020-06-09
US20230381288A1 (en) 2023-11-30
US9283187B2 (en) 2016-03-15
US20180318403A1 (en) 2018-11-08
US9662374B2 (en) 2017-05-30
US20160166655A1 (en) 2016-06-16
RS59243B1 (sr) 2019-10-31
AU2018274924A1 (en) 2019-01-03
AU2012247480B2 (en) 2016-09-22
BR122021017027B1 (pt) 2022-05-17
US10046034B2 (en) 2018-08-14
CN106390186A (zh) 2017-02-15
AU2012247480A1 (en) 2013-11-07
CA2830659C (en) 2021-02-16
US20170189499A1 (en) 2017-07-06
JP6050320B2 (ja) 2016-12-21
US20190282676A1 (en) 2019-09-19
AU2016277573B2 (en) 2018-09-06
CA3108894A1 (en) 2012-11-01
JP6235104B2 (ja) 2017-11-22
JP2017066150A (ja) 2017-04-06
BR112013027567B1 (pt) 2022-03-29
EP3513803B1 (en) 2021-05-19
EP3922261A1 (en) 2021-12-15
EP2701729B1 (en) 2019-05-22
AU2016277573A1 (en) 2017-01-12
WO2012146655A1 (en) 2012-11-01
AU2018274924B2 (en) 2020-11-19
PL3513803T3 (pl) 2021-11-22

Similar Documents

Publication Publication Date Title
CY1122251T1 (el) Αιμοστατικες συνθεσεις
JOP20180102B1 (ar) مركب صيدلاني
CY1118231T1 (el) Συνθεση λιποσωματος
CY1118416T1 (el) Υποκατεστημενες 4-φαινυλο-πυριδινες για τη θεραπεια ασθενειων που σχετιζονται με τον νκ-1 υποδοχεα
CY1114860T1 (el) Χρηση τετρα-καρβοξιμιδιων διθιινης για την καταπολεμηση φυτοπαθογονων μυκητων
RS54217B1 (en) SOME TRIAZOLOPIRAZINS, THEIR COMPOSITIONS AND THE METHODS OF USING THEM
CY1115708T1 (el) Τοπικες συνθεσεις για τη διατηρηση ή την ανακτηση της ακεραιοτητας των βλεννογονων
EA201590887A1 (ru) Композиция
WO2016061509A8 (en) Compositions and methods of treating muscular dystrophy
BR112014015909A8 (pt) composição
ECSP14004595A (es) 2-tiopirimidinonas
EA201491195A1 (ru) Способ получения композиции, содержащей галактоолигосахариды
MX2015015487A (es) NOVEDOSOS HIDRATOS CRISTALINOS DE 1-(ß-D-GLUCOPIRANOSIL)-4-METIL-3 -[5-(4-FLUORO-FENIL)-2-TIENIL-METIL]-BENCENO.
BR112018006314A2 (pt) composto da fórmula, composição, uso de composto da fórmula, método de combate a fungos fitopatogênicos e semente revestida
CR20150338A (es) Composiciones fungicidas sinérgicas
GEP201706760B (en) Novel abexinostate salt, associated crystalline form, preparation method thereof and the pharmaceutical compositions containing same
MX340147B (es) Composiciones farmacéuticas y nutracéuticas del ácido abscísico.
PH12015500231B1 (en) Injectable compositions comprising letrozole or anastrozole
CY1118514T1 (el) Μεθοδος για την παρασκευη πεμετρεξιδης και αλατος λυσινης αυτης
UA112556C2 (uk) Інсектицидні похідні 2-метоксибензамідів
PH12015501873B1 (en) Solid concentrate compositions containing zinc pyrithione
MX2018001517A (es) Derivados sustituidos de guanidina.
MX2016003566A (es) Composicion que contiene polietilen glicol.
MX2019004293A (es) Derivados de fenilamina sustituidos en la posicion 4 y uso de los mismos para proteger los cultivos combatiendo los microorganismos fitopatogenos no deseados.
BR112015002155A2 (pt) composição e método para prevenir a descoloração de composições contendo piritiona